제18차 대한비만학회 추계학술대회 및 창립 10주년 기념 심포지움 : 자유연제 ; 복부비만 여성에서 체중 감량 후 HOMA Index의 변화

최범희,손중천,정현주,김범택,박샛별,김광민 대한비만학회 2002 The Korean journal of obesity Vol.11 No.3

방사선(학)과 Apron 성능평가 및 관리 조사-대구, 경북지역 4개 대학교-

최범희,김용국,박서현,신용일,유영준,김예리,박창희,Choi, Beom-Hee,Kim, Yong-Gug,Park, Seo-Hyun,Shin, Yong-Il,You, Young-Jun,Kim, Ye-Ri,Park, Chang-Hee 대한디지털의료영상학회 2013 대한디지털의료영상학회논문지 Vol.15 No.1

This study evaluated the apron quality management and shield efficiency in the education laboratory for radiology students. For making a proposal of effective control of lead apron, Eighteen aprons, used in 4 university laboratories of dae-gu, Kyungpook area, were analyzed regarding their uniformities, transmission doses, lead equivalent and shield efficiencies. In conclusion, the lead apron uniformity was generally good. Also, the shield efficiency corresponding to lead equivalent was high. However, the quality control of lead apron was not satisfactory. Since there is a potentially possible chance for students to be exposed to a radiation during practical radiation-training in the education laboratory, the quality-control maintenance of the lead apron should be unceasingly maintained for the radiation protection.

중금속과 심혈관 질환

최범희(Beom-hee Choi) 대한기능의학회 2018 Journal of Korean Institute for Functional Medicin Vol.1 No.1

현대 사회를 살아가는 인간에게 중금속 노출은 아주 흔한 현상이다. 이런 중금속들 중에서 건강에 가장 악영향을 주는 것들에는 납, 수은, 카드뮴 및 비소가 대표적이다. 이 네 가지 중금속들은 혈압, 당뇨 및 암 등 만성 질환들과 관련이 많다고 알려져 왔다. 이런 중금속들이 체내로 들어오는 경로는 종류별로 다양하지만 결국에는 장기 간 독성 작용으로 인해 암, 혈압, 당뇨, 심혈관계 질환 등을 유발한다. 특히 심혈관 질환은 고령화와 더불어 전 세계적으로 사망률이 가장 높은 질환으로 매년 사망률이 증가하고 있다. 하지만 중금속들이 심혈관계 질환에 어떻게 영향을 주는지에 대한 관심은 많지 않았다. 그러므로 본고에서는 중금속들이 심혈관계에 어떤 영향을 주는지에 대해 자세히 살펴보고자 한다. There is increasing concern regarding the chronic diseases (hypertension, diabetes, cancer, cardiovascular diseases) to various heavy metals (mercury, lead, cadmium, arsenic) in the environment. Cardiovascular disease (CVD) is an increasing world health problem. But the association between heavy metals exposure and CVD has been less well defined. The mechanisms of heavy metals-induced CVD are also unknown. In this review, we will show the available evidence for their link with CVD and the proposed mechanisms of action by which their toxic effects might be explained.

심장주위지방과 혈청 고밀도 지단백 콜레스테롤 농도와의 관련성

이은섭,최범희,주남석 대한기능의학회 2019 Journal of Korean Institute for Functional Medicin Vol.2 No.1

혈청 고밀도지단백 콜레스테롤은 대사증후군과 관련이 있으며, 심혈관질환 예방효과를 가진다. 최근 심장주위지방과 대사성질환과의 연구는 활발히 이루어 지고 있는 반면, 한국인에서 고밀도지단백 콜레스테롤과 심장주위지방과의 연구는 거의 없다. 방법: 본 연구는 일개 병원의 건강 검진 자료 중, 심혈관 MDCT (multidetector computed tomography)를 시행한 361명의 대상자에서 고밀도지단백 콜레스테롤 자료가 있는 대상자의 자료를 선택하여 심장주위지방을 사분위로 나눈 군에 따라서 비교 분석하였다. 심장주위지방을 사분위로 나눈 후 고밀도지단백 콜레스테롤에 중점을 둔여러 대사성 지표를 비교하였으며, 또한 나이, 성별, 흡연 여부를 보정한 후 가장 낮은 고밀도지단백 콜레스테롤 사분위에 대한 비차비도 계산하였다. 결과: 혈청 평균 고밀도지단백 콜레스테롤 농도는 50.7 mg/dL, 평균 심장주위지방의 부피는 123.8 cm 3 이었다. 혈청 고밀도지단백 콜레스테롤 농도는 심장주위지방과 유의한 음의 상관관계를 보였으며(r=-0.133, P=0.012), 복부내장 지방량과도 유의한 음의 상관관계(r=-0.185, P<0.001)를 보였다. 나이, 성별, 흡연 여부를 보정한 후 가장 낮은 고밀 도지단백 콜레스테롤 사분위수를 가질 비차비는 제2 사분 위에서 2.86 (95% CI, 1.33-6.13; P for trend=0.007), 제3 분위수에서 2.87 (95% CI, 1.30 -6.31; P for trend= 0 .0 0 9), 제4 분위수에서 6.15 (95% CI, 2.65-14.3; P for trend< 0.001)를 보였다.방은 낮은 고밀도지단백 콜레스테롤농도와 연관이 있었다. Background: High-density lipoprotein cholesterol (HDLC) is a component of metabolic syndrome (MS) and has a cardio-protective role. Recent studies reported the association of pericardial adipose tissue (PAT) and MS. However, there is little study to demonstrate the correlation between the HDLC and PAT in Koreans. Methods: The data of three hundred sixty one subjects were analyzed to compare the HDLC according to the PAT quartiles, which was measured by the coronary multidetector computed tomography, cross-sectionally. After the PAT was divided into quartiles, various metabolic parameters were compared focused on HDLC. Furthermore, the odds ratio of having lowest HDLC quartile (lower 25%) was calculated after adjustment with age, sex, and smoking. Results: Mean HDLC and PAT was 50.7 mg/dL and 123.8 cm 3 , respectively. HDLC showed significant negative correlation with PAT (r=-0.133, P=0.012) and visceral fat area (r=-0.185, P<0.001). The odds ratio of having lowest HDLC quartile was 2.86 (95% CI; 1.33-6.13, P for trend=0.007), 2.87 (95% CI; 1.30-6.31, P for trend=0.009), and 6.15 (95% CI; 2.65-14.3, P for trend<0.001) in the second, third and fourth quartile of PAT after adjusting age, sex, and smoking. Conclusion: HDLC showed negative association with PAT, therefore, the increase of PAT may impact on low HDLC.

