방사선 조사 후 관찰한 가토 폐의 병리학적 변화

이형식(Hyung Sik Lee),최영민(Young Min Choi),허원주(Won Joo Hur),정진숙(Jin Sook Jeong),유영현(Young Hyun Yuh),이기남(Ki Nam Lee) 대한방사선종양학회 1994 Radiation Oncology Journal Vol.12 No.2

The damage which radiation produces in tissues such as the lungs can be discussed at the molecular, biophysical, cellular and organ levels. The cellular effects of irradiating the lungs are related to the histologic and clinical sequelae. In the present study the right lung of rabbits were exposed to single dose of 20 Gy of X-irradiation. Animals from each group wre sacrificed monthly for 6 months postexposure. Sections of lung were examined by light microscopy(LM) and by transmission electron microscopy(TEM). Multiple exudative lesions were seen at 2 months after the 20Gy irradiation and thery progressed to a proliferative and then reparative fibrotic lesion by 6 months. Changes in epithelial lining of lung components, particulary the presence of type Ⅱ pneumocytes were found by both LM and TEM. Capillary endothelial damages were less pronounced. The possible implication of cellular components in radiation pneumonitis and fibrosis is discussed.

약토 시용방법이 인삼 양직묘 뿌리 생육에 미치는 영향

이성식(Sung-Sik Lee),천성기(Seong-Ki Cheon),이장호(Jang-Ho Lee),안인옥(In-Ok Ahn),신성련(Seong-Lyon Shin),최광태(Kwang-Tae Choi),이갑수(Gab-Soo Lee),이형식(Hyung-Sik Lee),정재동(Jae-Dong Chung) 고려인삼학회 2004 Journal of Ginseng Research Vol.28 No.4

This experiment was conducted to determine economic application method of Yakto among 6 application method: amount of Yakto application 3 plots(70ℓ, 25.5ℓ, 13.3 ℓ/kan), and added side dressing(3ℓ/kan) each plot. The reduced Yakto application(25.5ℓ/kan) with side dressing(3ℓ/kan) showed similar root diameter, fresh weight of roots and yield of good seedlings to standard Yakto application(70ℓ/kan). And also this application method of Yakto gave similar content of Ca and Mg, but the lower content of N, P, K in roots to standard Yakto application(70ℓ/kan). These suggested that 25.5ℓ Yakto application added side dressing(3ℓ/kan) per kan might be economical application method of Yakto.

가공방법을 달리한 오미자 분말차의 품질 특성 분석

이현정(Hyeon-Jeong Lee),성준형(Jun-Hyung Sung),최지영(Ji-Young Choi),조정석(Jeong-Seok Cho),이영민(Yeong-Min Lee),정헌식(Hun-Sik Chung),문광덕(Kwang-Deog Moon) 한국식품과학회 2016 한국식품과학회지 Vol.48 No.1

오미자의 이용성 확대를 위한 건조 가공 제품의 가능성을 확인해보고자 생오미자 및 건조오미자를 이용하여 착즙, 추출, 동결건조, 과립성형 및 분무건조 등의 방법을 이용하여 다양한 오미자분말차를 제조하여 그 품질 특성을 비교 분석하였다. PG, EG 및 ES의 총가용성고형분 함량 및 탁도의 경우 다른 구에 비해 유의적으로 높았으며, pH 측정 결과 PG 및 EG가 다른 구보다 유의적으로 높았다. PG 및 EG의 색도 측정 결과 다른 구에 비해 높은 L*값, 낮은 a*값 및 b*값으로 나타나 오미자의 가공 형태에 따른 유의적 차이가 뚜렷함을 알 수 있었다. PG 및 EG의 경우 다른 구에 비해 유의적으로 높은 환원당 함량, 낮은 총 페놀성 화합물의 함량, 낮은 항산화활성, 낮은 총 안토시아닌 함량 및 낮은 schizandrin 함량을 보여 오미자의 가공 형태에 따른 유의적 차이를 확인할 수 있었다. 또한 관능검사 결과 PG 및 EG는 낮은 붉은색 정도, 낮은 탁도 정도, 낮은 신맛 정도, 높은 쓴맛 정도 및 높은 단맛 정도를 보였으며, 종합적 기호도에서 PG 및 ES의 경우 가장 높은 점수를 받았다. 이와 같은 결과에서 붉은색과 항산화 활성, 안토시아닌 및 schizandrin 함량이 우수한 오미자 분말 제품을 위해 과립차보다 동결건조 및 분무건조분말차가 바람직하다고 판단된다. The purpose of this study was to evaluate the quality characteristics in different types of Omija (Schizandra chinensis Baillon) powder tea. Raw Omija was prepared in three ways: 1) freeze-dried powder of whole Omija (FD), 2) freeze-dried powder of pressed Omija juice (PF), and 3) granules of pressed Omija juice (PG). Dried Omija was extracted and prepared in three ways: 4) freeze-dried powder (EF), 5) granules (EG), and 6) spray-dried powder (ES). The total soluble solid contents and turbidity were higher in PG, EG, and ES than those in other samples. L* value, pH, and reducing sugar contents were higher in PG and EG than those in other samples. Finally, a* value, b* value, total phenolic compounds contents, antioxidant activities, total anthocyanin contents, and schizandrin contents were lower in PG and EG than those in other samples. These results show that FD, PF, EF, and ES are more effective in outstanding redness and antioxidant activities compared to other Omija powder products.

