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The influence of diabetes mellitus on periodontal tissues: a pilot study
엄유정,정의원,김창성,박은정,차정헌,유윤정,최성호 대한치주과학회 2010 Journal of Periodontal & Implant Science Vol.40 No.2
Purpose: The purpose of this study was to preliminarily evaluate the influence of diabetes mellitus (DM) on periodontal tissue without establishment of periodontitis. Methods: Seven-week-old db/db mice were used for the diabetic experimental group and systematically healthy mice of the same age were used as controls. After 1 week of acclimatization, the animals were sacrificed for hard and soft tissue evaluation. The pattern of bone destruction was evaluated by stereomicroscope evaluation with alizarin red staining and radiographic evaluation by microscopic computerized tomography images. Histological evaluation was performed with hematoxylin and eosin stain for evaluation of soft tissue changes. Results: In both stereomicroscope evaluation and radiograph image analysis, aggressive form of bone destruction was observed in diabetic animals when compared to the systematically healthy controls. In histological evaluation, apical migration of junctional epithelium with slight inflammatory cell infiltration was observed with disarrangement of connective tissue fi-bers. Conclusions: Within the limits of this study, diabetic animals presented distortion in periodontal attachment and an aggressive bone loss pattern when compared to the healthy controls, suggesting that DM has an independent effect on periodontal tissue destruction irrespective of the presence or absence of periodontal disease.
토끼 두개골에서 새로 개발된 biphasic calcium phosphate의 골형성 효과 : A pilot study
엄유정,홍지연,김성태,이용호,박상현,박준효,조규성,김종관,최성호,Um, Yoo-Jung,Hong, Ji-Yeon,Kim, Sung-Tae,Lee, Yong-Ho,Park, Sang-Hyun,Park, Sun-Hyo,Cho, Kyoo-Sung,Chai, Jung-Kiu,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2008 Journal of Periodontal & Implant Science Vol.38 No.2
Purpose: Biphasic calcium phosphates have been of great interest recently. Mixing adequate ratios of hydroxyapatite(HA) and beta-tricalcium phosphate($\beta$-TCP) allowed to control the resorption rate without distorting its osteoconductive property. This study evaluated the bone formation effect of newly developed biphasic calcium phosphate(BCP) in calvarial defect of rabbits. Materials and Methods: 6 male New Zealand rabbits were used. Four defects with 8mm in diameter were created on each animal. BCP with HA/$\beta$-TCP ratio of 7:3 and particle size of $0.5{\sim}1.0\;mm$ was used as the test group and bovine bone with $0.25{\sim}1.0\;mm$ particle size, as the control group. Both test and control group materials were randomly implanted in the calvarial defects and were covered witha polymer membrane. The animals were sacrificed after 12, 24, and 48 weeks of implantation under general euthanasia. Resin blocks were obtained and were stained by masson's trichrome for histological observation. Results: Overall results were uneventful without any defect exposure or inflammation. The amount of new bone formation and bone maturity increased with increase in healing period at both groups. New bone in test group was mostly formed along the material particle surrounded by osteoblasts, and observation of osteoblastic stream was also present. Bone maturity increased as it was closer to thedefect margins. Under the same healing period, the test group showed more bone formation than the control group with more stable bovine bone particles remaining even after 48 weeks, whereas considerable resorption took place in BCP. Almost total defect closure was observed in test group with new bone formation in the central part of the defect. However, limited new bone formation was observed in the control group. Conclusion: Within the limits of the study, the present study reveals the newly developed BCP to be a good osteoconductive material. However, further studies are needed to be conducted in a different study model with a larger sample size.
