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뇌실내 Calcitonin 투여로 인한 위산분비 억제에 대한 뇌내 신경전달체의 역할
장우익(Woo Ick Jang),이동기(Dong Ki Lee),권상옥(Sang Ok Kwon),고창만(Chang Mann Ko),현재헌(Jae Hun Hyun),김상태(Sang Tae Kim),이상인(Sang In Lee),최흥재(Heung Jai Choi),김경환(Kyung Hwan Kim) 대한내과학회 1991 대한내과학회지 Vol.40 No.5
Peptides that are common to the brain and gut are thought to play intermediary roles as neurotransmitters or neuromodulators in the regulation of gut function. Calcitonin is a polypeptide hormone of 32 amino acid residues. Recently, much evidence has been accumulated to suggest that calcitonin may inhibit gastric acid secretion by a central action, but the neurohumoral pathways mediating the antisecretory effects of calcitonin in rats are not well elucidated. In the present study, using a gastric perfusion technique, the effects of ICV administration of calcitonin on gastric acid secretion stimulated by baclofen were investigated in rats. We also investigated whether the serotonergic system is involved in calcitonin's effect of gastric acid secretion. The results obtained were as follows: 1) ICV administration of baclofen stimulated gastric acid secretion in a dose-dependent manner. Central administration of baclofen was approximately 200-400 times more sensitive than subcutaneous administration. 2) Baclofen-induced gastric acid secretion was partially suppressed by bilateral vagotomy. 3) Gastric acid secretion stimulated by baclofen was markedly suppressed by ICV administration of calcitonin. 4) Depletion of brain serotonin with the neurotoxin 5, 7-dihydroxytryptamine did not influence calcitonin-induced gestric acid suppression. In this study it was demonstrated that centrally- administered calcitonin suppresses baclofen-induced gastric acid secretion. Also. it is suggested that the serotonergic system is not involved in calcitonin-induced gastric acid suppression.
조직학적으로 확진한 결핵성 복막염 환자의 복수 Adenosine deaminase ( ADA ) 활성도에 관한 연구
배선우(Seon Woo Bae),진춘조(Choon Jo Jin),심영학(Young Hak Shim),신계철(Kye Chul Shin),권상옥(Sang Ok Kwon),김남동(Nam Dong Kim),차신웅(Shin Woong Cha),이광훈(Kwang Hoon Lee),장우익(Woo Ick Jang) 대한내과학회 1989 대한내과학회지 Vol.36 No.1
N/A Recent investigations have suggested that the measurement of ADA activities in various body fluids is useful in the diagnosis of tuberculous effusion. In this study, ascitic fluid ADA activities were measured in 18 cases of tuberculous peritonitis, 18 cases of malignant ascites and 33 cases of liver cirrhosis with ascites. The results obtained were as fallows: 1) The mean ADA activity in tuberculous peritonitis was 184.96±27.55U/L, in malignant ascites 22.35±3.10U/L and in liver cirrhosis 7.37±0.61U/L. 2) The ADA activity in tuberculous effusion was significantly higher than in the rest of the groups(p<0.001). 3) The malignant effusion show no significant difference with transudative effusion(p>0.05). 4) As a screening test for tuberculous peritonitis, the ADA activities above 50-70U/L had a sensitivity and specificity of 100%. In conclusion, the measurement of ascitic fluid ADA activity may be a simple and reliable screening test for the diagnosis of tuberculous peritonitis.
