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Hui-Su Lee,Hwa-Yong Lee,Chang-Duck Koo 한국버섯학회 2010 한국버섯학회지 Vol.8 No.4
The effect of sterilization and incubation temperatures of fermented oak sawdust on Lentinula edodes hyphal growth was investigated. The pile of 33 tonnes of oak sawdust fermented in a plastic shed for 24 days. During the fermentation the acidity of the sawdust within the pile was lowered to pH 4.2 and temperatures increased to 58℃ in over 20cm depth. The sawdust samples collected at 20, 60, 80 and 100㎝ depth each and moistened to 65% water content were sterilized at 65, 100 and 121℃ each for an hour. The sterilized sawdust contained in 50㎖ test tubes was inoculated with L. edodes hyphae cultured on potato dextrose agar medium and then was incubated at 15, 20, 25℃ for four weeks. L. edodes hyphae grew faster, 94.6mm, on the sawdust collected from 60cm depth than other depths, and did at 25 incubation temperature after sterilization at 121℃. The hypahe grew only 9.9cm on the sawdust from 100cm depth. When the sawdust from 60cm depth was sterilized at 100℃, the hyphae grew best by 22.1cm at 15℃. However, on the sawdust sterilized at 65℃ the hyphae did not grow at all. Thus, we conclude that sawdust fermentation under 60㎝ depth and autoclaving it can improve L. edodes hyphal growth, but the sterilization of sawdust at 65℃ is not sufficient for the hyphal growth.
Survey-Based Analysis of the Clinical Treatment Status of Irritable Bowel Syndrome in Korea
Koo Hoon Sup,Son Hui Chang,이홍섭,Goong Hyeon Jeong,김주석,김기배,Kwon Yong Hwan,김재학,신현덕,Shin Ji Eun,지삼룡 대한의학회 2023 Journal of Korean medical science Vol.38 No.16
Background: The quality-of-life of patients with irritable bowel syndrome is low; incorrect diagnosis/treatment causes economic burden and inappropriate consumption of medical resources. This survey-based study aimed to analyze the current status of irritable bowel syndrome treatment to examine differences in doctors’ perceptions of the disease, and treatment patterns. Methods: From October 2019 to February 2020, the irritable bowel syndrome and Intestinal Function Research Study Group of the Korean Society of Neurogastroenterology and Motility conducted a survey on doctors working in primary, secondary, and tertiary healthcare institutions. The questionnaire included 37 items and was completed anonymously using the NAVER platform (a web-based platform), e-mails, and written forms. Results: A total of 272 doctors responded; respondents reported using the Rome IV diagnostic criteria (amended in 2016) for diagnosing and treating irritable bowel syndrome. Several differences were noted between the primary, secondary, and tertiary physicians’ groups. The rate of colonoscopy was high in tertiary healthcare institutions. During a colonoscopy, the necessity of random biopsy was higher among physicians who worked at tertiary institutions. ‘The patient did not adhere to the diet’ as a reason for ineffectiveness using low-fermentable oligo-, di-, and mono-saccharides, and polyols diet treatment was higher among physicians in primary/secondary institutions, and ‘There are individual differences in terms of effectiveness’ was higher among physicians in tertiary institutions. In irritable bowel syndrome constipation predominant subtype, the use of serotonin type 3 receptor antagonist (ramosetron) and probiotics was higher in primary/secondary institutions, while serotonin type 4 receptor agonist was used more in tertiary institutions. In irritable bowel syndrome diarrhea predominant subtype, the use of antispasmodics was higher in primary/secondary institutions, while the use of serotonin type 3 receptor antagonist (ramosetron) was higher in tertiary institutions. Conclusion: Notable differences were observed between physicians in primary/secondary and tertiary institiutions regarding the rate of colonoscopy, necessity of random biopsy, the reason for the ineffectiveness of low-fermentable oligo-, di-, and mono-saccharides, and polyols diet, and use of drug therapy in irritable bowel syndrome. In South Korea, irritable bowel syndrome is diagnosed and treated according to the Rome IV diagnostic criteria, revised in 2016.
