텐터 신장률이 다른 면/스판덱스 능직물의 반복세탁에 따른 역학적 특성 및 태 비교

정혜원,권진,김효정,석혜준,Chung, Hae-Won,Kwon, Jin,Kim, Hyo-Jeong,Seok, Hye-Joon 한국섬유공학회 2010 한국섬유공학회지 Vol.47 No.4

The effects of the tentering-extension rates and repeated washing on the mechanical properties and hand values of cotton/ spandex twill were examined. A 3% spandex containing cotton twill was treated by tenter extension at different rates of 0%, 5%, 10% and 15%. The processed fabric with a 0% extension rate was also dyed using a reactive dye. The KES-FB system was utilized to measure the mechanical properties of the twill, and the basic and total hand values were determined using a KN-201-MDY and KN-301-WINTER, respectively. The fabrics treated with greater tentering extension and dried in a clothes tumble dryer showed lower bending and shear properties, and became softer and smoother. The greatest change in the mechanical properties and hand values occurred after the first wash, but the differences in the washed and unwashed state decreased with increasing number of wash cycles. These results show that cotton/spandex twill should be extended 5% during tentering to yield less deterioration of the T.H.V., and be dried in a clothes tumble dryer to maintain a soft and smooth hand without affecting the shrinkage and elasticity.

$Ca^{2+}$ Inhibitor가 생쥐난자 성숙에 미치는 영향

정혜원,유한기,배인하,Chung, Hye-Won,Yoo, Han-Ki,Bae, In-Ha 대한생식의학회 1992 Clinical and Experimental Reproductive Medicine Vol.19 No.1

In the present study, it was aimed to find the role of calcium on the maturation of mouse follicular oocytes as well as for the role of calcium inhibitors, $Ni^{2+}$ and $La^{3+}$. Mouse follicular oocytes were cultivated in different media at $37^{\circ}C$, in 100% humidified $CO_2$ incubator for 3 and 17 hrs. The results were as follows; 1. There was no differences in GVBD between the control and experimental groups during the 3 hr culture. 2. Mouse oocytes were matured to higher rate in MHBS rather than HTF for 17 hr culture. 3. Maturation rate was significantly lower in $Ca^{2+}$-free and $Ca^{2+}$ 0.4 mM which were tested, compared to other calcium concentration used in the present study. 4. Calcium inhibitor, $Ni^{2+}$, it showed highest degeneration rate at all calcium concentrations and additionally in $Ni^{2+}$ $100{\mu}M$ treated group next. Maturation rate was significantly decrease as the $Ca^{2+}$ inhibitor concentration increased. 5. In all Lanthanum treated groups of calcium-free, degeneration were significantly high treated groups at 0.4 mM $Ca^{2+}$ concentrations degeneration rates of all group were significantly lower than that of the control but maturation rates were not significantly different in any group. In lanthanum $100{\mu}M$ treated group at 0.4 mM and 0.8 mM calcium concentration, its maturation rate was significantly higher than that of the control. Maturation rates of all groups of lanthanum treated at 1.71 mM calcium concentration were not significantly different among groups. 6. In the calcium treated group (0.4mM-1.7 mM), the presence of phosphate does not seem to be needed for oocyte maturation. However, the presence of phosphate at $Ca^{2+}$ 0.8 mM only seems to stimulated maturation.

37 Farnesyltransferase inhibitor의 세포 주기 및 활성화 Ras 단백의 신호전달체계 변화 양상 규명을 통한 암 성장 억제 기전 고찰

정혜원 ( Hye Won Chung ),김주원 ( Ju Won Kim ),송시영 ( Si Young Song ),김한수 ( Han Soo Kim ),박승우 ( Seung Woo Park ),정재복 ( Jae Bock Chung ),강진경 ( Jin Kyung Kang ) 대한소화기학회 2002 대한소화기학회 추계학술대회 Vol.2002 No.-

The Impact of Sample Sizes on Multiple Membership Multilevel Modeling Estimation

정혜원(Hye won Chung),김지선(Ji seon Kim),박령선(Ryoung sun Park),전현정(Hyeon jeong Jeon) 한국교육평가학회 2015 교육평가연구 Vol.28 No.1

