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Thymidylate Synthesis의 Multisubstrate analog Inhibitor의 합성
곽인영,유응걸,Kwak, In-Young,Ryu, Eung-K 배재대학교 자연과학연구소 1991 自然科學論文集 Vol.4 No.-
The pyrimidy1 derivative of 2'-deoxythmidine 5'-monophosphate, 3 has been synthesized for the development of anticanncer agents. The compound 3 derived from prototype inhibitor 2 by modifying the p-aminobenzoy1 glutamic acid portion has been designed to facilitate the membrane penetration. Variable temperature $^1H$ NMR spectrum for the protected nucleotide has indicated the existence of two conformers which are stable on the NMR time scale at ambient temperature.
새로운 5-치환 Uracil 유도체의 합성 및 생물활성
이원희(Won Hui Yi),박정섭(Jung Sup Park),원정희(Jeong Hee Won),이정옥(Chong Ock Lee),유응걸(Eung K. Ryu) 대한약학회 1991 약학회지 Vol.35 No.6
Six novel 5-substituted-1-[2-(3-methoxy-2-hydroxyphenyl)-l-methoxyethyl]uracils 2a-f were prepared by condensation of 2,4-bis(trimethylsilyloxy)-5-substituted uracils with 2,7-dimethoxy-2,3-dihydrobenzofuran (9) in the presence of Lewis acid. The 2,3-dihydrobenzofuran derivative 9 was obtained by intramolecular acetalization of 2-acetoxy-3-methoxyphenyl acetaldehyde (8) which was synthesized by oxidative cleavage of 1-allyl-2-acetoxy-3-methoxybenzene (7) using osmium tetroxide followed by NaIO4. Compounds 2a-f were evaluated for in vitro antiviral activity against HSV-1, HSV-2 and HRV. None of these compounds showed activity with ID50) values up to 100 mcg/ml except for 5-chlorouracil derivative 2d which exhibited antiviral activity against HSV-1 with ED50) 30 mcg/ml. In the antitumor activity against L1210 and P388 leukemia cell lines, 2d showed activity with ID50 values of 14 mcg/ml and 11.6 mcg/ml, and 2c with ID50 values of 22.9 mcg/ml and 8.8 mcg/ml, respectively.
Dong Ju Jeon(전동주),Young Mi Kim(김영미),Kwaun Yong Park(박관용),Hyoung Rae Kim(김형래),Jong Hwan Song(송종환),Jin-Seog Kim(김진석),Eung K Ryu(유응걸) 한국농약과학회 2001 농약과학회지 Vol.5 No.3
A series of bicyclic 4,5,6,7-tetrahydroindazole derivatives 6 have been synthesized, and their herbicidal activities were studied in flooded paddy condition. The compounds 6 showed herbicidal effects to bamyardgrass and Monochoria and good tolerance against rice at a rate of 0.063 ㎏/㏊~0.25 ㎏/㏊.
Synthesis and Herbicidal Activity of New N-{5-[(Pyrazolylmethyl)oxy]phenyl}imides
Kyoung-Mahn Kim(김경만),Jong Hwan Song(송종환),Dong Ju Jeon(전동주),Hyoung Rae Kim(김형래),Jung Sup Choi(최정섭),Do-Yeon Oh(오도연),Eung K. Ryu(유응걸) 한국농약과학회 2000 농약과학회지 Vol.4 No.2
3,4-Dimethyl-N-[4-chloro-2-fluoro-5-{(pyrazolylmethyl)oxy}phenyl]maleimides or 3,4,5,6-tetrahydro-N-[4-chloro-2-fluoro-5-{(pyrazolylmethyl)oxy} phenyl]phthalimides were prepared and evaluated their herbicidal activities under paddy conditions. Those compounds which have N-methyl-5-pyrazolylmethyloxy moiety showed good tolerance in transplanted rice and strong herbicidal activities on bamyardgrass below 60 g/㏊ of dose.
새로운 2-(5-Propargyloxyphenyl)-4,5,6,7-tetrahydro-2H-indazole의 합성과 제초활성
전동주(Dong Ju Jeon),박관용(Kwaun Yong Park),김영미(Young Mi Kim),김형래(Hyoung Rae Kim),송종환(Jong Hwan Song),황인택(In Taek Hwang),유응걸(Eung K Ryu) 한국농약과학회 2001 농약과학회지 Vol.5 No.4
Of the cyclic imide type compounds, S-275 was known to exhibit a potent herbicidal effects. We have designed and synthesized the compounds having diverse substituents in place of the chlorine group of bicyclic 4,5,6,7-tetrahydroindazole part of S-275. Their herbicidal activities were studied under flooded paddy conditions. The results showed that the most compounds gave relatively weak herbicidal activities, whereas the compound substituted with methylthio group showed potent herbicidal effects against paddy weeds at a rate of 0.015 ㎏/㏊ and improved tolerance on rice compared to S-275.