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가미윤조탕(加味潤燥湯)이 LPS로 유도된 RAW 264.7 대식세포에서의 항염 효과 연구
최종민,김용민,김희택,Choi, Jong-Min,Kim, Yong-Min,Kim, Hee-Taek 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.1
Objectives : Allergic disease has been well known as an IgE-dependent immunologic response. Recently, interest about the late inflammatory reaction has grown up as well as early allergic reaction characterized by IgE and mast cell. The purpose of this study was to find the anti-inflammatory effect of Gamiyunjo-tang(GMYJT) in allergic reaction. Methods : The experiment was performed using Raw 264.7 cells pretreated with GMYJT extracts. In this study, we observed the toxicity of cells by MTT analysis and measured the production of LPS-induced NO, $PGE_2$, IL-$1{\beta}$, IL-6 and TNF-${\alpha}$ at a concentration of 50, 100, 200 and $400{\mu}g/ml$. Results : No toxicity of GMYJT (50, 100, 200, $400{\mu}g/ml$) on RAW 264.7 cells was found after 24 hours incubation. LPS-induced NO production was reduced after treatment with GMYJT (100, 200, $400{\mu}g/ml$)(P<0.05). $PGE_2$ was reduced after treatment with GMYJT (100, 200, $400{\mu}g/ml$)(P<0.05). IL-$1{\beta}$ did not decrease at any dose. IL-6 decreased at 200, $400{\mu}g/ml$(P<0.05). TNF-${\alpha}$ production decreased only at $400{\mu}g/ml$(P<0.05). Conclusions : These data suggest that GMYJT has anti-inflammatory effects in late allergic reaction.
Human Liver Microsomes과 HepG2 세포를 이용한 약물유래 간독성 평가 방법의 최적화
최종민,전장수,김상겸,Choi, Jong Min,Jeon, Jang Su,Kim, Sang Kyum 대한약학회 2015 약학회지 Vol.59 No.5
The aim of the present study was to optimize in vitro method for the prediction of drug-induced liver injury using human liver microsomes (HLM). Cytotoxicity test of cyclophosphamide and acetaminophen in HepG2 cells cultured with HLM showed that the newly established condition using 0.375 mg/ml HLM for 24 hr incubation was comparable or more sensitive than the previously established condition using 0.75 mg/ml HLM for 12 hr incubation. Although the cytotoxic effect of troglitazone was completely attenuated by 0.75 mg/ml HLM, it was augmented by 0.375 mg/ml HLM in the presence of the NADPH-generating system. The cytotoxic effect of chlormezanone, a withdrawn drug due to hepatotoxicity in human, was increased by HLM in the presence of the NADPH-generating system. In contrast, the cytotoxic effect of methapyrilene, a withdrawn drug due to hepatotoxicity in rats, was decreased by HLM in the presence of the NADPH-generating system. The present study suggests that the optimized in vitro method using HLM can be useful for the prediction of drug-induced hepatotoxicity.
음성신호와 전기성문파를 이용하는 새로운 매개변수 ; 성대 폐쇄 지연비율(Glottal Closure Delay Ratio)
최종민,권택균,정은정,이명철,김광현,성명훈,박광석,Choi, Jong-Min,Kwon, Tack-Kyun,Jung, Eun-Jung,Lee, Myung-Chul,Kim, Kwang-Hyun,Sung, Myung-Whun,Park, Kwang-Suk 대한후두음성언어의학회 2007 대한후두음성언어의학회지 Vol.18 No.1
Background and Objectives: Biomedical signals have been usually used for the diagnosis of the laryngeal function such as speech, electroglottograph(EGG), airflow and other signals. But, in most cases these signals were analysed separately. Here, we propose a new interchannel parameter Glottal Closure Delay Ratio(GCDR) which is estimated from speech and EGG measured simultaneously. Materials and Method: Speech and EGG signal were recorded simultaneously from 13 normal subjects, 39 patients. The patients' data included 16 polyps and 23 vocal folds palsy. Time difference between glottal closing instance on EGG and the first maximum peak on speech in a pitch period was calculated. Glottal closing instance was defined as the maximum peak on the first derivative of EGG signal(dEGG). Results: The standard deviation and jitter were calculated using 20-30 GCDRs extracted from each data, and they are significant different between normal and vocal fold paralysis group. Conclusion: The GCDR may be the first index reflecting speech and EGG characteristics and the perturbation of this parameter was significant different between normal and vocal fold paralysis group.
