소아 만성 신질환 진행의 위험인자 분석-단일기관 연구

한경희,이성하,이현경,최현진,이범희,조희연,정해일,최용,하일수,Han, Kyoung-Hee,Lee, Sung-Ha,Lee, Hyun-Kyung,Choi, Hyun-Jin,Lee, Bum-Hee,Cho, Hee-Yeon,Cheong, Hae-Il,Choi, Yong,Ha, Il-Soo 대한소아신장학회 2007 Childhood kidney diseases Vol.11 No.2

목 적 : 소아에서 진행하는 신기능 저하는 그들의 인생에 일생 동안 심각한 영향을 준다. 소아 만성 신질환의 치료에 있어서 궁극적인 목표는 생명을 연장시키는 것뿐 아니라 만성 신질환에 이환됨으로써 발생하는 여러 합병증을 예방하고 성장과 발달을 향상시키는 것이다. 저자들은 소아 만성 신질환에서 신기능 감소와 관련된 위험요인을 분석하고자 한다. 방 법 : 1999년 8월부터 2007년 3월까지 만성 신질환에서 2기에서 4기에 해당하는 환자들의 임상적 특성을 후향적으로 조사하였다. 추정 사구체여과율은 혈중 크레아티닌과 키를 이용하여 Schwartz 공식으로 계산하였다. 연간 eGFR변화는 연구시작시의 eGFR과 마지막 추적 관찰시의 eGFR간의 차이를 추적 관찰 기간으로 나누어 계산하였다. 환자들을 추적 관찰중에 측정한 혈청 칼슘과 무기인과 함께 연령과 성별 및 원인 신질환도 연간 eGFR 변화와의 관련성을 조사하였다. 결 과 : 전체 환자는 61명이었고 이중 남자는 44명, 여자는 17명이었다. 연구 시작 시 환자들의 연령은 $7.1{\pm}4.7$세이었다. 전체 환자들의 연간 eGFR 변화는 $-1.2{\pm}11.9 mL/min/1.73m^2/year$이었다. 나이가 많거나(P=0.012), 저칼슘혈증이 있을 때(P=0.012), 고인산혈증인 경우(P=0.002) 신기능 감소와 유의한 관련이 있었다. 결 론 : 나이가 많거나, 저칼슘혈증과 고인산혈증은 소아 만성 신질환의 더 빠른 진행과 연관성이 있다. Purpose : The progressive deterioration of renal function in children can impose a serious and lifelong impact on their lives. The ultimate goal in the management of children with chronic kidney disease(CKD) is to prolong survival, to prevent complications, and to promote growth and neurodevelopment. The aim of this study is to investigate the risk factors for the decline of renal function in pediatric CKD patients. Methods : Data from patients who met the criteria for the Kidney Disease Outcomes Quality Initiative(K/DOQI) CKD stage 2 to 4 between August 1999 and March 2007 were retrospectively analyzed. The estimated glomerular filtration rate(eGFR) was calculated by the Schwartz formula, using serum creatinine levels and height. We calculated the annual eGFR change from the difference between the baseline eGFR and the last eGFR divided by the duration(years) of the follow-up period. We analyzed the association between the annual eGFR change and factors such as age, gender, K/DOQI stage, underlying renal disease, serum calcium, and inorganic phosphorous during the follow-up period. Results : Sixty one children(44 boys & 17 girls) were enrolled. The age at entry was $7.1{\pm}4.7$ years. The annual eGFR change was $-1.2{\pm}11.9 mL/min/1.73m^2/year$. Our study showed that older age(P=0.005). hypocalcemia(P=0.012), and hypenhosphatemia(P=0.002) were significantly related to more rapid decline in renal function. Conclusion : In pediatric CKD, older age, hypocalcemia and hyperphosphatemia are related to more rapid deterioration of renal function.

