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백동원,박지영,이수정,채의수 영남대학교 의과대학 2020 Yeungnam University Journal of Medicine Vol.37 No.3
Systemic therapy for metastatic triple-negative breast cancer (TNBC) still remains challenging because there are no targeted agents or endocrine therapies currently available. The present case report documents the successful use of cisplatin monotherapy to manage a heavily pretreated TNBC patient showing poor response to therapy. The patient was a 51-year-old woman who had already undergone several lines of systemic chemotherapy for widespread TNBC. Although the mutation analysis performed on DNA isolated from blood cells and progressed lesion samples confirmed the tumor to be germline BRCA wild-type, cisplatin monotherapy was administered based on the increasing evidence of safety and efficacy of platinum for breast cancer. After three cycles of cisplatin treatment, the patient’s metastatic lesions dramatically improved without any major toxicity, and she completed 17 cycles with good response. This case study indicates that patients with heavily pretreated TNBC can potentially achieve a good response to cisplatin monotherapy.
백동원,이수정,손상균,문준호,채이수 한국유방암학회 2019 Journal of breast cancer Vol.22 No.4
The cumulative risk of therapy-related myelodysplastic syndrome (t-MDS) in breast cancer patients exposed to chemotherapy and/or radiotherapy is significantly high compared to that in other cancer patients. This report reviews the use of hypomethylating agents (HMAs) to treat a 57-year-old woman newly diagnosed with MDS during palliative chemotherapy for metastatic breast cancer. Over a period of 6 years, the patient received several DNA-damaging chemotherapeutics including doxorubicin, cyclophosphamide, and paclitaxel. Repeated thrombocytopenia was the main reason for suspecting secondary hematologic malignancy. She was diagnosed with t-MDS based on bone marrow examination and her treatment history for breast cancer. While azacitidine was originally administered to stabilize MDS, it also stabilized the patient's lung and lymph node metastases without any major toxicity. Therefore, the current case highlights the promising effects of HMAs for treating t-MDS following heavily pretreated breast cancer.
백동원,박지영,이수정,채이수 한국유방암학회 2020 Journal of breast cancer Vol.23 No.5
Ectopic male breast cancer is very rare. Consequently, there is a lack of prospective clinical trials, and most recommendations for treatment are based on the experiences of clinicians and data from female breast cancer patients. The United States Food and Drug Administration has recently approved palbociclib combined with endocrine therapy for advanced male breast cancer because of the positive results of its use in metastatic female breast cancer. Therefore, it is worth considering cyclin-dependent kinase 4/6 inhibitors as alternatives to conventional chemotherapies for advanced male breast cancer patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative cancers. The present case report introduces the use of palbociclib plus letrozole as first-line therapy for an elderly male patient with relapsed ectopic breast cancer, notwithstanding the limitations of the current national health insurance policy.
반도체 포화 흡수체 반사경에 의해 모드 잠금된 Yb:YAG 레이저 출력의 공진기 모드 크기에 대한 의존성 연구
김현철,임한범,채동원,김현수,Kim, Hyun Chul,Lim, Han Bum,Chae, Dong Won,Kim, Hyun Su 한국광학회 2015 한국광학회지 Vol.26 No.6
We investigate the effect of laser-resonator mode size on the output of a Yb:YAG laser that is mode-locked by a semiconductor saturable absorber mirror (SESAM). We demonstrate that the smaller the product of the mode sizes at a SESAM and at a Yb:YAG crystal, the more stable the mode-locked output is. Also, we found numerically that there is a resonator length at which the mode-locked output occurs, regardless of the thermal lens effect of a Yb:YAG. 레이저 공진기 모드 크기가 반도체 포화 흡수체 거울(SESAM)을 이용하여 모드 잠금된 Yb:YAG 레이저의 출력에 주는 영향을 조사하였다. SESAM과 Yb:YAG 매질 위치에서 공진 모드들 크기를 곱한 값이 작을수록 모드 잠금이 안정적으로 발생함을 실험적으로 보였다. 수치적으로 레이저 매질의 열 렌즈 효과와 무관하게 모드 잠금이 이루어지는 공진기 길이 조건이 있음을 확인하였다.
장명철,김찬동,노혜린,채기봉,박원서,민동원,신형식,양대현,최원진 대한외과학회 2003 Annals of Surgical Treatment and Research Vol.65 No.4
A medullary carcinoma of the breast is an uncommon breast cancer subtype, but has a fair prognosis. The histopathological criteria for a medullary carcinoma were delineated by Ridolfi et al. in 1977, and most pathologists use these criteria. The authors experienced a huge carcinoma of the breast, which was diagnosed as an atypical medullary carcinoma. A 47-year old female visited our clinic due to a breast mass of six months duration. The mass was 16 cm in size and exophytic in the left lower breast. There had been necrosis, with a foul odor in most of the mass. A large fixed axillary lymph node was noted, but there was no evidence of distant metastasis. A radical mastectomy was performed due to invasion of the pectoralis major. On pathological examination, the tumor was diagnosed as an atypical medullary carcinoma. (J Korean Surg Soc 2003;65:353-355)