다중소속 다층자료가 교육현장자료에서 증가하고 있으나, 표본크기가 다중소속다층모형에 미치는 영향에 관한 연구는 매우 미흡하다. 이 시뮬레이션 연구에서는 표본의 크기가 다중소속다층모형의 모수 추정과 신뢰구간에 미치는 영향을 살펴보고자 하였다. 본 연구의 목적을 수행하기 위해 계층 내 상관계수 (ICC; 0.15, 0.25), 2수준 표본크기 (20, 30, 50, 100), 1수준 표본크기 (20, 30, 50, 100, 200)의 조건들이 고려되었다. 모든 실험조건에서 고정효과와 1수준 변량의 추정에서는 상대편의가 나타나지 않았다. 그러나 2수준 표본크기 조건에서는(<=50), 2수준 변량의 과대 추정되는 상대편의가 나타났다. 모든 실험조건에서, 고정효과와 변량의 95%신뢰구간 포함 비율은 명목수준인 5%보다 미만으로 나타났다. 본 연구에서는 연구자들에게 다중소속다층모형의 추정을 위해서 최소 50 그룹 및 각 그룹 당 30명 이상 참여자가 속해 있는 크기의 자료를 사용할 것을 제안하였다. Multiple membership data structures are increasingly encountered in the educational field, but few studies have investigated the impact of sample sizes on multiple membership multilevel modeling. This simulation study examines the parameter estimates and non-coverage rates of 95% credible intervals in multiple membership multilevel modeling under a variety of manipulated conditions including: the intraclass correlation coefficient (ICC; 0.15 and 0.25), the number of schools (20, 30, 50 and 100), and the number of students (20, 30, 50, 100 and 200). Across all conditions, no substantial relative bias was found for fixed effect and student level variance component estimates. However, in some of the smaller number of schools (<=50), school level variance component estimates were substantially positively biased. Across all conditions, non-coverage rates of 95% credible interval for the fixed effect and random variance component estimates were less than the nominal non-coverage rate (i.e., 5%). It is suggested that applied researchers should analyze sufficiently large dataset (at least 50 groups with 30 participants) for multiple membership multilevel modeling estimation.

A Comparison of Parameter Recovery in Multilevel Modeling Estimation: Maximum Likelihood versus Bayesian Estimation

정혜원(Hye won Chung),김지선(Ji seon Kim),박령선(Ryoung sun Park),전현정(Hyeon jeong Jeon) 한국교육평가학회 2015 교육평가연구 Vol.28 No.2

이 연구에서는 최대우도와 베이지안 추정방법 선택에 따른 다층모형의 모수 추정에 미치는 영향을 비교하고자 High School and Beyond(HS&B) 자료를 이용한 연구와 모의실험연구를 실시하였다. 구체적으로, 다층모형 추정의 정확성을 검사하기 위해서 반화최소자승법(iterative generalized least squares, 이하 IGLS), 제한반화최소자승법(restricted iterative generalized least squares, 이하 RIGLS)과 Markov chain Monte Carlo(이하 MCMC) 세 추정 방법이 사용되었다. 추가적으로, 두 가지 베이지안 점 추정값인 MCMC 사후 평균값과, MCMC사후 중간값이 비교되었다: HS&B자료 분석결과, 고정효과와 1수준 분산추정의 결과는 매우 비슷하게 나타났으나, 2수준 분산의 경우 MCMC 사후평균 추정값이 IGLS 또는 RIGLS값보다 약간 크게 추정되었다. 모든 실험결과에서도, 모든조건에서 고정효과와 1수준 분산의 추정에서는 상대편의가 나타나지 않았다. 그러나 IGLS 추정방법을 적용하였을 경우, 2수준 표본크기가 50미만인 조건에서 2수준 분산이 작게 추정되는 상대편의가 발생하였다. MCMC 사후 평균값을 적용하였을 경우, 2수준 표본크기가 30 미만인 조건에서, 2수준분산이 크게 추정되는 상대편의가 발생되었다. 모든 조건에서, IGLS와 RIGLS 추정방법을 적용하였을 경우, 신뢰구간이 명목수준 (95%) 보다 낮은 것으로 나타났다. 그러나, MCMC적용한 경우, 신뢰구간은 명목수준인 95%보다 약간 높은 것으로 나타났다. This study was designed to compare the parameter recovery between maximum likelihood and Bayesian estimation in multilevel modeling using the High School and Beyond (HS&B) Survey and simulated data. Specifically, maximum likelihood estimation via iterated generalized least squares (IGLS) and restricted iterated generalized least squares (RIGLS), and Bayesian estimation via the Markov chain Monte Carlo (MCMC) were used to test the accuracy of multilevel modeling parameter estimation. Additionally, two Bayes point estimates were compared: the MCMC posterior mean and the MCMC posterior median. In the HS&B data study, no substantial differences were found in fixed effect or level one variance component estimates across the three estimation methods. The MCMC posterior mean estimate, however, led to a larger level two variance component estimate compared that of IGLS and RIGLS. Similarly, in simulation study, no substantial relative bias was found for fixed effect and level one variance component across all conditions. With IGLS, however, level two variance component estimates were substantially under-estimated in the conditions of <=50 level two units. With MCMC posterior mean approach, level two variance component estimates were substantially over-estimated in the conditions of <= 30 level two units. Across all conditions, coverage rates of confidence intervals for the fixed effect and random variance component estimates with IGLS and RIGLS were less than the nominal rates (i.e., 95%). However, credible interval coverage rates with MCMC were slightly higher than the nominal rates across all conditions.

