랫드에서 두릅 추출물의 4주 반복투여 독성시험

진주연(Ju Youn Jin),양희경(Hee Kyoung Yang),김지민(Ji Min Kim),고문수(Mun Su Ko),홍현주(Hyun Ju Hong),진영건(Young Gun Jin),김동건(Dong Gun Kim),김상철(Sang Chul Kim),이일(Il Lee),현민경(Min Kyong Hyon),강상철(Sang Chul Kang),김재훈(Ja 한국독성학회 2006 Toxicological Research Vol.22 No.4

Aralia elata, a common medicinal and culinary herb, has been consumed for centuries without any reported adverse effects. However, due to its limited safety information, we decided to investigate the repeated-dose toxicity of ethanolic extract of Aralia elata. The test was administered once daily by the gavage to male and female rats at doses of 0, 250, 500 and 1,000 ㎎/㎏/day for four weeks. Throughout the study, no treatment-related deaths or clinical signs were observed. Also, no apparent changes were detected in ophthalmoscopy, urinalysis, serum biochemistry, hematology and gross necropsy. The test result showed a significant decrease in body and heart weight of males treated with 250 ㎎/㎏ of extract of Aralia elata compared to normal control, a significant increase in relative brain weight and adrenal weight in females treated with 250 ㎎/㎏ of extract compared to normal control. However, all these changes were not considered toxicologically important due to irrelevant dose-response relationship to gross and microscopic findings. Histopathologically, abnormal changes were not observed in any target organs. On the basis of these results, the NOAEL of extract of Aralia elata was estimated to be more than 1,000 ㎎/㎏/day under the tested conditions.

노인요양제도의 수발과 관련된 한국과 일본의 환경 비교

이 시 진(Si-Jin Lee),이 은 영(Eun-Young Lee,이 혜 진(Hey-Jin Lee) 대구보건대학 2008 대구보건대학 論文集 Vol.28 No.-

The study which shows sith theoretical data presented the client schedule of facility about Long-term Care insurance of Japan. And the process of service and the part of facility showed with the photograph. On the other side, the contents which executes from facility of Korea introduced. Also the founndation goal of korean facility and key note of Long-Term Care of Japan presented. Like this things leads, the study is will smoothly contribute for the settlement which the Long-Term Care Insurance System is enforced from Korea. The worker which does a best safely from day-service of Japan leads the service of direction adout Long-Term Care of korea. That becomes the big help. Finally, in camparison with Long-Term Care Insurance Korea and Japan, inorder to develop Long-Term Care System of Korea honestly, the study desires the central operating body does the fundamental self-govening body and National Health Insurance Corporation Supports with the setup.

국제물품매매 계약에서 전자기록의 유효성에 관한 고찰

이 창 숙(Chang-sook Lee)·강 원 진(Won-jin Kang) 한국국제상학회 2009 國際商學 Vol.24 No.1

In the contract for international sale of goods, electronic records instead of paper documents come to play vital roles for the negotiation and closing of contract between distant parties. It is necessary to review the effectiveness of electronic records. The legal recognition of electronic records is approved under USA Uniform Electronic Transactions Act, Supplement to the Uniform Customs and Practice for Documentary Credits for Electronic Presentation (eUCP) Version 1.1 and Korea Electronic Transactions Act. This paper examined retention and original of electronic records, effect of changes and errors in electronic records occurring in transmissions, the relationship between electronic records and signature, and legal recognition between electronic records and contract. In result, to be effective in the electronic records depends on the information contained in electronic records rather than relies on themselves. Electronic records will be attributed to a party if it is the act of the person, they may not contain an electronic signature. And electronic records can be effective if they comply with the requirements of Time and Place of Sending and Receipt under the Uniform Electronic Transactions Act.

