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RISS 인기검색어
- 검색키워드
- 저자 : 윤숙정 ( Sook Jung Yun ) (검색결과 125 건)
- 무료
- 기관 내 무료
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Hydroxyurea 장기복용 환자에서 발생한 광범위한 피부궤양과 편평세포암
윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.4
Hydroxyurea, one of conventional chemotherapies in chronic myelogenous leukemia(CML) and polycythemia vera inhibits ribonucleotide reductase, which catalyzes the rate-limiting step in the de novo synthesis of deoxynucleotide triphosphates required for DNA synthesis. Various cutaneous side effects due to hydroxyurea have been reported as follows alopecia, diffuse hyperpigmentation, scaling, poikiloderma, atrophy of the skin and subcutaneous tissues, nail changes with multiple pigmented nail bands or brittleness, erythema and scaling of acral sites simulating chronic dermatomyositis, lichen plans-like lesions, or skin tumors on the UV-light exposed areas. A 72-year-old woman, receiving hydroxyurea for CML during 5 years, revealed hydroxyurea dermopathy such as scaly papules, poikilodermatous patches, and acral ulceration, and unusually developed squamous cell carcinoma. This is a rare case of hydroxyurea dermopathy, and the first case of squamous cell carcinoma by hydroxyurear in Korea.
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윤숙정 ( Sook Jung Yun ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Importance: The pathogenesis of acral melanoma remains unclear, even though trauma may be a predisposing factor. A study about the association of chronic physical stress with the incidence and spreading patterns through detailed anatomic mapping may be important to understand the unique features of acral melanoma. Objectives: To analyze the epidemiological and clinicopathological characteristics of melanoma occurring on the acral site, and evaluated how chronic physical stress or pressure strength influenced acral melanoma based on the analysis of the differences in incidence, prognosis of the distinct site (weight or non-weight-bearing portion of sole, volar or subungual location) and the spreading pattern of melanoma located on the soles. Design: Cross-sectional, retrospective. Setting: Republic of Korea, January 1, 1994, through October 31, 2012. Patients: A total of 177 Korean patients with acral melanoma. Main Outcome Measures: Anatomical mapping and histolopathological examination of acral melanoma. Results: The male: female ratio was 1:1.03, and the mean age at first admission was 55.3 years. Acral lentiginous melanoma was the most common histopathological subtype (85.9%), and nodular melanoma was 12.8%. There was a high incidence of acral melanoma at more physically stressed sites such as the center area of heels and inner forefoot area. In addition, a peculiar spreading pattern, with the long axis, typically along naturally occurring creases due to chronic pressure on the soles was often observed. The prognostic index and survival rate showed no significant difference between volar and subungual locations, and between weight and non-weight-bearing portions of the soles. Conclusions and Relevance: Clinicohistopathology of acral melanoma diagnosed at an advanced stage and resulting in a low survival rate is not significantly different in Koreans from other Asians. Interestingly, based on our study, chronic physical stress or pressure strength can influence the incidence and spreading pattern of acral melanoma in a particular manner. Acral melanoma occurs on more physically stressed sites with long axis along natural creases on the sole. A further prospective investigation of especially in situ lesions about the location-based differences in incidence, progress and Importance: The pathogenesis of acral melanoma remains unclear, even though trauma may be a predisposing factor. A study about the association of chronic physical stress with the incidence and spreading patterns through detailed anatomic mapping may be important to understand the unique features of acral melanoma. Objectives: To analyze the epidemiological and clinicopathological characteristics of melanoma occurring on the acral site, and evaluated how chronic physical stress or pressure strength influenced acral melanoma based on the analysis of the differences in incidence, prognosis of the distinct site (weight or non-weight-bearing portion of sole, volar or subungual location) and the spreading pattern of melanoma located on the soles. Design: Cross-sectional, retrospective. Setting: Republic of Korea, January 1, 1994, through October 31, 2012. Patients: A total of 177 Korean patients with acral melanoma. Main Outcome Measures: Anatomical mapping and histolopathological examination of acral melanoma. Results: The male: female ratio was 1:1.03, and the mean age at first admission was 55.3 years. Acral lentiginous melanoma was the most common histopathological subtype (85.9%), and nodular melanoma was 12.8%. There was a high incidence of acral melanoma at more physically stressed sites such as the center area of heels and inner forefoot area. In addition, a peculiar spreading pattern, with the long axis, typically along naturally occurring creases due to chronic pressure on the soles was often observed. The prognostic index and survival rate showed no significant difference between volar and subungual locations, and between weight and non-weight-bearing portions of the soles. Conclusions and Relevance: Clinicohistopathology of acral melanoma diagnosed at an advanced stage and resulting in a low survival rate is not significantly different in Koreans from other Asians. Interestingly, based on our study, chronic physical stress or pressure strength can influence the incidence and spreading pattern of acral melanoma in a particular manner. Acral melanoma occurs on more physically stressed sites with long axis along natural creases on the sole. A further prospective investigation of especially in situ lesions about the location-based differences in incidence, progress and survival is necessary to better understand the pathophysiology of acral melanoma.survival is necessary to better understand the pathophysiology of acral melanoma.