포르말린에 의한 급성 부식성 위염에 병발한 급성 봉와직염성 위염 2 예
김현수(Hyun Soo Kim),장우익(Woo Ick Jang),이상수(Sang Soo Lee),이재갑(Jae Kab Lee),오미희(Mi Hee Oh),이동기(Dong Ki Lee),이광훈(Kwang Hoon Lee),권상옥(Sang Ok Kwon),조휘율(Whee Yul Cho),홍인수(In Soo Hong),김호근(Ho Geun Kim),윤광수(Kwa 대한내과학회 1991 대한내과학회지 Vol.40 No.2
Phlegmonous gastritis is a rare form of gastritis caused by a pus-forming bacterial infection of the wall of the stomach. Emphysematous gastritis is an unusual variant of phlegmonous gastritis caused by gasforming organisms. Two cases of phlegmonous gastritis subsequent to accidental ingestion of formalin is reported. One case showed bubble air in the gastric wall on plain abdominal X-ray, UGI barium study and abdominal C-T scan suggestive of emphysematous gastritis. Fiberoptic gastroscopy showed foul odor purulent discharge in the gastric lumen and diffuse ulcerative lesion from cardioesophageal junction to pylorus. Culture of gastric aspirates grew E. coli. Total gastrectomy with esophagojejunostomy, feeding jejunostomy, and pus evacuation with drainage from left paracolic gutter were performed. This patient was died on hospital 46 day. Another patient showed similar endoscopic finding to the first patient. Culture of gastric aspirate grew Pseudomonas aerugionsa. This patient was improved with intensive antibiotics. He returned to our hospital because of progression of dysphagia. UGI films and gastroscopic findings showed marked narrowing of gastric lumen. He was transferred to another hospital for proper surgery.
간세포암환자에서 C-DDP 단독 혹은 C-DDP와 Doxorubicin의 병합 간동맥화학요법의 비교
이종인(Chong In Lee),장우익(Woo Ick jang),김현수(Hyun Soo Kim),신승준(Seung Joon Shin),이성우(Seong Woo Lee),이동기(Dong Ki Lee),권상옥(Sang Ok Kwon),심영학(Young Hak Sim),김영주(Young Ju Kim),조휘율(Whee Yul Cho),홍인수(In Soo Hong) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.2
N/A Most of hepatocellular carcinomas, especially in Korea, are considered as inoperable due to extrerne tumor extension at the tirne of diagnosis and underlying advanced liver cirrhosis. The normal liver receives a dual blood supply from the hepatic artery and the portal vein whereas hepatoma is fed preferentially by the hepatic artery. With the background above mentioned, hepatic arterial chemotherapy or chemoembolization in hepatocellular carcinoma has been regarded as an important treatment modality for unresectable hepatocelluar carcino- ma. It has been found that the lipid lymphographic agent such as Lipiodol(ethiodized oil), which can be mixed with chemotherapeutic agents, is selectively retained within hepatocelluar carcinoma when it is injected into the hepatic artery. Based on recent promising therapeutic results in hepatocelluar carcinoma treated with hepatic arterial C DDP infusion combined with Lipiodol, we studied to elucidate the therpeutic efficacy of the hepatic arterial chemotherapy with C DDP combined with Lipiodol and to compare the differences in thera- peutic efficacy between C-DDP rnonotherapy group (Group 1) and C-DDP/doxorubicin combi- nation therapy group(Group 2). In all 42 cases there were 1 complete response(2%), 4 partial responses(10%), 7 rninimal responses(17%), 15 stab1e diseases(36%) and 15 progressive diseases (36%). There were no differences of response rate and survival duration between Group 1 and Group 2, and there was a significant difference of survival duration between responder group (CR+PR+MR) and nonresponder group(SD+PD) (P<0.01). In conclusion hepatic arterial chemotherapy with C DDP and/or doxorubicin and Lipiodol appears to have relatively weak activity in patients with hepatocellular carcinoma. (Korean J Gastroenterol 1994; 26: 298 304)
간경변증 환자의 비정형 선종성 증식성 결절 ( Atypical Adenomatous Hyperplastic nodule ) 에서 발생한 소 간세포암
권상옥(Sang Ok Kwon),노병선(Byoung Seon Rhoe),장우익(Woo Ick Jang),이동기(Dong Ki Lee),이용규(Yong Gyu Lee),한병근(Byoung Geun Han),심영학(Young Hak Sim),조미연(Mi Yeon Cho) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.4
Adenornatous hyperplasia (AH), defined as a sizable parenchymal nodules that may follow acute or chronic liver injury, has been reported as precursor lesion of hepatocellular carcinoma in the cirrhotic liver. These lesions often coexist with obvious rnalignant foci as small nodule-in-nodule. Morphologically AH can be divided into 'ordinary' and atypical (AAH)' types. The former consisted of hepatocytes similar to those of the surrounding liver. The latter type was composed of hepatocytes showing nuclear, cellular and structural atypia relative to the surrounding liver, and shoved irregular or sparse portal tracts. Cytological and structural pattens are characteristically heterogenous within a nodule. Now AAH are considered to be precancerous lesion evolving to early hepatocellular carcinoma. Authots report one case of hepatocellular carcinoma eithin an atypical adenomatous hyperplastic nodule in 55-years-old male with a review of literatures.
