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Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2
Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea
New Insight for Fluoroquinophenoxazine Derivatives as Possibly New Potent Topoisomerase Ⅰ Inhibitor
Kang, Da-Hye,Kim, Jung-Sook,Jung, Mi-Ja,Lee, Eung-Seok,Jahng, Yurngdong,Kwon, Youngjoo,Na, Younghwa 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.18
Fluoroquinolones, represented by ciproxacin and norfloxacin, are well known clinical antimicrobial agents, and their phenyl ring expanded quinophenoxazines are reported as possible antitumor active compounds. These quinophenoxazines are known to inhibit DNA topoisomerase II essential for cell replication cycle. But there were no reports for topoisomerase I inhibition study for these compounds. In this report, we have prepared a few quinophenoxazine analogues and tested their topoisomerases I and II inhibitory activities and cytotoxicity. From the result, we found that qumophenoxazine analogues possessed strong topoisomerase I inhibitory capacity as well as topoisomerase II inhibition. Among the compounds prepared, A-62176 analogues showed strong topoisomerases I and II inhibitory activities. Interestingly, compound 8 missing the 3-aminopyrrolidine moiety at C2 position has similar potent inhibitory capacity against topoisomerases I & II at higher concentrations (20 and 10 uM, respectively). But compound 8 inhibited topoisomerase I function more selectively at lower concentration, 2 uM. Our observation mi&ht strongly implicate that fluoroquinophenoxazines can be developed as efficient topoisomerase I inhibitor with the elaborate modification.
Da Eun Kwon,Da Mi Kim,Chang June Song,In Ho Lee,Yong Min Kim 대한영상의학회 2024 대한영상의학회지 Vol.85 No.1
Respiratory epithelial adenomatoid hamartoma (REAH) in the head and neck is a rare benign lesion containing glandular tissue covered with ciliated respiratory epithelium. In the head and neck, REAH of the nasal cavity, paranasal sinuses, and nasopharynx have been reported in literature. Due to rareness of REAH and insufficient knowledge of its imaging features, the diagnosis can be challenging when we encounter a non-specific cystic mass at an uncommon site in the head or neck. Here, we report the case of a pathologically confirmed REAH showing a cystic mass centered at the buccal space (retromaxillary fat pad) with CT and MRI findings.
RAW 264.7 대식세포에서 지질 다당류에 의한 미세먼지(PM<SUB>2.5</SUB>) 유발 염증 반응 증진에 미치는 ROS-NF-κB 신호 전달 경로의 역할
권다혜(Da Hye Kwon),김다혜(Da Hye Kim),김민영(Min Yeong Kim),황보현(Hyun Hwangbo),지선영(Seon Yeong Ji),박세광(Seh-Kwang Park),정지원(Ji-Won Jeong),김미영(Mi-Young Kim),이혜숙(Hyesook Lee),정재훈(JaeHun Cheong),남수완(Soo-Wan Nam),황혜 한국생명과학회 2021 생명과학회지 Vol.31 No.12
본 연구의 목적은 LPS가 처리된 RAW 264.7 대식세포에서의 염증 반응이 미세먼지(PM2.5)에 의해 더욱 증가될 수 있는지를 조사하는 것이다. 이를 위하여 LPS와 미세먼지(PM2.5)가 단독으로 처리되거나 LPS가 존재하는 조건에서 미세먼지(PM2.5)가 처리된 RAW 264.7 세포에서 염증 매개변수와 ROS의 생성 정도 및 염증 조절 유전자들의 발현 수준을 조사하였다. 본 연구의 결과에 의하면 세포 독성이 없는 범위에서 LPS가 처리된 세포에서 미세먼지(PM2.5)는 염증성 매개 인자(NO 및 PGE₂) 및 cytokine (IL-6 및 IL-1β)의 생성 수준이 각각의 단독 처리군에 비하여 매우 증가되었으며. 이는 이들의 생성에 관여하는 유전자들의 전사 및 번역 수준에서의 발현 증가와 연관성이 있었다. 또한, LPS가 처리된 RAW 264.7 세포에 미세먼지(PM2.5)가 노출되었을 때, 핵에서 NF-κB의 발현이 더욱 증가하였고, 세포질에서는 NF-κB 뿐만 아니라 IκB-α의 발현이 감소되었다. 이러한 결과는 LPS와 미세먼지(PM2.5)의 단독 처리에 비하여 동시 처리된 경우 NF-κB 신호계의 활성이 더욱 증가하여 염증성 유전자들의 전사 활성 촉진에 기여하였음을 의미한다. 나아가 LPS가 처리된 RAW 264.7 세포에서 미세먼지(PM2.5)에 의해 ROS 생성이 크게 증가되었지만 NF-κB 억제제는 ROS의 생성을 감소시키지 못하였다. 그러나, ROS 생성을 인위적으로 억제하였을 경우, 미세먼지(PM2.5)에 의해 증가된 염증 매개 인자의 발현 및 생성과 NF-κB의 활성화가 모두 감소되었다. 