치료반응이 좋은 증례 현저하게 좋은 치료반응을 보인 진행성 간세포암(stage IVa)

정혜원 ( Hye Won Chung ),정재연 ( Jae Youn Cheong ),송건훈 ( Kun Hoon Song ),한광협 ( Kwang Hyub Han ),문영명 ( Young Myoung Moon ),김병로 ( Byoung Ro Kim ),성진실 ( Jin Sil Seong ),김명진 ( Myoung Jin Kim ),이도연 ( Do Yun Lee 대한간암학회 2001 대한간암학회지 Vol.1 No.-

전이성 임신성 융모막암종에 의한 신장 파열 선택적 신장동맥색전술 보고

정혜원 ( Hye Won Chung ),최준용 ( Jun Yong Choi ),신소진 ( So Jin Shin ),조치흠 ( Chi Heum Cho ),차순도 ( Soon Do Cha ),권상훈 ( Sang Hoon Kwon ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.11

Choriocarcinoma is a rapidly growing tumor that characteristically outgrows its blood supply. We report a rare case of metastatic choriocarcinoma presenting with acute right flank pain due to kidney rupture secondary to renal metastasis. The renal metastasis was embolised to stanch blood for control of hemorrhage. A brief review of the imaging features and therapeutic options for the ruptured renal metastases is discussed along with the case.

Interleukin-1beta (IL-1b) Regulates u-PA, u-PAR, PAI-1 mRNA Expression Cultured Human Endometrial Stromal Cells

정혜원 ( Hye Won Chung ),( Yan Wen ),( Jung Ja Ahn ),( Han Ki Yu ),( Mary Lake Polan ) 대한산부인과학회 1999 대한산부인과학회 학술대회 Vol.84 No.-

다중소속 다층자료에 대한 모형의 명세화 오류 연구

정혜원(Hye won Chung) 한국교육평가학회 2016 교육평가연구 Vol.29 No.4

본 연구는 교차분류 다중소속 다층모형을 소개하고, 교차분류 다중소속 다층자료에 대한 명세화 오류가 모수추정에 미치는 영향을 연구하였다. 구체적으로, 본 모의실험 연구는 이러한 교차분류 다중소속 다층자료의 특성을 무시하는 두 가지 다층모형(전통적 다층모형, 교차분류 다층모형)을 적용할 경우 발생되는 모수추정치의 상대편의성을, 교차분류 다중소속 다층자료를 올바르게 모형화한 교차분류 다중소속 다층모형의 모수추정치의 상대편의성과 비교하였다. 모의실험 결과 전통적 다층모형과 교차분류 다층모형을 적용하였을 경우, 다중소속과 관련된 고정효과가 상대적으로 과소 추정되었다. 임의효과 분산추정값은 교차분류 다중소속 다층자료의 특성을 올바르게 추정하지 못할 경우, 심각한 상대편의성이 발생하였다. 또한 모형적합도를 비교한 결과 모든 실험조건에서 준거모형인 교차분류 다중소속 다층모형이 비교모형인 두 가지 다층모형보다 교차분류 다중소속 다층자료에 더 적합한 것으로 나타났다. This study introduced a cross-classified multiple membership multilevel model and investigated the effects of mis-specifying cross-classified multiple membership multilevel data structure in multilevel modeling estimation. The simulation study compared the relative parameter biases across three multilevel models that ignored one or more facets of a cross-classified multiple membership multilevel data structure, including a conventional multilevel model and a cross-classified multilevel model to the biases of the correctly specified cross-classified multiple membership multilevel model. The results were as follows. The fixed effect associated with multiple membership exhibited negative biases under the conventional multilevel model and cross-classified multilevel model. Variance component estimates were substantially biased when any facet of the cross-classified multiple membership multilevel data structure was incorrectly modeled. Additionally, model fit values using deviance information criterion supported the cross-classified multiple membership multilevel model over the two multilevel models across all conditions.

절개반흔 자궁내막증의 치료에서 성선자극호르몬유리호르몬작용제의 역할

정혜원 ( Hye Won Chung ),박소연 ( So Yun Park ),이사라 ( Sa Ra Lee ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.12

Objective To investigate the characteristics and to define the most effective diagnosis and treatment option for the scar endometriosis resulting from abdominal incision or episiotomy. Methods Medical records of thirty women with scar endometriosis who underwent mass excision between 1996 and 2008 in our hospital were reviewed retrospectively. Data on the age, parity, surgical history, symptom, menstrual history, characteristics of the mass, preoperative diagnosis, treatment method and recurrence were analyzed. Results Scar endometriosis were developed after Cㅊesarean section in 24 patients and episiotomy in 6 patients. Nearly all patients presented with a palpable mass with or without cyclic pain and mean duration of symptom was 23.8 months. Preoperative imaging study was performed in 14 patients, however there was no one whose preoperative imaging result was endometriosis. All scar endometriosis was completely excised with surrounding tissue. Gonadotrophin releasing hormone (GnRH) agonist was administered in 13 patients pre- or postoperatively. Recurrence of scar endometriosis after wide mass excision was noted in 4 patients (13.3%) who did not receive GnRH agonist therapy pre- or postoperatively. Conclusion This study supports that scar endometriosis is a result of the transplantation of endometrial tissue during procedures. The contribution of the imaging studies seems to be limited, so surgeon could perform mass excision for diagnosis and treatment with clinical history and physical exam without performing imaging study especially in for small scar endometriosis. Surgical excision accompanied by pre-, or postoperative GnRH agonist therapy may be helpful option for the prevention of recurrence however, we could not find any statistical significance in the effectiveness of GnRH agonist treatment.