비선형적 공간그래픽 특성 연구

진민선,이찬 한국문화공간건축학회 2016 한국문화공간건축학회논문집 Vol.- No.55

Society is diversifying in all fields, including economy, science, culture, and art. The urban environment has welcomed organic system changes, facing a turning point in most fields, including various genres’ emergence and domains’ expansion and convergence. Like post-structuralism, which embraces cultural complexity and diverse social discourses to create new domains and mutual influence by creating new elements, graphics and spaces are organically bonded and mutually grafted, resulting in spatialization of graphics and vice versa. This study aims to identify and analyze spatial graphics’ nonlinear nature by examining their theoretical backgrounds and concepts and analyzing cases in modern spaces. First, a literature review was used to define nonlinear space’s concepts and characteristics. Second, we defined the concept of nonlinear spatial graphics by considering the concept, formation, and background of spatial graphics through a variety of art trends. Lastly, we observed the characteristics of nonlinear spatial graphics in modern spaces by conducting various case analyses while interpreting the concept of spatial graphics in modern spaces in an extended concept. Through case analysis of different nonlinear spatial graphics, we discovered a common, distinctive repetition and expandability. There is a continuous appearance of complex irregular patterns, animated organic expression from dynamic images and sense of fluidity, and, sometimes, an atypical structure from the combination of non-geometric forms that are modified from the disassembling of Euclidean geometric forms. Nonlinear spatial graphics’ characteristics in specific spaces showed they were derived nonlinearly. When we observed the concept of nonlinearity as a concept of expansion, it was not divided into architecture, space, and graphics. The shift of the paradigm is influencing space and spatial graphics. It is possible that with spatial graphics, nonlinearity is an endless new paradigm that can evolve into a creative world.

음악적 운율을 이용한 아동의 영어 발음 지도 효과

박민선 ( Min Sun Park ),진상임 ( Sang Im Jin ) 글로벌영어교육학회(구 호남영어교육학회) 2006 Studies in English education Vol.11 No.1

This study tries to find that the musical rhythm and English pronunciation teaching could be connected in children`s English pronunciation lessons. To experiment effects of musical rhythm, 20 children who had been learning playing the piano more than one year were collected, and divided into two groups, the experimental group and the control group. The musical rhythm in addition to phonics was applied to the experimental group for about one month to teach English pronunciation. All children`s pronunciations were recorded and analyzed by an English native speaker. The analysis was focused on suprasegmentals like juncture, stress and intonation. The result of analysis shows that the experimental group improves a little more than the control group in English pronunciation. This means that the musical rhythm has some significance in teaching English pronunciation to the children. However, because the acquisition of pronunciation cannot be completed in a short time, we need to design more structured pronunciation lesson plans in relation to the musical rhythm in further research.

Prognostic Significance of Ezrin Expression in Liposarcoma

이재석,진민선,이정은,김민석,전대근,고재수 대한병리학회 2008 Journal of Pathology and Translational Medicine Vol.42 No.5

Background : Ezrin has been reported to be involved in the metastasis of solid tumors in both an animal model and clinical trials. However, questions remains as to whether an ezrin expression is an independent predictor of the event-free survival of liposarcoma patients. Methods : We analyzed 85 liposarcoma patients without metastasis at the time of presentation. We performed immunohistochemistry with anti-ezrin antibody, and we analyzed the association of an ezrin expression with the clinicopathological variables and event-free survival. Results : Twenty-nine patients (34.1%) showed an ezrin expression. Among the 30 low-grade liposarcoma patients, only one patient showed ezrin positivity. The patients who had an ezrin expression were found to be at a significantly increased risk for metastasis compared with the patients who had no ezrin expression (risk ratio: 3.4, 95% confidence interval: 1.3-9.1). The 10-year metastasis-free survival rate was 26.9% for the patients with an ezrin expression and 86.7% for the patients without an ezrin expression. The ezrin expression rate increased with an advanced tumor grade and stage. Conclusions : An ezrin expression is an independent predictor of distant metastasis for liposarcoma. Thus, ezrin has the potential to provide additional prognostic information and to be a novel target for the development of new adjuvant therapies for treating the patients who suffer from liposarcoma. Background : Ezrin has been reported to be involved in the metastasis of solid tumors in both an animal model and clinical trials. However, questions remains as to whether an ezrin expression is an independent predictor of the event-free survival of liposarcoma patients. Methods : We analyzed 85 liposarcoma patients without metastasis at the time of presentation. We performed immunohistochemistry with anti-ezrin antibody, and we analyzed the association of an ezrin expression with the clinicopathological variables and event-free survival. Results : Twenty-nine patients (34.1%) showed an ezrin expression. Among the 30 low-grade liposarcoma patients, only one patient showed ezrin positivity. The patients who had an ezrin expression were found to be at a significantly increased risk for metastasis compared with the patients who had no ezrin expression (risk ratio: 3.4, 95% confidence interval: 1.3-9.1). The 10-year metastasis-free survival rate was 26.9% for the patients with an ezrin expression and 86.7% for the patients without an ezrin expression. The ezrin expression rate increased with an advanced tumor grade and stage. Conclusions : An ezrin expression is an independent predictor of distant metastasis for liposarcoma. Thus, ezrin has the potential to provide additional prognostic information and to be a novel target for the development of new adjuvant therapies for treating the patients who suffer from liposarcoma.

