웹 서비스 애플리케이션의 동적 성장을 위한 ESB와 에이전트 기반 프레임워크

이창호,김진한,이재정,이병정,Lee, Chang-Ho,Kim, Jin-Han,Lee, Jae-Jeong,Lee, Byung-Jeong 한국정보처리학회 2007 정보처리학회논문지 A Vol.14 No.7

유비쿼터스 컴퓨팅 환경에서는 이기종 플랫폼간의 상호작용과 빠른 환경의 변화에 대처할 수 있는 능력이 필요하다. 웹 서비스는 이러한 문제를 위해 이종의 분산 서비스 또는 자원들을 활용하고 조직하기 위한 방법을 제공한다. 그렇지만 서비스 요청 시, 의미 정보의 부족으로 원하는 서비스를 찾기가 어렵다. 시맨틱 웹 서비스는 의미 정보는 제공하지만 다양한 매칭에 대한 방법은 지원하지 않고 있다. 또한 웹 서비스를 이용해서 소프트웨어에 적응과 확장 능력을 제공할 순 있지만, 서비스들을 관리하고 운영하는 방법이 필요하다. 따라서 본 논문에서는 웹 서비스 애플리케이션의 동적 성장을 위해 ESB(Enterprise Service Bus)와 에이전트 기반의 프레임워크를 제안하고 유용성을 보이기 위한 프로토타입을 제시한다. Software adaptation may be required to interact between heterogeneous platforms and to react to rapid change of environment in ubiquitous computing. Web service provides a way to use heterogeneous and distributed services or resources to utilize and organize them. But it is not easy to retrieve appropriate services when we search services because web service lacks of semantic information. Semantic web service provides additional information of services, but it does not support a method to match them in various ways. We can adapt and extend web applications by using web service, but a method for management and administration is still needed. Therefore in this paper, we propose a framework for dynamic growing of web service applications based on ESB(Enterprise Service Bus) and agent and provide a prototype to show its usefulness.

고속역류크로마토그래프의 분리효율에 미치는 작동조건의 영향

이창호,이부용,이철호 ( Chang Ho Lee,Boo Yong Lee,Cherl Ho Lee ) 한국산업식품공학회 1997 산업 식품공학 Vol.1 No.3

식품 및 환경 , 기타 Acinetobacter sp . A54 에 의한 Arabian Light 원유의 분해

이창호,김희식,서현효,최성훈,오희목,윤병대 ( Chang Ho Lee,Hee Sik Kim,Hyun Hyo Suh,Soung Hun Choi,Hee Mock Oh,Byung Dae Yoon ) 한국미생물생명공학회 1997 한국미생물·생명공학회지 Vol.25 No.5

논토양에 3요소비료 시용시 이들 비료성분의 토양내 잔존 형태와 용탈에 의한 수질오염에 관한 연구

이창호,임수길 ( Chang Ho Lee,Soo Kil Lim ) 한국물환경학회 1995 한국물환경학회지 Vol.11 No.4

In order to investigate the behavior of N,P,K fertilizers applied in submerged paddy soils and the water pollution caused by these leachate, Ammonium sulfate(AS), Urea, Superphosphate(SP), Fused phosphate(FP), Potassium chloride(PC) were applied in three levels in the columns filled with silty clay loam(SiCL) and sandy loam(SL), respectively. Distributions of N,P,K in soil were detertmined, and concentrations of N,P,K in leachate were also analyzed, separately. The obtained results were summarized as follows. In terms of residual amounts in soils, AS induced decreasing amount NH₄-N from top to bottom whereas Urea revealed reverse phenomenon. SL soil rather than SiCL soil and AS rather than Urea had a much effect on the water pollution. Residual amount of NO₃-N showed higher amount in SL soil than in SiCL soil regardless of fertilizer and application rates. In SiCL soil, main source of soluble phosphorus was SP whereas FP was the one in SL soil. Conc. of phosphorus in leachate were very small due to high adsorption ability of soils for phosphorus, the soil pollution was more considered than the water pollution. Leaching conc. of K^+ was higher from SL soil than SiCL soil, leaching conc. of K^+ increased as fertilizer application rates increasing on both SiCL and SL soils. Leaching concentrations(Y) of K^+ decreased with increasing leaching frequency(X), fitting the equation of exponential function could be expressed as Y=aX^b egardless of soil textures and potassium fertilizer application rates. The value of b is in between 0.41 and 0.63.

