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- 저자 : Ae Ran Park (검색결과 297 건)
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김용구,박일웅,안윤근,배애란,최상덕 國立麗水大學校 環境問題硏究所 2004 環境硏究論文集 Vol.6 No.-
This present study was conducted to determine the effects of sea water quality and sediment quality on growth and body composition in poly culture system, Paralichthys olivaceus and Urechis unicinctus. The seawater temperature of the experimental groups was ranges of 17.1~23.8℃, the lowest in 0 day and the highest in 70 day. The concentration of COD was 1.2~1.6㎎/ℓ, DIN 6.19~28.89㎎/ℓ in the D group. Mean IL concentration was 5.42~5.07% and it was maximum in 0 day and relatively minimum 70day. The concentration of AVS was 0.36~0.22㎎/g-dry, COD 4.36~4.08㎎/g-dry in the D group. Growth and feed intake of fish were affected by diets and feeding frequencies(P<0.05). There were differences at all experimental groups especially C group and control group but A, B group and C, D group were not difference. The lowest increased body weight was observed 4.7g in the D experimental group and the highest experimental group was observed 8.6g in the C group.
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대학생의 의복행동과 심리적 특성과의 관계 : 의복의 상황적 적절성, 한복에 대한 태도 및 유행을 중심으로
강혜원,고애란,박은주 연세대학교 대학원 1988 延世論叢 Vol.24 No.-
The purposes of this study were: (1) to investigate the relation of 4 aspects of clothing behavior to locus of control, (2) to ascertain whether differences exist between males and females on clothing behaviors, and (3) to develop measures of attitudes toward Korean traditional clothing and clothing appropriateness. Locus of control was assessed by Rotter's Internal-External Locus of Control Scale as modified by Jeho Cha and others. The existing clothing interest measures were slightly modified to assess interest in fashion, modesty and clothing importance. Additional measures of attitudes toward Korean traditional clothing (Ⅰ)&(Ⅱ), clothing appropriateness, and attitudes toward the latest male and female fashion styles were developed. The sample consisted of 627 male and 453 female students in Yonsei University in Seoul, Korea. The data were collected by means of self-administered questionnaires and were analyzed by correlation, Z-tests, and X^2 tests. The results indicated that: 1) Locus of control was significantly related to attitudes toward Korean traditional clothing (Ⅰ)&(Ⅱ), fashion interest, and 2 aspects of clothing appropriateness: those who were high on internal reinforcement had more positive attitudes to various aspects of Korean traditional clothing and they also accepted more varied male outfits for campus wear. They also considered Korean clothing as more suitable to more varied social occasions. On the other hand, those who were high on external reinforcement were more interested in fashion. 2) As for sex differences on clothing behavior, females scored significantly higher on interest in fashion, modesty, and clothing importance. Compared with males they preferred the latest fashion style of clothing for both sexes. There were no significant differences between males and females on clothing appropriateness scores and attitudes toward Korean traditional clothing. 3) Attitudes toward Korean traditional clothing were related negatively to fashion interest, whereas it was related positively to modesty in clothing. 4) Fashion interest was related positively to clothing importance and negatively to modesty in clothing. 5) The measures developed for this study had high reliability, thus, these could be of use for further clothing behavior studies.
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특발성 과호산구 증후군 환자의 치료 도중 발생한 간혈종 1례
이영태,김동기,박지훈,김윤정,김기향,박보민,권민정,김애란,이원식,주영돈,손창학 白中央醫療院 2005 仁濟醫學 Vol.26 No.1
Idiopathic hypereosinophilic syndrome is characterized by marked elevation of eosinophil count ( >1,500/㎣) in peripheral blood without explaining etiology. It shows tissue involvement in many organs such as liver, G-I tract, myocar dium, lung, skin, kidney and nerve. Some case of hypereosinophilic syndrome with hepatic involvement have been reported, but not much. We have recently experienced a case with idiopathic hypereosinophilic syndrome of a 40 year old man who presented with RUQ pain. By abdominal CT, ill- defined subcapsular hematoma was detected. Liver biopsy showed eosinophilic infiltration within the portal tract and sinusoid. Drain procedure and corticosteroid adminiiatbrought marked improvement of clinical manifestation, hematologic abnormality and radiologic abnormality.