제18차 대한비만학회 추계학술대회 및 창립 10주년 기념 심포지움 : 자유연제 ; HOMA Index와 신체계측치, 체성분, 혈청지질과의 상관관계

손중천,최범희,김광민,김범택 대한비만학회 2002 The Korean journal of obesity Vol.11 No.3

Vitamin K Supplement Along with Vitamin D and Calcium Reduced Serum Concentration of Undercarboxylated Osteocalcin While Increasing Bone Mineral Density in Korean Postmenopausal Women over Sixty-Years-Old

제상현,주남석,최범희,김광민,김범택,박샛별,조두연,김규남,이득주 대한의학회 2011 Journal of Korean medical science Vol.26 No.8

There are inconsistent findings on the effects of vitamin K on bone mineral density (BMD)and undercarboxylated osteocalcin (UcOC). The present intervention study evaluated the effect in subjects over 60-yr-old. The vitamin K group (vitamin K + vitamin D + calcium supplement; 15 mg of vitamin K2 [menatetrenone] three times daily, 400 IU of vitamin D once a day, and 315 mg of calcium twice daily) and the control group (vitamin D + calcium supplement) were randomly assigned. During the six months of treatment, seventy eight women participated (38 in the vitamin K group and 40 in the control group) and 45women completed the study. The baseline characteristics of study participants did not differ between the vitamin K and the control groups. In a per protocol analysis after 6months, L3 bone mineral density has increased statistically significantly in the vitamin K group compared to the control group (0.01 ± 0.03 g/cm^2 vs -0.008 ± 0.04 g/cm^2, P =0.049). UcOC concentration was also significantly decreased in the vitamin K group (-1.6± 1.6 ng/dL vs -0.4 ± 1.1 ng/dL, P = 0.008). In conclusion, addition of vitamin K to vitamin D and calcium supplements in the postmenopausal Korean women increase the L3BMD and reduce the UcOC concentration.

The Cutoff Pericardial Adipose Tissue Volume Associated with Metabolic Syndrome

김동선,옥은정,최범희,주남석 대한가정의학회 2018 Korean Journal of Family Medicine Vol.39 No.5

Background: Metabolic syndrome (MS) is a well-known risk factor of cardiovascular diseases that is focused on central obesity. Recent studies have reported the association between pericardial adipose tissue (PAT) volume and MS. However, no studies have demonstrated the cutoff PAT volume that represents the best association with MS.Methods: The data of 374 subjects were analyzed cross-sectionally to compare PAT, measured on coronary multi-detector computed tomography, and various metabolic parameters according to MS. After PAT volumes were di-vided into tertiles, various metabolic parameters were compared among tertiles; furthermore, the odds ratio for de-veloping MS was calculated. Finally, we demonstrated the cutoff PAT volume that represented the best association with MS by using the receiver-operating characteristic curve.Results: We found that 27.5% of the subjects had MS, and the mean PAT volume was 123.9 cm3. PAT showed a sig-nificant positive correlation with body mass index, waist circumference, and levels of glucose, triglyceride, high-sensitivity C-reactive protein, uric acid, and homocysteine, but a negative correlation with high-density lipoprotein cholesterol. Furthermore, after dividing into tertiles, PAT volume was also significantly associated with various met-abolic parameters. The odds ratio for having MS was 4.19 (95% confidence interval, 2.27–7.74) in the top tertile of PAT volumes after adjusting for age, sex, and smoking. The cutoff PAT volume that represented the best association with MS was 142.2 cm3.Conclusion: PAT was significantly associated with MS and various metabolic parameters. The cutoff PAT volume of 142.2 cm3 showed the best association with MS.