($Nanogide-C^{(R)}$와 $Biomesh^{(R)}$를 이용한 이개부 결손부에 대한 조직유도재생술의 임상효과

한경희,정종원,현하나,김지만,김윤상,피성희,신형식,Han, Kyung-Hee,Jung, Jong-Won,Hyun, Ha-Na,Kim, Ji-Man,Kim, Yun-Sang,Pi, Sung-Hee,Shin, Hyung-Shik 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.4

This study was designed to compare the effects of treatment using chitosan membrane $(Nanogide-C^{(R)})$ resorbable barrier with control treated by polylactic acid/polylacticglycolic acid membrane(PLA/PLGA membrane, $Biomesh^{(R)}$). 44 furcation defecs from 44 patients with class 2 furcation degree were used for this study, 22 sites of them were treated by chitosan membrane as experimental group and 22 site were treated by PLA/PLGA membrane as control group. Clinical parameters including probing depth, gingival recession, attachment level and radiographic examination were evlauated at base line, 1 month, 2 month and 3 month. after surgery. Statistical test used to analyze these data included paired t-test, one way ANOVA. The results are as follows : 1. Probing depth was significanlly decreased in the two group and there were significant differences between groups(p<0.05). 2. Gingival recession was not significanlly increased in the two group and there were no significant differences between groups(p<0.05). 3. Loss of attachment was statistically decreased in the two group and there were no significant differences between groups(p<0.05). 4. Horizontal bone level was significanlly increased in the two group and there were significant differences between groups(p<0.05). On the basis of these results, chitoans resorbable membrane has similar potential to PLA/PLGA membrane in GTR for furcation defect.

가족 내에서 전파된 설사-연관형 용혈성 요독 증후군

한경희,이현경,이성하,조희연,정해일,최용,배현미,김성권,하일수,Han, Kyoung-Hee,Lee, Hyun-Kyung,Lee, Sung-Ha,Cho, Hee-Yeon,Cheong, Hae-Il,Choi, Yong,Bae, Hyun-Mi,Kim, Suhng-Gwon,Ha, Il-Soo 대한소아신장학회 2006 Childhood kidney diseases Vol.10 No.2

Diarrhea-associated hemolytic uremic syndrome(D+ HUS) is induced by enterohemorrhagic Escherichia coli(EHEC) and is characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. The disease is usually transmitted by meat and water contaminated by excreta of domestic animals. We report a son and his mother with diarrhea-associated hemolytic uremic syndrome that spread within the family.

임옥인 소설에 나타나는 월남 체험의 서사화와 사랑의 문제

한경희(Han, Kyung-hee) 춘원연구학회 2014 춘원연구학보 Vol.- No.7

경관급식 유동액의 점도와 삼투압이 체외에서 비장관 튜브를 통한 흐름속도에 미치는 영향

한경희(Han Kyung Hee),조금호(Cho Kum Ho),김평자(Kim Pyung Ja) 韓國營養學會 1993 Journal of Nutrition and Health Vol.26 No.6