종설논문 : 의료법 쌍벌죄 규정에 대한 의료법리학적 문제제기
신은희 ( Eun Hee Shin ),김경원 ( Ken Won Kim ),장우익 ( Woo Ick Jang ),손영수 ( Young Soo Son ) 한국의료윤리학회 2011 한국의료윤리학회지 Vol.14 No.3
The recently revised "Medical Law" in Korea gives rise to at least three questions. First, should doctors be subject to criminal punishment on the grounds that that the "Monopoly Regulation and Fair Trade Act" has not been effective in regulating the circulation of medicine and medical supplies? Second, will the provision of dual punishment in the new law achieve the desired results? Third, will social justice and ethics be promoted through the threat of criminal punishment? In this article we address these questions and argue for the following claims: (1) that the provision of dual punishment in the new law is illegitimate from a jurisprudential point of view, (2) that the provision of dual punishment will impede medical progress, and (3) that the tyranny of the majority and the problem of procedure in lawmaking will hinder the establishment of political justice and respect for the rule of law in Korea. The overall view defended in this article is that doctors and professional medical organizations should be granted autonomy in developing codes of conduct and professional ethics to regulate and promote the practice of medicine in Korea.
김영경(Young Kyung Kim),이동기(Dong Ki Lee),이성우(Seong Woo Lee),김준명(Jun Myeong Kim),이상철(Sang Chul Lee),권상옥(Sang Ok Kwon),장우익(Woo Ick Jang),조미연(Mee Yen Cho) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.6
N/A Background/Aims: The aim of this study is to investigate the clinical characteristics of minute gastric cancer, less than 5mm in the largest diameter of the lesion. Methods: We reviewed 8 patients of minute gastric cancer among 100 patients of early gastric cancer(EGC) and 474 patients of advanced gastric cancer who received operation at our hospital from January 1989 to July 1993. Results: The incidence of minute gastric cancer was 8% among early gastric cancer and 1.4% among stomach cancer who received operation. The patients ages ranged from 32 to 74 years old (mean age 60) and most frequently found in their six and seven decade in 75%(6/8). The ratio of male to female was 1.7:1. The multiplicity of minute gastric cancer was 37.5%(3/8), relatively higher than that of EGC 6%(6/100). Before operation we observed 7 lesions of minute gastric cancer by endoscopy. In Suzukis endoscopic classification for minute gastric cancer, most common type of the lesion was depressed type in 4(57.1%), and flat type in 2(28.6%) and elevated type in one(14.2%) patient. The location of minute gastric cancer was antrum in 4, body in 3 and fundus in one. The histologic type of minute gastric cancer was moderate to well differentiated adenocarcinoma in 7, signet ring cell carcinoma in one. The depth of invasion of minute gastric cancer was mucosal cancer in 7, submucosal cancer in one. There was no lymph node metastasis in all minute gastric cancers. Conclusions Almost minute gastric cancers were confined to the mucosa with rare lymph node metastasis. These characteristics of minute gastric cancer may provide the opinion less invasive operation or endoscopic treatment with curative aim. Further study is warranted to assess its significance of endoscopic treatment for minute gastric cancer. (Korean J Gastroenterol 1995;27: 635 - 644)
김남동(Nam Dong Kim),권상옥(Sang Ok Kwon),김현수(Hyun Soo Kim),이동기(Dong Ki Lee),배선우(Sun Woo Bae),장우익(Woo Ick Jang),김호근(Ho Guen Kim),박찬일(Chan Il Park) 대한내과학회 1992 대한내과학회지 Vol.43 No.2
Background: Alcoholic liver disease (ALD) is caused by chronic drinking. The amount and duration of drinking which develop ALD have been reported variously for the different studies. Also the state of liver is various from normal liver to liver cirrhosis or hepatoma for chronic drinkers. Even though the interest on the ALD is growing recently due to the increase of the drinking population and the alcohol consumption in Korea, the clinical research is still insufficient. So this study was started to get the characteristics of the histologic pattern of ALD, required minimum amount of alcohol to develop ALD and clinical differences in various types in Korea. Methods: Authors analysed drinking history, clinical and laboratory findings of 126 patients who were con- firmed as ALD by liver biopsy. Results: 1) In histologic types, 13 fatty liver, 2 alcoholic hepatitis, 69 alcoholic hepatic fibrosis, 18 alcoholic chronic active hepatitis and 24 liver cirrhosis were found. 