선별검사 목적으로 시행된 관상동맥 CT의 석회수치에 따른 임상경과 관찰

정인현 ( In Hyun Jung ),김정순 ( Jeong Soon Kim ),남효정 ( Hyo Jung Nam ),김희성 ( Hee Sung Kim ),김홍규 ( Hong Kyu Kim ),박덕우 ( Duk Woo Park ),이승환 ( Seung Whan Lee ),김영학 ( Young Hak Kim ),이철환 ( Cheol Whan Lee ),김재중 대한내과학회 2010 대한내과학회지 Vol.78 No.4

Background/Aims: In general, multidetector computed tomography (MDCT) is not recommended as a screening tool for asymptomatic individuals. However, the programs for general health evaluation at several hospitals in Korea include MDCT to detect cardiac disease. The objectives of this study were to evaluate the clinical outcomes of asymptomatic individuals according to the coronary artery calcium score (CACS) obtained from screening MDCT and to assess the eligibility of risk stratification in the NCEP-ATP III guidelines for predicting a significant stenosis on MDCT. Methods: We reviewed the medical records of 845 asymptomatic subjects (age 53±9 years, 67% men) who underwent MDCT as part of a general health evaluation at Asan Medical Center, Seoul, Korea, from January to December 2008. Results: Atherosclerotic plaques were identified in 332 (39.3%) subjects. Sixty (7.1%) individuals had significant stenosis (≥50% diameter stenosis). The prevalence of significant stenosis was higher in the group that had more than a 10% risk of coronary heart disease (CHD) at 10 years (p<0.05). Among the patients with occult coronary artery disease (CAD), 28 received coronary angiography, which resulted in 20 revascularizations (17 percutaneous interventions and three bypass surgeries) and eight medical treatments. In patients with significant narrowing, the CACS cutoff value for predicting coronary revascularization was 111.0 (AUC=0.87, 95% confidence interval; 0.76~0.97; sensitivity 80.0%, specificity 92.1%). Conclusions: According to the NCEP-ATP III guidelines, the prevalence of occult CAD on MDCT was significantly higher in the group with a 10% or higher risk for CHD at 10 years. A CACS≥110 was associated with a significantly higher rate of coronary revascularization in asymptomatic patients with significant stenosis on MDCT. (Korean J Med 78:466-476, 2010)

급성전신발진농포증 환자의 임상 및 조직학적 분석

정인순 ( In Soon Jung ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee-bum Lee ),김성진 ( Seong-jin Kim ),이승철 ( Seung-chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.10

Background: Acute generalized exanthematous pustulosis (AGEP) is typically a medication-induced acute febrile eruption. Few large-scale studies have reported clinical data regarding AGEP in Korea. Objective: This study analyzed the clinical and histopathological features of AGEP in Koreans to identify recent trends in this context. Methods: This study retrospectively reviewed 31 patients with AGEP. Age, sex, clinical features, etiologies, laboratory findings, histopathological features, and treatment outcomes were obtained from patients’ medical records and photographs. Results: The mean age of onset was 43.6 years, and the male:female ratio was 2.1:1. All patients showed non-follicular tiny pustules and erythema. Fever was reported in 13 patients and neutrophilia in 17 patients. Medications were considered the most common etiological contributors. Twenty patients showed drug-induced AGEP, and 11 of 20 patients showed antibiotic-induced AGEP. Serum C-reactive protein and lactate dehydrogenase levels increased in 93.8% and 77.8% of the patients, respectively. Histopathologically, all patients showed subcorneal or intraepidermal pustules, followed by exocytosis and neutrophilic dermal infiltrate. Twenty-five patients improved within a mean period of 7.5 days after the onset of the skin rash. The percentage of women in the drug-induced AGEP group was significantly higher than that in the non-drug-induced AGEP group. Conclusion: This report describes a large-scale study that analyzed the clinical and histopathological features of AGEP in Koreans and seems to accurately reflect the recent trends in this context. Clinically, it is important to note that the percentage of women in the drug-induced AGEP group was higher than that in groups showing other etiologies of AGEP. (Korean J Dermatol 2018;56(10):594∼602)

