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RISS 인기검색어
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- 저자 : 정윤섭(Jun Sop Chong) (검색결과 5 건)
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만성폐질환에서 haemophilus influenzae 의 분리 및 약제 감수성에 관한 연구
김성규(Sung Kyu Kim),조철호(Chul Ho Cho),장상호(Sang Ho Jang),장준(Joon Chang),임명기(Myung Gi Lim),이원영(Won Young Lee),정윤섭(Jun Sop Chong) 대한내과학회 1990 대한내과학회지 Vol.39 No.3
N/A Hemophilus influenzae is being recognized with increasing frequenzy in various literature as a cause of pneumonia and of acute exacerbations of chronic lung disease indluding COPD and bronchiectasis. Currently, however, the incidence of H. influenzae ae a respiratory pathogen in adults is often underestimated in our country, In this study, the prevalence of H. iefluenzae and the antimicrobial resistance rate and efficacy of Cefaclor were assessed among a total of 155 patients with chronic lung diseases during the period from July 198S to June 1989. The following results were obtained: 1) The prevalence of H. influenzae in chronic airway diseases was 16.1% when routine media were used. With selective media, the positive rate was significantly highter (66.5%). 2) Among the 101 strains, 2% were serotype b and 90.1% were non-typable. 3) In the total 98% H. influenzae isolates studied, 18.4%, were resistant to ampicillin and none to Cefaclor and tetracycline, 4) The overall bacterialogical response of H. influenzae to Cefaclor, which is one of the two most active drugs, was found to be as follows: Eliminated 60.0%, Reduced markedly 22.9%, Persistent 11.4% and lncreased 5.7%, However, the results of Persistent and Increased could be found in selective media only. This study revealed the relatively high prevalence of H. influenzae in patients with Chronic airway diseases. The prevalence of H. influenzae was significantly higher when selective media was used for culture.
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Campylobacter fetus subsp. jejuni에 의한 장염 4예
정윤섭,김경숙,유영해,이삼열,고창준,고윤웅,문영명,한동관 대한감염학회 1981 감염 Vol.13 No.1
Campylobacter was isolated from stool specimens taken from 2 pediatric and 2 adult patients with enteritis. All of the 4 isolates showed typical characteristics of C. fetus subsp. jejuni in morphology, gram reaction, cultural and biochemical tests. Two isolates were resistant to cephalothin only, while the third one was resistant to co-trimoxazole, as well. The last isolate was different from others being resistant to amikacin, gentamicin, kanamyin and tobramyin. During this study period of time, a total of 871 stool specimens were cultured, and 12.1% of them yielded shigella while only 0.5% yielded campylobacter.
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임상검체에서의 Haemophilus aphrophilus 분리 5예
김태숙,정윤섭,이삼열,설준희,양성익,이의웅 대한미생물학회 1985 大韓微生物學會誌 Vol.20 No.1
Haemophilus aphrophilus is a fastidious gram-negative bacillus found in mouth of normal individuals. Though H. aphrophilus infection is quite rate, it includes such serious ones as endocarditis and brain abscess. The authom isolated H. aphrophilus from five patients with the diagnosis of lung abscess, conjunctivitis, brain abscess and facial masticator space abscaa Two of the patients died. Three of the patients also yielded other species of bacteria from the same specimens. One of the isolate was intermediately susceptible to amikacin and resistant to tobramycin, indicating the necessity of a routine susceptibility test in order to select the proper antimicrobial agents. Since FS. Aphrophilus can be diffetentiated from other similar organisms by morphological and biochemical chamcteristics, one should determie the possibility of this organisrn when faptidious gram-negative bacilli are isolated from blood or from sites adjacent to upper respiratory tract.
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Pasteurella Multocida 에 의한 패혈증 1 예
조준구,정윤섭,박인서,이동기,최흥재 대한내과학회 1987 대한내과학회지 Vol.32 No.1
This is a case of pasteurella multocida septicemia. A 50-year-old man was admitted to Severance Hospital, Yonsei University College of Medicine because of fever and dyspnea for 2 days. There was a past history of liver cirrhosis and hepatic coma 3 months ago. On examination, the patient had a temperature of 39.1℃, right side pleural effusion and ascites. Initial therapy with ampicillin and gentamicin was started after culture study. Pasteurella multocida was recovered from the blood culture. Patient improved under antibiotic therapy.
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담석환자의 담즙 세균배양 및 배양된 균주의 Beta-Glucuronidase 활성도
김원호,정윤섭,강진경,박인서,정준표,김명욱,송시영,강명서,최흥재,임대순 대한소화기학회 1992 대한소화기학회지 Vol.24 No.6
Gallstones can be classified into cholesterol stones and pigment stones which further can be divided into calcium bilirubinate stones and black pigment stones. Calcium bilirubinate stones differ from cholesterol stones not only in clinical manifestations but also in composition, implying a difference in pathogenesis. The presence of β-glucuronidase, produced by bacteria, in bile may lead to an increased amount of unconjugated, water-insoluble bilirubin, which may precipitate as calcium bilirubinate. Another hypothesis is activation of glucuronidase produced in hepatocytes or leukocytes, which has been shown to be present in human bile. To examine the role of bacterial β-glucuronidase activity in the pathogenesis of gallstone formation, we cultured the bile of the gallbladder and common bile duct obtained from 8 controls, 3 patients with cholesterol gallstone and 21 patients with calcium bilirubinate gallstone and tested β-glucuronidase activity of isolated bacterial strains. The results obtainad are as follows: The bacterial culture rate of bile obtained from patients with calcium bilirubinate stones were higher than that of bile obtained from patients with cholesterol stones. E. coli was the most common bacteria isolated from bile followed by Klebsiella pneumoniae, Klebsiella oxytoca, Enterococcus fecalis, Clostridium perfringens, Enterococcus cloacae, and Citrobacter freuedii. Most of the isolated E. coli strains showed β-glucuronidase activity (92.9%). All 11 patients, from whose bile β-glucuronidase producing bacteria were isolated, had calcium bilirubinate stones. Ten of 11 patients (90.9%), from whose bile β-glucuronidase producing bacteria were isolated, had bile duct stones. From these results, we concluded that β-glucuronidase producing bacterial infections of bile may be related with the pathogenesis of calcium bilirubinate stone formation.
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