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Impact of Cyclooxygenase-2 Expression on the Survival of Glioblastoma
Youngmin Choi(최영민),Dae-Cheol Kim(김대철),Ki-Uk Kim(김기욱),Young-Jin Song(송영진),Hyung-Sik Lee(이형식),Won-Joo Hur(허원주),Sun-Seob Choi(최순섭),Su-Yeong Seo(서수영) 대한방사선종양학회 2007 Radiation Oncology Journal Vol.25 No.3
목 적: 다형성아교모세포종 환자들에서 cyclooxygenase-2 (COX-2) 단백의 발현 정도와 생존율에 미치는 영향을 조사 하고자 한다. 대상 및 방법: 1997년부터 2006년까지 다형성아교모세포종으로 수술 및 방사선치료를 받은 환자들 중에서, 의식 상태의 악화로 40 Gy 전에 방사선치료가 중단된 3명을 제외한 30명을 대상으로 하였다. 조직에서의 COX-2의 발현은 면역조직화학염색으로 검사하였다. 생존 분석과 성별, 나이, 활동도, 수술 정도, 방사선량, COX-2 발현 정도 등이 생존율에 미치는 영향을 Kaplan Meier 법과 log rank test로 분석 및 검증하였다. 결 과: 중앙추적관찰기간은 13.3개월이었다(6∼83개월). 전체 환자들에서 COX-2의 발현이 관찰되었고, 종양 세포의 5% 이상에서 COX-2가 양성이었던 환자가 24명이었다: 종양 세포의 25% 미만, 3명(10.0%); 25∼50%, 1명(3.3%);50∼75%, 2명(6.7%); 75∼100%, 24명(80.0%). 중앙생존기간이 13.5개월이었고, 2년 생존율은 17.5%였다. 수술 정도(50% 이상 종양 제거)와 방사선량(59 Gy 이상 조사)이 생존율에 유의하게 영향을 주었다(p<0.05). 종양 세포의 75% 미만에서 COX-2가 발현되었던 환자군과 75% 이상에서 발현되었던 환자군에서 중앙생존기간은 각각 15.5개월과 13.0개월이었고(p>0.05), 2년 생존율은 각각 33.3%와 13.3%였다(p>0.05). 결 론: 다형성아교모세포종에서의 COX-2 양성도는 높았지만, 다형성아교모세포종 환자들에서 COX-2 발현의 정도와생존율 간에는 통계적인 유의성이 없었으므로, 향후 보다 많은 환자들을 대상으로 COX-2 발현 정도가 생존율에 미치 는 영향에 대한 연구가 필요하다. Purpose: To investigate the degree and effect of cyclooxygenase (COX)-2 expression on the survival of patients with glioblastoma multiforme (GM). Materials and Methods: Between 1997 and 2006, thirty consecutive GM patients treated with surgery and postoperative radiotherapy (dose range: 44∼65.1 Gy, median dose: 61.2 Gy) were included in the study. Three patients were excluded that discontinued radiotherapy before receiving a dose of 40 Gy due to mental deterioration. The expression of the COX-2 protein in surgical specimens was examined by immunohistochemical analysis. Survival analysis and verification were performed with respect to sex, age, performance status, resection extent, radiotherapy dose, and degree of COX-2 expression using the Kaplan-Meier method and the log rank test. Results: The median length of follow-up was 13.3 months (range: 6∼83 months). Staining for COX-2 was positive in all patient samples. Staining for COX-2 that was positive for over 75% of the tumor cells was found in 24 patients. Staining for COX-2 that was positive in less than 25% of tumor cells was found in 3 patients (10.0%), staining for COX-2 that was positive in 25 to 50% of tumor cells was found in 1 patient (3.3%), staining for COX-2 that was positive in 50 to 75% of tumor cells was found in 2 patients (6.7%) and staining for COX-2 that was positive in 75 to 100% of tumor cells was found in 24 patients (80.0%). The median survival and two-year survival rate were 13.5 months and 17.5%, respectively. The survival rate was influenced significantly by the degree of resection (tumor removal by 50% or more) and radiotherapy dose (59 Gy or greater) (p<0.05). The median survival of patients with staining for COX-2 that was positive in less than 75% of tumor cells and in at least 75% of tumor cells was 15.5 and 13.0 months, respectively (p> 0.05), and the two-year survival for these groups was 33.3 and 13.3%, respectively (p>0.05). Conclusion: The absence of a statistical correlation between the degree of COX-2 expression and survival in GM patients, despite the high rate of COX-2 positive tumor cells in the GM patient samples, requires further studies with a larger series to ascertain the prognostic value of the degree of COX-2 expression in GM patients.
박상수(Sang Soo Park),노규태(Kyu Tae Noh),최순섭(Sun Seob Choi),황규근(Kyu Geun Hwang) 대한소아신경학회 2004 대한소아신경학회지 Vol.12 No.2
저자들은 생후 6개월 환아에서 급성 호흡기 감염 후 급격하게 발생한 의식 장애와 경련 등의 신경학적 증상과 뇌자기공명영상으로 양측 시상, 뇌간, 뇌실 주위의 백직을 대칭적, 다발적으로 침범한 전형적인 급성 괴사상 뇌증을 진단하였고, steroid를 투여하여 입상 증상 및 뇌 병변의 호전을 보인 1례를 경험하였기에 보고하는 바이다. Acute necrotizing encephalopathy predominantly affects young children and infants living in Japan and Taiwan, and is characterised by acute encephalopathy with seizures and decreased level of consciousness. The Hallmark of the disease is diffuse and symmetrical CNS lesions of both thalami, brainstem tegmentum, cerebral periventricular white matter and cerebellar medula. The clinical, radiological and pathological features of this disease, a disease entity established recently, is proposed by Masashi Mizuguchi et al in 1995. The aetiology is unknown but infectious or parainfectious process seems likely. The diagnosis can be made without difficulty on the basis of the combination of a typical clinical figures and characteristic radiologic findings. There is no specific therapy or prevention. The prognosis was poor in the 1980s but has improved recently. We experienced a case of 6-month-old female infant with acute necrotizing encephalopathy and a thalamic hemorrhage. We report this case with a review of the related literatures.
