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고지방혈중에서 Bezafibrate ( Bezalip(R)) 의 효과에 대한 연구
이웅구(Woong Ku Lee),김병옥(Byung Ok Kim),조현명(Hyeon Myeong Cho),장양수(Yang Soo Jang),정남식(Nam Sik Chung),심원흠(Won Heum Shim),조승연(Seung Yun Cho),김성순(Sung Soon Kim),양주영(Joo Young Yang) 대한내과학회 1991 대한내과학회지 Vol.40 No.6
N/A Among the risk factors associated with coronary artery disease, hyperlipidemia is one of the most important. Bezafibrate has been shown to effctively reduce elevated levels of low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) in hyperlipidemia. It has also been claimd to be particularly effective in increasing high-density lipoprotein (HDL) concentrations. In the present study, 22 hyperlipidemic patients were investigated before and after 8 weeks treatment with bezafibrate (300 mg to 400 mg daily) in an effort to clarify futher the effects and side effects of the drug. In the group of 9 patients with hypertriglyceridemia (TG level>230mg%), the serum triglycerides decreased by 63%(p<0.01) and the HDL cholesterol increased by 45%, (p<0.01) corresponding to a significant reduction of total cholesterol/HDL cholesterol ratio. In the group of 9 patients with hypercholesterolemia (cholesterol level > 240 mg%), the total cholesterol decreased by 20% (p<0.01), the LDL cholesterol decreased by 25% (p<0.01) and HDL cholestrol increased by 44% (p<0.01) corresponding to a significant reduction of LDL/HDL ratio. In the group of 4 patients with combined hyperlipidemia (TG level > 230 mg% and cholesterol level > 240 mg%), the total cholesterol decreased by 23% (p<0.01), the serum triglyceride decreased by 62% (p<0.01) and the HDL-cholesterol increased by 19% (p<0.05) corresponding to a significant reduction of total cholesterol/HDL cholesterol ratio. In the total of 22 patients, the total cholesterol decreased by 15% (p<0.05), the serum triglyceride decreased by 59% (p<0.01) and the HDL cholesterol increased by 39% (p <0. 01) corresponding to a significant reduction of total cholesterol/HDL cholesterol ratio. No subjective side effects were noted from the drug, except in one patient with mild gastrointestinal symptoms. In conclusion, it was noted that the bezafibrate was an effective and safe drug useful in the treatment of hyperlipidemia in Korean adult patients.
대뇌 침범이 확인된 Henoch-Schonlein 자반증 1 예
홍천수,최인준,홍순원,한광협,최규헌,허균,정경섭,김경철,조현명 대한내과학회 1991 대한내과학회지 Vol.40 No.3
Henoch-Schonlein purpura is a generalized small vessel vasculitis of the hypersensitivity type characterized by the association of cutaneous lesions with gastrointestinal, joint and/or renal symptoms. The syndrome may occur in infants as well as in adults, but it occurs most commonly in childhood. Neurologic involvement was recognized in 1914 by Osler who described a child with $quot;allergic purpura$quot; associated with a hemiplegia. Since then, relatively little has been written in the medical literature concerning the neurologic manifestations of this illness. The neurologic symptoms and signs may be due to the involvement of the meningeal and cerebral parenchymal vessels by the fibrinoid necrotizing arteriolitis or arteritis of this disease causing the diffuse cerebral ischemia. And it may be aggrevated by a consequence of the hypertension and metabolic derangements that can accompany renal involvement. We report a case of Henoch-Schonlein purpura with neurologic involvement, which was menifestated by typical clinical pictures including severe headache and generalized seizure associated with multifocal low density on computed tomography and abnormal EEG findings.