엄유정,손수영,정동현,허문석,김창무,박선영,신우창,이상진,어중혁,김계원,박천석 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.4
We used multilocus sequence typing (MLST) to analyze the diversity of natural isolates of Saccharomyces cerevisiae, the most important microorganism in alcoholic fermentation. Six loci, ADP1, RPN2, GLN4, ACC1, MET4, and NUP116, in S. cerevisiae genome were selected as MLST markers. To investigate genetic diversity within S. cerevisiae, 42 S. cerevisiae isolated from natural sources in Korea as well as six S. cerevisiae obtained from Genbank and four industrial S. cerevisiae were examined using MLST. Twenty-six polymorphic sites were found in the six loci. Among them, ACC1 had the most genetic variation with eight polymorphic sites. MLST differentiated the 52 strains into three clades. Alcohol fermentation results revealed that S. cerevisiae in Clade III produced less alcohol than those in Clades I and II. These results suggested that MLST is a powerful tool to differentiate S. cerevisiae and can potentially be used to select S. cerevisiae suitable for industrial use.
엄유정,Jung-Suk Lee,Ui-Won Jung,Sung-Tae Kim,김창성,정성민,이인섭,최성호 한국생체재료학회 2009 생체재료학회지 Vol.13 No.1
Rough surfaced implants have been reported to favor early bone healing than smooth surfaced implants. Amongvarious methods introduced to roughen the implant surface, coating with calcium phosphate(CaP) is one of them. The purpose of this study was to evaluate the bone healing response of anodized implants with two different coatingthickness of CaP(200 nm and 500 nm) deposited by ion beam assisted method. CaP coated implants wereplaced on circumferencial coronal defects of four mongrel dogs and the amount of defect fill was evaluated histologicallyafter 8 weeks. The amount of coronal defect filling varied among the implants according to its surface characteristics. The CaP coating thickness of 500 nm showed the greatest amount of defect fill than implants with200 nm of CaP coating thickness and non coated implants. Within the limits of this study, when coating implantswith CaP by ion-beam assisted deposition method, coating thickness of 500 nm seemed to be effective.
단백질 전달 영역 융합-Bone Morphogenetic Protein-2가 백서 두개골 결손부에서 골 조직 재생에 미치는 효과
엄유정,조규성,김종관,최성호,채중규,김창성,Um, Yoo-Jung,Cho, Kyoo-Sung,Kim, Chong-Kwan,Choi, Seong-Ho,Chai, Jung-Kiu,Kim, Chang-Sung 대한치주과학회 2008 Journal of Periodontal & Implant Science Vol.38 No.2
Purpose: Recombining bone morphogenetic protein (BMP) is usually acquiredfrom high level animals. Though this method is effective, its high cost limits its use. The purpose of this study was to evaluate the effect of bone morphogenetic protein-2 with protein transduction domain (BMP-2/PTD;TATBMP-2) on bone regeneration. Rat calvarial defect model and osteoblastic differentiation model using MC3T3 cell were used for the purpose of the study. Materials and Methods: MC3T3 cells were cultured until they reached a confluence stage. The cells were treated with 0, 0.1, 1, 10, 100, 500 ng/ml of BMP-2/PTD for 21 days and at the end of the treatment, osteoblastic differentiation was evaluated usingvon Kossa staining. An 8mm, calvarial, critical-size osteotomy defect was created in each of 48 male Spraque-Dawley rats (weight $250{\sim}300\;g$). Three groups of 16 animals each received either BMP-2/PTD (0.05mg/ml) in a collagen carrier, collagen only, or negative surgical control. And each group was divided into 2 and 8 weeks healing intervals. The groups were evaluated by histologic analysis(8 animals/group/healing intervals) Result: In osteoblastic differentiation evaluation test, a stimulatory effect of BMP-2/PTD was observed in 10ng/ml of BMP-2/PTD with no observation of dose-dependent manner. The BMP-2/PTD group showed enhanced local bone formation in the rat calvarial defect at 2 weeks. New bone was observed at the defect margin and central area of the defect. However, new bone formation was observed only in 50% of animals used for 2weeks. In addition, there was no new bone formation observed at 8 weeks. Conclusion: The results of the present study indicated that BMP-2/PTD(TATBMP-2) have an positive effect on the bone formation in vitro and in vivo. However, further study should be conducted for the reproducibility of the outcomes.