따라서, 본 연구의 결과는 LPS가 처리된 RAW 264.7 세포에서 미세먼지(PM2.5)에 의해 유도된 NF-κB 매개 염증 반응의 증가는 ROS 생성 의존적 현상임을 시사한다. The purpose of this study was to investigate whether the inflammatory response in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages could be promoted by particulate matter 2.5 (PM2.5) stimulation. To this end, the levels of inflammatory parameters, reactive oxygen species (ROS) and inflammation-regulating genes were investigated in RAW 264.7 cells treated with PM2.5 in the presence or absence of LPS. Our results showed that the production levels of pro-inflammatory mediators (nitric oxide and prostaglandin E₂) and cytokines (interleukin-6 and -1β) were significantly increased by PM2.5 stimulation in LPS-treated RAW 264.7 cells, which was correlated with increased expression genes involved in their production. In addition, when LPS-treated RAW 264.7 cells were exposed to PM2.5, nuclear factor-kappaB (NF-κB) expression was further increased in the nucleus, and the expression of inhibitor of NF-κB as well as NF-κB in the cytoplasm was decreased. These results suggest that the co-treatment of PM2.5 and LPS further increases the activation of the NF-κB signaling pathway compared to each treatment alone, thereby contributing to the promotion of transcriptional activity of inflammatory genes. Furthermore, although the generation of ROS was greatly increased by PM2.5 in LPS-treated RAW 264.7 cells, the NF-κB inhibitor did not reduce the generation of ROS. In addition, when the generation of ROS was artificially suppressed, the production of inflammatory mediators and the activation of NF-κB were both abolished. Therefore, our results suggest that the increase in the NF-κB-mediated inflammatory response induced by PM2.5 in LPS-treated RAW 264.7 macrophages was a ROS generation-dependent phenomenon.
Ha, Soojin,Ahn, Il Young,Kim, Da-eun,Lee, Jong Kwon,Sohn, Soojung,Jung, Mi-Sook,Heo, Yong,Omori, Takashi,Bae, SeungJin,Lim, Kyung-Min Elsevier 2017 Regulatory toxicology and pharmacology Vol.85 No.-
<P><B>Abstract</B></P> <P>Recently UN GHS has introduced the sub-categorization of skin sensitizers for which ECt (concentration estimated to induce stimulation index above threshold) of the murine local lymph node assay (LLNA) is used as criteria. Non-radioisotopic variants of LLNA, LLNA: DA, LLNA: BrdU-ELISA, LNCC and LLNA: BrdU-FCM were developed yet their utilities for potency sub-categorization are not established. Here we assessed the agreement of LLNA variants with LLNA or human data in potency sub-categorization for 22 reference substances of OECD TG429. Concordance of sub-categorization with LLNA was highest for LLNA: BrdU-FCM(91%, κ = 0.833, weighted kappa) followed by LLNA: BrdU-ELISA (82%, κ = 0.744) and LLNA: DA (73%, κ = 0.656) whereas LNCC only showed a modest association (64%, κ = 0.441). With human data, LLNA agreed best (77%) followed by LLNA: DA and LLNA: BrdU-FCM(73%), LLNA: BrdU-ELISA (68%) and LNCC(55%). Bland-Altman plot revealed that ECt's of LLNA variants largely agreed with LLNA where most values fell within 95% limit of agreement. Correlation between ECt's of LLNA and LLNA variants were high except for LNCC(pair-wise with LLNA, LLNA: DA, <I>r</I> = 0.848, LLNA: BrdU-ELISA, <I>r</I> = 0.744, LLNA: BrdU-FCM, <I>r</I>=0.786, and LNCC, <I>r</I> = 0.561 by Pearson). Collectively, these results demonstrated that LLNA variants exhibit performance comparable to LLNA in the potency sub-categorization although additional substances shall be analyzed in the future.</P> <P><B>Highlights</B></P> <P> <UL> <LI> LLNA and LLNA variants were assessed for potency subcategorization of skin sensitizers. </LI> <LI> LLNA and LLNA variants were compared with human data for 22 reference chemicals. </LI> <LI> LLNA variants exhibit performances comparable to LLNA (55–73% vs 77%). </LI> </UL> </P>
Development of skin bioactive care medical device material using red algae derived λ-carrageenan.