Blood Mercury and Insulin Resistance in Nondiabetic Koreans (KNHANES 2008–2010)

김규남,주남석,박수정,최범희 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.4

Purpose: Blood mercury levels are associated with inflammation, and chronic low-grade inflammation is a cause of insulin resistance. This study aimed to investigate the association between serum mercury and insulin resistance. Materials and Methods: Subjects from the 2008‒2010 Korean National Health and Nutrition Examination Survey were selected (n=29235) and the relevant data of 5388 subjects (2643 males and 2745 females) were analyzed cross-sectionally. Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) was compared according to blood mercury quartiles,and the odds ratio (OR) of having the highest quartile of HOMA-IR according to blood mercury quartiles was calculated. Results: Blood mercury levels in men and women were 29.4 nmol/L and 20.5 nmol/L, respectively, and fasting blood sugar (FBS), insulin, and HOMA-IR were significantly correlated with blood mercury levels. The correlation was stronger in men than in women. In men, FBS and HOMA-IR showed step-wise increases as the quartiles of blood mercury increased; only HOMA-IR differed significantly in the third and fourth blood mercury quartiles, compared to the first quartile. In women, however, both FBS and HOMA-IR differedsignificantly in the third and fourth blood mercury quartiles, compared to the first quartile. Among men, the OR of being in the highest HOMA-IR quartile was greatest for the highest blood mercury quartile (OR=1.720, 95% CI; 1.172‒2.526), compared with the lowest quartile. Conclusion: In this large population-based study, blood mercury levels were weakly correlated with HOMA-IR and may be a risk factor for insulin resistance in nondiabetic Koreans.

Dietary Calcium and Framingham Risk Score in Vitamin D Deficient Male (KNHANES 2009–2011)

최성진,주남석,염경진,박수정,최범희 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.3

Purpose: The association between excess calcium intake and cardiovascular mortalityhas already been reported. In the present study, we investigated the relation between dietary calcium intake and Framingham Risk Score (FRS) according to serum 25-hydroxyvitamin D [25(OH)D] status. Materials and Methods: A total of 7809 subjects (3452 males and 4357 female) aged over 40 years were selected for this cross-sectional study from data obtained from the Korea National Health and Nutrition Examination Survey (2008‒2011). Daily dietary calcium intake was categorized into <300, 300‒600, 600‒900, 900‒1200, and >1200 mg/day and serum25(OH)D concentration classified into <50, 50‒75, >75 mmol/L. The FRS was compared by the daily dietary calcium intake categories according to 25(OH)D concentration after adjustment with relevant variables in both genders. Results: Higher FRS was observed in males with both <300 mg and >1200 mg of dietary calcium intake and females with <300 mg of dietary calcium intake without adjustment. The significantly higher FRS remained in the <300 mg and >1200 mg of dietary calcium intake groups in both genders after adjustments for relevant variables. FRS was significantly higher in the group with >1200 mg of dietary calcium intake and serum 25(OH)D <50 nmol/L, which was the male only vitamin D deficientgroup. Conclusion: Very low (<300 mg/day) and excess (>1200 mg/day) dietarycalcium intake were related with higher FRS in both genders. In particular, higher FRS was observed in the excess (>1200 mg/day) dietary calcium intake male group under vitamin D deficiency (<50 nmol/L).

Dietary Calcium Intake May Contribute to the HOMA-IR Score in Korean Females with Vitamin D Deficiency (2008–2012 Korea National Health and Nutrition Examination Survey)

김진호,이석훈,박수정,YEUMKYUNG JIN,최범희,주남석 대한비만학회 2017 The Korean journal of obesity Vol.26 No.4

Background: Vitamin D and calcium are important factors involved in the regulation of blood glucose and insulin secretion. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score is a useful variable for evaluating insulin resistance, and therefore we cross-sectionally compared HOMA-IR scores according to serum vitamin D levels and dietary calcium intake. Methods: We selected data from healthy males (n=5,163) and females (n=7,506) analyzed over 5 years (2008–2012) via the Korea National Health and Nutrition Examination Survey (KNHANES). We calculated HOMA-IR scores and compared them according to serum 25-hydroxyvitamin D (25(OH)D) concentration classification (<20, 20–30, >30 ng/mL) and dietary calcium quintile after adjustment for relevant variables using complex sample analysis. Comparisons were done after data weighting. Results: The mean dietary calcium intake in males and females was 558.1 mg/day and 445.9 mg/day, respectively. The mean serum 25(OH)D concentration in males and females was 19.4 ng/mL and 16.8 ng/mL, respectively. After adjustment for relevant variables, HOMA-IR score was significantly correlated with serum 25(OH)D concentration and dietary calcium intake in females, whereas it was only correlated with serum 25(OH)D concentration in males. HOMA-IR was significantly lower in the top quintile of dietary calcium intake (mean, 866 mg/day) within females with vitamin D deficiency (P=0.047). Conclusion: Adequate dietary calcium intake may be important for normal HOMA-IR in females with vitamin D deficiency.