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Skin cancer: long-term management strategy for difficult patients
윤숙정 ( Sook Jung Yun ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2
Which skin cancer is the most difficult in terms of long-term management? Because most skin cancers are just widely excised, and that is the cure, except some invasive melanomas and other rare cancers. Among them, in this presentation, I will present a difficult extramammary Paget’s disease (EMPD) patient and review recent therapies on EMPD and present some patients from my experience. Then, I want to suggest long-term management strategy of EMPD.
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폐암 환자들에서 Gefitinib (Iressa)에 의한 피부 부작용
윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김규식 ( Kyu Sik Kim ),김영철 ( Young Chul Kim ) 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.2
Background: Gefitinib (ZD 1839, Iressa) is a new anticancer agent; more specifically, it is a selective epidermal growth factor receptor tyrosine kinase inhibitor that is, widely used for various solid cancers, including lung cancer. Cutaneous adverse reactions induced by gefitinib have recently been reported; however, not much on this topic has been reported in the Korean literature. Method: We studied cutaneous adverse reactions of gefitinib in 23 patients who suffered with non-small cell lung cancer at Chonnam National University Hwasun Hospital from October 2004 to September 2005. Result: The patients ranged from 23-72 years old, and there were 17 patients with adenocarcinoma, 5 with squamous cell carcinoma and 1 with bronchioloalveolar carcinoma. The most common adverse reaction was acneiform eruptions in 15 patients (65.2%). This reaction appeared within 2 months after medication, and it didn`t correlate with the therapeutic response and tumor type. Pruritus was the second most common reaction (39.1%), which was mild and generalized, especially around eyelid area. Xerosis (26.1%), exfoliation on palm and sole (21.7%), and paronychia (21.7%) followed. Hair breakage and intertrigo were rare adverse reactions. Conclusion: Various cutaneous adverse reactions were observed in patients with non-small cell lung carcinoma after gefitinib treatment. The skin complications could be alleviated with dermatologic consultations and treatments, skin complications could be alleviated. (Tuberc Respir Dis 2006; 61: 150-156)
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Skin tumors that dermatologists should know
윤숙정 ( Sook Jung Yun ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
As a dermatologist, all of us should know skin tumors. Especially, we should not mis-diagnose malignant skin tumors. However, in reality, there are lots of skin cancers that mimicking benign skin tumors or inflammatory skin diseases. In this talk, I want to show various interesting skin cancers that dermatologists should know. In addition, I will introduce various benign mimickers of each skin cancers. Epidermal skin cancers Actinic keratosis Squamous cell carcinoma in situ, Bowen’s disease Squamous cell carcinoma, Verrucous carcinoma Basal cell carcinoma Melanoma Skin appendage tumors Eccrine and apocrine tumors Sebaceous tumors Paget’s disease and extramammary Paget’s disease Mycosis fungoides and Lymphoma Leiomyosarcoma Kaposi’s sarcoma Angiosarcoma Dermatofibrosarcoma protuberans Metastatic carcinoma
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