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가시오갈피 열매 추출물의 항돌연변이원성 및 세포독성 효과
전윤영,최승필,이효진,문선영,이득식,함승시 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2003 한국식품저장유통학회지 Vol.10 No.3
가시오갈피(Eleutherococcus senticous Maxim) 열매의 에탄올 추출물 및 분획물의 항돌연변이성 및 항암활성을 규명하였다. 항돌연별이원성 실험결과에서는 직접변이원인 MNNG, 4NQO 그리고 간접변이원인 B(α)P, Trp=P-1에 대해서 농도의존적인 돌연변이 억제활성을 나타내었다. MNNG (0.4㎍/plate)의 경우 S. typhimurium TA100 균주에서는 시료농도 200㎍/plate에서 클로로포름 분획물을 제외한 모든 분획물들에서 90%이상의 높은 억제효과를 나타내었다. 4NQO(0.15㎍/plate)에 대한 S. typhimurium TA98 균주의 경우 물 분획물의 경우 88.3%, TA100 균주에서는 에틸 아세테이트 분획물이 84.4%의 억제효과를 보였다. 간접변이원의 경우 B(α)P(10㎍/plate)에선느 에탄올 추출물과 핵산 분획물은 시료농도 200㎍/plate에서 각각 96.1%와 97.5%로 가장 높은 억제효과를 나타내었다. 그리고 Trp-P-1(0.15㎍/plate)에서는 TA100 균주의 경우 200㎍/plate 농도에서 에탄올 추출물과 물 분획물이 각각 95.5%와 90%로 높은 억제율을 보여주었고, TA98 균주에 대해서는 에틸아세티에트 분획물이 88.3%로 비교적 높은 억제효과를 나타내었다. 인간의 암세포인 폐암세포(A549), 위암세포(AGS), 간암세포(Hep3B), 유방암세포(MCF-7)에 대한 세포독성 억제 효과를 검토한 결과 모든 암세포에서 각분획물들은 1㎎/mL 농도에서 60% 이상의 비교적 높은 암세포 성장 효과를 나타내었다. 특히 MCF-7에서 높은 암세포 성장억제 효과를 나타내었는데 핵산 분획물(1㎎/mL)에서 92.7%의 높은 암세포 성장 억제 효과를 나타내었고 Hep3B에서는 부탄을 분획물(1㎎/mL)에서 82%의 비교적 높은 성장 억제효과를 나타내었다. This study was carried out to investigate the antimutagenic and cytotoxic effects of Eleutherococcus senticosus Maxim fruits ethanol extract on Salmonella typhimurium TA98, TA 100 and cancer cell lines using Ames test and SRB assay, respectively. They were extracted with ethanol and then fractionated with hexane, chloroform, ethyl acetate, butanol and water to get active fractions. In the Ames test, most of the extract had strong antimutagenic effects against the mutagenesis induced by MNNG, 4NQO, B(α)P Trp-P-1. The ethanol extract (200 ㎍/plate) of Eleutherococcus senticosus fruits showed 87.2% inhibitory effect on the mutagenesis induced by MNNG against TA100. And also, The suppression ratio against B(α)P and AGS, MCF-7, Hep3B), the value value of inhibition were mostly above 60% for each fraction (1 ㎎/mL). Hexane fraction (1 ㎎/mL) against showed the strongest cytotoxic effects of 92.7% compared to those of other fraction and butano fraetion against Hep3B was relatively high growth inhibitory effect of 82%.
전윤영(Yoon-Young Jeon),정유진(Eugene Chung) 한국중원언어학회 2021 언어학연구 Vol.- No.60
This study aims to analyze the types of responses to impolite speech and to show how the hearer’s response determines the subsequent direction of the discourse. It raises the question as to why the hearer’s role has been regarded as fixed by existing research focusing on the behavior of the speaker. Modern Family, an American sitcom is used as the discourse analysis data. The show features people of different races and age groups and focuses on diverse family relationships such as multicultural families, same-sex couples, families with adopted children, and blended families. For this study, we attempted to analyze impolite discourse using the H-Intentions mechanism presented by Bach & Harnish (1979). Hearer’s responses to impolite speech were classified into four types for active responses: confrontation, request for an apology, request for correction, and retort. Six groups were identified for passive responses: showing-off, avoidance of the situation, explanation, de-escalation, euphemism, and silence. This study contributes to break away from the framework of speaker-oriented discourse analysis of impolite speech by examining the response type of the hearer.
발화 의도와 담화 방향성 연구 -영어 정도부사 중심으로-
전윤영 ( Jeon Yoonyoung ),정유진 ( Chung Eugene ) 한국텍스트언어학회 2021 텍스트언어학 Vol.51 No.-
The purpose of this study is to analyze the semantic prosody and direction of discourse based on the subjectification of speakers’ intentions. Interlocutors do not consider propositional meanings alone. Pragmatic meanings also play an important role in communication. Adverbs of degree are produced according to the subjectification of the speaker, which enables interpretation of the pragmatic meaning of speech. Adverbs of degree, taken together with the speaker's subjective intention, affect the semantic prosody and direction of discourse by exhibiting a Gestalt phenomenon. It determines the final profile of the sentence and is projected throughout the discourse. In other words, the semantic prosody of one speech unit may display positive or negative prosody in relation to the overall discourse depending on the adverbs of degree. Therefore, semantic prosody and direction of discourse are important in contextual understanding. In the process of understanding the semantic prosody of discourse, interlocutors recognize the category and frequency of the adverbs of degree used along with their inherent subjectification.
전윤영(Yoon-Young Jeon),정유진(Eugene Chung) 한국사회언어학회 2023 사회언어학 Vol.31 No.3
Based on conceptual metaphor theory and speech act, this study aims to examine the communicative functions of language use by analyzing texts used in Seoul’s urban design. Considering that life in a modern society is based on the ecosystem of its cities, the importance of urban design in increasingly felt by modern individuals who share limited space and move along predetermined routes. According to El-Khoury and Robbins (2004), urban design is both an abstract and relative concept, and the purpose of a city can be interpreted differently according to differences in experience and perspective. Conceptual metaphorical language expressions not only have a communicative function but also provide the hearer with a certain perspective by concretizing the events or phenomena indicated by the speaker. Metaphorical language expressions based on metaphors created by the speaker perform speech acts by serving as an effective means of persuasion and communication (Searle 1979). We examine the linguistic aspects based on the metaphor of the development of illocutionary forces in Seoul’s urban design texts.