http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Bao Yi-Ni,Dai Wen-Ling,Fan Ji-Fa,Ma Bin,Li Shan-Shan,Zhao Wan-Li,Yu Bo-Yang,Liu Ji-Hua 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Dopamine D1 receptor (D1DR) and D2 receptor (D2DR) are closely associated with pain modulation, but their exact effects on neuropathic pain and the underlying mechanisms remain to be identified. Our research revealed that intrathecal administration of D1DR and D2DR antagonists inhibited D1–D2DR complex formation and ameliorated mechanical and thermal hypersensitivity in chronic constriction injury (CCI) rats. The D1–D2DR complex was formed in the rat spinal cord, and the antinociceptive effects of D1DR and D2DR antagonists could be reversed by D1DR, D2DR, and D1–D2DR agonists. Gαq, PLC, and IP3 inhibitors also alleviated CCI-induced neuropathic pain. D1DR, D2DR, and D1–D2DR complex agonists all increased the intracellular calcium concentration in primary cultured spinal neurons, and this increase could be reversed by D1DR, D2DR antagonists and Gαq, IP3, PLC inhibitors. D1DR and D2DR antagonists significantly reduced the expression of p-PKC γ, p-CaMKII, p-CREB, and p-MAPKs. Levo -corydalmine ( l -CDL), a monomeric compound in Corydalis yanhusuo W.T. Wang, was found to obviously suppress the formation of the spinal D1–D2DR complex to alleviate neuropathic pain in CCI rats and to decrease the intracellular calcium concentration in spinal neurons. l- CDL-induced inhibition of p-PKC γ, p-MAPKs, p-CREB, and p-CaMKII was also reversed by D1DR, D2DR, and D1–D2DR complex agonists. In conclusion, these results indicate that D1DR and D2DR form a complex and in turn couple with the Gαq protein to increase neuronal excitability via PKC γ, CaMKII, MAPK, and CREB signaling in the spinal cords of CCI rats; thus, they may serve as potential drug targets for neuropathic pain therapy.
Transverse vibration of flexible hoisting rope with time-varying length
Ji-hu Bao,Peng Zhang,Chang-Ming Zhu,Wei Sun 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.2
The nonlinear vibration of a flexible hoisting rope with time-varying length is investigated. The governing equations of the flexible hoistingrope are developed based on Hamilton’s principle. Experiments performed evaluated the theoretical model and found that the experimentaldata agree well with the theoretical prediction, which validates the mathematical model of the flexible hoisting system. The resultsof the simulations and experiments show that the flexible hoisting system dissipates energy during downward movement (thus is stabilized)and gains energy during upward movement (thus is unstabilized). In addition, a passage through resonance in the hoisting system withperiodic external excitation is analyzed. Due to the time-varying length of the hoisting rope the natural frequencies of the system varyslowly, and transient resonance may occur when one of the frequencies coincides with the frequency of an external excitation.
Bao-Ji Zhang,Zhu-Xin Zhang 대한조선학회 2015 International Journal of Naval Architecture and Oc Vol.7 No.5
To obtain low resistance and high efficiency energy-saving ship, minimum total resistance hull form design method is studied based on potential flow theory of wave-making resistance and considering the effects of tail viscous separation. With the sum of wave resistance and viscous resistance as objective functions and the parameters of B-Spline function as design variables, mathematical models are built using Nonlinear Programming Method (NLP) ensuring the basic limit of displacement and considering rear viscous separation. We develop ship lines optimization procedures with intellectual property rights. Series60 is used as parent ship in optimization design to obtain improved ship (Series60-1) theoretically. Then drag tests for the improved ship (Series60-1) is made to get the actual minimum total resistance hull form.
Zhang, Bao-Ji,Zhang, Zhu-Xin The Society of Naval Architects of Korea 2015 International Journal of Naval Architecture and Oc Vol.7 No.5
To obtain low resistance and high efficiency energy-saving ship, minimum total resistance hull form design method is studied based on potential flow theory of wave-making resistance and considering the effects of tail viscous separation. With the sum of wave resistance and viscous resistance as objective functions and the parameters of B-Spline function as design variables, mathematical models are built using Nonlinear Programming Method (NLP) ensuring the basic limit of displacement and considering rear viscous separation. We develop ship lines optimization procedures with intellectual property rights. Series60 is used as parent ship in optimization design to obtain improved ship (Series60-1) theoretically. Then drag tests for the improved ship (Series60-1) is made to get the actual minimum total resistance hull form.
ZNF204P is a stemness-associated oncogenic long non-coding RNA in hepatocellular carcinoma
( Ji-hyun Hwang ),( Jungwoo Lee ),( Won-young Choi ),( Min-jung Kim ),( Jiyeon Lee ),( Khanh Hoang Bao Chu ),( Lark Kyun Kim ),( Young-joon Kim ) 생화학분자생물학회 2022 BMB Reports Vol.55 No.6
Hepatocellular carcinoma is a major health burden, and though various treatments through much research are available, difficulties in early diagnosis and drug resistance to chemotherapy-based treatments render several ineffective. Cancer stem cell model has been used to explain formation of heterogeneous cell population within tumor mass, which is one of the underlying causes of high recurrence rate and acquired chemoresistance, highlighting the importance of CSC identification and understanding the molecular mechanisms of CSC drivers. Extracellular CSCmarkers such as CD133, CD90 and EpCAM have been used successfully in CSC isolation, but studies have indicated that increasingly complex combinations are required for accurate identification. Pseudogene-derived long non-coding RNAs are useful candidates as intracellular CSC markers - factors that regulate pluripotency and self-renewal - given their cancer-specific expression and versatile regulation across several levels. Here, we present the use of microarray data to identify stemness-associated factors in liver cancer, and selection of sole pseudogenederived lncRNA ZNF204P for experimental validation. ZNF204P knockdown impairs cell proliferation and migration/invasion. As the cytosolic ZNF204P shares miRNA binding sites with OCT4 and SOX2, well-known drivers of pluripotency and self-renewal, we propose that ZNF204P promotes tumorigenesis through the miRNA-145-5p/OCT4, SOX2 axis. [BMB Reports 2022; 55(6): 281-286]
Bao, Le Quoc,Phuong, Ho,Thuy, Chau Thi Thanh,Lee, Ji Won,Kim, Jae Hong,Thogiti, Suresh Informa UK (TaylorFrancis) 2017 Molecular Crystals and Liquid Crystals Vol.653 No.1
<P>Two double branched organic dyes (T1I and T2I) were synthesized, characterized, and employed as photosensitizers in p-type dye-sensitized solar cells (p-DSSC); we have compared with corresponding single branched dye (TC1) and reference dye P1. The absorbance of the dyes in solution was red shifted and the oxidation potential gradually decreased with increasing the donating ability. It was found that modification from single branched (TC1) to double branched (T1I and T2I) system resulted in increased photocurrent density leading to the higher photovoltaic performances. The charge transporting ability is increased with the introduction of double branching, as evidenced from electrochemical impedance analysis.</P>