족삼리(足三里) 배혈(配穴)에 따른 전침(電鍼)이 흰쥐 대뇌피질(大腦皮質)의 NADPH-diaphorase와 nNOS, NPY, VIP 신경세포(神經細胞)에 미치는 영향(影響)

정인기,이재동,김창환,Jung, In-gy,Lee, Jae-dong,Kim, Chang-hwan 대한침구의학회 2003 대한침구의학회지 Vol.20 No.5

Objective: The aim of this study was to investigate the effects of Joksamni(ST36) combination on NAD PH-diaphorase, neuronal nitric oxide synthase(nNOS), neuropeptide Y(NPY) and vasoactive intestinal peptide (VIP) in the cerebral cortex of spontaneously hypertensive rat. Methods: The experimental groups were divided into four groups: Normal, Joksamni(ST36), Joksamni(ST36)+Eumneungcheon(SP9), and Joksamni(ST36)+Gokji(LI11). Needles were inserted into acupoints at the depth of 0.5cm with basic insertion method. Electroacupuncture was done under the condition of 2Hz electrical biphasic pulses with continuous rectangular wave lasting for 0.2ms until the muscles produced visible contractions. Such stimulation was applied continuously for 10 minutes, 1 time every 2 days for 10 sessions of treatments. Thereafter we evaluated changes in NADPH-d positive neurons histochemically and changes in nNOS, NPY and VIP positive neurons immunohistochemically. Results: The optical densities of NADPH-d positive neurons of the Joksamni(ST36)+Eumneungcheon(SP9) group in all areas of cerebral cortex and Joksamni(ST36)+Gokji(LI11) group in primary somatosensory cortex, visual cortex, auditory cortex, perirhinal cortex were significantly increased as compared to the Joksamni(ST36) group. The optical densities of NADPH-d positive neurons of the Joksamni(ST36)+Gokji(LI11) group were significantly decreased as compared to the Joksamni(ST36)+Eumneungcheon(SP9) group with the exception of primary somatosensory cortex. The optical densities of nNOS positive neurons of the Joksamni(ST36)+Eumneungcheon(SP9) group in all areas of cerebral cortex and Joksamni(ST36)+Gokji(LI11) group in auditory cortex, perirhinal cortex, insular cortex were significantly increased as compared to the Joksamni(ST36) group. The optical densities of nNOS positive neurons of the Joksamni(ST36)+Gokji(LI11) group were significantly decreased in all areas of cerebral cortex as compared to the Joksamni(ST36)+Eumneungcheon(SP9) group. The optical densities of NPY positive neurons of the Joksamni(ST36)+Gokji(LI11) group were significantly decreased in primary motor cortex, primary somatosensory cortex, cingulate cortex as compared to the Joksamni (ST36) and Joksamni(ST36)+Eumneungcheon(SP9) groups. The optical densities of VIP positive neurons of the Joksamni(ST36)+Eumneungcheon(SP9) group were significantly increased in all areas of cerebral cortex except for cingulate cortex as compared to the Joksamni(ST36) group. The optical densities of VIP positive neurons of the Joksamni(ST36)+Gokji(LI11) group were significantly decreased in auditory cortex, cingulate cortex, perirhinal cortex as compared to the Joksamni(ST36) group. The optical densities of VIP positive neurons of the Joksamni(ST36)+Gokji(LI11) group were significantly decreased in all areas of cerebral cortex as compared to the Joksamni(ST36)+Eumneungcheon(SP9) group. Conclusions: The result demonstrated that electroacupuncture on Joksamni(ST36) and its combination change the activities of the NO system and peptidergic system in the cerebral cortex of SHR and that acupoint combination is one of the important parameters for the effects.