2) The subjects were 42. 7 years old in average with no difference in types, all male except 2 cases. 3) 106 patients whose drinking history was known drank 149.9 gm per day and 808.3 kg in total amout in average. Alcoholic chronic active hepatitis or liver cirrhosis patients drank more than fatty liver patients in daily amount (p < 0. 05), but the duration of drinking had no difference in types with 16.9 years in average. Also 98.1% of the subjects drank more than 45 gm of alcohol in daily average and 99.1% of the subjects had been drinking for more than 3 years. 4) Symptoms were various such as fatigue or general weakness, abdominal pain, nausea or vomiting, anorexia. Physical signs were also various such as hepatomegaly, jaundice and spider angioma. But any statistical meaning between types cannot be given due to the small number of subjects. 5) In hematologic and biochemical tests, the albumin level was lower in liver cirrhosis than fatty liver or alcoholic hepatic fibrosis (p<0.05), and the platelet count was lower in alcoholic chronic active hepatitis or liver cirrhosis than fatty liver or alcoholic hepatic fibrosis (p<0.05), but there was no laboratory finding to distinguish the types. Conclusions: Results of this study suggest that alcoholic hepatitis is rare and alcoholic hepatic fibrosis is the most frequent in histologic types of ALD. 98,1% of the subjects drank more than 45 gm of alcohol in daily average for more than 3 years. The types of ALD cannot be distinguished by the symptoms, physical signs, hematologic and biochemical tests.
뇌실내 Calcitonin 투여가 위산분비에 미치는 영향에 관한 연구
최흥재(Heung Jai Choi),홍사석(Sa Suk Hong),김경환(Kyung Hwan Kim),이상인(Sang In Lee),권상옥(Sang Ok Kwon),안영수(Young Soo Ahn),장우익(Woo Ick Jang),연규홍(Kyu Hong Yeon),고창만(Chang Mann Ko) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.4
N/A Peptides that are common to the brain and gut are thought to plav intermediary roles as neurotrans- mitters or neuromodulators in the regulation of gut function. Calcitonin is a polypetide hormone of 32 amino acid residues. Intracerebroventricular (ICV) administration of calcitonin does not alter plasma calcium or phosphorus concentrations. Recently, much evidence is accumulating to suggest that calcitonin may inhibit gastric acid secretion by a central action. But the neurohumoral pathways mediating antitsecretory effects of calcitonin in rats are not well elucidated. In the present study, using a gastric perfusion technique, effects of ICV administration of calcitonin on gastric acicl secretion and stress ulceration and its mechanism were investigated in rats. The results obtained are as follows: 1) ICV administration of calcitonin suppressed basal gastric acid secretion in a dose-dependent manner. 2) Gastric acid secretion stimulated by histamine, bethanechol or pentagastrin was not suppressed by ICV administration of calcitonin. 3) Gastric acid secretion stimulated by TRIl was markedly suppressed by ICV administratioti of calcitoninl. 4) Bilateral vagotomy did not influence calcitonin-induced gastric acid suppressionl. 5)Pretreatment metyrosine did not itnfluence cailcitoinin-induced gaitric acid suppression. 6) Intravenous administration of high dose (25 IU) of calcitonin suppressed gastric acid secretion. Central administration of calcitonin was approximately 250 times more sensitive than intravenous administration. 7) Stress ulcers induced by cold restraint and TRH administration were diminished by ICV admitnistration of calcitonin. In this study it is demonstrated that calcitonin suppresses gastric acid secretion, and this inhibitory effcct is centrally mediated. In particular, calcitonin suppresses TRH induced gastric acid secretion and stres ulcer formation. And it is suggested that calcitonin seems to play an inhibitorv role in gastric acid secretion as a neuromodulator in the central nervous system.