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콜레스테롤 산화 생성물 7-Ketocholesterol에 의한 세포자멸사에 미치는 Extracellular Signal-Regulated Kinase 억제의 효과
황정연,이선화,한정호,김두응,이정수 대한신경과학회 2011 대한신경과학회지 Vol.29 No.4
Background: Defects in mitochondrial function have been shown to participate in the induction of neuronal cell injury. The extracellular-signal-regulated kinase (ERK) signaling pathway plays a crucial role in almost all cell functions,including proliferation, differentiation, survival, and death. However, the effect of ERK inhibition on oxysterol-induced apoptosis remains uncertain. Methods: This study assessed the effect of ERK inhibition on the apoptotic effect of 7-ketocholesterol. Results: Treatment with 7-ketocholesterol increased phosphorylated-ERK1/2 levels in differentiated PC12 cells, while the total amount of ERK was not altered. 7-Ketocholesterol decreased Bid and Bcl-2 levels, increased Bax and p53 levels,and promoted cytochrome c release, which elicits the activation of caspases (-8, -9, and -3), nuclear damage, and cell death. ERK and farnesyltransferase inhibitors inhibited the 7-ketocholesterol-induced phosphorylation of ERK1/2,activation of apoptosis-related proteins, and cell death in PC12 cells. Conclusions: The ERK and farnesyltransferase inhibitors, which did not exhibit toxicity, may inhibit the 7-ketocholesterol toxicity on differentiated PC12 cells by suppressing the activation of the caspase-8-dependent pathway as well as activation of the mitochondria-mediated cell-death pathway, leading to the activation of caspases. The inhibition of ERK may confer a beneficial protective effect against the neuronal cell injury induced by cholesterol oxidation products.
황인하,하상원,한정호 대한치매학회 2017 Dementia and Neurocognitive Disorders Vol.16 No.2
Traumatic brain injury (TBI) is common, and is often the leading cause of disability and death. Complications after TBI include increased risk for chronic central nervous system disease, such as Alzheimer’s disease (AD). However, the pathophysiology relating acute injury to neurodegeneration is unclear. Here we present a case of a patient whose cognition declined after TBI, and whose 18F fluorodeoxyglucose positron emission tomography scan showed an AD pattern.
급성 심근경색증으로 재관류 치료를 시행받은 환자에서 내원시 백혈구 수와 심근 손상의 관계
한정호,연태진,홍의실,윤수인,문기원,김학의,한지숙,김기석,배장환,황경국,김동운,조명찬 대한심장학회 2004 Korean Circulation Journal Vol.34 No.8
Background and Objectives:The presence of leukocytosis in patients with acute myocardial infarction (AMI) has been reported to be related to the extent of MI and with the prognosis. However, whether the leukocytosis itself is a cause or result of the myocardial injury has not been determined. The relationship between the leukocyte count and the extent of myocardial injury was investigated in patients with AMI that had undergone reperfusion therapy. Subjects and Methods:Patients with AMI that had undergone thrombolysis (n=60) or primary PCI (n=36) were included. The initial leukocyte counts were analyzed with regard to the peak and initial CK-MB levels. The relationship between leukocytosis and the time elapsed from the onset of symptoms, infarct related coronary arteries and the proximity of the lesions were also investigated. Results:In both groups, the initial leukocyte count did not show a significant relationship with the initial CK-MB level or the time elapsed from symptoms onset, which could be an indication of the extent of early myocardial injury. Furthermore, no significant relationship was shown with the infarct related coronary artery or proximity of the lesion. However, a relationship was shown with the maximum CK-MB level, which could be an indication of the extent of myocardial injury following reperfusion therapy in both groups (p<0.01). Conclusion:This study suggests that the initial leukocyte count in patients with AMI might is an important prognostic factor that determines the extent of myocardial injury following reperfusion therapy, rather than being a simple indicator of the extent of early myocardial injury. 배경 및 목적: 급성 심근경색증 환자의 내원시 백혈구증가증은 심근경색의 크기와 양의 상관관계가 있으며, 환자의 불량한 예후와 연관이 있다고 알려져 있다. 그러나, 손상된 심근의 양이 많을수록 백혈구수가 증가하는지 혹은 증가된 백혈구가 더 큰 심근 손상을 유발하는지는 알려져 있지 않다. 본 연구는 급성 심근경색증으로 혈전용해치료를 시행 받은 환자와 관동맥중재술을 시행 받은 환자를 대상으로 응급실 내원 당시의 백혈구수와 재관류 치료 후의 심근 손상 정도와의 연관관계를 알아보고자 하였다. 방 법: 충북대병원 응급실을 방문하여 급성 심근경색증으로 진단 받은 환자 중 혈전용해치료(n=60) 혹은 관동맥중재술(n=36)을 시행 받은 환자들을 대상으로 하였다. 모든 환자들을 대상으로 내원시 말초혈액 백혈구수를 측정하였으며, 이를 증상 발현부터 응급실 내원시까지의 경과 시간, 내원시 Creatine Kinase(CK)-MB 수치, 재관류 치료 후 CK-MB의 최고치 및 상승치, 경색 관련 혈관 및 혈관 내 병변의 위치와 비교 분석하였다. 결 과: 혈전용해치료군과 관동맥중재술군 모두에서 내원시 백혈구수는 초기 심근 손상의 정도를 대변할 수 있는 내원시의 CK-MB 값 및 흉통의 발생부터 응급실에 도착할 때까지의 시간과는 유의한 상관관계가 없었고, 경색 관련 혈관 및 혈관 내 병변의 위치와도 유의한 상관관계를 보이지 않았다. 그러나, 양군 모두에서 내원시 백혈구수는 급성 심근경색증에 대한 재관류 치료 후의 심근 손상을 대변할 수 있는 입원 중 CK-MB의 최고치와 유의한 상관관계를 보였다(혈전용해치료군;r=0.34, p<0.01, 관동맥중재술군;r=0.45, p<0.01). 결 론: 급성 심근경색증 환자에서 응급실 내원시의 백혈구수는 초기 심근 손상의 정도에 의해 결정되는 단순한 변수라기보다는, 재관류 치료 후의 심근 손상의 정도를 결정하는 예후 인자중의 하나로 작용할 수도 있다고 생각된다.