성인 두부백선의 임상 및 진균학적 분석(61증례, 1990∼2018)

정인순 ( In Soon Jung ),류건욱 ( Geon Wook Ryu ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.1

Background: Tinea capitis, a superficial dermatomycosis, is caused by a dermatophyte infection on the scalp and hair. Recently, the number of adult patients with tinea capitis have been increasing; therefore, the clinical and mycological features of tinea capitis may be different from those of previous reports. However, only a few studies on adult tinea capitis have been conducted in Korea. Objective: This study aimed to analyze the clinical and mycological features of Korean adult patients with tinea capitis. Methods: A retrospective review of 61 adult patients with tinea capitis was conducted. Clinical features including age, sex, clinical type, and treatment outcome were obtained from medical records and images. The mycological features, including the result of KOH smear and fungal culture, were also analyzed. Results: The mean onset age was 61.3 years, and the male-to-female ratio was 1:4.1. Two patients (3.3%) had a family history of developing the same symptoms, and 17 (27.9%) had a history of close contact with animals. The most predilection site was the vertex, followed by the frontal and parietal areas. Microsporum canis was cultured in 66.7% patients, and Trichophyton rubrum was cultured in 28.6% patients. The number of adult patients with tinea capitis has been increasing constantly. The proportion of patients infected by T. rubrum has been increasing since 2000. Of the 51 patients who received treatments, 42 showed improvements. No significant difference was observed between patients treated with terbinafine and itraconazole. Conclusion: This is the large-scale study that analyzed the clinical and mycological features of Korean adult patients with tinea capitis. (Korean J Dermatol 2020;58(1):1∼6)

자연개념의 관점에서 본 사회생태학적 건축의 이해

정인아(Jung In-A),김흥만(Kim Heung-Man),이인희(Lee In-Hee) 대한건축학회 2011 대한건축학회논문집 Vol.27 No.5

This study is an attempt to understand architecture linking between nature and society focused on the concept of nature in social ecology advocated by Murray Bookchin in 1960s. Social ecology firmly opposes to the position of environmental fascism which insists that ecological crisis’s reason is human because it detests human. So Bookchin proposes new concept of nature to prevent from a partial point of view about nature and he aims to ecological society by ecological dialectic. Meanwhile contemporary ecological buildings have been tried to build for overcoming the dichotomous relations. But it has shared the conceptual properties appearing in various ecological thoughts and theories. It can also give confusion to architectural decisions. Because of this reason, we need to understand architecture being between nature and society. With this study, we will expect ecological society both consisting of social-ecological building in having potential abilities and interacting nature with society.

성인 피부근염 환자 52명의 임상적 분석

정인순 ( In Soon Jung ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.1

Background: Dermatomyositis is one of the idiopathic inflammatory myopathies, characterized by unique cutaneous features. Unfortunately, there is little data regarding the clinical features of dermatomyositis in Korea patients. Objective: The study aimed to analyze the clinical features of Korean patients with adult-onset dermatomyositis. Methods: A total of 52 patients from 2002 to 2016 were analyzed retrospectively. Clinical features such as sex, age, symptoms, associated connective tissue disorders and malignancy were studied using medical records. Results: The mean onset age was 43.4 years, and the male to female ratio was 1 : 1.9. Forty-two patients (80.8%) were classified as having dermatomyositis, and 8 patients (15.4%), as having amyopathic dermatomyositis. Skin rash (94.2%) was the most common clinical feature, followed by proximal muscle weakness (61.5%), itching (55.8%), arthralgia (36.5%), and muscle pain (32.7%). Among skin rashes, symmetric violaceous erythema (67.3%) was the most frequent, followed by heliotrope rash (63.5%) and Gottron’s papule (59.6%). Serum aldolase level was elevated in 77.8%, and LDH in 69.6%. The prevalence of malignancy (23.1%) was similar to that in previous studies. Cervical cancer made up 25% (3/12) of the associated malignancies, followed by ovarian cancer and lung cancer (16.7%). Ten patients (19.2%) had other accompanying connective tissue diseases. Conclusion: To date, this is the first large-scale case study that analyzed the clinical features of Korean patients with adult-onset dermatomyositis. (Korean J Dermatol 2018;56(1):24∼29)

BIPV 용 결정질 태양광 모듈 및 재료의 투과 특성에 대한 연구

정인성(Jung, In sung),이범수(Lee, Bum-Su) 한국태양에너지학회 2012 한국태양에너지학회 학술대회논문집 Vol.2012 No.11

In 21st century, the photovoltaic industry is growing almost 30% annually worldwide. Also, the technology of solar cells is shifting to the Building Integrated systems. It is the situation which is unsatisfactory about the transmittance quality of the solar cell and module which are applied windows in buildings and vehicles. Considering the BIPV market, a research on the glass-to-glass module type is described in this paper. We analyzed the transmittance of glass-to-glass module type solar cells using Ethylene Vinyl Acetate (EVA) sheet and Poly Vinyl Butyral (PVB) sheet. We found that the EVA sheet is approximately 3% better than the PVB sheet in terms of transmittance. And, we performed an experiment on each module using 16 plates and 25 plates of 6 inch wafer size solar cell. We observed that 16-plate module has about 36.5% increase in improved transmittance and about 38% reduced in efficiency.

