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Changing Wheat Quality with the Modification of Storage Protein Structure
Tamas, Laszlo,Bekes, Ferenc,Morrell, Matthew K.,Appels, Rudi The Korean Society of Plant Biotechnology 1999 Plant molecular biology and biotechnology research Vol.1 No.1
The visco-elastic properties of gluten are major determinants of the processing properties of doughs. These visco-elastic properties are strongly influenced by the ratio of monomeric and polymeric proteins and the size distribution of the polymeric proteins, which make up the gluten fraction of the dough. Recent studies have revealed that other features, such as the number of the cysteine residues of the HMW-GS, also play an important role in determining the functional characteristics. To modify the processing properties at molecular level, the relationship between the structure of molecules and dough properties has to be understood. In order to explore the relationships between individual proteins and dough properties, we have developed procedures for incorporating bacterially expressed proteins into doughs, and measuring their functional properties in small-scale equipment. A major problem in investigating the structure/function relationships of individual seed storage proteins is to obtain sufficient amounts of pure polypeptides from the complex families of proteins expressed in the endosperm. Therefore, we have established a simplified model system in which we produce specific protein genes through bacterial expression and test their functional properties in smallscale apparatus after incorporation into base flour. An S poor protein gene has been chosen as a template gene. This template gene has been modified using standard recombinant DNA techniques in order to test the effects of varying the number and position of cysteine residues, and the size of the protein. Doughs have been mixed in small scale apparatus and characterized with respect to their polymeric composition and their functional properties, including dough mixing, extensibility and small scale bating. We conclude that dough characteristics can be manipulated in a predictable manner by altering the cysteine residues and the size of high molecular weight glutenins.
Appel Margie,이무성 한국다문화교육학회 2023 Multicultural Education Review Vol.15 No.3
Amidst a background of inequality and rising global tensions, the need for effective intercultural understanding is paramount, facilitated by well-prepared teachers. Small-scale, qualitative studies indicate potential positive effects of scaffolded study abroad during initial teacher education on teaching in increasingly diverse classrooms. The study utilizes large scale data from teachers to explore teacher self-efficacy in multicultural classrooms and the interrelationship with study abroad during teacher education. Survey data from teachers in England and Australia is sourced from Teaching and Learning International Survey (TALIS) 2018, as well as a small-scale survey from Australian Capital Territory (ACT). These teachers reported a lack of preparedness for teaching in multicultural classrooms from teacher education. Findings from hierarchical regression analysis suggest that study abroad during teacher education is significant in improving teacher self-efficacy, after controlling for significant variables related to teaching in a multicultural classroom. We argue for the inclusion of study abroad in initial teacher education for much needed intercultural understanding.
Mariana Appel Hort,Elke Zuleika Schuldt,ˆ ngela Cristina Bet,Silvia DalBo,Jarbas Mota Siqueira,,Carla Ianssen,Fa´tima Abatepaulo,Heraldo Possolo de Souza,Beatriz Veleirinho,Marcelo Maraschin,Rosa Mari 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.10
Moderate wine intake (i.e., 1–2 glasses of wine a day) is associated with a reduced risk of morbidity and mortality from cardiovascular disease. The aim of this study was to evaluate the anti-atherosclerotic effects of a nonalcoholic ethyl acetate fraction (EAF) from a South Brazilian red wine obtained from Vitis labrusca grapes. Experiments were carried out on low-density lipoprotein (LDL) receptor knockout (LDLr−/−) mice, which were subjected to a hypercholesterolemic diet and treated with doses of EAF (3, 10, and 30 mg/kg) for 12 weeks. At the end of the treatment, the level of plasma lipids, the vascular reactivity, and the atherosclerotic lesions were evaluated. Our results demonstrated that the treatment with EAF at 3 mg/kg significantly decreased total cholesterol, triglycerides, and LDL plus very low-density lipoprotein levels compared with control hypercholesterolemic mice. The treatment of mice with EAF at 3 mg/kg also preserved the vasodilatation induced by acetylcholine on isolated thoracic aorta from hypercholesterolemic LDLr−/− mice. This result is in agreement with the degree of lipid deposit on arteries. Taken together, the results show for the first time that the lowest concentration of an EAF obtained from a red wine produced in southern Brazil significantly reduced the progression of atherosclerosis in mice.