엄유정 ( Yu-jeong Eom ),박병대 ( Byung-dae Park ) 한국목재공학회 2018 목재공학 Vol.46 No.3
본 연구에서는 기록으로 남아있는 밀성박씨 경주 손곡문중의 박씨문헌록(朴氏文獻錄)과 지당실기(智堂實紀)의 인쇄에 사용된 목판의 수종을 식별하고자 수행되었다. 전체 282장의 목판 중 88장을 무작위로 선정하여 광학현미경으로 목재해부학적 특징을 비교분석한 결과, 7개의 목재수종이 식별되었다. 즉 가장 많이 사용된 수종은 서어나무로 39.8%를 차지하였고, 그 다음으로 돌배나무가 25.0%, 고로쇠나무가 15.9%, 산벚나무가 10.2%, 피나무가 3.4%, 감나무가 3.4%, 그리고 거제수나무가 2.3%가 사용된 것으로 조사되었다. 이 같은 결과는 일반적으로 목판인쇄에 사용된 목재수종의 범주에 속하는 것이다. 또 식별된 모든 수종들은 활엽수 산공재로 복잡한 한자를 새기기 쉽고 여러 번 인쇄를 하더라도 글자가 쉽게 닳지 않고 용이하게 구할 수 있는 목재수종이 사용된 것으로 판단된다. This study was conducted to identify wood species of two printing woodblocks either from the Park clan’s documentary or Ji-dang documentary of Songok clan of the Milseong Park, Songok, Gyeongju, Korea. Eighty-eight woodblocks out of the total 282 woodblocks were randomly selected to compare anatomical features for the identification of wood species, using a light microscope. As a result, seven wood species were identified, and all of them were diffuse-porous hardwood species. The most significant portion, i.e., 39.8% of wood species was Carpinus laxiflora Blume. Then, Pyrus pyrifolia Nakai, Acer mono Maxim, Prunus sargentii Rehder, Tilia amurensis Rupr, Diospyros kaki Thunb, and Betula costata Trautv was 25.0%, 15.9%, 10.2%, 3.4%, 3.4% and 2.3%, respectively, indicating that all diffuse-porous hardwood species had been used for the woodblocks. It was believed that diffuse-porous hardwoods had been used because they provided an easy of engraving complex Chinese letters, of acquiring these wood species in Gyeongju areas, and a high resistance to repeated printing.
특정혈 취혈법에 대한 고찰 -LU7의 자침 깊이와 BL62 KI6 혈위를 중심으로-
금유정 ( Yujeong Keum ),임향기 ( Hyanggi Lim ),최서영 ( Seoyeoung Choi ),정지훈 ( Jihun Jung ),엄동명 ( Dongmyung Eom ),송지청 ( Jichung Song ) 경락경혈학회 2020 Korean Journal of Acupuncture Vol.37 No.1
Objectives : The purpose of this study is to review needling depth and location of LU7, BL62 and KI6 by the medical classics’ records. Methods : 1. We researched the medical classics describing LU7, KI6 and BL62, and reorganized data about the location and needling depth. 2. We compared the medical classics’ records on LU7, KI6 and BL62 with description of WHO standard acupuncture point location. 3. We reviewed different location and needling depth of LU7, BL62, and KI6 recorded in the medical classics with the anatomical structure. Results : 1. The common needling depth of LU7 is about 0.2 chon. But in some medical classics, the depth of LU7 is 0.8 chon. Needling depth of LU7 varied depending on the patient’s hand posture. In the ‘half-up’ position with the thumb upward, it is possible to stimulate acupuncture on LU7 by 0.8 chon because there is a space between the tendons. 2. In WHO standard acupuncture point location, the locations of BL62 and KI6 are just below the lateral and medial malleolus. But in some medical classics, the locations of BL62 and KI6 are between the bones and muscles below the malleolus. In the locations between the bones and muscles below the malleolus, it is possible to stimulate acupuncture on BL62 and KI6 by penetrating acupuncture because there is no bone structure. Conclusions : 1. By the ‘half-up’ position with the thumb upward, it is possible to stimulate vertically acupuncture on LU7 by 0.8 chon. 2. By the locations of BL62 and KI6 between the bones and muscles below the malleolus, it is possible to stimulate on BL62 and KI6 by penetrating acupuncture.