Fine Needle Aspiration Cytologic Features of Well-Differentiated Papillary Mesothelioma in the Pleura - A Case Report -

류한석,진민선,최희승,백희종,고재수 대한병리학회 2009 Journal of Pathology and Translational Medicine Vol.43 No.6

Well-differentiated papillary mesothelioma (WDPM) is a rare subtype of malignant mesothelioma, which is considered to have low malignant potential. Because of its rare occurrence in the pleura, cytopathologists are not familiar with the cytologic features of WDPM, and to date only one report regarding the cytomorphology of aspiration biopsies of WDPM in pleura has been released. The authors present the findings of fine needle aspiration cytology of WDPM in the pleura in a 53-year-old woman. Aspiration smears showed papillary clusters composed of one to three layers of surface tumor cells and a central hyalinized stromal core. Tumor cells were round, ovoid, and spindle like with minimally atypical nuclei and small conspicuous nucleoli. Mitotic activity was virtually absent. Excisional biopsy histologic and immunohistochemical findings were wholly compatible with WDPM findings. Knowledge of the specific cytologic findings of WDPM is crucial for accurate diagnosis and appropriate treatment. Well-differentiated papillary mesothelioma (WDPM) is a rare subtype of malignant mesothelioma, which is considered to have low malignant potential. Because of its rare occurrence in the pleura, cytopathologists are not familiar with the cytologic features of WDPM, and to date only one report regarding the cytomorphology of aspiration biopsies of WDPM in pleura has been released. The authors present the findings of fine needle aspiration cytology of WDPM in the pleura in a 53-year-old woman. Aspiration smears showed papillary clusters composed of one to three layers of surface tumor cells and a central hyalinized stromal core. Tumor cells were round, ovoid, and spindle like with minimally atypical nuclei and small conspicuous nucleoli. Mitotic activity was virtually absent. Excisional biopsy histologic and immunohistochemical findings were wholly compatible with WDPM findings. Knowledge of the specific cytologic findings of WDPM is crucial for accurate diagnosis and appropriate treatment.

Lyn Expression in Osteoblastic Osteosarcoma Tissues and Its Correlation with Clinicopathologic Factors

고재수,진민선,강신광,김민석,최희승,이정은,김길호,전대근 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.2

Background : The Src family kinases (SFKs) are involved in multiple aspects of tumorigenesis, such as, proliferation, migration, and angiogenesis, and are involved in the generation and progression of many types of tumors. Furthermore, dasatinib, a general SFKs inhibitor was recently approved for use in chronic myeloid leukemia. This study was performed to evaluate the expression of Lyn, a member of the SFKs, in osteosarcoma tissues. Methods : One hundred and sixteen patients with osteoblastic osteosarcoma were selected for Lyn expression analysis. The correlation between Lyn expression in tumor sections and patients’ clinicopathologic characteristics and the prognostic significance of Lyn expression were evaluated. Results : Lyn was found to be expressed in 52 of the 116 patients (44.8%), and Lyn positive tumor was found to be significantly associated with a lytic tumor pattern on plain radiographs (p = 0.04). Furthermore, those positive for Lyn showed longer metastasis free survival (5-year metastasis free survival, 65.2% for Lyn positive and 46.8% for Lyn negative; p = 0.06), though this was only marginally significant. Conclusions : Lyn was found to be overexpressed in osteosarcoma tissues, and this overexpression was found to be correlated with osteolysis.

High Cytoplasmic CXCR4 Expression Predicts Prolonged Survival in Triple-Negative Breast Cancer Patients Treated with Adjuvant Chemotherapy

심보배,진민선,문지혜,박인애,류한석 대한병리학회 2018 Journal of Pathology and Translational Medicine Vol.52 No.6