PSEN1 p.Met233Val in a Complex Neurodegenerative Movement and Neuropsychiatric Disorder
Silke Appel-Cresswell,Ilaria Guella,Anna Lehman,Dean Foti,Matthew J. Farrer 대한파킨슨병및이상운동질환학회 2018 Journal Of Movement Disorders Vol.11 No.1
Mutations in presenilin 1 (PSEN1) are the most common cause of autosomal dominant Alzheimer’s disease. Here, we report a Canadian-Vietnamese family carrying a PSEN1 p.Met233Val mutation with an exceptionally early and severe presentation that includes a wide range of atypical symptoms, including prominent ataxia, Parkinsonism, spasticity, dystonia, action tremor, myoclonus, bulbar symptoms, seizures, hallucinations and behavioral changes. Whole-exome sequencing (WES) was performed on the affected proband after many assessments over several years proved diagnostically inconclusive. The results were analyzed using the AnnEx “Annotated Exomes” browser (http://annex.can.ubc.ca), a web-based platform that facilitates WES variant annotation and interpretation. High-throughput sequencing can be especially informative for complex neurological disorders, and WES warrants consideration as a first-line clinical test. Data analyses facilitated by web-based bioinformatics tools have great potential for novel insight, although confirmatory, diagnostically accredited Sanger sequencing is recommended prior to reporting.
Guidelines for the next 10 years of proteomics
Wilkins, Marc R.,Appel, Ron D.,Van Eyk, Jennifer E.,Chung, Maxey C. M.,Gö,rg, Angelika,Hecker, Michael,Huber, Lukas A.,Langen, Hanno,Link, Andrew J.,Paik, Young-Ki,Patterson, Scott D.,Pennington, WILEY-VCH Verlag 2006 Proteomics Vol.6 No.1
<P>In the last ten years, the field of proteomics has expanded at a rapid rate. A range of exciting new technology has been developed and enthusiastically applied to an enormous variety of biological questions. However, the degree of stringency required in proteomic data generation and analysis appears to have been underestimated. As a result, there are likely to be numerous published findings that are of questionable quality, requiring further confirmation and/or validation. This manuscript outlines a number of key issues in proteomic research, including those associated with experimental design, differential display and biomarker discovery, protein identification and analytical incompleteness. In an effort to set a standard that reflects current thinking on the necessary and desirable characteristics of publishable manuscripts in the field, a minimal set of guidelines for proteomics research is then described. These guidelines will serve as a set of criteria which editors of PROTEOMICS will use for assessment of future submissions to the Journal.</P>
빌 하이빌스,낸시 비치,진 애플 두란노 2004 목회와 신학 Vol.- No.178
이번호에서는 1년 내내 지속되는 목회자 사역 중 어떻게 휴식을 통해 자신의 영을 새롭게 하여 사역의 활력과 에너지를 창출할 것인지에 대해 오랜경험과 합리적인 답안들을 진솔하게 서로 나누는 시간을 가졌다.적절한 휴식의 리듬은 회복뿐 아니라 미처 생각지 못한 창의성까지 더해준다는 점에서 매우 중요한 셀프 리더쉽의 요소로 볼수 있다.이 좌담에는 사회를 맡은 낸시 비치(Nancy Beach)와 윌로크릭의 담임 빌 하이벨스(Bill Hybels)목사,그리고 네바다 주 라스베가스의 센트럴 크리스천 교회의 담임목사로 있으면서 여러해 동안 윌로크릭 컨퍼런스에서 강의해오다 윌로크릭의 새로운 부목사(Associate Pastor)가 된 진 애플 (Gene Appel)이 참석했다.