건강생활체조가 비만 고령여성의 신체구성 염증인자 및 β-아밀로이드에 미치는 영향
김은희(Kim, Eun-Hee),박상갑(Park, Sang-Kab),박경원(Park, Kyong-Won),최순섭(Choi, Sun-Seob),박현태(Park, Hyun-Tae),권유찬(Kwon, Yoo-Chan),정현훈(Jung, Hyun-Hun),임승택(Lim, Seung-Taek),홍가람(Hong, Ga-Ram) 한국체육과학회 2014 한국체육과학회지 Vol.23 No.6
The purpose of this study was to investigate the effects of 20-week health life gymnastics on body composition, inflammation factors and β-amyloid in elderly women with obesity. We recruited 24 elderly women with obesity: a Health Life Gymnastics (n=10) and control group (n=10). The frequency of exercise for the Health Life Gymnastics (i.e., resistance, aerobics, yoga & meditation) group was 4 times per week (i.e., Monday, Tuesday, Wednesday, and Friday) for 20 weeks. Each 60-minute exercise programme included 10 minutes of warm-up activities and 10 minutes of cool-down activities. The results of this study showed that Health Life Gymnastics decrease Body weight, BMI, % Fat and IL-6 after 20 weeks. In addition, the static relationship appears momentum regular, β-amyloid, inflammatory cytokines decrease β-amyloid, of obesity and IL-6 and weight reduction of body weight, and increased physical activity in older women, improved it is believed that a decrease in TNF-α, CRP, and more effective in IL-6. Therefore, it is determined to be capable of healthy living gymnastics program was carried out in this study are expected to improve positive effect on inflammatory diseases and dementia and weight loss in an obese elderly women.
Dandy Walker 증후군이 동반된 Neurocutaneous Giant Melanosis 1례
홍수영(Su Young Hong),반지은(Ji Eun Ban),류재호(Jae Ho Rhu),최순섭(Sun Seob Choi),황규근(Kyu Geun Hwang) 대한소아신경학회 2001 대한소아신경학회지 Vol.9 No.1
저자들은 3세 남아에서 Dandy-Walker 증후군이 동반된 neurocutaneous giant melanosis 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Neurocutaneous melanosis is a rate congenital phacomatosis, characterized by the presence of multiple pigmented skin nevi at birth. Meningeal melanosis tending to become malignant and seizure. Dandy-Walker syndrome is a developmental disorder of brain characterized by cystic dilatation of the fourth ventricle and agenesis of hypoplasia of the cerebellat vermis. We studied a case of Dandy-Walker syndrome with neurocutaneous giant melanosis in a 3 years old boy.
항암 단독 요법으로 치료한 기저핵에서 발생한 낭종성 배아종 -증례보고-
심재현 ( Jae Hyone Shim ),김기욱 ( Ki Uk Kim ),김대철 ( Dae Chul Kim ),김재석 ( Jae Suk Kim ),최순섭 ( Sun Seob Choi ),송영진 ( Young Jin Song ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2006 대한뇌종양학회지 Vol.5 No.2
Germinoma arising in the basal ganglia is a rare, well-documented entity representing 5% to 10% of all intracranial germinomas. And it has been known that the germinoma of the basal ganglia is usually associated with cystic formation on brain CT and MRI findings. We report a case of cystic germinoma in the basal ganglia. Although pure germinoma in the basal ganglia is generally radiosensitive and potentially curable, we have chosen chemotherapy alone in order to prevent late sequelae of radiotherapy. The patient began to receive chemotherapy without radiotherapy. After eight cycles of treatment every 4 weeks, the patient displayed a nearly complete response and was improved. No neurologic sequelae was seen at discharge. Follow-up brain CT showed no residual enhancing lesion. The patient was asymptomatic for 2 years follow-up.
심종은 ( Jong Eun Sim ),성순기 ( Soon Ki Sung ),송영진 ( Young Jin Song ),김대철 ( Dae Chul Kim ),한진영 ( Jin Young Han ),최순섭 ( Sun Seob Choi ),김기욱 ( Ki Uk Kim ) 대한뇌종양학회 2006 대한뇌종양학회지 Vol.5 No.2
Objective£ºBrain tumors develop by genetic alterations at gene level. Genetic alteration may be different according to each tumor and subtype. Even though major genetic alterations for the particular tumors are known, there are many minor genetic alterations for the tumors. Authors designed the study in order to see the difference in the genetic profile of meningiomas. Methods£º16 patients of meningioma were operated between Jun 2004 and May 2005. Surgical specimens were prepared for chromosomal study and karyotyping was done by traditional G-banding method. Results£ºChromosome abnormalities have been observed in many cases in meningiomas. In meningiomas, loss of chromosome 22 was the most common, and other abnormalities were translocation between the long arm of chromosome 13 and 22, whole arm translocation between the chromosome 1 and 19, loss of Y chromosome and hyperdiploidy and monosomies for various chromosome. Conclusion£ºChromosomal abnormalities seem to be variable and genetic changes are present in meningioma.