Synthesis of Fluorescent Carbon Dot Probe from Natural Sources for Novel Bioimaging Agent

( Phuong ),김슬기,박성영 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0

We synthesized biocompatible and stable fluorescent carbon dot probe from a natural source, Curcuma longa. The fluorescent nanoparticles (C-FNPs) derived from carbonization process showed multi-color fluorescence emissions which had small particle size (~17 nm) and were water-soluble. The surface passivated with polyethylene glycol (PEG) capped with amine groups in FNPs (P-FNPs) generated a sensor with higher quantum yield and longer fluorescence lifetime than obtained with C-FNPs. Furthermore, the prepared material showed an excellent biocompatibility with almost 100% cell viability, even at high concentrations of materials. Due to their stability and small size in water, this system offers a potential method to generate a novel cell imaging agent. Therefore, fluorescence sensors from natural sources may be useful for numerous biomedical research applications.

1P-177 Design of Surface-coatable NIR-responsive Fluorescent Nanoparticles with PEI Passivation for Bacterial Detection and Killing

( Phuong ),노상규,박성영 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1

We successfully synthesized a polyethyleneimine (PEI)-passivated polydopamine-based fluorescent carbon nanoparticle detection probe (FDA:PEI), generating a cationic adhesive material for bacterial detection that can be coated, owning photothermal, and antibacterial properties. Using fluorescence on/off system, FDA:PEI displayed ability to detect bacteria in both aqueous and solid phase assays. Scanning electron microscopy demonstrated the interaction between FDA:PEI and bacterial surfaces, in solution and on the surface of coated polypropylene films. In addition, this versatile material displayed antibacterial potential, by using near infrared irradiation to induce heat for killing bacteria through thermolysis. By exploiting the cationic and catechol moieties on the surface of pDA carbon dots, we have developed a novel bacterial detection platform that can be applied over a broad range of conditions. ^**This work was supported by Korea National University of Transportation in 2017.

Coatable pH-sensitive Fluorescent Carbon Nanoparticles for Visualizing Antifouling Activity based Fluorescence “ON/OFF” Behavior

( Phuong ),박성영 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0

pH-responsive fluorescent carbon nanoparticles (FNPs) combined with fluorescent, colorimetric, and electrochemical signals generated from coated surfaces, we have discovered a fast and convenient method to observe antifouling performance of FNP-coated surfaces with mamma-lian cell and bacterial based on fluorescent off/on signal. FNPs were carbonized from zwitterionic polymer, which is coatable on various surfaces and highly sensitive in a broad range of pH. The coated surfaces showed excellent antifouling effect of mammalian cells adhesion and exhibited a strong interaction with bacteria surface as observed in a fluorescence behavior. FNP-modified electrode showed a decrease in electrochemical current attributed high sensitivity to biofouling formation in various pH. In conclusion, a pH-switchable zwitterionic FNP-coated surface is introduced as a fast and accurate method for detection and control the biological adhesion onto diverse surfaces based on fluorescent behavior.

pH-sensitive Polymer Dot Coated Surfaces as Electrochemical and Fluorescent Bacterial and Cell Sensing Probe

( Phuong ),박성영 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1

Overcoming the recent drawbacks for detection the presence of cells on the surface, a pH-switchable zwitterionic polymer dot (PD) is proposed here as a fast and efficient method to detect and control the biological adhesion of cells and bacteria in accordance with fluorescent ON/OFF phenomena and electrochemical signals generated. The surfaces coated with PD showed high sensitivity under different pH conditions, expressing effective resistance to cellular attachment in acidic and basic environments as well as ionic interactions with the bacterial surface. These interactions could be identified rapidly and with high accuracy by analyzing the fluorescent behavior and current signal generated by cyclic voltammetry. Therefore, PD-coated surfaces represent as a smart surface to visualize and controll biological cell attachment with high sensitivity, biocompatibility, selectivity, and accuracy. This work was supported by Korea National University of Transportation in 2019.

Controllable Photothermal Temperature of Redox-responsive Polymer Dot-incorporated Hydrogel for Cancer Therapy

( Phuong ),이기백,박성영 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1

Herein, a near-infrared light-induced redox-sensitive hydrogel was synthesized by incorporation of IR825 loaded-polymer dot (PD-IR825) into thermosensitive poly(N-isopropylacrylamide) hydrogel for study of nanoparticles mobility inside network via reversible temperature memory by redox changes. PD-IR825 inside the hydrogel network performed fluorescent and photothermal properties, exhibiting shrinking in volume behavior upon NIR at redox condition. The photothermal effect, fluorescence, and microstructure of hydrogel could be controlled under NIR on/off cycles. Furthermore, MDAMB cancer cells were incubated with composite hydrogel and exogenous GSH showed enhanced photothermal effect, that effectively killed cancer cells under NIR laser. Hence, light-induced redox-sensitive composite hydrogel has shown its potential in photothermal cancer treatment with study nanoparticles mobility inside hydrogel networks. ** This work was supported by Korea National University of Transportation in 2019.

pH/Redox-responsive Cationic Polymer Dot for Selective and Controllable Photothermal Cancer Therapy

( Phuong ),박성영 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0

Herein, pH/redox responsive cationic polymer dot (CD) was synthesized for controllable photothermal effect using off/on fluorescent system to control therapeutic agent’s release. The disulfide crosslinked polyethyleneimine (bPEI) was carbonized and conjugated with folic acid (FA) and partially ionic complexed with indocyanine green (ICG), resulting in bPEI-based CD (ICG-CD). ICG-CD was internalized into cancer cells via FA-receptor and endocytosis in OFF-state, and fluorescence partially recovered in high GSH, then internalized into acidic endosomes to proceed complete fluorescence restoration. This tumorselective degradability also allowed controllable photothermal therapy under NIR irradiation, improving anticancer efficiency. As a result, ICG-CD displayed potential in tumor targeting, intracellular imaging, and controllable therapeutic delivery via fluorescence off/on assay.