안동지역 근대문학 연구의 가능성 모색

한경희(Han Kyung-hee) 한국국학진흥원 2007 국학연구 Vol.11 No.-

이 논문은 지역문학 연구를 모색하는 과정에서 시도되었다. 지역문학 연구는 지역단위별 작가와 작품의 역사를 찾아가는 문학사의 시선을 지닌다. 지역 안에 살아가는 사람처럼 문학도 역시 동일한 역사를 나누며 그들의 삶을 중심에 두고 창작활동을 한다. 그러므로 지역문학 연구의 의의는 작품과 작가의 관련성을 실제 지리적 공간에서 시도하는 데 있다. 작품 속에 등장하는 언어를 통해 공간을 상상력으로 구성하는 것이 아니라 작품 이해의 출발 자체를 실제 삶의 공간, 즉 지역으로 설정한다. 이렇게 생생하게 살아있는 작가의 삶의 현장이나 작품의 터전으로 정소가 부상한다. 그러므로 지역문학은 생동감 있는 생활영역에서의 문학이며, 유사한 문화현상을 겪고 이웃하는 사람과의 소통로이기도 하다. 지역문학 연구의 필요성을 언급했으나 실제 연구대상을 만나기는 매우 어려운 일이다. 특히 역사시간을 과거로 되짚어 갈수록 난감해진다. 특히, 근대전환기 지역문학의 지형도 그리기는 자료면에서 더욱 힘든 점이 있다. 이 시기는 근대문학의 다양한 양식이 시도되거나 실험되었다. 그러나 대부분 지역의 문학이란 전근대 문학양식이 그대로 이어지는 수준에서 크게 벗어나지는 못했다. 이 과도기 상황 가운데 근대문학의 특정으로 가장 대표적인 것을 제시해보면 근대공간에서 창작된 한시를 들 수 있다. 이렇듯 전통 장르는 낯선 문화와의 충돌, 접합의 시간을 보내면서 새로운 양식으로 변화되었던 것이다. 안동지역의 경우, 근대전환기는 사상의 전환과 거주의 변화가 문중단위로 일어난다. 겉으로 드러나는 변화의 근본적인 목적은 일제히 조국의 해방과 독립으로 모아진다. 이런 변화의 중심에 석주 이상룡이란 인물이 있다. 물론 이상룡을 단순히 시인이나 문장가로 고집하려고 하는 것이 아니다. 이상룡이 살았던 시대의 역사와 철학 역시 문학의 이름으로 불렀음을 헤아릴 필요가 있다. 근대라는 공간으로의 완전한 이동 이전의 세계, 지역 안에서 유학적 지식인들의 문학적 소양과 능력은 매우 놀라울 정도로 탁월했고, 이들의 문집이 바로 그것을 증거하고 있다. 이들 작품이 바로 당시 지역의 문학을 담당하였다. 지역문학사 연구는 지역 역사의 흐름을 통해 문학현상을 파악하고 문학적 의미를 묻는 데로 나아가는 것이 필요하다. 지역문학 연구의 길찾기 방법이란 특별하게 있는 것이 아니라 지역 현장을 찾아나서는 일에서 시작된다. 이것이야말로 별로 새로울 것도 없는 방법론이지만, 지역 단위별 문학자료와 문헌과 관련한 조사에서는 절대적으로 필요한 조사방법이다. 근대로의 변화과정에서 유학적 지식인으로서 신념과 명분을 지속했던 석주 이상룡의 문집에 실린 다양한 기록과 여정들을 통해 근대 전환기의 안동지역 유학자의 문학세계를 고찰한다. 이 글은 지역문학 연구의 길찾기는 물론이고 지속적인 연구의 가능성을 모색하는데 연구목적이 있다. Meaning of area literature research is to a diversification of literature research. Our literature history description as fragmentary tendency of literature research of Seoul and the condition center is a possibility of doing. Literature history it writes newly and must see an area literature with new gaze the small cymbal. The area always newly will be interpreted is report of the data which it is being lived. It arranges the necessity of area literature research. The area literature research interprets the area newly and becomes the force which it composes with the culture space which is competitive power. To the area there is a many author and it continues the activity which is excellent. To the area the literature group and the literature group are active and it does a literature activity. Also the literature magazine publishes every year, the authors cultivate the area in the city of culture and they are endeavoring. Like this the area is born again is endeavoring in the city which is culture competitive power. There is an area literature person to this composition inside and is literature activity describing minutely the thing important. This essay have a vision of regional literature in andong area. Studying on region is very difficult point which have lack of literature data. Region literature of history is as general same as to study history. Many people in andong area are described as focussing their living dealing with another area people. Therefore meaning of region literature researching is attempted on real area space relationships of works and writers. These active writer's life and region are rebirth of origin the making space. And region literature is reality living area, placed in neighborhood man feel with a same culture. For example, andong region is changed of thoughts and livings by family groups. A basic ends of outgoing change is together with nation of freedoms and independence. A middle of these changes is being name as suk-ju Lee sang yong. Of course suk-ju Lee sang yong is not only poet and a good writer. Modem history and philosophy as colonialism period Suk-ju Lee sang yong is determination to come to Maju as an exile. Living a meaning confucianism intellectual in andong Suk-ju Lee sang yong is recognized of necessity in colonial period. Suk-Ju's the poem and prose of above Ryong the good object at the day when it draws the literature topographical map of modem time converter andong are. Suk-Ju' s books the place where it grasps the area literature of this time are the work which is important, Suk-ju' s the colony situation which it gives with study belief and it is an intellectual interest author whom it practices. The whole life it leads and it practices a study value in the actuality world to leave a beautiful countenance, it put. Like this people it leads and area literature to be abund ant more a quality possibility.

