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이은정 ( Eun Jung Lee ),이정옥 ( Jeong Ock Lee ),배광학 ( Kwang Hak Bae ),진보형 ( Bo Hyoung Jin ),백대일 ( Dai Il Paik ) 대한예방치과·구강보건학회 2011 大韓口腔保健學會誌 Vol.35 No.4
연구목적. 우리나라 국민의 우식발생을 억제시킬 목적으로 녹차폴리페놀의 우식예방효과를 구강내우식원세균수 변화와 구강내완충능 변화를 통해 간접적으로 관찰하여, 녹차의 우식예방효과를 측정하고자 한다. 연구방법. 우식발생가능성이 높은 연령대의 집단을 대상으로 녹차가 아동의 치아우식 발생에 미치는 영향을 조사하기 위하여서울시에 소재하는 초등학교 4학년 254명을 연구대상으로 하여 실험군(n=131)에게 아침 등교 후와 점심식사 후 매일 2회 신선한 녹차를 12개월 동안 마시도록 하였고 대조군(n=97)은 녹차를 마시지 않도록 하였다. 세계보건기구의 기준에 따라 연구시작시점과 6, 12개월 후의 우식경험영구치아를 조사 하였으며, 연구대상자의 자극성타액을 수집하여 구강 내 S. mutans수와 Lactobacillus 수 및 타액완충능의 변화를 비교 검토하였다. 연구결과. 우식경험영구치아수는 녹차비음용군보다 녹차음용군에서 둔화되었고(p=0.8065) S. mutans는 녹차음용군에서 녹차비음용군보다 감소하였다(p=0.0031). Lactobacillus는 녹차음용군과 녹차비음용군 간에 유의적으로 감소하였으며(p=0.0006), 타액완충능은 녹차음용군에서 녹차비음용군보다 증가하였다(p<0.0001). 결론. 녹차 음용에 의해 구강 내 S. mutans수의 증가가 억제되고 타액 완충능이 증가 되는 양상을 보이므로, 우식발생 가능성이 높은 집단에서의 녹차음용법은 구강건강을 증진시키는 모델로 활용될 수 있을 것으로 검토되었다.
이형규(Hyeong Kyu Lee),변순정(Soon Jung Byon),오세량(Se Ryang Oh),김정일(Jung Il Kim),김영호(Young Ho Kim),이정옥(Chong Ock Lee) 한국생약학회 1995 생약학회지 Vol.25 No.4
A new diterpene, agastanol[l] with dehydroagastol[2] was isolated from the root of Agastache rugosa, and their structures were elucidated by chemical and instrumental analysis. Agastanol[1], its derivatives, agastanone[3] and methylagastanol [5], and dehydroagastol[2] showed cytotoxic activities against in vitro human cancer cell lines. Agastanol[1] showed weak antifungal activity against Trichophyton rubrum.
한국산 고등균류의 성분 연구 (제41보) : 깔대기버섯의 항암성분
김유진(Yoo Jin Kim),우정원(Jung Won Woo),이정옥(Chong Ock Lee),정경수(Kyung Soo Chung),최응칠(Eung Chil Choi),김병각(Byong Kak Kim) 한국생약학회 1982 생약학회지 Vol.13 No.4
A macromolecular fraction prepared from the aqueous extract of the carpophores of Clitacybe infundibuliformis, an edible mushroom, which were collected at the Gwang-neung area, Gyeong-Gi Province in 1981, was investigated for antitumor activity against sarcoma 180 in mice. The inhibition ratio of this fraction against the tumor was 55% at the dose of 20㎎/㎏/day. This fraction was found to contain a polysaccharide and a protein. The hydrolysate of the polysaccharide yielded four monosaccnarides: xylose (68. 5%), glucose (14. 6%), galactose (6. 8%), mannose(10.1%).
새로운 5-치환 Uracil 유도체의 합성 및 생물활성
이원희(Won Hui Yi),박정섭(Jung Sup Park),원정희(Jeong Hee Won),이정옥(Chong Ock Lee),유응걸(Eung K. Ryu) 대한약학회 1991 약학회지 Vol.35 No.6
Six novel 5-substituted-1-[2-(3-methoxy-2-hydroxyphenyl)-l-methoxyethyl]uracils 2a-f were prepared by condensation of 2,4-bis(trimethylsilyloxy)-5-substituted uracils with 2,7-dimethoxy-2,3-dihydrobenzofuran (9) in the presence of Lewis acid. The 2,3-dihydrobenzofuran derivative 9 was obtained by intramolecular acetalization of 2-acetoxy-3-methoxyphenyl acetaldehyde (8) which was synthesized by oxidative cleavage of 1-allyl-2-acetoxy-3-methoxybenzene (7) using osmium tetroxide followed by NaIO4. Compounds 2a-f were evaluated for in vitro antiviral activity against HSV-1, HSV-2 and HRV. None of these compounds showed activity with ID50) values up to 100 mcg/ml except for 5-chlorouracil derivative 2d which exhibited antiviral activity against HSV-1 with ED50) 30 mcg/ml. In the antitumor activity against L1210 and P388 leukemia cell lines, 2d showed activity with ID50 values of 14 mcg/ml and 11.6 mcg/ml, and 2c with ID50 values of 22.9 mcg/ml and 8.8 mcg/ml, respectively.
