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- 저자 : Ahn Sang‐Hoon (검색결과 3,197 건)
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( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche
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Epidemiological studies of Clonorchis sinensis in the coastal areas of Kyungpook, Korea
Ahn,Sung Hoon,Lee,Soo Hyeong,Joo,Chong Yoon 啓明大學校 醫科大學 1996 계명의대학술지 Vol.15 No.4
In order to determine the epidemiological patterns of the liver fluke, the infection rates for Clonorchis larvae in the snails and fish hosts, and the prevalence of C. sinensis among the residents in the coastal areas of Kyungpook Province were studied from April, 1992 to September, 1993. Four snail habitats were found in the river Hyungsan and come streams. One area had snails infected with Clonorchis cercaria, but the proportion of infected snails was very low, the average rates varying from zero to 0.081 percent. Of the 19 species of fish, 3 species were infected with the encysted larvae of C. sinensis. Infection rates varied greatly by the fish species, and ranged from 6.7 percent in P. herzi to 88.9 percent in G. artomaculatus. In the intensity of infection with C. sinensis, G. atromaculatus was the most heavily infected species, the average number of cysts per gram of the fish flesh being 72.2 followed by P. herzi with 53.0 cysts. The infection rate for C. sinensis among the residents was relatively high, being found to be 5.9 percent with a prevalence of 7.0 percent in males and 5.1percent in females. the difference in the rate of infection between males and females is found to be statistically significant(t>2). For the quantitative analysis of epidemiology of C. sinensis, a special type of simple catalytic model was applied to the sex and age infection rates revealed by stool examination for Clonorchis eggs. The simple catalytic curve for males was y=0.21(1-e-0.021t), and females was y=0.19(1-e-0.013t). From these equations the force of infection of 2.1 and 1.3 effective infections giving positive stool examination per 1,000 residents annually was suggested. And the asymptote is at about 21.0 percent of males and 19.0 percent of females, the estimated values of the limit of possible positive cases in the residents. For the analysis of the age prevalence patterns of Clonorchis positives applied the two-stage catalytic model, and the equation is y=0.511(e-0.0093t-e-0.0275t). for the analysis of the intensity of infection, the frequency distribution by the Clonorchis egg counts was calculated as well as the cumulative percentage to the total number of positive cases, and the regression equation is y=1.07+1.50 log X. This study indicate that endemic foci of C. sinensis exist in the coastal areas of Kyungpook Province and the prevalence of the liver fluke among the residents is still high, and that the infection rates with Clonorchis larvae in the fresh-water fish and snails varied greatly by the species of fish and its habitats.
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Sang Hun Lee,Myung Ho Jeong,Joon Ho Ahn,Dae Young Hyun,Kyung Hoon Cho,Min Chul Kim,Doo Sun Sim,Young Joon Hong,Ju Han Kim,Youngkeun Ahn,Jin Yong Hwang,Weon Kim,Jong Seon Park,Chang-Hwan Yoon,Seung Ho 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.4
Background/Aims: Recurrent acute myocardial infarction (AMI) is an adverse cardiac event in patients with a first AMI. The predictors of recurrent AMI after the first AMI in patients who underwent successful percutaneous coronary intervention (PCI) have not been elucidated. Methods: We analyzed the data collected from 9,869 patients (63.2 ± 12.4 years, men:women = 7,446:2,423) who were enrolled in the Korea Acute Myocardial Infarction Registry-National Institute of Health between November 2011 and October 2015, had suffered their first AMI and had received successful PCI during the index hospitalization. Multivariable logistic regression analysis was performed to identify the independent predictors of recurrent AMI following the first AMI. Results: The cumulative incidence of recurrent AMI after successful PCI was 3.6% (359/9,869). According to the multivariable logistic regression analysis, the significant predictive factors for recurrent AMI were diabetes mellitus, renal dysfunction, atypical chest pain, and multivessel disease. Conclusions: In this Korean prospective cohort study, the independent predictors of recurrent AMI after successful PCI for the first AMI were diabetes mellitus, renal dysfunction, atypical chest pain, and multivessel disease.