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베체트병 환자에서 Azathioprine으로 유발된 급성 췌장염 1례
김기향,권민정,김동기,김애란,김윤정,박지훈,이영태,박보민,김동욱 白中央醫療院 2005 仁濟醫學 Vol.26 No.1
Although many drug are thought capable of initiating acute pancreatitis, following azathioprine administration represents the 5% incidence by far the highest recorded incidence to date. We report a 35-year-old male who developed acute pancreatitis in the course of treatment with azathioprine for Behcet's disease. He was admitted due to abdominal pain, diarrhea, and fever for 10 days. Serum amylase and lipase levels were 510U/L and 3702U/L respectively. The abdominal CT scan revealed diffuse enlargement of the pancreas. There was no history of alcohol use or gall bladder disease. We considered drugs, especially azathioprine, as the cause of acute pancreatitis. We diagnosed it as acute pancreatitis. The patient was treated conservatively with hydration and analgesics. The symptom subsided within four days. Five days later, azathioprine was resumed. And the patient complained of abdominal pain. The elevated levels of serum amylase and lipase confirmed the recurrence of pancreatitis. His symptom subsided when azathioprine intake the stopped, and the serum amylase and lipase levels returned to normal level within five days.
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Park, Haeng Ran,Kim, Se‐,Heon,Lee, Sei Young,Sung, Ji Min,Park, Ae Ran,Kang, Suki,Kim, Baek Gil,Choi, Yoon Pyo,Kim, Yong‐,Bae,Cho, Nam Hoon Wiley Subscription Services, Inc., A Wiley Company 2011 Cancer Vol.117 No.9
<P><B>Abstract</B></P><P><B>BACKGROUND:</B></P><P>Although radiation resistance is a primary issue in radiation therapy, attempts to find predictors of radiation resistance have met with little success. The authors therefore aimed to determine predictors for radiation resistance to improve the prognosis of head and neck squamous cell carcinoma (HNSCC).</P><P><B>METHODS:</B></P><P>HNSCC cell lines, SCC15, SCC25, and QLL1, irradiated with an acute dose of 4 grays (Gy) (RR‐4), a cumulative dose of 60 Gy (RR‐60), and a booster dose of 4 Gy over 60 Gy (RR‐60 + 4), were used with nonirradiated cell lines. Those were used in cDNA microarray, proteomics, Western blotting, and immunofluorescence, respectively. One hundred five HNSCC tissue samples with radiation resistance were analyzed by immunohistochemistry.</P><P><B>RESULTS:</B></P><P>Western blot analysis of RR‐60 cell lines was identical to the data of Nm23‐H1 overexpression by cDNA array and proteomic screening. Immunofluorescence demonstrated significant nuclear translocation of Nm23‐H1 in RR‐4 and RR‐60 cell lines, and less but still intense nuclear shuttling in RR‐60 + 4. Similarly, Nm23‐H1 nuclear localization was observed in 20% (21 of 105) of tissue samples. Univariate analysis demonstrated that Nm23‐H1 nuclear localization was strongly associated with overall and recurrence‐free survival. Multivariate stepwise Cox regression analysis showed that Nm23‐H1 nuclear localization (odds ratio [OR], 7.48) and N stage (OR, 2.13) were associated with overall survival, and Nm23‐H1 nuclear localization (OR, 3.02), T stage (OR, 1.43), and insufficient tumor margin (OR, 3.27) were associated with recurrence‐free survival.</P><P><B>CONCLUSIONS:</B></P><P>Overexpression of Nm23‐H1, specifically its nuclear translocation, may be a powerful predictor of radiation resistance in HNSCC. Cancer 2011. © 2010 American Cancer Society.</P>
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( Ae Ran Park ),( Jongmun Kim ),( Bora Kim ),( Areum Ha ),( Ji-yeon Son ),( Chan Woo Song ),( Hyohak Song ),( Jin-cheol Kim ) 한국미생물생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.5
Among abiotic stresses in plants, drought and chilling stresses reduce the supply of moisture to plant tissues, inhibit photosynthesis, and severely reduce plant growth and yield. Thus, the application of water stress-tolerant agents can be a useful strategy to maintain plant growth under abiotic stresses. This study assessed the effect of exogenous bio-based 2,3-butanediol (BDO) application on drought and chilling response in tomato and turfgrass, and expression levels of several plant signaling pathway-related gene transcripts. Bio-based 2,3-BDOs were formulated to levo-2,3-BDO 0.9% soluble concentrate (levo 0.9% SL) and meso-2,3-BDO 9% SL (meso 9% SL). Under drought and chilling stress conditions, the application of levo 0.9% SL in creeping bentgrass and meso 9% SL in tomato plants significantly reduced the deleterious effects of abiotic stresses. Interestingly, pretreatment with levo-2,3-BDO in creeping bentgrass and meso-2,3-BDO in tomato plants enhanced JA and SA signaling pathway-related gene transcript expression levels in different ways. In addition, all tomato plants treated with acibenzolar-S-methyl (as a positive control) withered completely under chilling stress, whereas 2,3-BDO-treated tomato plants exhibited excellent cold tolerance. According to our findings, bio-based 2,3-BDO isomers as sustainable water stress-tolerant agents, levo- and meso-2,3-BDOs, could enhance tolerance to drought and/or chilling stresses in various plants through somewhat different molecular activities without any side effects.
