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증례보고 : 간부전 환자에서 Midazolam의 지속적 주입 후 지연된 의식회복
강효석 ( Hyo Seok Kang ),임종오 ( Jong Oh Lim ),박소진 ( So Jin Park ),최수경 ( Soo Kyeong Choi ),박혜진 ( Hae Jin Park ),임태하 ( Tae Ha Lim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.3
Benzodiazepines are frequently administered for sedation to surgical intensive care unit patients who require postoperative intubation and mechanical ventilation. Midazolam is the most commonly used drug, which is water soluble, short-acting benzodiazepine and rapidly metabolized by the liver. Continuous intravenous infusion of midazolam was administered to the man who was 40 years old for mechanical ventilation in the intensive care unit for 58 hours. After discontinued midazolam, patient who had acute hepatic dysfunction had been sedated with endotracheal intubation for 5 days. Even flumazenil was tried twice to reverse the effect of midazolam, the response was limited by the time. Finally he awaked as recovery of his hepatic function. (Korean J Anesthesiol 2006; 51: 363~6)
UX(사용자 경험)분석을 통한 앱 인터페이스 개선에 관한 연구 - 대학생 학사관리 사이트를 중심으로
김예람(Yea Ram Kim),서원영(Won Young Seo),임성빈(Seong Bin Im),임태하(Tae Ha Lim),이원섭(Won Seop Lee) 한국HCI학회 2021 한국HCI학회 학술대회 Vol.2021 No.1
This study aims to research and propose a mobile application interface design prototype for college student’s academic management from the user’s point of view. Interviewing users who have experienced the student website of Handong University to which the research team belongs, the academic management system (HISNet) is causing inconvenience in terms of visibility, accessibility, and ease of use, and is not optimized for mobile size and not providing personalized information. Based on the user’s experience, we designed a new app interface and applied the Kansei engineering theory to conduct the user test from an emotional engineering perspective. This study’s significance is that it finds problems from students’ experiences who are the primary agents of the use of the academic management system and that it is a design designed directly by students.
임상연구 : 제왕절개술을 위한 척추마취 시 척수강 내 투여된 Fentanyl과 Meperidine이 마취 후 전율에 미치는 효과 비교
한재원 ( Jae Won Han ),강효석 ( Hyo Seok Kang ),최수경 ( Soo Kyeong Choi ),박소진 ( So Jin Park ),박혜진 ( Hae Jin Park ),임태하 ( Tae Ha Lim ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.52 No.6
Background: Meperidine has proved a far more effective treatment for shivering after spinal anesthesia than equianalgesic doses of opioid agonist. We performed this prospective, double-blinded, randomized study to compare the antishivering effect of fentanyl and meperidine when added to intrathecal hyperbaric bupivacaine during Cesarean delivery under spinal anesthesia. Methods: Sixty ASA I or II patients undergoing Cesarean delivery under spinal anesthesia were randomly assigned into three groups. Fentanyl 12.5 ug (group F) or meperidine 12.5 mg (group M) or normal saline 2.5 ml (group C) were added to 0.5% hyperbaric bupivacaine 8.5 mg for spinal anesthesia. Data including mean arterial pressure, heart rate, sensory block level, core temperature, shivering incidence and intensity were collected every 2 min for 10 min and then every 5 min until the end of surgery. Results: There were no significant statistical differences in patient characteristics, the mean arterial pressure, heart rate and core temperature among the groups. The incidences of shivering in fentanyl and meperidine group were significantly lower than in the control group, but there were no significant differences between fentanyl and meperidine group. Shivering intensity was significantly lower in fentanyl and meperidine group than in the control group. Conclusions: Intrathecal fentanyl and meperidine added to 0.5% hyperbaric bupivacaine are effective in reducing the incidence and intensity of shivering associated with spinal anesthesia. (Korean J Anesthesiol 2007; 52: 657~62)
신경병증 백서에서 척수신경절 신경원의 Capsaicin에 대한 반응성 및 나트륨 전류의 변화
신광일,임정길,이정락,임태하,김종욱,황재현 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.2
Background : Allodynia, one of the most debilitating symptoms of neuropathic pain syndromes, can be defined as `pain due to a stimulus that does not normally provoke pain'. Subsets of dorsal root ganglion (DRG) neurons involved in nociception are characteristically expressed capsaicin sensitivity and high proportion of tetrodotoxin resistant sodium current (TTX-R INa). We performed an experiment to elucidate whether nerve injury induced mechanical allodynia could be resulted from elctrophysiological modulation of large, nonnociceptive afferent neurons to nociceptors. Methods : Whole cell patch clamp recordings were made from acutely dissociated dorsal root ganglion (DRG) neurons of normal and experimental neuropathic rats. We compared the proportion of capsaicin sensitive neurons which responded to capsaicin (1uM) with an inward current ≥ 100 pA in amplitude and the proportion of sodium channel subtypes measured in the absence and presence of tetrodotoxin (1 M), in small and large DRG neurons. Results : Th proportion of capsaicin sensitive cells to total number of cells tested was not changed by nerve injury in both small and large cell populations. In large cell population of nerve injured rats, the proportion of TTX-R INa was significantly increased as compared with normal group (p<0.05), and in small cell population of nerve injured rats, TTX-S INa was increased, but there was no statistical significance. Conclusions : These data indicate that expression of the sensitivity to capsaicin in DRG neurons would not be altered by nerve injury and increased TTX-R INa in large cell population of nerve injured DRG may underlie increased excitability. (Korean J Anesthesiol 1998; 35: 259∼268)
이동명,최규택,박정원,서병태,임태하 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.33 No.3
Background : It has been a standard practice in many institutions to combine light general anesthesia with epidural block for abdominal and pelvic surgery. We attempted to prove the effectiveness of prehydration and to find an suitable epidural local anesthetic dose in terms of hemodynamic stability for upper abdominal surgery. Methods : For preliminary studies, 11 patients scheduled for elective upper abdominal surgery had received general anesthesia immediately after epidural anesthesia. After epidural injection of 10∼16 mL of 2% plain lidocaine into the T9∼10 intervertebral space, the changes in blood pressure were observed. Thirty-two patients scheduled for elective upper abdominal surgery were divided into two groups. In group A(study group), after prehydration with Hartmann solution(10 mL/kg), 5∼7 mL of 2% plain lidocaine was injected into T8∼9 or T9∼10 intervertebral space and general anesthesia was then induced. Group B(control group) received general anesthesia only. Results : There were no signnt differences in hemodynamics between the epidural with general anesthesia and the control group except SVR(systemic vascular resistance). SVR in group A increased in contrast to the group B in which it remained unchanged. Conclusions : The combined epidural and general anesthesia, using prehydration and 0.5∼1 mL/segment of 2% plain lidocaine at the T8∼9 or T9∼10 intervertebral space was safe without significant hemodynamic changes. (Korean J Anesthesiol 1997; 33: 472∼476)