Benzotriazepin 유도체의 암세포에 대한 다약제내성 억제효과
김미혜(Mi Hye Kim),최상운(Sang Un Choi),최은정(Eun Jung Choi),김성수(Sung Soo Kim),최중권(Jung Kwon Choi),안진희(Jin Hee Ahn),이정옥(Chong Ock Lee),권광일(Kwang ll Kwon) 대한약학회 2005 약학회지 Vol.49 No.1
The occurrence of resistance to chemotherapeutic drugs is a major problem for successful cancer treatment. This resistant phenotype of cancer cell frequently reveals a broad spectrum to structurally and/or functionally unrelated anti-cancer drugs, termed multidrug resistance (MDR). Overexpression of P-glycoprotein (P-gp), a transmembrane drug efflux pump, is a major mechanism of MDR. Accordingly, considerable effort has been directed towards to development of compounds that inhibit P-gp, reverse the MDR phenotype and sensitize cancer cells to conventional chemotherapy without undesired toxicological effects. In an effort to search for novel MDR reversal agent, we tested the cytotoxicity of paclitaxel, a well-known substrate of P-gp, against P-gp-expressing HCT15 and HCT15/CL02 human colorectal cancer cells in the presence or absence of benzotriazepin analogues, as well as against P-gp-negative A549 human non-small cell lung and SK-OV-3 human ovarian cancer cells in vitro. Among the compounds tested, the agents that have phenyl amide moiety at 3 position remarkably increased the cytotoxicity of paclitaxel against P-gp-expressing cancer cells, but not against P-gp-negative cancer cells. BTZ-15 and BTZ-16 at 4μM revealed similar MDR reversal activity to 10μM verapamil, a well-known MDR reversal agent.
권학철(Hak Cheol Kwon),문형인(Hyung In Moon),최상훈(Sang Hoon Choi),이정옥(Jung Ock Lee),조세연(Sae Yun Cho),정이연(I Yeon Jung),김선여(Sun Yeou Kim),이강노(Kang Ro Lee) 대한약학회 1999 약학회지 Vol.43 No.2
The acivity-guided fractionation on the MeOH extract of Bombycis corpus inoculated by Beauberia bassiana 101A led to the isolation of two steroids, 24-ethylcholest-4-ene-3,6-dione (1) and ergosterol peroxide (2), as active principles. Compounds 1 and 2 exhibited cytotoxicity against cultured human tumor cell fines, A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 with ED50 values ranging from 3.42 to 11.37mcg/ml.
김정우,김성원,김병각,최응칠,이정옥,이경림,김하원 한국균학회 1985 韓國菌學會誌 Vol.13 No.1
Antitumor components were obtained from the cultured mycelia of Pleurotus pulmonarius by ethanol precipitation. The protein-bound polysaccharide was subjected to DEAE-Sephadex column chromatography and Sephadex G-200 gel filtration. The antitumor fraction C₁ was isolated. The inhibition ratio of fraction C₁ was 81.8% in the doses of 10 ㎎/㎏/day for 10 days. The antitumor fraction C₁ consisted of a polysaccharide and a protein. The protein-moiety was composed of 14 amino acids. From the peritoneal cell populations in the mice given antitumor fraction C₁, the injection of the fraction caused the influx of peritoneal macrophages at two days when compared with those of soluble starch. This was named pulmonaran after its species name.
Cytotoxic Constituents from Solidago virga-aurea var. Gigantea MIQ
Sung, Jong Hoon,Lee, Jung Ock,Son, Jong Kun,Park, No Sang,Kim, Mi Ran,Kim, Jae Gil,Moon, Dong Cheul 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-
Activity-guided fractionation of the whole plant of Solidago virga-aurea var. gigantea M_(IQ)(Compositae) has led to the isolation of three cytotoxic compounds, erythrodiol-3-acetate(1), α-tocopherol-quinone (2), and trans-phytol (3) from the hexane soluble fraction. It is the first report of those compounds from the genus.