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대황황련해독탕의 사염화탄소 유발 간장해 보호효과 미치 급성독성
김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-
ABSTRACT - This study was performed to evaluate hepatoprotective effect of daewhang-whangryunhaedok-Tang(DWT) on liver injured rats induced by CCI_4 and the acute oral toxicity of it in mice. The activities of serum transaminase(ALT/AST), alkaline phosphatase(ALP) and lactic dehydrogenase(LDH), the levels of serum total cholesterol(TC) and triglyceride(TG), change of liver enlargement, and inhibitory activities of lipid perotidation, catalase and glutathione-S-transfrease(GST) in liver microsome were determined in hepatotoxic rats induced by CCI_4. DWT was significantly reduced the serum ALT, AST, ALP, LDH. TC and TG lecels. And, the increase of lipid peroxidation, decrease of catalase and GST activities in the liver microsome of CCI_4-intoxicated rat were significantly improved by the treatment of DWT. Male and female mice were administered maximum dosages of 5.000 mg/kg b.w. of DWT. After single oral administration of DWT to mice, we observed them daily for 2 weeks.DWT did not induce any toxic signs in the mortalitie, clinical signs, body weight changes, and gross necropsy finfings of mice. Based in these results. It is concluded that DWT may have the hepatoprotective effect on CCI_4 induced hepatotoxicity in rats. Also. DWT may have no side effect and its LD_50 value may be over 5.000mg/kg b.w. in mice.
김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
Whangryunhaedok-Tang (WT) is formulated with Coptidis Rhizoma, Phellodendri Cortex, Scutellariae Radix and Gardeniae Fructus, and Daewhang-whangryunhaedok-Tang (DWT) is made by the combination of Rhei Rhizoma, a wellknown anticostipation drug in WT. Therefore, DWT has been evaluated for antihyperlipidemic effects on experimental hyperlipidemic rats and mice induced by corn oil and high cholesterol-diet. Oral administration of DWT significantly inhibited the increase of serum triglyceride and LDL-cholesterol levels, and the decrease of serum HDL-cholesterol levels in hyperlipidemic rats induced by corn oil. Also, oral administration of DWT significantly prevented the increase of serum total cholesterol, triglyceride and LDL-cholesterol, and liver total cholesterol and triglyceride in 1% cholesterol-diet fed mice. These results suggest that DWT is effective for the treatment of hyperlipidemia.
Deep Red Phosphorescence of Cyclometalated Iridium Complexes by <i>o</i>-Carborane Substitution
Bae, Hye Jin,Chung, Jin,Kim, Hyungjun,Park, Jihyun,Lee, Kang Mun,Koh, Tae-Wook,Lee, Yoon Sup,Yoo, Seunghyup,Do, Youngkyu,Lee, Min Hyung American Chemical Society 2014 Inorganic chemistry Vol.53 No.1
<P>Heteroleptic (C<SUP>∧</SUP>N)<SUB>2</SUB>Ir(acac) (C<SUP>∧</SUP>N = 5-MeCBbtp (<B>5a</B>); 4-BuCBbtp (<B>5b</B>); 5-BuCBbtp (<B>5c</B>); 5-(<I>R</I>)CBbtp = 2-(2′-benzothienyl)-5-(2-<I>R</I>-<I>ortho</I>-carboran-1-yl)-pyridinato-C<SUP>2</SUP>,N, R = Me and <I>n</I>-Bu; 4-BuCBbtp = 2-(2′-benzothienyl)-4-(2-<I>n</I>-Bu-<I>ortho</I>-carboran-1-yl)-pyridinato-C<SUP>2</SUP>,N, acac = acetylacetonate) complexes supported by <I>o</I>-carborane substituted C<SUP>∧</SUP>N-chelating ligand were prepared, and the crystal structures of <B>5a</B> and <B>5b</B> were determined by X-ray diffraction. While <B>5a</B> and <B>5c</B> exhibit a deep red phosphorescence band centered at 644 nm, which is substantially red-shifted compared to that of unsubstituted (btp)<SUB>2</SUB>Ir(acac) (<B>6</B>) (λ<SUB>em</SUB> = 612 nm), <B>5b</B> is nonemissive in THF solution at room temperature. In contrast, all complexes are emissive at 77 K and in the solid state. Electrochemical and theoretical studies suggest that the carborane substitution leads to the lowering of both the HOMO and LUMO levels, but has higher impact on the LUMO stabilization than the HOMO, resulting in the reduction of the triplet excited state energy. In particular, the LUMO stabilization in the 4-substituted <B>5b</B> is more contributed by carborane than that in the 5-substituted <B>5a</B>. The solution-processed electroluminescent device incorporating <B>5a</B> as an emitter displayed deep red phosphorescence (CIE coordinate: 0.693, 0.290) with moderate performance (max η<SUB>EQE</SUB> = 3.8%) whereas the device incorporating <B>5b</B> showed poor performance, as well as weak luminance.