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유영희,정태충 慶熙大學校 材料科學技術硏究所 1990 材料科學技術硏究論集 Vol.3 No.-
In our information society, new type instruction and learning should be developed to overcome "the flood of information" effetively. For this reason, information retieval system can be utilized in the feild of CAI. In this paper, we show the full text retrieval which is designed by us. This system has some facilities such as full-down menu, key word searching, indx searching, graphic representation, ect.
벡트래킹 방법과 분기 및 한계 방법의 성능 비교 : O/1 Knapsack 문제를 대상으로
김명재,정태충 慶熙大學校 1990 論文集 Vol.19 No.-
Many Al problems have a common property of NP-complexity. Such problem can be solved effectively using the heuristic knowledges of the problem. There are two typical algorithmic methods to deal with Al problem, i.e. backtracking method and Branch-and-bound method. In this paper, the methods are compared using the developed programs when to solve a NP problem, such as O/I Knapsack problem. As a result, The least cost branch-and-bound method is prefer to backtracking method except for some simple and best cases.
강국희,전태욱,정충일 성균관대학교 생명과학자원연구소 1996 生命資源科學硏究 Vol.3 No.1
A case study was conducted on decrease of bacteria and somatic cell count in the raw milk for the raw milk quality improvement. This study was carried on SK dairy farm in Suwon city that had 4 dairy milking cows. The experiment was tested on 2 cows each for control group and treatment group respectively. Criteria of evaluation on raw milk quality were number of total bacteria, Psychrotrophic bacteria, thermophilic bacteria, coli group and somatic cells. All the cows were applied the same feeding system for 86 days (Mar, 14∼Jane, 7) The results obtained were as follows : Milk contents were fat 3.1%∼4.19% for control group and 3.21%∼4.76% for treatment group; protein 2.65%∼4% for control and 3.04%∼4.37% for treatment; carbohydrate 4.09%∼4.86% for control and 4%∼4.94% for treatment. SNF 7.78%∼9.45% for control and 8.05%∼9.7% for treatment. There was no significant difference in milk contents between control group and treatment. The number of total bacteria was about 8.0×10 exp(5)/ml for control group and 1.0 × 10 exp(5)/ml for treatment group. Psychorotophic bacteria were distributed from 1.79 × l0P/ml to 9.55×10 exp(5) /ml for control group and 5.4×10 exp(3)/ml to 8.95×10 exp(5)/ml for treatment group. Thermophilic bacteria indicated from 6.0×10 exp(3)/ml to 8.95×10 exp(5)/ml for control group, and 5.5×10 exp(2)/ml to 1.1×10 exp(4)/ml for treatment group. The coli group indicated about from 1.6×10 exp(3)/ml to 2.3×10 exp(4)/ml for control group and 1.0×10 exp(2)/ml to 2.9×10 exp(4)/ml for treatment group. The number of somatic cells were 1,534,000(±234,012) for cow No. 2; 197,000 (±59,681) for cow No. 4; 4,240,000 (±1,094,459) for cow No. 9; 951,000 (±784,990) for cow No. 13 respectivley during the experiment period. The somatic cell count did not decrease by the sanitary handling on cows and the tools during experiment period.
최연수,박일,죄희충,김원식,양태영,허경,안기완,정춘해 조선대학교 1993 The Medical Journal of Chosun University Vol.18 No.2
Histiocytic medullary reticulosis (HMR) is a malignant noeplastic process, with tumor cells belonging to the histiomonocytic line, and originally described by Scott and Robb-Smith in 1939 characterized by its acute onset, progression to death within a few months and its clinical features are fever, lymphadenopathy, hepatosplenomegaly, jaundice, and purpura common laboratory findings are characterized by severe anemia, leukopenia, thrombocytopenia and histologically by systemic progressive invasion of morphologically atypical histiocytes or of their precursor. 61 and 37-year-old males were admitted with camplaints of high fever and chilling sensation and were treated by cyclophosphamide, vincristine, prednison and antiobiotics, but patients all died 17 and 14 days after admission due to probably sepsis and respiratory failure.