Immobilization of Tungsten Catalyst in Processing Microreactors Based Catechol Chemistry for Photothermal Killing of Bacteria

( Phuong ),박성영 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0

Herein, an antibacterial polydimethylsiloxane (PDMS) microreactors immobilized with Tungsten bronze-type compound of C_s0.33WO₃ based on catechol chemistry. Specifically, catechol was grafted into poly (N-vinylpyrrolidone) polymer backbone to create CA-PVP for controlling the adhesive properties on the coated surface. After treated with bacteria, the microreactor showed excellent antibacterial activity after near-infrared (NIR) irradiation during 30-days operation. The C_s0.33WO₃ nanoparticles were confirmed not to be stabilized inside the channels, showing the robust immobilization of photothermal agents using excellent adhesive ability of catechol. The immobilized C_s0.33WO₃ inside microreactors could be removed easily by acid solution, confirming the recycling ability of the microreactors.

NIR-responsive Fluorescent Carbon Dot Platform for Targeting Combined Thermotherapy and Mitochondrial Dysfunction in Cancer Treatment

( Phuong ),박성영,이기백 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.1

TIEP CAN TRUYEN KIEUTU HUONG SO SANH VAN HOC VA PHUONG PHAP SO SANH LOAI HINH LICH SU

Tran,Thi Phuong Phuong,Bae, Yang Soo 부산외국어대학교 어문학연구소 2000 外大語文論集 Vol.15 No.-

우리는 흔히 비교를 통해서 서로의 관련 현상의 특수성을 확인할 수 있고 그로부터 일반적 혹은 독특한 가치나 발전의 규칙을 발견할 수 있다. 본고는 이와 같은 관점에서 베트남 쯔놈문학의 걸작으로 불리우는 끼에우전의 비교에 있어서 역사유형 방법론의 적용에 관해서 살펴보고자 한다. 역사유형 방법론(historical typology)은 19세기 말에 러시아에서 출현했으며, 문학이라는 것은 민족이라는 배경 속에 존재하는 동시에 세계의 배경 속에도 놓여 있다는 것이다. 따라서 세계 역사 발전과정의 공통적인 규칙을 통해 공간적으로 멀리 떨어져 있음에도 불구하고 유사한 문학현상을 보인다고 주장한다 이러한 주장은 공간적 배경이 다르며 접촉관계가 없음에도 불구하고 유사한 문학현상이 존재하고 있다는 것을 설명하는데 유용한 방법이 된다. 그럼에도 불구하고 이 방법론은 작가들로부터 창작자의 독창성을 간과하고 있다는 비판을 받고 있다. 예를 들어, 베트남의 끼에우전과 한국의 춘향전을 비교하면 인도적 감흥과 예술 형식(인물, 줄거리, 쟝르 등)에 있어서의 유사성을 볼 수 있다. 이러한 경우에 영향 관계에 의한 유사성 측면에서는 설명이 아주 힘들어지게 된다 따라서 작품이 탄생되는 시기의 역사, 사회적 상황의 유사성을 통해서 민족 및 세계 문학의 발전의 규율을 찾아낼 수 있을 것이다. 베트남의 민족문학인 끼에우전과 외국작품을 비교할 때, 역사유형 방법론은 유럽 중심주의나 민족주의의 극단을 피할 수 있는 보다 객관적인 연구방법이 될 수 있으며 특히, 같은 동아시아 문학인 한국의 춘향전과의 비교도 중화사상의 극단을 피하면서 중국문학, 문화의 영향을 객관적으로 조명하는데 도움을 줄 수 있는 방법이 될 것이다.

Public Debt Management and Its Impact on Economic Development: The Case of Vietnam

Phuong Lan Vo THI(Phuong Lan Vo THI ) 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.9

Public investment is the process of investing capital in projects that serve national interests and thereby create a driving force for economic development in each country. Especially in developing countries, investment capital is limited, so improving the efficiency of public investment becomes a decisive factor for economic development and enhancing the country’s status and ultimately making the country a should be rich. Vietnam has a low starting point, has gone through the doi moi process, and has gradually become a middle-income country, and public investment is attracting attention to improve the quality of the country’s infrastructure. The objective of this study is to evaluate the factors affecting the effectiveness of public debt management in Vietnam, through a survey of 150 experts with knowledge of public investment and public debt management, using the results of the estimation through the Using SPSS software, the research results show that the monitoring system and human resource quality have an impact on the effectiveness of public debt management. The study could not, however, discover any proof of the influence of institutional quality, geographic location, or accountability on the effectiveness of public debt management. The research also addresses several policy recommendations for Vietnam that would help the country manage its public debt better in the future.