Kim, Chin,Koo, Chang-Hui,Choi, Dong-Young,Cho, Yong-Joon,Choi, Jae-Ho,Im, Doo-Hyeon,Jhoo, Wang-Kee,Kim, Hyoung-Chun The Pharmaceutical Society of Korea 1996 Archives of Pharmacal Research Vol.19 No.5
The antioxidant efficacy of aspalatone, a new antithrombotic agent, has been recognized in the neurotoxic model and in the cardiotoxic model in proliminary studies. We examined the specific activity of antiosidnat enzyme in the rat blood following administrations of aspirin, maltol, aspirin together with maltol, salicylmaltol (major metabolite of aspalatone) and aspalatone, respectively. Our assessment showed that salicylmaltol, maltol, aspalatone enhanced antiperoxidative activity. In addition, neither aspirin nor combination of aspirin and maltol, showed any significant effect on the activity of antioxidant enzyme. Because $H_{2}$$O_{2}$ accumulation may stimulate the thrombogenesis in blood, the result suggests that the induction of blood antiperoxidative activity produced by aspalatone may have beneficial effects on the thrombogenesis.
박세희 ( Se Hui Park ),이화용 ( Hwa Yong Lee ),박용우 ( Yong Woo Park ),이희수 ( Hee Su Lee ),구창덕 ( Chang Duck Koo ),조경진 ( Kyung Jin Cho ) 한국임학회 2014 산림과학 공동학술대회 논문집 Vol.2014 No.-
본 연구의 목적은 국내 자생 뽕나무버섯속 버섯들의 형태적 변이 차이를 알아보는데 있다. 뽕나무버섯속의 자실체는 충북 괴산과 청주의 재래시장에서 구매 하였으며, 충북 월악산, 충남 계룡산, 경북 문경, 전북 완주, 경기 가평, 강원 평창에서 채집하였다. 채집한 자실체는 형태학적 그리고 분자생물학적으로 동정하였다. 채집된 자실체에서 갓의 직경과 색, 대의 길이와 색, 담자기와 포자의 형태와 크기 등을 관찰 및 측정하였다. 갓 직경은 Armillaria mellea는 28.43±4.1 ㎜, A. solidipes는 47.6±9.3 ㎜, A. gallica는 26.8±3.4 ㎜, A. sinapina는 54.5±9.0 ㎜ 이었다. 갓의 색은 A. mellea는 흐린황갈색, A. solidipes와 A. sinapina는 연한황갈색, A. gallica는 노란갈색이었다. 대 길이는 A. mellea는 58.7±5.2 ㎜, A. solidipes는 68.7±13.6 ㎜, A. gallica는 49.7±5.1 ㎜, A. sinapina는 62.6±4.8㎜이었다. 갓의 직경/대 길이 비는 A. sinapina가 약 0.83, A. solidipes는 약 0.67, A. gallica는 약 0.52, 그리고 A. mellea는 약 0.51이었다. 뽕나무버섯속 버섯은 일반형의 담자기를 가지고 있으며, A. solidipes와 A. gallica는 담자기의 기부에서 클램프가 관찰되었다. 뽕나무버섯속 버섯은 타원형의 포자를 가지고 있으며, 장경길이는 8.0±0.6 ㎛, 단경길이는 5.4±0.7 ㎛ 이었다. The purpose of this study was to identify morphological variance of Armillaria sp. Fruit bodies of Armillaria sp purchased traditional market at Goesan and Cheongju, and collected Jecheon, Gyeryong, Mungyeong, Wanju, Gapyeong, Pyeongchang. The collected fruit bodies were identified by morphological and molecular biology, and were observed cap diameter and color, stipe length and color, shape and size of basidium and spore. Cap diameter of A. mellea was 28.43 ± 4.1 ㎜, A. solidipes was 47.6 ± 9.3 ㎜, A. gallica was 26.8 ± 3.4 ㎜, and A. sinapina was a 54.5 ± 9.0 ㎜. Cap color of A. mellea was dark grayish yellow, A. solidipes and A. sinapina was moderate yellow, and A. gallica was light olive brown. Length of stipe was A. mellea was 58.7 ± 5.2 ㎜, A. solidipes was 68.7 ± 13.6 ㎜, A. gallica was 49.7 ± 5.1 ㎜, and A. sinapina was 62.6 ± 4.8 ㎜. Cap diameter/stipe length ratio of A. sinapina was about 0.83, A. solidipes was about 0.63, A. gallica was about 0.52, and A. mellea was about 0.51. Basidium of Armillaria sp was homobasidum, and A. solidipes and A. gallica is observed basal clamp. Spore of Armillaria sp was ellipsoid, and major axis length of 8.0 ± 0.6 ㎛, and a minor axis length was 5.4 ± 0.7 ㎛.