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만성 B 형 활동성 간염 환자에서 Prednisolone 이탈요법후의 알파인터페론 병용투여의 치료 효과
한광협(Kwang Hyup Han),김경희(Kyung Hee Kim),홍성표(Sung Pyo Hong),김원호(Won Ho Kim),전재윤(Chae Yoon Chon),이상인(Sang In Lee),문영명(Young Myoung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park),최홍재(Heung Jai Choi),박찬일(Chan 대한내과학회 1990 대한내과학회지 Vol.39 No.3
N/A To evaluate the efficacy of a short course of prednisolone withdrawal followed by recombinant alpha interferon (rIFNa 2-a) treatment with chronic active hepatitis B (CAHB), forty patients with peritoneoscopic, liver biopsy-proven CAHB were randomized to receive either a 3 week tapered course of prednisolone followed by rIFNa 2-a (Alpha-Feron) or no treatment. All patients were HBeAg positive and two groups were comparable with respect to age, sex and biochemical and histologic data. Interferon was administered at a dose of 6 million units (mu) given I.M. qd for 1 week and at the same dose thvee times a week for 15 weeks after prednisolone withdrawal. Transient side effects occurred in all treated patients, but the treated patients all tolerated and concluded treatment without side effects serious enough to give up the trials. Twelve of 20 treated patients (60%) cleared HBeAg and eleven patients (55%) seroconverted from HBeAg to antiHBe, whereas five of 20 control patients (25%) cleared HReAg and only two control patients (10%) seroconverted during a mean follow-up interval of 12 months. The seroconversion rate of HBeAg was significantly higher in treated groups than control (p<0.05). None of the treated or control patients became negative for HBsAg. The ALT normalization rate at last followup was higher in treated groups (60%) than control groups (35%) but there was no significant difference. Comparison of responders (n=10) to non-responders (n=10) indicated that there was no significant difference in age, sex and pretreatment ALT levels and HBV-DNA values. The responsers who had follow-up liver biopsy had improvement in liver histology. In conclusion, these results suggest that a short course of prednisolone withdrawal followed by rIFNa 2-a can be effective for selected patitns with HBeAg-positive CAHB.
만성 B형 간염 환자의 간조직내 B형 간염바이러스 유전자와 유전자 발현양상과의 상관관계
한광협(Kwang Hyup Han),오승희(Seung Hee Oh),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),박인서(In Suh Park),박영년(Young Nyun Park),박찬일(Chan Il Park) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.2
N/A To understand the pathogenesis of hepatitis B virus(HBV)-induced chronic liver disease, we studied the relationship between HBV DNA and antigens and subsequent correlation with pathologic findings in liver tissue. Routine paraffin-embedded liver specimens from 52 patients with HBV related chronic liver diseases(HBV carrier 8, chronic persistent hepatitis 15, chronic active hepatitis 15, and liver cirrhosis 14) were evaluated by using in situ hybridization(ISH) and immunohistochemistry(IHC). Using the IHC techniques, we detected intrahepatic HBcAg in all of 37 HBeAg positive pa- tients and four of 15 HBeAg negative patients. However, regardless of the presence of HBeAg, HBsAg was detected in most of the patients. Using the ISH techniques, HBV DNA was dectected in 23 of 37 HBeAg postive patients and 4 of 15 HBeAg patients. Intrahepatic distri- bution of HBcAg correlated well with the distribution of HBV DN A whereas HBsAg did not correlate well. According to the progression of the liver disease, the distributional pattern of intrahepatic HBV DN A and antigens was different. In addition, the simultaneous in situ de- tection analyses revealed that some hepatocytes containing high levels of HBV DN A were de- void of detectable HBcAg suggesting a mechanism by which restricted expression of HBV an- tigens on infected hepatocytes may escape host immune surveillance system resulting persis- tent HBV infection. (Korean J Gastroenterol 1994; 26: 289 297)
원발성 간암환자에서 절제술후 간내재발에 미치는 요인분석
박형석(Hyung Seok Park),송시영(Si Young Song),한광협(Kwang Hyup Han),전재윤(Chae Youn Chon),문영명(Young Myong Moon),강진경(Jin Kyung Kang),박인서(In Seo Park),민진식(Jin Sik Min) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.1