흉부 X-Ray 검사실에서 Auto Voice Device의 유용성과 방사선사의 편의성에 관한 고찰

정인아(In-A Jung),이동희(Dong-Hee Lee),이민우(Min-Woo Lee),김순배(Sun-Bae Kim) 대한영상의학기술학회 2012 대한영상의학기술학회 논문지 Vol.2012 No.-

목적: 음성안내가 많은 흉부 X-ray 검사실에서 사용할 Auto voice device를 제작하여 장비의 유용성과 이에 따른 방사선사의 업무 편의성에 대해 알아보고자 하였다. 대상 및 방법: 2012년 01월 09일 부터 02월 24일에 걸쳐 방사선사 87명에게 검사방법과 장비사용법이 담긴 동영상을 보여준 후 연구목적과 취지를 설명하고 협조를 요청하여 설문 지를 배부하여 분석하였다. 방사선사의 일반적 특성은 성별은 남성이 58명(67.7%)으로 9 명(33.3%)인 여성의 약 2배이고, 평균연령은 36(35.89±7.90)세이며, 근무기간은 13(13.41±7.54)년, 검사건수는 300~399건이 41명(28.7%)으로 가장 많은 비중을 차지했 다. 조사결과 분석은 방사선사의 검사에 대한 일반적 견해와 개선사항과 장비의 질에 대한 견해를 파악하기 위해 빈도와 백분율을 산출하고, 검사장비도입의 효과 및 효능의 통계적 처리는 SPSS를 이용하여 일원배치 분산분석(ANOVA)을 하였다. 결과: 설문조사 결과 연령과 근무기간에 따른 Auto voice device의 유용성은 유의확률이 0.05 이상으로 모두 통계적으로 유의하지 않아 상관관계가 적은 것으로 나타났다. 그러나 검사건수에 따른 검사자의 피로도 감소는 유의확률 0.000 (p<0.01)으로 매우 유의한 결과를 얻었고, 검사건수에 따른 업무의 편의성도 유의확률 0.001 (p<0.01)으로 매우 유의하다는 결과가 나왔다. 결론: Auto voice device를 사용함으로써 업무의 편의성 증가와 목의 피로도 감소는 매우 높은 평가를 얻었다. 하지만 장비를 조작하는 시간이 추가됨에 따라서 전체적인 검사시간은 단축되지 않았고, 호흡조절도 장비를 사용하는 것과 육성을 사용하는 것을 비교하였을 때크게 다르지 않았다. 향후 개선사항들을 토대로 장비의 음질 개선과 언어의 다양화, 자막기 능을 추가하여 현재 장비의 업그레이드를 진행 중이며, 더 발전된 Auto voice device로 방사선사의 업무에 보다 더 효율을 줄 것으로 기대한다. Purpose: This study investigated usefulness of the device and its work convenience for radiologic technologist by making auto voice device used at chest X-ray lab where many voice guidance is made. Materials and Methods: The subjects are 87 radiologic technologists and they were asked to see video clip where how to use the device and method of applying to examination was introduced during the period from Jan. 9, 2012 to Feb. 24, 2012. Since then, study purpose was explained to ask for cooperation. For general characteristics of the subjects, the gender is 58 males (67.7%); 29 females (33.3%) - male is double female. Average age is 36 (35.89±7.90). Working period is 13 (13.41±7.54) years. As for number of examination by radiologic technologist, 41 radiologic technologists (28.7%) did 300-399 cases each person. To show general opinion of the subjects about examination, and opinion about improvements and quality of device, percentage was used. Effect and efficiency of using Auto voice device was analyzed using ANOVA through statistical processing by SPSS. Results: For reduction of fatigue in radiologic technologist s throat according to number of examination, p-value 0.000 (p<0.01) - this is very significant result. For work convenience according to number of examination, p-value 0.000 (p<0.01) -this is also very significant result. Conclusion: Using auto voice device brought increase of work convenience and reduction of fatigue in throat. But whole time for examination was not saved because maneuvering device requires additional time. In controlling breathing, there is no much difference between using device and human voice. It is expected that if auto voice device is improved in sound quality, variety in provided language etc. through this study results, this device would be more useful for work of radiologic technologists in the future.