( Da-in Choi ),( Gun-hee Lee ),( Mi-hyang Sin ),( Byung-kwon Moon ),( Jin Kim ),( Min-sung Kim ),( Sook-young Lee ) 한국피부장벽학회 2023 한국피부장벽학회지 Vol.25 No.2
The purpose of this study is to develop a skin bioactive care medical device material that promotes skin bioactivity and has proven anti-aging, anti-inflammatory, and moisturizing effects by extracting λ-carrageenan from red algae species such as G. verrucosa, G. vermiculophylla, C.tenellus, and G.furcata. We have established an extraction and refining process for λ-carrageenan from the four red algae species, which yielded a 12.2% extraction efficiency according to the Food Safety Korea guidelines. The comparison of the FT-IR spectra revealed that λ-carrageenan exhibited a characteristic peak at 830 cm-1, in the region of β-D-galactose-2-sulfate, and showed a similar overall pattern to the control group. The quantitative analysis of the monosaccharide composition of λ-carrageenan indicated that it contained 55.32% galactose and 25.14% glucose. In the MTT assay conducted on Raw264.7 and HaCaT cells, λ-carrageenan demonstrated a cell survival rate of over 80% even at a concentration of 5000 μg/mL. To evaluate the anti-aging, anti-inflammatory, and moisturizing efficacy of λ-carrageenan, the levels of MMP-1 (collagenase) production, nitric oxide (NO) production, and hyaluronic acid (HA) production were examined in both Raw264.7 and HaCaT cell lines. The concentrations tested were 100, 300, and 500 μg/mL. The results of the study demonstrated that λ-carrageenan had significant effects on the production of nitric oxide (NO) and MMP-1 (collagenase), showing inhibition compared to the control group. Additionally, the production of hyaluronic acid (HA) was increased. The stability testing of the bioactive care medical device cream containing λ-carrageenan was conducted using various conditions. These conditions included light exposure, temperatures of 5℃, 25℃, and 40℃, and durations of 1, 7, 15, and 30 days. The pH changes, separation and precipitation, discoloration, and odor were examined, and it was confirmed that the material remained stable. Therefore, it can be inferred that λ-carrageenan derived from red algae is suitable as an effective component in skin bioactive care medical devices, medical device creams, and cosmeceutical materials for skin damage treatment and regeneration. Additionally, it can also contribute to skincare and beauty routines.
Injectable in situ-forming hydrogel for cartilage tissue engineering
Kwon, Jin Seon,Yoon, So Mi,Kwon, Doo Yeon,Kim, Da Yeon,Tai, Guo Zhe,Jin, Ling Mei,Song, Boram,Lee, Bong,Kim, Jae Ho,Han, Dong Keun,Min, Byoung Hyun,Kim, Moon Suk The Royal Society of Chemistry 2013 Journal of materials chemistry. B, Materials for b Vol.1 No.26