N/A Background/Aims: The prognosis of hepatocellular carcinoma is very grave. The most effective method of improving survival in patients with hepatocellular carcinoma is early diagno. ' and curative hepatic resection. Recently, diagnosis of HCC at early stage has been greatly enhanced by the advent of screening techniques. However long-term survival after curative resection remains low because of high recurrence rate. To identify factors affecting intrahepatic recurrence and to analyze patterns of intrahepatic recurrence, we evaluated 72 patients who underwent curative hepatic resection. Methods: Total 72 patients were evaluated and 33 recurred cases were divided into the three patterns according to the recurrence pattern. Pattern I;recurrence near the resected margin, and pattern II;nodular recurrence, and pattern III;widespread multinodular recurrence. Results: We found 33 cases of intrahepatic recurrence. The serum AFP level of recurred group was significantly higher than that of non-recurred group, and tumor size was larger in recurred group. No difference was noted in age, sex, serum albumin, bilirubin and HBsAg between two groups. The recurrence time of pattern I was earlier than other patterns, and cirrhosis combining rate was higher in pattern 11. The portal vein and bile duct invasion rate was higher in pattern I and III than pattern Il. The survival rate of recurred group was lower than that of non-recurred group, and survival of pattern I was lower than other groups. Conclusions: It is suggested that careful follow-up is needed when tumor size is larger than 10 cm, portal vein and bile duct is infiltrated by tumor cel), and AFP is higher than 400 ng/ml. (Korean J Gastroenterol 1995;27:72-82)
한국인 non - A , non - B 간질환에서 C 형 간염바이러스 항체 ( anti - HCV ) 의 검출에 관한 연구
김경희(Kyung Hee Kim),문영명(Young Myoung Moon),정미령(Mi Ryoung Chung),한광협(Kwang Hyup Han),전재윤(Chae Yoon Chon),이관식(Kwan Sik Lee),김원호(Won Ho Kim),이상인(Sang In Lee),강진경(Jin Kyung Kang),박인서(In Suh Park),최홍재(Heung 대한내과학회 1990 대한내과학회지 Vol.39 No.2
N/A An epidemiological study of the hepatitis C virus (HCV) infection and its etiological significance in non- A, non-B acute and chronic liver disease in Korea was performed by testing serum samples from patients for antibody to HCV (anti-HCV). Anti-HCV was detected by enzyme-linked immunoassay (Ortho Diagnostic Systems). 1) Anti-HCV was detected in sera of 3 (30.0%) out of 10 cases with non-A, non-B acute hepatitis. Anti-HCV was detected in 30 (69.7%) out of 43 cases with non-A, non-B chronic hepatitis, and in 9 (60.0%) out of 15 cases with non-A, non-B liver cirrhosis. In 12 (10.2%) out of 118 patients with ESRD in hemodialysis units, anti-HCV was detected. Forty healthy controls and 51 cases with fatty liver had no detectable anti-HCV, and 24 HBsAg carriers were negative in all but one. 2) Three (50.09p) out of six cases with posttransfusion non-A, non-B acute hepatitis were seroconverted, but none of the four cases with sporadic non-A, non-B acute hepatitis were anti-HCV positive. 3) Nine (30.0%) out of 30 anti-HCV positive cases with non-A, non-B chronic hepatitis had a history of blood transfusion and multiple acupuncture. 4) There was no significant difference between anti-HCV positive patients and anti-HCV negative patients with non-A, non-B chronic liver disease in the history of blood transfusion or the liver function test. 5) Seropositivity to HCV was unrelated to the presence of anti-HBc or anti-HBs in patients with liver cirrhosis. We concluded that anti-HCV is colosely associated with non-A, non-B liver disease in Korea, and HCV seems to have a correlation with the etiology and pathogenesis of non-A, non-B liver diseases.
대뇌 침범이 확인된 Henoch - Schonlein 자반증 1 예
정경섭(Kyung Sup Chung),김경철(Kyung Cheol Kim),조현명(Hyeon Myeong Cho),최규헌(Kyu Hun Choi),한광협(Kwang Hyup Han),홍천수(Chein Soo Hong),허균(Kyoon Huh),홍순원(Soon Won Hong),최인준(In Joon Choi) 대한내과학회 1991 대한내과학회지 Vol.40 No.3
Henoch-Schonlein purpura is a generalized small vessel vasculitis of the hypersensitivity type characterized by the association of cutaneous lesions with gastrointestinal, joint and/or renal symptoms. The syndrome may occur in infants as well as in adults, but it occurs most commonly in childhood. Neurologic involvement was recognized in 1914 by Osler who described a child with allergic purpura associated with a hemiplegia. Since then, relatively little has been written in the medical literature concerning the neurologic manifestations of this illness. The neurologic symptoms and signs may be due to the involvement of the meningeal and cerebral parenchymal vessels by the fibrinoid necrotizing arteriolitis or arteritis of this disease causing the diffuse cerebral ischemia. And it may be aggrevated by a consequence of the hypertension and metabolic derangements that can accompany renal involvement. We report a case of Henoch-Schonlein purpura with neurologic involvement, which was menifestated by typical clinical pictures including severe headache and generalized seizure associated with multifocal low density on computed tomography and abnormal EEG findings.
