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한국 남자 청소년의 VO<sub>2</sub>max 추정을 위한 새로운 20-m PST 프로토콜과 추정식의 타당도 및 신뢰도
박동호 ( Dong-ho Park ),이상현 ( Sang-hyun Lee ),김도윤 ( Do-youn Kim ),천정우 ( Jeon-woo Cheon ),김창선 ( Chang-sun Kim ) 한국운동생리학회(구 한국운동과학회) 2017 운동과학 Vol.26 No.1
PURPOSE: To develop and validate regression models to estimate maximal oxygen uptake (VO<sub>2</sub>max) from the new 20-m Progressive Shuttle Test (20-m PST) in Korean male youths aged 13-18 years. METHODS: The new 20-m PST and VO<sub>2</sub>max were assessed in a sample of 80 participants. Participants underwent a treadmill test (TT) in the laboratory and the new 20-m PST protocol (starting at 5.0 km/h and increasing by 0.75 km/h every 1 min) in a gymnasium. Par ticipants in the validation study performed the TT with the stationary metabolic cart and the 20-m PST with a portable metabolic cart once, as well as the 20-m PST without the portable metabolic cart twice for test-retest reliability. All tests were conducted at least three days apart and in a random order. RESULTS: Mean measured VO<sub>2</sub>max (55.4±6.7 mL/kg/min) from the potable metabolic cart was significantly increased from that mea sured during the GXT from stationary metabolic cart (52.6±7.0 mL/kg/min, p=.001) using the new 20-m PST protocol. But it was a narrow range (2.8 mL/kg/min). The measured VO<sub>2</sub>max from the potable and stationary metabolic cart correlated at r=.89 (p<.001). Test-retest of the 20-m PST yielded comparable results (Laps r=.94 & final speed r=.89). New regression equations were developed from present data to predict VO<sub>2</sub>max for male youths: y=.875×BMI+2.031×DT (min.sec)+51.856 (r=.60, SEE=5.54 mL/kg/min). CONCLUSIONS: It is concluded that (a) the new 20-m PST protocol is a valid and reliable test and (b) this equation developed in this study provides valid estimates of VO<sub>2</sub>max of Korean male youths aged 13-18 years.
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Genuine traditional Korean medicine, BaekJeol-Tang for the treatment of rheumatoid arthritis
한나라,심우문,설무창,김민철,이창희,김동원,이세훈,이호철,류중민,남봉수,김종옥,문성오,장현록,김영석,이인,양진영,황규선,천창선,정현석 셀메드 세포교정의약학회 2013 셀메드 (CellMed) Vol.3 No.2
Inflammation in rheumatoid arthritis is characterized by immune cell infiltration and cytokine secretion. In particular, mast cells and their cytokines play an important role in the pathogenesis of rheumatoid arthritis. Korean medicine, BaekJeol-Tang (BT) was designed by traditional Korean medicine theory. We already reported therapeutic effect of BT in rheumatoid arthritis. Here, we report the specific underlying mechanism of BT in activated human mast cells, HMC-1 cells. In addition, we report for the first time that BT significantly inhibited the production and mRNA expression of proinflammatory cytokines including thymic stromal lymphopoietin, interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-α in activated HMC-1 cells. BT also decreased the activation of mitogen-activated protein kinases, nuclear factor-κB, and caspapase-1. Taken together, these results indicate that BT has potential as a regulator of inflammatory reactions for the treatment of arthritis such as osteoarthritis and rheumatoid arthritis.
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탈진 운동 후 세로토닌 운반체 유전자다형성에 따른 혈중 FFA, f-Trp, BCAAs 및 f-Trp/BCAAs의 반응
박동호 ( Dong Ho Park ),김창선 ( Chang Sun Kim ),정동식 ( Dong Sik Chung ),이종각 ( Jong Kak Lee ),이명천 ( Myung Chun Lee ),윤재량 ( Jae Ryang Yoon ),김영수 ( Young Soo Kim ),성봉주 ( Bong Ju Sung ) 한국스포츠정책과학원(구 한국스포츠개발원) 2005 체육과학연구 Vol.16 No.2