Background: Chemokine receptor CXC chemokine receptor type 4 (CXCR4) and its ligand CXC motif chemokine 12 (CXCL12; stromal cell-derived factor-1) are implicated in tumor growth, metastasis, and tumor cell-microenvironment interaction. A number of studies have reported that increased CXCR4 expression is associated with worse prognosis in triple-negative breast cancer (TNBC), but its prognostic significance has not been studied in TNBC patients treated with adjuvant chemotherapy. Methods: Two hundred eighty-three TNBC patients who received adjuvant chemotherapy were retrospectively analyzed. Tissue microarray was constructed from formalinfixed, paraffin-embedded tumor tissue and immunohistochemistry for CXCR4 and CXCL12 was performed. Expression of each marker was compared with clinicopathologic characteristics and outcome. Results: High cytoplasmic CXCR4 expression was associated with younger age (p = .008), higher histologic grade (p = .007) and lower pathologic stage (p = .045), while high CXCL12 expression was related to larger tumor size (p = .045), positive lymph node metastasis (p = .005), and higher pathologic stage (p = .017). The patients with high cytoplasmic CXCR4 experienced lower distant recurrence (p = .006) and better recurrence-free survival (RFS) (log-rank p = .020) after adjuvant chemotherapy. Cytoplasmic CXCR4 expression remained an independent factor of distant recurrence (p = .019) and RFS (p = .038) after multivariate analysis. Conclusions: High cytoplasmic CXCR4 expression was associated with lower distant recurrence and better RFS in TNBC patients treated with adjuvant chemotherapy. This is the first study to correlate high CXCR4 expression to better TNBC prognosis, and the underlying mechanism needs to be elucidated in further studies.

Female urethral adenocarcinoma : A report of two rare cases

심향섭,진민선,진종률,전상훈,이국진 대한내과학회 2017 대한내과학회 추계학술대회 Vol.2017 No.1

Downregulation of N-myc and STAT Interactor Protein Predicts Aggressive Tumor Behavior and Poor Prognosis in Invasive Ductal Carcinoma

최지은,현창림,진민선,이경민,문지혜,류한석 한국유방암학회 2020 Journal of breast cancer Vol.23 No.1

Purpose: We investigated the expression of the N-myc and STAT interactor (NMI) protein in invasive ductal carcinoma tissue and estimated its clinicopathologic significance as a prognostic factor. The expression levels and prognostic significance of NMI were also analyzed according to the molecular subgroup of breast cancers. Methods: Human NMI detection by immunohistochemistry was performed using tissue microarrays of 382 invasive ductal carcinomas. The correlation of NMI expression with patient clinicopathological parameters and prognostic significance was analyzed and further assessed according to the molecular subgroup of breast cancers. Moreover, in vitro experiments with 13 breast cancer cell lines were carried out. We also validated NMI expression significance in The Cancer Genome Atlas cohort using the Human Protein Atlas (HPA) database. Results: Low NMI expression was observed in 190 cases (49.7%). Low NMI expression was significantly associated with the “triple-negative” molecular subtype (p < 0.001), high nuclear grade (p < 0.001), high histologic grade (p < 0.001), and advanced anatomic stage (p = 0.041). Patients with low NMI expression had poorer progression-free survival (p = 0.038) than patients with high NMI expression. Low NMI expression was not significantly associated with patient prognosis in the molecular subgroup analysis. In vitro, a reduction of NMI expression was observed in 8 breast cancer cell lines, especially in the estrogen receptor-positive and basal B type of triple-negative breast cancer molecular subgroups. The HPA database showed that low NMI expression levels were associated with a lower survival probability compared with that associated with high NMI expression (p = 0.053). Conclusion: NMI expression could be a useful prognostic biomarker and a potential novel therapeutic target in invasive ductal carcinoma.

유방에 생긴 과립세포종양의 세포 소견 -1예 보고-

정수영,노우철,진민선,이승숙,고재수,Chung, Soo-Young,Noh, Wo-Chul,Jin, Min-Sun,Lee, Seung-Sook,Koh, Jae-Soo The Korean Society for Cytopathology 2007 대한세포병리학회지 Vol.18 No.2

Granular cell tumor (GCT) of the breast is a rare clinical entity, and is believed to be of schwannian origin and to follow a benign clinical course. A 50-year-old woman presented with a slowly growing mass in the right breast. Fine needle aspiration cytology revealed a cellular smear containing isolated or clustered cells showing round to oval nuclei with abundant oncocytic granular cytoplasm. Nuclei showed a fine granular chromatin pattern and occasional small single nucleoli. Cell boundaries were poorly defined, and naked nuclei were frequently found, Histologically, the tumor showed features of typical GCT, and immunohistochemical staining findings strongly supported the diagnosis. The present study demonstrates that GCT of the breast can mimic malignant lesions of breast both clinically and radiologically. The recognition of its cytologic features and suspicion of this lesion would undoubtedly aid the correct diagnosis of mammary GCT.

Two cases of peritoneal epithelioid mesothelioma showing different pathologic feature and prognosis

김현민,전상훈,이국진,진민선 대한내과학회 2019 대한내과학회 추계학술대회 Vol.2019 No.1