</P><P>The introduction of an <I>o</I>-carborane to the 4- or 5-position of the pyridine ring of a btp ligand in heteroleptic (C<SUP>∧</SUP>N)<SUB>2</SUB>Ir(acac) complexes leads to deep red phosphorescence, which is substantially red-shifted compared to that of (btp)<SUB>2</SUB>Ir(acac). The solution processed PhOLED devices incorporating the 5-carborane substituted Ir(III) complex as an emitter display moderate performance with deep red phosphorescence.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2014/inocaj.2014.53.issue-1/ic401755m/production/images/medium/ic-2013-01755m_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic401755m'>ACS Electronic Supporting Info</A></P>
Bae, Hye Jin,Kim, Hyungjun,Lee, Kang Mun,Kim, Taewon,Eo, Maengsun,Lee, Yoon Sup,Do, Youngkyu,Lee, Min Hyung The Royal Society of Chemistry 2013 Dalton transactions Vol.42 No.24
<P>Heteroleptic tris-cyclometalated Ir(<SMALL>III</SMALL>) complexes supported by the <I>o</I>-carboranyl-pyridine (<I>CBpy</I>) as a novel <I>C</I><SUP>∧</SUP><I>N</I> chelating ligand were synthesized and characterized. While the <I>CBpy</I> ligand contributes to the electronic stabilization of complexes, their photophysical properties are dominated by 2-arylpyridine ligands.</P> <P>Graphic Abstract</P><P>Novel heteroleptic tris-cyclometalated Ir(<SMALL>III</SMALL>) complexes supported by the <I>o</I>-carboranyl-pyridine ligand (<I>CBpy</I>) were synthesized and their photophysical and electrochemical properties were investigated. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3dt51019k'> </P>
Porcine PD-L1: cloning, characterization, and implications during xenotransplantation
Jeon, Dae-Hyun,Oh, Keunhee,Oh, Byoung C.,Nam, Dong H.,Kim, Chi H.,Park, Hyung-Bae,Cho, Jaejin,Lee, Jeong R.,Lee, Dong-Sup,Lee, Gene Blackwell Publishing Ltd 2007 Xenotransplantation Vol.14 No.3
<P>Abstract: Background: </P><P>Effective intervention achieved by manipulating cell-mediated xenogeneic immune responses would critically increase the clinical feasibility of xenotransplantation as immediate hyperacute rejections become controllable through genetic modulations of donor organs. Endogenous negative regulatory signals like the programmed death 1 (PD-1)-programmed death ligand 1 (PD-L1) system are candidate targets for the control of cell-mediated xenogeneic immune response.</P><P>Methods: </P><P>A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology based on the human PD-L1 sequence. The functional effects of cloned porcine PD-L1 were tested on human CD4<SUP>+</SUP> T cell activation using porcine PD-L1-transfected bystander cells. Cellular proliferation was monitored by [<SUP>3</SUP>H] thymidine incorporation, and human T cell apoptosis was measured by flow cytometry.</P><P>Results: </P><P>Porcine PD-L1 (GenBank accession number AY837780) was found to have 73.8% sequence homology with human PD-L1 and to contain two immunoglobulin domains in its extracellular region. Moreover, porcine PD-L1 expressed on Chinese hamster ovary (CHO) cells inhibited human CD4<SUP>+</SUP> T cell proliferation stimulated with anti-CD3 only or anti-CD3 plus anti-CD28. Percentages of apoptotic activated human T cells increased by over 30% in the presence of porcine PD-L1/CHO cells, and the addition of recombinant human PD-1-Fc fusion proteins during human T cell activation reversed the inhibitory effects of porcine PD-L1.</P><P>Conclusions: </P><P>Cloned porcine PD-L1 showed high sequence homology with human PD-L1 and a similar molecular structure. Moreover, porcine PD-L1 inhibited human CD4<SUP>+</SUP> T cell activation in human PD-1-dependent manner, and this involved activated T cell apoptosis. The authors suggest that PD-1-PD-L1 might play an important endogenous immune regulatory role during xenogeneic transplantation, and that the effective application of this system would improve transplanted xenogeneic organ survival.</P>