인플루엔자 B 바이러스와 연관된 근염의 임상적 고찰

정인아 ( In Ah Jung ),서수영 ( Soo Young Seo ),김지훈 ( Ji Hoon Kim ),조경순 ( Kyoung Soon Cho ),빈중현 ( Joong Hyun Bin ),이원배 ( Won Bae Lee ),강지민 ( Ji Min Kahng ),김현희 ( Hyun Hee Kim ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.2

Purpose: Influenza B-associated myositis is an infrequent and poorly known complication of influenza B virus infection in children. The aim of this study was to describe the clinical and laboratory manifestations, diagnosis, and outcomes of influenza B-associated myositis in Korean children. Methods: A retrospective analysis was conducted in patients aged <16 years who had been diagnosed with influenza B-associated myositis at the Catholic University Bucheon Saint Mary`s Hospital between April 2010 and May 2010. Results: Overall, 16 cases were analyzed. Influenza B-associated myositis typically occurred in preschool-aged children with a 3:1 male predominance. The mean age was 4.6 years (range, 3 to 7 years). The median interval between onset of influenza infection and onset of influenza B-associated myositis was 3 days (range, 1 to 7 days). Only the calf muscles were involved in all patients. Blood creatine phosphokinase concentration was elevated in most patients. Median duration to clinical recovery was 3 days (range, 1 to 4 days). No patient had rhabdomyolysis, renal failure, or related sequelae. All patients had a favorable outcome without administration of antiviral drugs. Conclusion: Clinical and laboratory findings of influenza B-associated myositis are very characteristic and allow a rapid diagnosis during the influenza season. Outcomes of influenza B-associated myositis are good with only proper supportive treatment. [Pediatr Allergy Respir Dis(Korea) 2011;21:86-90]

자궁근종 환자의 수술 전후 혈중 렙틴의 농도 변화

정인국 ( In Kook Jung ),김기형 ( Ki Hyung Kim ),나용진 ( Yong Jin Na ),이규섭 ( Kyu Sup Lee ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.8

Objective: To investigate possible relationship between uterine leiomyoma and serum leptin levels, we compared serum leptin levels between women with uterine leiomyoma and women without leiomyoma, and then investigate the effects of hysterectomy on serum leptin levels. Methods: Serum leptin levels were measured before (day-1) and after (day+5) surgery for 32 women with uterine leiomyoma and were measured when they visit our health promotion center for 32 normal women. We compared serum leptin levels between two groups, and then we analyzed perioperative changes of serum leptin levels in women with uterine leiomyoma. Pearson correlation test was performed between pre-/postoperative leptin ratio and resected uterine weight to investigate whether the changes of serum leptin levels are directly related with resection of leiomyoma. Results: In women with uterine leiomyoma, serum leptin levels were lower compared with normal group (7.41±4.31ng/㎖ vs. 17.56±8.65ng/㎖) (P<0.05). Postoperative serum leptin levels were decresed than preoperative serum leptin levels (6.07±2.98ng/㎖ vs. 7.41±4.31ng/㎖) (P<0.05). Pearson correlation coefficient between pre-/postoperative leptin ratio and resected uterine weight showed no statistical significance. Conclusion: Serum leptin levels were lower in women with uterine leiomyoma. And serum leptin levels were more decreased after hysterectomy. There were significant postoperative decrease in serum leptin levels but the result between pre-/postoperative leptin ratio and resected uterine weight revealed no direct correlation. It seems that lower serum leptin levels maybe due to postoperative stress and neuroendocrinological response rather than myoma itself. In conclusion, further investigation is needed for clinical use of serum leptin levels as a serum marker after conservative treatment of uterine leiomyoma.