최종민,김희택,류주현,이인수,Choi, Jong-Min,Kim, Hee-Taek,Ryu, Ju-Hyun,Lee, In-Su 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.1
Objective : The purpose of this study was to know the clinical effect of Hydrotherapy based Ultasonic spa on Atopic Dermatitis and Allergic Rhinitis. Methods : Allery Test(MAST CLA Allergy system, inhalant panel), DITI, Bio Chemistry, Hematology were investigated in 20 patients(Atopic Dermatitis 10, Allergic Rhinitis 10) who visited Department of Ophthalmology & Otolaryngology & Dermatology, Semyung Oriental medicine hospital from November 2004 to January 2005. Results : 1. In atopic dermatitis patients, there was good in 7 cases(70%), excellent in 3 cases(30%). 2. In allergic rhinitis patients there was improved in 5 eases(50%), good in 2 cases(20%), unimproved in 3cases(30%). 3. In conclusion, there was good(doctor and patients ail) in 6(60%), unimproved in 3(30%) Conclusion : Hydrotherapy based Utasonic spa showed useful effect on Atopic Dermatitis and Allergic Rhinitis.
극저탄소강의 고용 탄소 함량에 미치는 시멘타이트 석출 속도 모델링
최종민 ( Jong Min Choi ),박봉준 ( Bong June Park ),김성일 ( Sung Il Kim ),이경섭 ( Kyung Sub Lee ),이경종 ( Kyung Jong Lee ) 대한금속·재료학회 2010 대한금속·재료학회지 Vol.48 No.3
The solute carbon content in ferrite is one of the important factors to obtain good formability in low carbon steels. Although most of the carbons are consumed by the formation of grain boundary cementite during coiling after hot-rolling, the carbon content after coiling is normally observed much more than that of equilibrium. In this study, a classical nucleation and growth model is used to simulate the precipitation kinetics of the grain boundary cementite from coiling temperature (CT) to room temperature (RT). The predicted precipitation behaviors depending on the initial carbon content and the cooling rate are compared with the reported. As a result, the lateral growth of thickening of cementite is a major factor for the sluggish reaction of grain boundary cementite. The reduction of solute carbon content after coiling is divided into three regions: a) increase due to no cementite precipitation, b) decrease due to the fast length-wise growth of cementite, c) increase due to the slow thickness-wise growth of cementite.
AT42 Mg 합금의 크리프 특성에 미치는 Sr의 영향
최종민 ( Jong Min Choi ),김대한 ( Dae Han Kim ),조대현 ( Dae Hyun Cho ),최윤석 ( Yoon Suk Choi ),박익민 ( Ik Min Park ) 대한금속재료학회(구 대한금속학회) 2014 대한금속·재료학회지 Vol.52 No.5
Creep rupture properties and microstructures of an as-cast Mg-4Al-2Sn alloy with and without Sr contents (1 wt% and 2 wt%) were investigated. Creep rupture tests were performed at 150℃ and 200℃ at 50 MPa and 70 MPa. The microstructure of the Mg-4Al-2Sn alloy initially had Mg17Al12 and Mg2Sn phases. The addition of Sr resulted in the formation of a ternary MgSnSr phase. Creep strength increased with an increasing Sr due to thermally stable MgSnSr precipitates, which suppressed coarsening of the Mg17Al12precipitates during creep. Scanning electron microscopy showed that Mg17Al12 phases at the grain bounda-ries are the starting point of void initiation, the cracks propagated along the grain boundaries. However, the MgSnSr phase interrupted crack propagation.