악골내 낭종성 병소의 감압술과 적출술에 관한 임상적 연구

정영수(Young-Soo Jung),백성흠(Song-Hum Paek),이의웅(Eui-Wung Lee),박형식(Hyung-Sik Park) 대한구강악안면외과학회 2004 대한구강악안면외과학회지 Vol.30 No.1

Purpose: Among the various surgical methods used for the effective treatment of cystic lesion in the jaws historically, decompression procedure has some of superior prognosis compare to direct enucleation. In order to propose the efficacy of decompression we performed this retrospective study to compare decompression procedure with one-stage enucleation in clinical results and prognosis. Patients and Methods: We reviewed 175 patients who had been histopathologically diagnosed cystic lesions from 1996 to 2000 in our department. Patients who had been received decompression alone or secondary enucleation after decompression were 31 cases, and enucleation alone were 144 cases. The age and sex of the patients, the area, size, and histological type of the lesions, and detailed operation and complications including recurrence were investigated. The minimal follow-up period was 2 years. Results: In 31cases of decompression, male patients were 22cases(71%) similar to male predilection(62.3%) in total 175 cases. Cystic lesions were developed evenly in all age groups totally. Decompression was mainly performed in teenagers but enucleation was used in elder decades. In decompression cases the lesions were located in mandibular posterior, maxillary posterior, mandibular anterior, and maxillary anterior in order, which had some differences in total and enucleation cases. In enucleation cases, less than 3cm in size was 77.1% but larger than 3cm was 93.5% in decompression cases. Histopathologically, dentigerous cysts(54.8%), unicystic ameloblastomas(16.1%), and odontogenic keratocysts(12.9%) were seen in decompression cases and no recurrence or metaplasia and infection was observed. On the other hand, permanent tooth loss, numbness, recurrence, and so on were accompanied after enucleation. Conclusion: Although decompression procedure has disadvantages such as many of visiting times and slow recovery of the surgical defect, decompression is the best choice of treatment for large cystic lesions of the jaws, because it prevents functional and cosmetic defect, allows bone regeneration, and makes easy secondary enucleation.

구강 수술 후 투여 시기에 따른 진통 요법의 효과

정영수(Young-Soo Jung),김문기(Moon-Key Kim),박형식(Hyung-Sik Park),이의웅(Eui-Wung Lee),강정완(Jeong-Wan Kang) 대한치과의사협회 2003 대한치과의사협회지 Vol.41 No.9

남해 대륙붕 도미분지 탄성파자료의 층서해석을 고려한 전산처리

정순흥,김원식,구남형,이호형,신원철,박근필,Cheong, Snons,Kim, Won-Sik,Koo, Nam-Hyung,Lee, Ho-Young,Shin, Won-Chul,Park, Keun-Pil 대한자원환경지질학회 2010 자원환경지질 Vol.43 No.6