산모의 고열이 Hsp70 KO 생쥐 아래턱뼈 치아의 초기발생에 미치는 영향에 관한 면역조직화학적연구

유진영(Jin Young Yoo),심윤택(Yun Tak Shim),이 진(Jin Lee),안상길(Sangil Ahn),김종룡(Jong Ryong Kim),김원규(Won Kyu Kim) 대한해부학회 2007 Anatomy & Cell Biology Vol.40 No.1

발생중인 실험동물 및 사람에서 고열은 선천성기형을 유발하는 요인의 하나로 인정되고 있다. 세포가 고열에 노출되면 방어기전으로 열충격단백질을 합성, 분비한다. Hsp70은 열충격단백질의 한 종류로서 정상발생 과정뿐만 아니라 고열과 같은 스트레스에 의한 세포자멸사를 억제하는 기능을 갖는 것으로 알려져 있다. 따라서 Hsp70이 결손된 실험동물이 고열에 노출되면 배아 혹은 태아에서 성장지연 및 선천성기형이 유발된다. 본 연구에서는 임신한 Hsp70 KO 생쥐를 고열에 노출한 후 치아 초기발생과정에 중요한 역할을 수행하는 FGF-4와 FGF-8의 발현양상을 면역조직화학법으로 연구하고자 하였다. 실험군은 고열에 노출된 Hsp70 KO 생쥐 태아를, 대조군으로 고열에 노출되지 않은 Hsp70 WT 생쥐 태아를 사용하였다. 실험군은 임신 제8.5일에 43˚C 수조에서 5분간 열충격을 주었고, 대조군에는 아무런 조작도 가하지 않았다. 임신 제13.5, 15.5 및 17.5일에 모체를 희생하여 자궁내의 태아를 적출한 후 머리를 절취하였다. 머리에서 아래턱을 절취하여 통상적인 방법에 따라 파라핀에 포매한 후 조직표본을 제작하여 FGF-4 및 FGF-8 면역조직화학염색을 시행하고 광학현미경으로 관찰하여 다음과 같은 결과를 얻었다. FGF-8 발현은 발생 13.5일 대조군에서는 치아판(dental lamina) 내부와 치아싹 첨부의 세포에서 양성반응을 보였고, 실험군에서는 극히 일부의 세포만 양성반응을 나타내었다. 발생 15.5일 및 17.5일 대조군에서는 치아속질(dental pulp)에 인접한 사기질모세포(ameloblast) 바닥막에서 양성반응을 나타내었으나, 발생 15.5일 실험군에서는 대부분의 치아상피에서 양성반응을 보였고, 발생 17.5일 실험군에서는 치아목고리 주변의 바깥 및 속치아상피에서 강한 양성반응을 나타내는 등 발생이 진행되어도 지속적으로 발현하고 있었다. FGF-4 발현은 발생 13.5일 대조군에서는 치아상피의 첨부에서 양성반응을 보였고, 발생 13.5일 실험군에서는 반응이 관찰되지 않았다. 발생 15.5일 대조군에서는 치아상피의 바닥막과 치아목고리에 위치한 치아상피세포에서 양성반응을 나타내었으며, 실험군에서는 치아싹은 초기 모자시기 단계였고, 치아판 입구와 치아목고리에 위치한 치아상피에서 양성반응을 보였다. 발생 17.5일 대조군에서는 이차사기질결절로 분화할 부위에서 양성반응을 보였고, 발생 17.5일 실험군에서는 구강상피에 인접한 치아판에서 강한 양성반응을 보였으나 나머지 부위에서는 미약하거나 음성반응을 나타내었다. 이상의 결과를 종합하면 임신 중 고열은 치아발생이 진행되어도 FGF-8을 지속적으로 발현시키고, 또한 FGF-4의 발현을 저해하여 치아의 발생과정을 억제하는 것으로 생각된다. To investigate the effects of maternal hyperthermia on early odontogenesis, pregnant Hsp70 knockout and wild type mice at embryonic day (ED) 8.5 were immersed in a 43�C water bath until their core body temperature reached that temperature, and then given a further 5min of hyperthermia. Untreated Hsp70 WT mice fetuses were used as the control group. Fetuses were collected at EDs 13.5, 15.5 and 17.5. Developing teeth in the mandible were processed for histological and immunohistochemical studies. Tissue sections were immunostained for FGF-8 and FGF-4 and observed using light microscopy. In the controls, FGF-8 immunolocalization was observed in cells within the dental lamina and in apically located dental epithelium at ED 13.5. However, a few cells were immunopositive in the heat shocked (HS) group. At EDs 15.5 and 17.5 of the control group, the basal lamina adjacent to the dental pulp showed positive immunostaining. In contrast, most of the dental epithelium was immunopositive at ED 15.5 in the HS group and inner and outer dental epithelial cells were continuously immunopositive by ED 17.5. FGF-4 immunolocalization was found in apical dental epithelium at ED 13.3 in the control group, but no such positive reaction was observed in the HS group. At ED 15.5 in the controls, basal lamina and dental epithelium near the cervical loop were immunopositive. In contrast, early cap-stage teeth had cells near the mouth of the dental bud and cervical loop that were immunopositive to FGF-4 in the HS group. In controls at ED 17.5, cells near the future secondary enamel knot were immunopositive, whereas most of the dental epithelium except for cells in the mouth of the dental lamina was negative in the HS group. Thus, maternal hyperthermia may inhibit normal odontogenesis through sustained production of FGF-8 and downregulation of FGF-4.

