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장하영,박민영,이정수,김창수,박수형 한국원예학회 2019 원예과학기술지 Vol.37 No.1
Resistant cultivars have been developed as a response to clubroot disease, which poses a challengeto Kimchi cabbage cultivation in Korea. However, the recent problem of disease vulnerability inresistant varieties has led to collective efforts to promote genetically diverse resistant sources. TheNational Institute of Horticultural & Herbal Science (NIHHS, Vegetable Research Division) promotesand conserves resistant resources, and despite using the molecular markers reported thus far inanalyzing the resources, a need for novel molecular markers has become apparent owing to the largenumber of resources that could not be amplified. To address this problem, 96 resources for resistanceand vulnerability were selected among the ones conserved at the NIHHS, from which 20,540 SNPswere detected using genotype-by-sequencing (GBS) analysis. Subsequently, a molecular markerassociated with resistance to the Yeoncheon strain that causes clubroot disease was developed usinga genome-wide association study (GWAS). The corresponding gene had an SNP (G↔T) at the23098380 position of A07, which was used to develop the CAPS marker that can differentiateresistance and susceptibility to the Yeoncheon strain causing clubroot disease. The gene at theposition of the CAPS marker was found to be an associated gene within 21 kb, encoding aglucose-methanol-choline (GMC) oxidoreductase family protein with four V-type H+-transportingATPase subunit Gs. In this study, a molecular marker specific for the Yeoncheon strain wasdeveloped. Its use, alongside other previously developed markers in selecting resistance resources,is expected to prove useful in the selection of a wide array of disease-resistant breeding sources. Furthermore, the resulting GBS data could be used for future analysis of the resistance genesassociated with various strains causing clubroot disease.
소포자 배양으로 육성된 구가 크고 곧은 배추 계통 ‘원교20038호’
장하영,박민영,장석우,윤무경,이정수,박수형 한국육종학회 2017 한국육종학회지 Vol.49 No.3
Kimchi cabbage (known as Chinese cabbage) is major vegetable in Korea. An inbred line of ‘Wonkyo20038ho’, was developed by the National Institute of Horticultural & Herbal Science, RDA in Republic of Korea. The microspore culture was carried out using ‘Chunhuigohangwang’ which was introduced from China in 2002. Among 3 DH inbred lines, ‘Wonkyo20038ho’ inbred line was finally selected after field exhibition in 2009. The horticultural traits of ‘Wonkyo20038ho’ inbred line; half-open head, white inner leaf colour, and dark green outer leaf colour. The average (for four years) head weight was 2025.3g, and head width and height were 15.8cm and 32.4cm, respectively. Head shape was narrow elliptic and degree of overlapping leaf was medium. Numbers of outer and internal leaves were 14.1 and 49.8, respectively. Harvest maturity was mid-late maturing type and average of seed yield for five years was 926 seeds. In addition, ‘Wonkyo20038ho’ inbred line is suitable for salad in that it possessed few trichome and narrow elliptic head shape.
장하영,이보라,남궁효선,윤헌영,한현정,김준영,정순욱 한국임상수의학회 2009 한국임상수의학회지 Vol.26 No.3
A 1 year 4 months old, male Poodle was presented with a history of non weight bearing lameness and pain of the right forelimb by trauma. Orthopedic examination and radiographs were revealed medial shoulder luxation and scapular fracture. Biceps tendon was translocated to the lesser tubercle and secured to the humerus. Despite of it could be a potential cause of degenerative change of the joint, a favorable result was achieved for more than 3 years follow-up. 1년 4개월령의 수컷 푸들견이 외상으로 인한 우측 전지의 통증과 들림 파행증으로 내원하였다. 정형 검사와 방사선 검사상에서 내측 견관절 탈구와 견갑골 골절이 확인되었다. 이두근의 힘줄을 작은 결절로 전위시켜 상완골에 고정시켰다. 이 교정은 잠재적인 관절의 퇴행성 변화의 원인이 될 수 있으나 본 환축에서는 3 년 이상의 관찰기간 동 안 좋은 결과를 보였다.
장하영,Kongara Damodar,김진경,전종갑 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.12
An efficient first synthesis of 2,5-diaryloxazoles 1–5 was accomplished from commercially inexpensive precursors and in overall yields of 38–48%. The synthesis proceeds via α-aminoketones and cyclodehydration (Robinson–Gabriel reaction) as key step. Next, these oxazoles were examined for their inhibitory effect against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells and were found to display concentration-dependent inhibition of NO production without cytotoxicity. Of note, compound 3 (70.7%; IC50 = 2.33 μM) was identified as a potent inhibitor in view of its comparable inhibitory effect with the positive control, NG-monomethyl-L-arginine acetate (L-NMMA) (79.3%; IC50 = 4.51 μM) followed by compounds 5 (68.3%; IC50 = 2.30 μM) and 2 (53.9%; IC50 = 6.31 μM). As a whole, compound 3 may hold great promise for further development of NO production targeted anti-inflammatory agent.
The Demand for Quantitative Techniques in Biomedical Image Informatics
장하영,김혜련,강미선,김명희,장병탁 대한의용생체공학회 2014 Biomedical Engineering Letters (BMEL) Vol.4 No.4
With recent technological advances, biomedical imageinformatics has become a quickly rising field. It focuses onthe use of computational techniques to process and analyzebiomedical images. Its goal is to obtain useful knowledgefrom complicated and heterogeneous images from differentmodalities for biomedical research. Although the advancementof imaging technologies has provided a data explosion, mostbiomedical images are only used by the researchers whocreate them. The lack of a canonical procedure, from dataacquisition to data analysis, contributes to this issue. As thenumber of biomedical images increases, the demand forquantitative techniques rises. In order to increase awarenessof the needs and importance of quantitative techniques forbiomedical image informatics, this paper reviews severalaspects including biomedical imaging, image repositories,and image processing. We explore the state of the arttechnology available in quantitative techniques for biomedicalimage informatics. The essential techniques for quantification,such as imaging devices, biomedical image management,and image processing, are further summarized.
장하영,이준섭,이보라,김경희,정순욱 한국임상수의학회 2009 한국임상수의학회지 Vol.26 No.3
A 6-year-old castrated male Shih-tzu was presented because of a 1-month history of progressive tetraplegia. On the basis of the findings of neurological examination, radiographs and magnetic resonance imaging, herniated intervertebral disc of C4 - C5, C5 - C6 and C6 - C7 compressed spinal cord. The oxygen-ozone was intra-operatively injected into the C4 - C5 and C6 - C7 intervertebral disc and a ventral decompression performed at C5 - C6 intervertebral space. Immediately after the surgery, neck pain was disappeared and three weeks after surgery, there was complete resolution of the neurological deficits with normal gaits. On magnetic resonance images at 2-month after surgery, herniated disc materials of C5 - C6 and C6 - C7 were completely removed and that of C4 - C5 remarkably reduced. Consequently decompression which was performed at all of the three lesions resulted in good clinical outcome without additional internal fixation for minimizing postoperative instability