남해 대륙붕 도미분지는 제주분지의 북동단에 위치하는 지역으로 동해의 울릉분지와 인접해 있으며 그 발달시기에 대한 연구가 지속적으로 수행되고 있다. 본 연구에서는 도미퇴적분지의 해석에 적합한 탄생파자료 전산처리 모듈을 시험하고 매개변수를 도출하였다. 도미분지 천부 퇴적층인 제3기 층의 경우 반사파 신호의 연속성 향상과 페그레그(peg-leg) 다중반사파 억제가 요구되었고 이를 위하여 중합 층서속도분석(Horizon Velocity Analysis, HVA)과 표면-연관 파동방정식 다중반사파 제거(Surface Relative Wave Equation Multiple Rejection, SRWEMR)모듈을 조합하여 중합단면의 품질을 제고하였따. 연구결과 제작된 도미분지 탄성파 중합단면에서 퇴적층서가 구분되는 부정합면이 인지되었다. 분지의 발달양상 규명에 적절한 중합단면이 도출되었고 다중반사파의 억제로 백악기 기반암의 해석에 도움이 되었다. 본 연구를 통하여 검증된 전산처리과정은 도미분지와 인근 소라분지, 북소라분지의 탄성파 자료 전산처리 품질의 규격화 및 처리속도 향상에 기여할 것으로 기대된다. The Domi Basin in the South Sea of Korea is located between the Jeju Basin and Ulleung Basins, and is characterized by several sediment sags that are interested to have formed by crustal extension. This paper aims to derive an optimized seismic data processing procedure which helps stratigraphic interpretation of the Domi Basin. In particular, our data processing flow incorporated horizon velocity analysis (HVA) and surface-relative wave equation multiple rejection (SRWEMR) to improve the quality of stack section by enhancing the continuity of reflection events and suppressing peg-leg multiples respectively. As a result of processing procedures in this study, unconformities were recognized in the stack section that defines the early and middle Miocene, Eocene-Oligocene sequences. In addition, the overall quality of the stack section was increased as essential data to investigate the evolution of the basin. The suppression of multiple resulted in the identification of the Cretaceous basement. The data processing scheme evaluated through this study is expected to improve the standardization of processing sequences for seismic data from the Domi and adjacent Sora and north-Sora Basins.

악교정 수술시 유도저혈압 마취를 위해 사용되는 Esmolol과 Nitroglycerin의 효과에 대한 비교 연구

정영수(Young Soo Jeong),강정완(Jeong Wan Kang),박형식(Hyung Sik Park),이충국(Choong Kook Yi),이의웅,(Eui Woong Lee) 대한구강악안면외과학회 1998 대한구강악안면외과학회지 Vol.24 No.4

Induced hypotension is used to help control bleeding during procedures where surgical hemostasis is technically difficult to achieve. A mean arterial blood pressure(MABP) as low as 50-60 mmHg appears to be well tolerable in healthy patients. The present study was designed to compare the efficacy of Esmolol and Nitroglycerin as primary drug for hypotensive anesthesia during 22 cases of orthognathic surgery, and compare their effects on blood loss, duration of surgery, quality of the surgical field, hormonal response, and patient outcome. The results obtained are as follows. 1. During the induced hypotension, mean arterial blood pressure was similarly reduced in esmolol group and nitroglycerin group. And any significant difference was not seen in the time of inducing hypotension from starting the drug administration, preoperative mean blood pressure and mean blood pressure during the period of postoperative recovery. 2. Difficulty of the operation, quality of the surgical field and total operation time in 2 groups show no difference but the time during hypotension was significantly reduced in esmolol group. 3. Urine output, administered fluid volume, transfusion volume of autologous blood, preoperative and postoperative base excess, preoperative and postoperative hematocrit had no difference between 2 groups. 4. The change of the plasma renin activity was more lowered in esmolol group than in nitroglycerin group. Based on the above results, esmolol can replace the nitroglycerin as a new primary drug for hypotensive anesthesia. Especially, esmolol is more recommendable than nitroglycerin on the effect of stability in renin-angiotensin system and prevent rebound hypertension in posthypotensive period.