생약 열수추출물의 근력향상 효능 평가

이창호,김영언,김인호,한대석,성기승,양동흠,송태철,Lee, Chang-Ho,Kim, Young-Eon,Kim, In-Ho,Han, Dae-Seok,Seong, Ki-Seung,Yang, Dong-Heum,Song, Tae-Cheol 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.6

생약 열수추출물의 근력 향상 효능을 평가하기 위하여 근력 측정 및 혈액의 피로요소를 분석한 결과 간 글리코겐 함량은 모든 식이군들이 대조군에 비하여 높은 수치를 나타내었다. 특히 맥문동, 오미자, 오가피, 함초 식이군의 경우 높은 글리코겐 함량을 나타내었다. 4주간 측정한 근력 향상효능은 오가피, 함초, 홍삼 열수추출물 섭취군의 경우 다른 열수추출물 섭취군에 비하여 높은 근력 향상 효과를 보여주었다. 무기인산은 맥문동, 오미자, 오가피, 두충, 구기자, 홍삼 열수추출물 섭취군의 경우 대조군에 비하여 낮은 수준을 나타내었다. 젖산 함량은 모든 생약재 열수추출물 식이군에서 대조군과 비교하여 낮은 함량을 나타내어 생약 열수 추출물을 이용한 근력 향상용 기능성 식품의 개발 가능성을 보여주었다. Effects of medicinal herbs on the improvement of muscular strength along with the related fatigue factors were evaluated in SD rats. Nine types of treatment groups were fed diets supplemented with 1% herb hot-water extracts (Liriope spicata (LS), Schizandra chinensis (SC), Acanthopanax sessiliflorus (AS), Saliconia herbacea (SH), Eucommia ulmoides (EU), Lycium chinensis (LC), Panax ginseng (red ginseng) (PG), Polygonum multifloum (PM), Glycyrrhizae uralensis (GU)) for 4 weeks. The muscular strength of all groups were measured weekly for 4 weeks. After 4 weeks serum was collected and liver dissected out for the analysis of glycogen and fatigue factors. The liver glycogen contents of all treatment groups ($21.0{\sim}25.9mg/g$) were higher than that of control group (18.1 mg/g). A significantly increase of muscular strength in the fourth week were found in the AS (282.5 gf), SH (277.4 gf), PG (287.2 gf) groups (p<0.05). LS (7.88 mg/dL), SC (7.85 mg/dL), AS (7.64 mg/dL), EU (7.54 mg/dL), LC (7.81 mg/dL) and PG (7.75 mg/dL) groups were significantly reduced in serum inorganic phosphorus concentration measured after 4 weeks (p<0.05). Serum lactate levels of treatment groups ($8.61{\sim}12.18{\mu}g/dL$) were significantly lower than that of control group ($17.45{\mu}g/dL$). These results suggest that medicinal herbs enhanced muscular strength of rats by delaying accumulation of muscular fatigue factor.

C형 간염바이러스(HCV)의 NS5B RNA Replicase에 의해 활성이 유도되는 Hammerhead 리보자임에 의한 HCV 복제 억제 연구

이창호,이성욱,Lee, Chang-Ho,Lee, Seong-Wook 한국미생물학회 2011 미생물학회지 Vol.47 No.3

C형 간염바이러스(hepatitis C virus; HCV) 증식을 효과적이며 특이적으로 제어할 수 있는 유전산물로서, HCV 증식조절인자인 NS5B RNA replicase 존재에 의해 allosteric하게 활성이 유도될 수 있는 HCV internal ribosome entry site (IRES) 표적 hammerhead 리보자임을 개발하였다. 이러한 리보자임은 HCV IRES 염기서열 중 +382 nucleotide 자리를 인지하는 hammerhead 리보자임, NS5B RNA replicase와 특이적으로 결합하는 RNA aptamer 부위, 그리고 aptamer와 NS5B와의 결합에 의해 리보자임 활성을 유도할 수 있도록 구조적 변이를 전달할 수 있는 communication module 부위 등으로 구성되어 있다. 이러한 allosteric 리보자임에 의해 세포 배양에서 HCV의 replicon 복제가 효과적으로 억제됨을 실시간 PCR 분석을 통하여 관찰하였다. 특히, HCV 지놈을 표적하는 리보자임 단독, 또는 HCV NS5B에 대한 RNA aptamer 단독에 의한 HCV 복제 억제능보다 allosteric 리보자임에 의한 HCV 복제 억제능이 더 뛰어났다. 따라서 개발된 allosteric 리보자임은 HCV 증식의 효과적인 증식 억제 선도물질로 활용될 수 있을 것이다. As a specific and effective therapeutic genetic material against hepatitis C virus (HCV) multiplication, HCV internal ribosome entry site (IRES)-targeting hammerhead ribozyme which activity is allosterically regulated by HCV regulatory protein, NS5B RNA replicase, was constructed. The allosteric ribozyme was composed of sequence of RNA aptamer to HCV NS5B, communication module sequence which can transfer structural transition for inducing ribozyme activity upon binding NS5B to the aptamer, and sequence of ribozyme targeting +382 nucleotide of HCV IRES. With real-time PCR analysis, the ribozyme was found to efficiently inhibit HCV replicon replication in cells. Of note, the allosteric ribozyme was shown to inhibit HCV replicon replication more efficiently than either HCV genome-targeting ribozyme or NS5B aptamer only. This allosteric ribozyme can be used as a lead genetic agent for the specific and effective suppression of HCV replication.

