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캡부착 내시경이 대장내시경의 질을 향상시키는데 도움을 주는가?
최동현,신현근,이영찬,임청호,정승규,이석환,양형규 대한대장항문학회 2010 Annals of Coloproctolgy Vol.26 No.2
Purpose: Recently, the use of a transparent cap attached to the tip of the colonoscope has been revealed to be helpful in both detecting colorectal polyps and shortening the intubation time to the cecum. The aim of this study was to examine the usefulness of transparent cap-attached colonoscopy (CAC) as compared with conventional colonoscopy (CC) in terms of the technical ease and efficiency. Methods: Colonoscopies from a total of 228 patients between May and October 2008 were prospectively collected. All colonoscopies were performed by single colorectal surgeon whose experience exceeded 3,000 colonoscopies. Patients were assigned to the CAC group (n=114) or to the CC group (n=114). The cecal intubation rate and time, the polyp detection rate, the adenoma detection rate, the withdrawal time, and the visual analogue scale (VAS) of the patient’s pain were compared. Results: There were no significant differences in the age, sex, body mass index, previous history of abdominal operation,diverticulosis, and the degree of bowel preparation between the two groups. The cecal intubation rate was 100% in both groups. The cecal intubation time was significantly shorter in the CAC group than in the CC group overall (5.3±4.0 min vs. 7.6±4.3 min, P<0.001), as well as for female (6.1±2.8 min vs. 9.1±4.7 min, P<0.001) patients. There were no statistically significant differences in the total colonoscopy time (13.1±6.3 min vs. 14.5±5.2 min, P=0.066), the polyp detection rate (38.6% vs. 33.3%, P=0.408), the adenoma detection rate (28.1% vs. 25.4%, P=0.654), and the VAS scale of pain (2.48 vs. 2.74, P=0.353) between the CAC and the CC groups. Conclusion: The transparent cap is effective in shortening the cecal intubation time, especially in female patients.
최동현,이일권,최준식 한국임상약학회 2007 한국임상약학회지 Vol.17 No.2
The aim of this study was to investigate the effect of fluvastatin on the pharmacokinetics of nicardipine in rats. Pharmacokinetic parameters of nicardipine were determined after an oral administration of nicardipine (12 mg/kg) to rats coadministered with fluvastatin (0.5 and 1.5 mg/kg). Compared with the control (given nicardipine alone), coadministration of fluvastatin (0.5 mg/kg) significantly (p<0.01) increased the area under the plasma concentration (AUC) and peak plasma concentration (Cmax) of nicardipine. The toral plasma clearance (CL/F) of nicardipine was decreased significantly (p<0.01, 0.5 mg/kg) compared to the control group. The relative bioavailability (RB%) of nicardipine increased from 1.23- to 1.68-fold. However there were no significant changes in tmax, Kel and t1/2 of nicardipine. The enhanced oral bioavailability of nicardipine suggests that intestinal-mediated CYP3A4 metabolism of nicardipine are competitively inhibited by fluvastatin. Based on these results, the concurrent use of fluvastatin significantly enhanced the oral exposure of nicardipine in rats.