황정연,하상원,조은경,한정호,이선화,이승연,김두응 대한신경과학회 2012 Journal of Clinical Neurology Vol.8 No.4
Background Metamorphopsia includes a broad spectrum of visual perceptual distortions, such as alteration of perceived object size or, rarely, altered perception of faces, termed prosopometamorphopsia. Case Report This report describes a patient who complained of metamorphopsia restricted to the center of the face, particularly the lower part of the face (nose and mouth), following infarction of the right medial temporooccipital lobe that included the fusiform face area. Conclusions The fusiform face area is commonly believed to be a face-selective cortical region dedicated to the visual analysis of face stimuli. We speculate that any injury to this brain area could bring about prosopometamorphopsia involving whole or unilateral face perception, or very rarely, as in our case, distortion restricted to the central area of the face. Furthermore, there could be topographical correspondences between facial structures and the fusiform face area.
흰쥐 부분 근육 절제 모델에서 지방유래줄기세포의 치료 효과
황옥경 ( Ok Kyung Hwang ),홍일화 ( Il Hwa Hong ),기미란 ( Mi Ran Ki ),( Se Il Park ),박진규 ( Jin Kyu Park ),한정연 ( Jung Youn Han ),홍경숙 ( Kyung Sook Hong ),지애리 ( Ae Ri Ji ),정재호 ( Jae Ho Jeong ),강경선 ( Kyung Seon Ka 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Adipose tissue derived stem cells(ASCs) are multipotent cells capable of forming bone, cartilage, and other connective tissues. In this study we evaluated the effect of stem cells derived from adipose tissue on the muscle regeneration in partial removed skeletal muscle in rats. Male sprague-dawley rats were randomly divided into three groups: control, PBS-injected and ASCs-injected group. Stem cells were isolated from rat abdominal adipose tissue by collagenase digestion and ASCs labeled with superparamagnetic iron oxide(Feridex) were used. Muscle injury was subjected to rat bypartial removal of quadriceps femoris muscle. The labeled cells were directly injected into the muscle injured area after muscle injury an hour. After 2 weeks, histological analysis was performed using H&E staining and prussian blue staining. The muscle regeneration markers were examined by immunohistochemistry and RT-PCR. ASCs labeled with Feridex were detected by prussian blue staining in injured muscle area. Microscopical muscle regeneration and neovascularization were more increased in ASCs-injected group compared to PBS-injected group. The expression level of Pax7, MyoD and myogenin were more significantly increased in ASCs-injected group compared with the PBS-injected group. This preliminary observation shows that ASCs may be directly involved in the regeneration process of injured skeletal muscle; therefore the possibility of using ASCs as a stem cell therapy for muscle regeneration need to be further investigated for the purpose of clinical trials.
Hypertension and Neuropsychiatric Symptoms in Patients with Drug-Naïve Alzheimer’s Disease
황인하,백경화,한정호,하상원,양영순 대한치매학회 2017 Dementia and Neurocognitive Disorders Vol.16 No.3
Background and Purpose Neuropsychiatric symptoms (NPS) such as anxiety, depression, and delusions affect up to 90% of all patients with Alzheimer’s disease (AD). NPS is associated with significant caregiver burden and patient distress. Given the severe burden of NPS in AD, it is critical to know potential modifiable risk factors of NPS in AD. This study explores the association between hypertension and NPS in patients with drug-naïve AD. Methods We reviewed medical records of 149 patients with AD with (n=80) and without (n=69) hypertension. NPS were assessed using the Korean version of Neuropsychiatric Inventory (K-NPI). Affective, psychotic, and behavior symptom clusters were assessed separately. Results The total score of K-NPI was not significantly different between patients with AD with and without hypertension. Among K-NPI domains, scores of depression/dysphoria (p=0.045), anxiety (p=0.022), and apathy/indifference (p=0.037) were significantly higher in patients with AD with hypertension. Systolic blood pressure (BP) was associated with higher total K-NPI and affective symptom cluster scores. Diastolic BP was associated with affective symptom cluster scores. Conclusions Results suggest that hypertension increases risk of specific NPS in patients with AD. Among NPS, hypertension was associated with affective symptom cluster.