저궤도 상용위성 개발을 위한 시스템 신뢰성 엔지니어링 적용사례

이창호,Lee, Chang-Ho 한국시스템엔지니어링협회 2003 시스템엔지니어링워크숍 Vol.1 No.-

수술을 시행한 갑상선 우연종의 임상적 고찰

이창호,윤현조,정성후,Chang Ho Lee,Hyun Jo Youn and Sung Hoo Jung 대한갑상선-내분비외과학회 2006 The Koreran journal of Endocrine Surgery Vol.6 No.1

Purpose: An incidentaloma is a tumor that is found incidentally without clinical symptoms. This study was carried out to evaluate the clinicopathologic characteristics and to offer the optimal diagnostic and therapeutic strategies for surgical treated thyroid incidentaloma. Methods: We reviewed the medical records of 139 consecutive patients who were operated on for incidentally detected thyroid nodules from January 2000 to June 2005, and we retrospectively investigated the clinicopathologic characteristics, preoperative diagnostic methods, operative methods and histologic diagnosis of surgical treated thyroid incidentaloma. Results: The male-to-female ratio was 1:9.7 (13:126) and the mean age was 45.8 years. The mean tumor size was 1.27 cm and 122 cases (87.8%) were 1.5 cm or less in diameter. 138 patients underwent ultrasonography and 34 patients (24.6%) were diagnosed with malignant nodules. US-guided fine needle aspiration cytology (FNAC) was performed in 118 patients and 42 patients (35.6%) were diagnosed with papillary carcinoma. According to postoperative histologic diagnosis, 70 cases (50.3%) were adenomatous goiter, 14 cases (10.2%) were follicular adenoma and 54 cases (38.8%) were papillary carcinoma. Among the papillary carcinoma, capsular invasion were presented in 3 cases (5.6%) and lymph node metastasis were presented in 5 cases (9.3%). According to the TNM staging, 33 cases (61.1%) were stage I, 16 cases (29.6%) were stage II, and 5 cases (9.3%) were stage? By the AMES scoring system, 2 cases (3.7%) were in the high risk group.Conclusion: Although most patients with incidental thyroid carcinomas were low stage, their clinicopathologic characteristics were similar to those of general thyroid carcinoma. Therefore, high risk patients with thyroid incidentaloma should have active diagnostic methods performed such as FNAC for confirming the presence of carcinoma. (Korean J Endocrine Surg 2006;6:12-16)

현미의 기능성

이창호,Lee, Chang-Ho 한국식품연구원 1998 食品技術 Vol.11 No.1

알칼리성 Prottease를 생산하는 Xanthomonas sp. YL-37의 분리 및 조효소의 성질

이창호,권태종,강상모,서현효,권기석,오희목,윤병대,Lee, Chang-Ho,Kwon, Tae-Jong,Kang, Sang-Mo,Suh, Hyun-Hyo,Kwon, Gi-Seok,Oh, Hee-Mock,Yoon, Byung-Dae 한국미생물 · 생명공학회 1994 한국미생물·생명공학회지 Vol.22 No.5

A bacterial strain, which showed the high protease activity at low temperature and the high tolerance for the surfactant, was isolated from soil and identified as Xanthomonas sp. YL-37. The optimal temperature, initial pH, and cultivation time for the production of the alkaline protease by Xanthomonas sp. YL-37 were 20$\circC , 11.0, and 84 hours, respectively. In the jar fermenter culture of Xanthomonas sp. YL-37, the alkaline protease activity was about 15,000 DU/ml/-broth after cultivating for 108 hours. The optimal pH and temperature for the protease activity were 70$\circC and 11.0, respectively. The protease was relatively stable at the pH range of 7.0~12.0 and at the temperatures below 50$\circC . The protease activity at 20$\circC was about the level of 40% of its activity at 70$\circC . The enzyme was suggested as a serine protease because the enzyme activity was inhibited by phenylmethane sulfonyl fluoride, a serine modifier.