한국 소방관에서 보이는 외상 후 스트레스 증상과 음주의 연관성

이문인(Moon-In Lee),류권호(Kwon-Ho Ryu),김학렬(Hack-Ryul Kim),박상학(Sang-Hag Park),김상훈(Sang-Hoon Kim),이 진(Jin Lee) 한국중독정신의학회 2010 중독정신의학 Vol.14 No.1

Objectives:This study aimed to assess the relationship bet-ween Korean firefighters’ posttraumatic symptoms and alcohol use problems. Methods:Study participants were 59 firefighters working in Kwangju in 2009. We collected information about the participants’ demographic and job-related characteristics, and we administered the Alcohol dependence scale (ADS), Clinician Ad-ministered PTSD Scale (CAPS), and the Symptoms checklist 90-Revised version (SLC 90-R) to them. Statistical analyses utilized the Wilcoxon rank-sum test & and the Kruskal-Wallis test. Results:We used the CAPS scores to divide the participants into a PTSD (Post Traumatic Stress Disorder) symptom group (total score ≥20, n=7) and a “no symptoms” group (total score ≤19, n=52). We estimated the PTSD symptoms prevalence in fire-fighters as 11.86% by CAPS score. Participant ADS scores were independent of PTSD symptoms, but 16.94% of the firefighters showed moderate to severe alcohol-use problems. Conclusion:PTSD symptoms had no correlations with alcohol problems. However, alcohol problems are more common than PTSD symptoms among firefighters, so clinicians should carefully evaluate such patients’ alcohol problems, not just their post-trauma symptoms.

常壓燒結한 SiC-ZrB2 導電性 複合體의 特性에 미치는 In Situ YAG의 影響

신 용 덕(Yong-Deok Shin),주 진 영(Jin-Young Ju),고 태 헌(Tae-Hun Ko),이 정 훈 (Jung-hoon Lee ) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.7

위의 양성 및 전암성 병변에서 Telomerase 활성화와 Helicobacter pylori 감염의 연관성

장현주(Hyun Joo Jang),김정한(Jung Han Kim),홍수진(Su Jin Hong),강승식(Seung Sik Kang),계세협(Sea Hyub Kae),이 진(Jin Lee),주상언(Sang Aun Joo) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.1