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Ahn, Sang-Hoon,Kang, So Hyun,Lee, Yoontaek,Min, Sa-Hong,Park, Young Suk,Park, Do Joong,Kim, Hyung-Ho The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.1
Purpose: Despite an increased acceptance of laparoscopic gastrectomy (LG) in early gastric cancer (EGC), there is insufficient evidence for its oncological safety in advanced gastric cancer (AGC). This is a prospective phase II clinical trial to evaluate the feasibility of LG with D2 lymph node dissection (LND) in AGC. Materials and Methods: The primary endpoint was set as 3-year disease-free survival (DFS). The eligibility criteria were as follows: 20-80 years of age, cT2N0-cT4aN3, American Society of Anesthesiologists score of 3 or less, and no other malignancy. Patients were enrolled in this single-arm study between November 2008 and May 2012. Exclusion criteria included cT4b or M1, or having final pathologic results as EGC. All patients underwent D2 lymphadenectomy. Three-year DFS rates were estimated by the Kaplan-Meier method. Results: A total of 157 patients were enrolled. The overall local complication rate was 10.2%. Conversion to open surgery occurred in 11 patients (7.0%). The mean follow-up period was $55.0{\pm}20.4months$ (1-81 months). The cumulative 3-year DFS rates were 76.3% for all stages, and 100%, 89.3%, 100%, 88.0%, 71.4%, and 35.3% for stage IB, IIA, IIB, IIIA, IIIB, and IIIC, respectively. Recurrence was observed in 37 patients (23.6%), including hematogenous (n=6), peritoneal (n=13), locoregional (n=1), distant node (n=8), and mixed recurrence (n=9). Conclusions: In addition to being technically feasible for treatment of AGC in terms of morbidity, LG with D2 LND for locally advanced gastric cancer showed acceptable 3-year DFS outcomes.
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( Sang Hoon Lee ),( Sang Hun Lee ),( Seung Up Kim ),( Beom Kyung Kim ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Kwang Hyub Han ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/ Aims: Liver stiffness (LS) values measured using transient elastography (TE) can accurately assess the degree of liver fibrosis. The degree of liver fibrosis is significantly associated with the risk of hepatocellular carcinoma (HCC) development. Thus, this study investigated whether LS values at radiofrequency ablation (RFA) can predict HCC recurrence after RFA. Methods: Between May 2005 and April 2011, a total of 56 patients with HCC who underwent RFA and LS value measurement at the same day were analyzed in this retrospective study. All were followed up for monitoring the development of HCC recurrence until March 2013. Results: The mean age of the patients (40 men, 16 women) was 62.1 years, and the median LS value was 23.0 kPa. During the follow-up period (median 27.9 [range, 1.1-77.3] months), 33 (58.9%) patients experienced HCC recurrence and 18 (32.1%) were dead. Median time to recurrence was 17.1 (range, 2.5-67.8) months and median time to mortality was 27.9 (range, 1.1-77.3) months. Patients with recurrence showed significantly higher prevalence of liver cirrhosis, spleen size, multiple tumors, and LS values, whereas they had significantly lower platelet count than patients without recurrence (all P<0.05). On multivariate analysis, together with previous anti- HCC treatment history, patients with a higher LS value >13.0 kPa were at a significant greater risk for HCC recurrence after RFA with a hazard ratio of 6.981 (P<0.05; 95% confidence interval, 1.650-28.782) compared with those with LS value ≤13.0 kPa. However, LS values were not predictive for overall survival (P=0.237). Conclusions: Our data suggest that LS values measured using TE can be a useful predictor of HCC recurrence after RFA. Further studies with large sample size are warranted for the validation of our results.
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A New Measurement Method of a Radial Pulse Wave Using Multiple Hall Array Devices
Sang-Suk Lee,Myoung-Chone An,Sung-Hoon Ahn 한국자기학회 2009 Journal of Magnetics Vol.14 No.3
This study investigated the radial pulse waveform obtained by a medical pulsimeter sensor. A pulse-sensing part array consisting of multiple Hall devices was located over a skin-contacting part with a hard magnetic material. The periodic movement of the magnetic material of the skin-contacting part affected the magnetic field in the pulse-sensing part array and was detected by multiple Hall devices. The analysis of a radial pulse waveform that is measured noninvasively by detecting the changes of the magnetic field can be used to develop a new diagnostic algorithm of oriental medical apparatus.
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