이현철(Hyun Chul Lee),허갑범(Kap Bum Huh),홍성관(Sung Kwan Hong),노현정(Hyun Jung Roh),최병주(Byung Joo Choi),안상훈(Sang Hoon An),서일(Il Suh),한광협(Kwang Hyup Han) 대한내과학회 1999 대한내과학회지 Vol.57 No.3
The insulin resistance and the altered glucose metabolism in chronic liver disease increase the alteration of glucose intolerance and the prevalence of diabetes mellitus. The prevalence of DM is higher in advanced cirrhosis than in early cirrhosis and higher in C-viral hepatitis or alcoholic liver disease than in B-viral hepatitis. The purpose of this study is to assess the prevalence of DM in chronic liver disease in Korea. Methods : We reviewed the medical records of 417 patients with chronic liver disease who visit the Yonsei University Sevrance Hospital from January 1994 to March 1998. We examined fasting blood sugar, biochemical study and abdominal ultrasonography. DM was defined on the basis of fasting hyperglycemia (fasting blood sugar exceeding 140 mg/dl) at least two consecutive samples or active treatment with insulin or oral hypoglycemic agents. Results :1) The DM prevalence was 16.8%(70 cases) in total patients and 25.0% (56 cases) in cirrhotic patients. 2) According to sex, there was no statistically significant difference in DM prevalence(16.8% in men and 18.1% in women P=0.78). 3) The DM prevalence was increased with increasing of age(0% in below 30 years, 4.9% in 31-40, 19.6% in 41-50, 22.9% in 51-60, 21.3% in 61-70 and 44.4% in over 71 years, P<0.01). 3) According to severity of liver disease, the DM prevalence was higher in uncompensated cirrhosis than in compensated cirrhosis(2.3% in chronic viral carrier, 8.8% in chronic hepatitis, 17.9% in cirrhosis Child class A, 33.9% in class B, 29.5% in class C). 4) According to cause of liver disease, the DM prevalence was higher in C-viral hepatitis and alcoholics than in B-viral hepatitis(12.1% in B-viral hepatitis, 35.1% in C-viral hepatitis, 40.0% in alcoholics). Conclusion : The prevalence of diabetes in the patients with chronic liver disease is much higher than in general population. And the DM prevalence is increased in advanced cirrhosis and C-viral or alcoholic hepatitis. The early diagnosis and treatment of DM in chronic liver disease patients are important. (Korean J Med 57:281-287, 1999)
전재윤,문영명,박영년,백용한,박찬일,한광협 대한소화기학회 2000 대한소화기학회지 Vol.36 No.2
Background/Aims: This study was designed to assess the etiology and characteristics of chronic liver disease among the young male adults. It was also investigated whether grades of activity and status of fibrosis defined by the new histopathologic classification system of chronic hepatitis are related with alanine aminotransferase (ALT) level and HBeAg status in HBsAg-positive case. Methods: Peritoneoscopic findings, clinical features and histopathologic features of liver were investigated for 140 young men who received liver biopsy for military medical certificate from January 1994 to December 1997. These features were evaluated according to the grade and stage of chronic hepatitis. Results: In Korea, hepatitis B virus was the main cause of chronic hepatitis (87.7%) in young male adults and the infection of hepatitis C virus was rare (1.4%). Among HBsAg-positive cases with normal ALT level, 82.2% of them revealed chronic liver disease, and 48.3% of them showed chronic active hepatitis/cirrhosis in biopsy specimens. The grade of chronic hepatitis showed weak correlation with ALT level and the stage did not. There was no significant difference in the grade and stage of chronic hepatitis according to the serum HBeAg status. Conclusions: The most common cause of chronic liver disease in Korean young male adults was hepatitis B virus, and most (92.6%) of HBsAg-positive cases were proved to have chronic liver diseases histologically, regardless of the serum ALT level. According to new histopathologic classification system of chronic hepatitis, serum ALT level correlated with necroinflammatory activity of chronic hepatitis B, but not with fibrosis in HBsAg-positive cases.