Background/Aims: It has been considered that motor abnormalities of the oropharynx might play a role in the pathogenesis of oropharyngeal dysphagia. This study aimed to evaluate the motility change in patients with oropharyngeal dysphagia using circumferential solid state manometry. Methods: Nineteen patients with oropharyngeal dysphagia and 12 healthy volunteers of similar age underwent circumferential solid state manometry and lateral videofluoroscopic studies to assess oropharyngeal motility. The patients were divided into 3 groups by videofluoroscopic findings: group 1, patients with delayed oral transit; group 2, patients with increased pharyngeal residue; group 3, patients with aspiration alone. Results: The group 2 showed less upper esophageal sphincter relaxation and lower amplitude of hypopharyngeal contractions. The time interval from the onset of hypopharyngeal contractions to the onset of complete upper esophageal sphincter relaxation was delayed in the group 3. Post-swallow aspiration was caused by high pharyngeal residue in patients with oropharyngeal dysphagia. Conclusions: These results suggest that a high pharyngeal residue is related to a weak contraction of the hypopharynx, and aspiration is related to a slowed swallow response, presumably with delayed laryngeal closure. (Korean J Gastroenterol 2001;38:9-14)

SiC-TiB2 電導性 複合體의 特性에 미치는 加壓의 影響

신 용 덕(Yong-Deok Shin),서 재 호(Je-Ho Seo),주 진 영(Jin-Young Ju),고 태 헌(Tae-Hun Ko),이 정 훈 (Jung-hoon Lee ) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.7

재발한 급성 괴사성 뇌병증 1례

윤종서(Jong Seo Yoon),박소현(So Hyun Park),김동언(Dong Un Kim),김영훈( Young Hoon Kim),이 진(Jin Lee),장필상(Pil Sang Jang),김진택(Jin Tack Kim),황경태(Kyung Tai Whang) 대한소아신경학회 2003 대한소아신경학회지 Vol.11 No.2

저자들은 15개월에 급성 괴사성 뇌병증을 않았던 4세 남아에서 발열 및 경한 상기도 감염의 증상 후 갑자기 의식이 나빠지고 전신발작을 일으키며 뇌 MRI상 T2 강조영상에서 고 신호 강도를 보이는, 양측 시상을 대칭적으로 침범하는 원형의 병변이 관찰되었던 재발된 급성 괴사성 뇌병증 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. A 4-year-old boy showed two episodes of encephalitis/encephalopathy involving disturbed consciousness, convulsion, and paresis associated with the elevated levels of protein and no pleocytosis of the cerebrospinal fluid. MRI studies of the brain revealed symmetrical lesions in the brain stem and thalamus at the first episode, and their sizes were regressed. The lesions were enlarged to the previous size in the second episode. These episodes were not followed by an elevation of the anti-viral antibody titer. In the second episode, intravenous methylprednisolone therapy and intravenous immunoglobulin therapy were introduced.

전립선 특이항원과 체질량지수 및 허리둘레의 연관성

이 진,신황식,조용진,오정은 순천향대학교 순천향의학연구소 2021 Journal of Soonchunhyang Medical Science Vol.27 No.2

Objective Prostate-specific antigen (PSA) is widely used as a screening tool of prostate cancer, although there has been a controversy about efficacy. In Korea, rapid growth of obesity prevalence in adult men is a one of the biggest health problems. The objective of this study was to evaluate the potential association between body mass index (BMI), waist circumference (WC) and PSA. Methods We calculated BMI and WC of a total of 25,603 males who visited the Soonchunhyang University Cheonan Hospital Health Promotion Center from January 2016 to December 2020. This was categorized as follows: BMI < 23 kg/m2 (normal), 23 kg/m2 ≤ BMI < 25 kg/m2 (overweight), BMI ≥ 25 kg/m2 (obesity) and WC < 90 cm (normal), WC ≥ 90 cm (abdominal obesity). We analyzed the association between BMI, WC and PSA. Results The mean PSA value was 1.08 ng/mL, 1.03 ng/mL, and 0.97 ng/mL at normal, overweight, and obesity group, respectively. The mean PSA value was 1.04 ng/mL and 0.96 ng/mL at normal and abdominal obesity group. Thus, the mean PSA value decreased with an increase in BMI and WC category (P < 0.001). The correlation coefficient between BMI, WC and PSA was -0.055, -0.044 and they were statistically significant (P < 0.001). Conclusion We observed a significant negative correlation between BMI, WC and PSA value. Therefore, PSA value should be considered in relation to BMI and WC.