이동통신 서비스 품질 측정

한경희 ( Kyung Hee Han ),조재립 ( Jai Rip Cho ) 한국품질경영학회 2010 한국품질경영학회 학술대회 Vol.2010 No.1

우리나라 고가의료장비 분포 및 노후화 현황 분석

한경희 ( Kyung Hee Han ),고수경 ( Su Kyoung Ko ),정설희 ( Seol Hee Jeong ) 한국병원경영학회 2007 병원경영학회지 Vol.12 No.1

This study was carried out to analyze the present condition of high-price medical technologies in South Korea and to compare it with OECD countries. This study included 10 high-price medical equipments and used medical equipment registry data of Health Insurance Review Agency. The major findings of this study are as follows; Firstly, The number and growth of high-price medical equipments in South Korea is much higher than those in other OECD countries. There are many of high-price medical equipments even in clinics. Secondly, the percentage of old poor-quality medical equipments is very high, especially in clinics. This is because of high-price of medical equipments. The results of this study implicated that there is high possibility of inappropriate use of high-price medical technologies. This may result in the increase of health expenditure; therefore, there should be a kind of regulation policy to control amount and quality of medical equipment.

유방암의 조직학적 악성도에 따른 에스트로겐 수용체(ER)와 프로게스테론 수용체(PR), 그리고 C-erbB-2 종양단백질 발현과의 상관관계

한경희 ( Kyung Hee Han ),김태전 ( Tai Jeon Kim ) 대한임상검사과학회 2004 대한임상검사과학회지(KJCLS) Vol.36 No.2

Overexpressions of the estrogen receptors(ER), progesterone receptors(PR) and C-erbB-2 protein are important determiners of the response to chemotherapy in the breast cancer. For detecting ER, PR and C-erbB-2, immunohistochemistry are currently regarded as standard method. The purposes of this study compared to histologic grade and expression of the ER, PR and C-erbB-2 in breast cancer. We examined overexpression of ER, PR and C-erbB-2 protein in 84 breast carcinomas by using immunohistochemical stains. The following results were obtained. For histologic grade, 10 cases(11.9%) showed carcinoma in situ, 16 cases(19%) showed grade Ⅰ, 36 cases (42.9%) showed grade Ⅱ, and 22 cases(26.2%) showed grade Ⅲ among the 84 test samples. The average positive rate ER and PR was 63%, 46% showed carcinoma in situ, 80%, 60% showed grade Ⅰ, 64%, 41% showed grade Ⅱ, 34%, 23% showed grade Ⅲ, respectively. The induction of PR increased when induction of ER increased, thus showing significant relationship(p<0.05). The expression of C-erbB-2 protein was 9 cases(10.7%) in one positive(1+), 9 cases(10.7%) in two positive(2+), and 9 cases(10.7%) in three positive(3+). C-erbB-2 protein expression showed no statistical significance. In conclusion, ER and PR positive rates were inversely associated with histologic grades significantly(p<0.05). C-erbB-2 showed no significant difference with histologic grade. However ER, PR and C-erbB-2 showed significant relationship with each other(p<0.05). Therefore, these findings might be an important prognostic factor and might be arranged as a regular pathological examination in cases of breast cancer.

간 조직내 HBcAg 및 HBsAg의 면역조직화학염색에 의한 발현양상과 Victoria blue 염 색 과의 비교연구

한경희 ( Kyung Hee Han ) 대한임상검사과학회 1998 대한임상검사과학회지(KJCLS) Vol.30 No.3

The expression pattern of HBcAg and HBsAg in the liver of 01 serum HBsAg positive and 21 serum anti-HCV positive patients were studied by immunohistochemical stain method (Avidin-biotin conjugate). The sensitivity and specificity of irrmmohistochemical stain were compared with those of victoria blue stain and the results are as follows. 1. The expression of HBcAg and HBsAg in liver were 46.3%(31cases) and 1000/0 of serum HBsAg positive patients by irrmmohistochemical stain. 2. Victoria blue stain showed positive reaction in 83.6%(56cases) of serum HBsAg positive patients. Most of victoria blue negative cases showed membranouses expression of HBsAg by immunohistochemical stain. 3. The expression pattern of HBsAg and HBcAg in the liver were type II(3.0%), type III (46.3%) and type IV(50.7%) and the major expression pattern of inactive carrier was type III. 4. All cases of serum anti-HCV positive and HBsAg negative patients showed negative reaction by victoria blue stain and irrmmohistochemical stain for HBsAg and HBcAg. In conclusion, Imrrnmohistochemistry and victoria blue stain evaluated to the specific method for HBcAg and HBsAg. Immunohistochemical stain is necessary to study expression of hepatitis B virus maker, because of the sensitivity of victoria blue is &3.6% and lower than that of irrmmohistochemical stain.