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틸리나 라자팍셔(Thilina Rajapakse),이정주(LEE Jeong Ju) 영남대학교 박정희새마을연구원 2016 새마을학연구 Vol.1 No.1
The purpose of this research is to compare integrated rural development models of Saemaul Undong and Rural Centric Integrated development initiatives of Sri Lanka and offer an application of a system model for Senge s five disciplines of Learning Organization in Integrated rural development initiatives. The study utilizes a conceptual framework for the analysis of antecedents and outcomes of Senge s five disciplines of learning organization, focusing on specific factors unique to rural community development organizations. The explication of the model manifests its relevance and applicability for Saemaul Undong: it represent how Saemaul Undong operate as a learning organization and posits the anticipated interactions among specific constructs associated with Senge s five disciplines within Saemaul Undong community organization.
김태환,틸리나,김재훈,이광녕,박종현,김철중,이종수,Kim, Tae-Hwan,Herath, Thilina U. B.,Kim, Jae-Hoon,Lee, Kwang-Nyeong,Park, Jong-Hyeon,Kim, Chul-Joong,Lee, Jong-Soo 한국미생물학회 2017 미생물학회지 Vol.53 No.4
구제역 바이러스 연구가 BSL-3 시설에 제한되기 때문에 여러 가지 소독제나 항바이러스 제제에 대한 효력 및 효능 평가가 쉽게 이루어질 수 없다. 따라서 구제역 바이러스와 계통학적으로 유사한 bovine rhinovirus (BRV)와 human rhinovirus (HRV)의 특성을 열, pH 그리고 여러가지 소독제를 이용하여 평가하였다. 그 결과 구제역 바이러스의 성상과 매우 흡사한 것을 확인할 수 있었다. 이러한 결과로 BRV와 HRV는 구제역 바이러스를 대체할 수 있는 모델 바이러스로 이용이 가능하다. Researchers have comparatively fewer opportunities to conduct experiments on foot-and-mouth disease virus (FMDV), owing to the limited availability of biosafety level 3 facilities. Bovine rhinovirus (BRV) and human rhinovirus (HRV), which are genetically closely related to FMDV, have been evaluated in this study as model viruses for FMDV. To discover whether BRV and HRV have similar physicochemical properties as FMDV, virus susceptibility tests have been performed in different physical (pH and heat) and chemical (acidic/alkaline solutions and commercial disinfectants) conditions in vitro. Our data revealed that the physicochemical characteristics of BRV and HRV were nearly similar to those of FMDV.
Dense Granule Protein-7 (GRA-7) of Toxoplasma gondii inhibits viral replication in vitro and in vivo
Prasanna Weeratunga,틸리나,김태환,이현철,김재훈,이병훈,이은서,Kiramage Chathuranga,W. A. Gayan Chathuranga,양철수,마진열,이종수 한국미생물학회 2017 The journal of microbiology Vol.55 No.11
Dense granule protein-7 (GRA-7) is an excretory protein of Toxoplasma gondii. It is a potential serodiagnostic marker and vaccine candidate for toxoplasmosis. Previous reports demonstrated that GRA-7 induces innate immune responses in macrophages by interacting with TRAF6 via the MyD88- dependent pathway. In the present study, we evaluated the antiviral activity and induction of an antiviral state by GRA-7 both in vitro and in vivo. It was observed that GRA-7 markedly reduced the replication of vesicular stomatitis virus (VSVGFP), influenza A virus (PR8-GFP), coxsackievirus (H3- GFP), herpes simplex virus (HSV-GFP), and adenovirus-GFP in epithelial (HEK293T/HeLa) and immune (RAW264.7) cells. These antiviral activities of GRA-7 were attributed to the induction of type I interferon (IFN) signaling, resulting in the secretion of IFNs and pro-inflammatory cytokines. Additionally, in BALB/c mice, intranasal administration of GRA-7 prevented lethal infection by influenza A virus (H1N1) and exhibited prophylactic effects against respiratory syncytial virus (RSV-GFP). Collectively, these results suggested that GRA-7 exhibits immunostimulatory and broad spectrum antiviral activities via type I IFN signaling. Thus, GRA-7 can be potentially used as a vaccine adjuvant or as a candidate drug with prophylactic potential against viruses.