본 연구의 목적은 5-HTT 유전자다형성과 운동성 중추피로와의 관계를 규명하는데 있었다. 피험자 선정을 위해 대학교에 재학중인 교양(111명) 및 체육관련 학과 남학생(162명) 273명을 대상으로 혈액을 채취하여 5-HTT 유전자형(SS형, LS형, LL형)을 검사하였다. 이들 중 본 연구 목적에 맞는 40명의 피험자들이 최종적으로 선정되었다. 선정된 피험자를 대상으로 유전자형에 따라 3개 집단으로 구분하여(SS형 집단 16명, LS형 집단 15명, LL형 집단 9명), 장시간의 운동(1차 VT 강도, 2차 VO2max 강도, 3차 VT 강도 = 평균 58분의 운동소요시간)을 처치하여 피로를 유발시킨 후 5-HTT 유전자형에 따른 혈중 FFA, f-Trp, BCAAs, 및 f-Trp/BCAAs의 변화를 관찰하여 다음과 같은 결과를 얻었다. FFA의 경우, SS형은 안정시와 비교하여 운동종료 30분후에(p<.01) 그리고 운동직후와 운동종료 30분후를 비교할 때 유의하게 증가(p<.05)하였고, 24시간후에는 운동종료 30분후와 비교하여 유의하게 감소하였다(p<.05). LS형은 안정시에 비하여 운동종료 30분후(p<.05) 유의하게 증가한 반면 LL형은 안정시에 비하여 운동종료 30분후 유의한 증가를(p<.05) 그리고 24시간후가 운동종료 30분후에 비하여 유의한 감소를 보였다(p<.05). f-Trp는 시기간 세 집단 모두 비슷한 경향을 보였으나, LS형에서만 운동직후와 비교할 때 24시간후에 유의하게 감소하였다(p<.05). BCAAs에서는 LL형을 제외한 SS형과 LS형에서 운동종료 30분후를 안정시 및 운동직후와 각각 비교할 때 유의하게 감소하였다(p<.01, p<.01). f-Trp와 BCAAs(f-Trp/BCAAs)의 비율에서는 세 집단 모두에서 시기에 따른 경향은 비슷하였으나, 단지 LS형에서만 24시간후를 운동종료 30분후와 비교할 때 유의하게 감소하였다(p<.05). 24시간후의 혈장 f-Trp/BCAAs 비율 감소는 BCAAs의 증가와 f-Trp의 감소에 의한 것으로 나타났다. 유전자 타입과 대립형질의 빈도 분포(n=273)에서는 SS형 62.7%(n=171), LS형 30.0%(n=82), LL형 7.3%(n=20), 그리고 S 대립형질 77.7%(n=424), L 대립형질 22.3%(n=122)로 나타났다. 즉, LL형이 SS형 및 LS형에 비해 매우 낮은 분포를 보였다. 이상의 결과에서 비록 통계적으로 유전자형에 따른 집단간 유의한 차이는 없었으나, f-Trp의농도 및 f-Trp/BCAAs의 비율 모두 LL형이 SS형과 LS형보다 높게 나타났다. 이것은 안정시 및 장시간의 고강도 운동시 5-HT의 합성과 방출의 증가, 즉 5-HT의 신경전달이 LL형에서 높을 수 있음을 간접적으로 시사하는 것이다. 그러나 유전자형에 따른 집단간 유의한 차이가 없어 이러한 결과의 일반성을 단정하기 어렵지만, 전체 채혈 시기에 걸쳐 SS형과 LS형에서 LL형보다 낮은 경향을 보인다는 것은 특히 장시간의 고강도 훈련을 반복적으로 지속하는 선수들은 5-HTT SS형과 LS형이 유리하게 작용할 수 있을 것으로 판단할 수 있다. The purpose of this study was to verify the relationship between 5-HTTLPR gene polymorphism and exercise-induced central fatigue. Polymorphisms in the 5-HTTLPR were determined in genormic DNA obtained from 273 college aged mem. Forty out of 273 college aged mem were participated into this study and divided into three groups according to their genetypes (SS= 16, LS= 15, and LL= 9). All participants performed exhausted exercise, consisting of running them on a treadmill (with a 6° slope) for 3min at 5km/hour, 30min at ventilatory threshold intensity and, after 3min rest, sprints of 1min at 100%VO2max with 2min of walking between each sprint until re-exhasted, to lead fatigue. For the trial, blood samples were collected at pre-exercise (baseline), immediately post-exercise (IPE), 30m post-exercis (30m PE), and 24hours post-exercise (24h). Serum and plasma samples were analyzed for free-trpytophan (f-Trp), branched-chain amino acids (BCAAs), free fatty acids (FFAs), and f-Trp/BCAAs. Regardless of genotypes, the significant increases in 30m PE FFAs compared to baseline (p< .01 or p< .05) occurred while the decreases in 24h FFAs concentration compared to 30m PE occurred. The significant decrease in f-Trp (p< .05) at the 24h occurred only in LS genotype while the decrease in 24h BCAAs compared to both baseline (p< .01) and 30m PE BCAAs (p< .01) except LL genotype was observed, respectively. In assessing the f-Trp/BCAAs, the decrease in 24h f-Trp/BCAAs compared to 30m f-Trp/BCAAs occurred only in LS genotype (p < .05)although a similar decrease-tendency was observed in SS genotype. The significant reduction in f-Trp/BCAAs (p < .05) at the 24h was due to the increase in BCAAs and the decrease in f-Trp. In 273 subjects as general population, L allele frequencies were lower (77.66%) than S allele frequencies (22.34%) and the genotype frequencies were SS, 62.7%; LS, 30.0%; and LL, 7.3%. The genotypic frequencies in each group conformed to the Hardy-Weinberg equilibrium (X2 = 2.559, d.f. = 2, p = .278). Consequently, although no significant group difference was determined in changes of f-Trp and f-Trp/BCAAs ratio, the LS and SS genotypes showed a trend for lower levels or ratio of these variables, as compared with the LL genotype. This may imply that especially long distance runners with the LS and SS genotypes may have relative hypofunction of the 5-HT system due to the lower 5-HT level in the extracellular space, compared to the athletes with the LL genotype. This means that 5-HTTLPR genotype may be associated with endurance performance and elite endurance athletes with S allele might gain advantage over athletes with L allele.
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