선행적 진통 요법의 효과성에 대한 연구 -발치 전과 후 진통 요법의 효과 비교-

정영수,김문기,박형식,이의웅,강정완,Jung, Young-Soo,Kim, Moon-Key,Park, Hyung-Sik,Lee, Eui-Wung,Kang, Jeong-Wan 대한치과마취과학회 2003 Journal of Dental Anesthesia and Pain Medicine Vol.3 No.1

Background: Studies on the pain have been dealing with many different ways for last several centuries. Especially, preemptive analgesia is being used as a method to control the postoperative pain. Many studies on its efficacy have been processed in different ways about various drugs, administration methods and times for various operations. And the value of preemptive analgesia are still controversial regarding the results of other clinical studies. The authors performed a clinical study on efficacy of preemptive analgesia using an non-steroidal anti-inflammatory drug (NSAID) for the surgical extraction of impacted third molar teeth and present the more effective pain treatment after oral surgery with literature review. Methods: Using a randomized double blind test design, this study compared the analgesic efficacies of an NSAID, Talniflumate 370 mg. This drug administrated first either 1 hour preoperatively (experimental group) or when the pain developed moderately to severely over 5 scale of verbal rating scales (0-10) to respective 30 patients undergoing the removal of impacted third molars. Pain intensity and the time from the end of surgery were assessed postoperatively whenever the patients demanded additional drug over 5 scale for forty eight hours using same verbal rating scales. Results: The sex distribution, the age of the patients. and the time required for surgery in two groups were similar. The average first time for demanding additional drug after surgery was 163.9 minutes in experimental group and 191.5 minutes in control group. At this time, the average pain intensity was 5.8 in experimental group and 6.1 in control group. And the average second time for demanding additional drug was 365.5 minutes in experimental group and 351.8 minutes in control group. At this time. the average pain intensities were 6.6 in experimental group and 6.2 in control group. No statistically significant difference was found between the average first times and second times, and the average pain intensities at first and second times in two groups. Conclusions: From these results the efficacy of preemptive analgesia used in this study was not appeared. This clinical study indicates that many NSAIDs administrated preoperatively in present practices have weak efficacy of preemptive analgesia for postoperative pain, thus the authors recommend that only postoperative analgesics are adequate without preoperative use of analgesics.

비스테로이드성 항염진통제의 투여시기가 구강외과 술 후 통증에 미치는 효과에 대한 연구

정영수,김문기,엄유정,박형식,이의웅,강정완,Jung, Young-Soo,Kim, Moon-Key,Um, Yoo-Jung,Park, Hyung-Sik,Lee, Eui-Wung,Kang, Jeong-Wan 대한치과마취과학회 2004 Journal of Dental Anesthesia and Pain Medicine Vol.4 No.2

Background: Many studies on efficacy of preemptive analgesia have been processed in different ways. But the value of preemptive analgesia is still controversial. The goal of this study was to compare analgesic effect of an NSAID according to three different administration times for oral surgical pain. Patients and Methods: Using a randomized, parallel-group, single-center, and active-controlled test design, this study was conducted to healthy 80 patients undergoing a surgical removal of an impacted mandibular third molar requiring bone removal. The oral NSAID was first administered 1 hour preoperatively, or 1 hour postoperatively, or no scheduled administration in pre or postsurgery. Whenever patients felt at least moderate pain (score ${\ge}$ 5 on a 10-point scale) after surgery, they were instructed to take the same drug. Pain intensities and times to the first and second onset of postoperative pain from end of surgery were assessed for 24 hours. Results: Of the enrolled eighty subjects in this study, 25 patients were assigned to preemptive, 26 to post-treatment and 29 to no treatment group. The demographic distribution and duration of surgery in the three groups were statistically similar. The mean time to first onset of postoperative pain was significantly prolonged in post-treatment group (277.2 minutes, p < 0.05) compared to preemptive (158.4 minutes) and no treatment group (196.5 minutes). The mean time to second onset of postoperative pain was not significantly different among the three groups. No significant statistical difference was found among the mean pain intensities at the first and second onset of postoperative pain in the three groups. Conclusions: In this small selected group of subjects and limited study design, the analgesic effects of NSAID administered preoperatively were no longer effective for postoperative pain. The results in this population imply that scheduled postoperative analgesics before pain development are adequate for postoperative analgesia without preoperative administration.

릴럭턴스 토크 활용을 극대화한 스포크 타입 페라이트 영구자석 전동기 설계에 관한 연구

정민재(Min-Jae Jeong),이성구(Sung-Gu Lee),공형식(Hyung-Sik Kong),표현조(Hyun-Jo Pyo),남동우(Dong-Woo Nam),양서희(Seo-hee Yang),이승현(Seung-hyeon Lee),김원호(Won-Ho Kim) 대한전기학회 2019 대한전기학회 학술대회 논문집 Vol.2019 No.7