ORIGINAL ARTICLE : CAPE suppresses VEGFR-2 activation, and tumor neovascularization and growth
( Tae Wook Chung ),( Seok Jo Kim ),( Hee Jung Choi ),( Choong Hwan Kwak ),( Kwon Ho Song ),( Seok Jong Suh ),( Keuk Jun Kim ),( Ki Tae Ha ),( Young Guk Park ),( Young Chae Chang ),( Hyeun Wook Chang ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
The growth and metastasis of human solid tumors and the development of conditions such as diabetic retinopathy, rheumatoid arthritis, inflammatory psoriasis, and others are regulated by the balance between angiogenic stimulators and inhibitors released in the angiogenic-pathological microenvironment. Vascular endothelial growth factor (VEGF), an angiogenic factor, is a potent endothelial-specific mitogen that activates endothelialcells in pathological angiogenesis. Recently, we demonstrated that caffeic acid phenethyl ester (CAPE) inhibits tumor growth, invasion, and metastasis. However, the precise molecular mechanism underlying the inhibitory effect of CAPE on VEGF-mediated angiogenesis remains unknown. Here, we show that CAPE suppressed VEGF-induced proliferation, tube formation, migration, the formation of actin stress fibers and loss of VE-cadherin at cell-cell contacts in endothelial cells, indicating the inhibition of VEGF-mediated VEGF receptor-2 (VEGFR-2) and its downstream signal activation in vitro. CAPE blocked VEGF-stimulated neovascularization in the Matrigel plugs assay, and reduced vascular permeability in mouse skin capillaries in vivo. CAPE inhibited the growth and neovascularization of primary tumor cells in C57BL/6 and BALB/c mice inoculated with Lewis lung carcinoma, colon carcinoma, and melanoma cells. These results suggest that CAPE negatively modulates VEGF-induced angiogenesis by suppressing VEGFR-2 activation, and might be a therapeutic avenue for anti-angiogenesis.
The Ganglioside GM3 Is Associated with Cisplatin-Induced Apoptosis in Human Colon Cancer Cells
( Tae Wook Chung ),( Hee Jung Choi ),( Seok Jo Kim ),( Choong Hwan Kwak ),( Kwon Ho Song ),( Un Ho Jin ),( Young Chae Chang ),( Hyeun Wook Chang ),( Young Choon Lee ),( Ki Tae Ha ),( Cheorl Ho Kim ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Cisplatin (cis-diamminedichloroplatinum, CDDP) is a well-known chemotherapeutic agent for the treatment of several cancers. However, the precise mechanism underlying apoptosis of cancer cells induced by CDDP remains unclear. In this study, we show mechanistically that CDDP induces GM3-mediated apoptosis of HCT116 cells by inhibiting cell proliferation, and increasing DNA fragmentation and mitochondria-dependent apoptosis signals. CDDP induced apoptosis within cells through the generation of reactive oxygen species (ROS), regulated the ROS-mediated expression of Bax, Bcl-2, and p53, and induced the degradation of the poly (ADP-ribosyl) polymerase (PARP). We also checked expression levels of different gangliosides in HCT116 cells in the presence or absence of CDDP. Interestingly, among the gangliosides, CDDP augmented the expression of only GM3 synthase and its product GM3. Reduction of the GM3 synthase level through ectopic expression of GM3 small interfering RNA (siRNA) rescued HCT116 cells from CDDP-induced apoptosis. This was evidenced by inhibition of apoptotic signals by reducing ROS production through the regulation of 12-lipoxigenase activity. Furthermore, the apoptotic sensitivity to CDDP was remarkably increased in GM3 synthase-transfected HCT116 cells compared to that in controls. In addition, GM3 synthase-transfected cells treated with CDDP exhibited an increased accumulation of intracellular ROS. These results suggest the CDDP-induced oxidative apoptosis of HCT116 cells is mediated by GM3.