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( Ae Ran Park ),( Minmin Fu ),( Ji Young Shin ),( Hokyoung Son ),( Yin Won Lee ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.5
Zearalenone (ZEA) is an estrogenic mycotoxin that is produced by several Fusarium species, including Fusarium graminearum. One of the ZEA biosynthetic genes, ZEB2, encodes two isoforms of Zeb2 by alternative transcription, forming an activator (Zeb2L-Zeb2L homooligomer) and an inhibitor (Zeb2L-Zeb2S heterodimer) that directly regulate the ZEA biosynthetic genes in F. graminearum. Cyclic AMP-dependent protein kinase A (PKA) signaling regulates secondary metabolic processes in several filamentous fungi. In this study, we investigated the effects of the PKA signaling pathway on ZEA biosynthesis. Through functional analyses of PKA catalytic and regulatory subunits (CPKs and PKR), we found that the PKA pathway negatively regulates ZEA production. Genetic and biochemical evidence further demonstrated that the PKA pathway specifically represses ZEB2L transcription and also takes part in posttranscriptional regulation of ZEB2L during ZEA production. Our findings reveal the intriguing mechanism that the PKA pathway regulates secondary metabolite production by reprograming alternative transcription.
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Development and Evaluation of an Obesity Ontology for Social Big Data Analysis
Kim, Ae Ran,Park, Hyeoun-Ae,Song, Tae-Min Korean Society of Medical Informatics 2017 Healthcare Informatics Research Vol.23 No.3
<P><B>Objectives</B></P><P>The aim of this study was to develop and evaluate an obesity ontology as a framework for collecting and analyzing unstructured obesity-related social media posts.</P><P><B>Methods</B></P><P>The obesity ontology was developed according to the ‘Ontology Development 101’. The coverage rate of the developed ontology was examined by mapping concepts and terms of the ontology with concepts and terms extracted from obesity-related Twitter postings. The structure and representative ability of the ontology was evaluated by nurse experts. We applied the ontology to the density analysis of keywords related to obesity types and management strategies and to the sentiment analysis of obesity and diet using social big data.</P><P><B>Results</B></P><P>The developed obesity ontology was represented by 8 superclasses and 124 subordinate classes. The superclasses comprised ‘risk factors,’ ‘types,’ ‘symptoms,’ ‘complications,’ ‘assessment,’ ‘diagnosis,’ ‘management strategies,’ and ‘settings.’ The coverage rate of the ontology was 100% for the concepts and 87.8% for the terms. The evaluation scores for representative ability were higher than 4.0 out of 5.0 for all of the evaluation items. The density analysis of keywords revealed that the top-two posted types of obesity were abdomen and thigh, and the top-three posted management strategies were diet, exercise, and dietary supplements or drug therapy. Positive expressions of obesity-related postings has increased annually in the sentiment analysis.</P><P><B>Conclusions</B></P><P>It was found that the developed obesity ontology was useful to identify the most frequently used terms on obesity and opinions and emotions toward obesity posted by the geneal population on social media.</P>
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