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A Study on Cerebral Ischemia-Reperfusion Injury: Involvement of Platelet-Activating Factor
이원석,임병용,홍기환,Lee, Won-Suk,Rhim, Byung-Yong,Hong, Ki-Whan The Korean Society of Pharmacology 1993 대한약리학잡지 Vol.29 No.1
뇌의 허혈-재관류 손상에 있어서 혈소판 활성인자 (PAF, platelet activating factor)의 관련을 증명하기 위하여 흰쥐와 생쥐에서 양측 총경동맥을 10분간 결찰하고 그후 6시간동안 재관류시켜 허혈-재관류 손상을 야기시켰다. 생쥐에 PAF 길항제인 BN52021과 CV6209 (각각 1 mg/kg, i.p.)를 총경동맥결찰 10분전 또는 재관류 시작 1시간 후에 투여시 McGram stroke index는 심하게 억제되었다. 흰쥐와 생쥐에서 뇌허혈-재관류에 의한 뇌수분함량의 증가는 BN52021 또는 CV6209 전처치에 의하여 유의하게 억제되었다. BN52021 전처치는 허혈 후의 혈압변동을 개선시켰을 뿐만 아니라 뇌연막동맥의 확장지연에 대하여도 효과가 있었다. 이러한 실험결과로 보아 PAF가 뇌허혈-재관류 손상의 발생에 내인성 인자로서 중요한 역할을 하는 것으로 사료된다. 나아가 PAF 길항제가 뇌허혈후의 병리학적 후휴증의 개선 내지는 예방에 사용 될 수 있을 것으로 기대된다. To elucidate involvement of platelet-activating factor (PAF) in cerebral ischemia-reperfusion injury, male Sprague-Dawley rats and albino mice of either sex were subjected to a 10-min bilateral carotid artery occlusion and 6-hr recirculation. The McGraw stroke index in mice was markedly inhibited by PAF antagonists, BN 52021 and CV 6209 (1 mg/kg, i.p., each) When they were administered 10 min before bilateral carotid artery occlusion or 1 hr after reperfusion. The increases in brain water content were significantly attenuated by treatment with BN 52021 or CV 6209 in both animals. BN 52021 exhibited a significant improvement in the postischemic blood pressure change in association with a beneficial effect on the delayed dilatation of pial arterioles after 10 min of ischemia. Thus it is suggested that PAF plays an important role as an endogenous mediator in development of cerebral ischemia-reperfusion injury, and further, specific antagonists to PAF will be able to prevent or reverse the pathological sequelae of cerebral ischemia.
이원석,신동민,이규철,Lee, Won-Suk,Shin, Dong-Min,Lee, Kyu-Chul 한국정보통신학회 2007 한국정보통신학회논문지 Vol.11 No.8
유비쿼터스 환경으로 발전하면서 이종의 디바이스들을 자연스럽게 연동시킬 수 있는 기술에 대한 요구가 크게 증가하고 있으며, 이를 해결하기 위한 하나의 대안으로 웹서비스가 주목받고 있다. 최근 디바이스 연동을 선언적인 ECA(Event-Condition-Action) 룰로 정의하고 이를 이용하여 디바이스 연동을 수행할 수 있는 웹서비스 기반의 WS-ECA(Web Services-ECA) 프레임워크가 제안되었다. 본 논문에서는 WS-ECA 프레임워크에 대한 구체적인 모듈 단위의 설계 부분을 제안하고, 이를 기반으로 WS-ECA 프레임워크를 구현하였다. Requirement of coordination among heterogeneous devices is significantly increasing to meet the challenges presented by the evolvement of the ubiquitous computing environment. The web services technology is receiving much attention as a promising solution to support the inter-operability between such heterogeneous devices by means of well-defined protocol. Recenlty, ECA(Event-Condition-Action) rule-based framework for coordinating devices is proposed, which is called WS-ECA(Web Services-ECA) framework In this paper we propose a specific design and an implementation methodology for WS-ECA framework.
이원석,임병용,홍기환,Lee Won-Suk,Rhim Byung-Yong,Hong Ki-Whan The Korean Society of Pharmacology 1986 대한약리학잡지 Vol.22 No.1
후신경구절제(OB) 흰쥐에 있어서 muricide의 발생은 중추성 ${\alpha}$-adrenoceptors의 기능항진과 밀접한 관계가 있다는 가설하에 다음 실험을 행하였다. Muricide를 일으키는 OB 흰쥐의 전뇌내 noradrenaline(NA)의 전환율은 대조군에 비하여 현저히 낮았으나 $_{{\alpha}_2}$-adrenoceptor 길항약물인 yohimbine이나 idazoxan 투여시 NA 전환은 muricide의 억제와 함께 현저히 증가되었다. OB흰쥐의 전뇌 피질막의 $[^3H]$ yohimbine에 대한 최대결합능(Bmax)은 대조군에 비하여 현저히 높았다. ${\alpha}$-Adrenoceptor 효능약물 및 길항약물에 대한 친화도는 아무런 변동이 없었다. 이상의 결과로 보아 OB흰쥐에서 야기되는 muricide는 중추성 ${{\alpha}_2}$-adrenoceptor의 기능 항진과 밀접한 관련이 있다고 사료되는 바이다. The involvement of central $_{{\alpha}2}$-adrenoceptors in the development of muricide (mouse-killing behavior) in the olfactoly bulbectomized (OB) rats was strudied. The fractional turnover rate of noradrenaline (NA) in forebrain from OB muricidal rats was significantly lowered than that from sham rats. However, after yohimbine or idazoxan treatment, NA turnover was significantly increased in concert with inhibition of the development of muricide in OB rats. By radioligand binding studies with $[^3H]$ yohimbine, the maximum binding $(B_{max})$ of $[^3H]$ yohimbine to cerebral cortical membrane from OB rats was significantly higher than that from sham rats without change of affinity for agonists and antagonists$(K_i)$. With these results it was suggested that muricidal behavior of OB rats has a close relevance to the hyperactivity of central $_{{\alpha}2}$-adrenoceptor system.
빅데이터기반 귀농·귀촌 통합플랫폼 사용의도에 영향을 미치는 요인에 관한 연구
이원석 ( Won Suk Lee ),장상현 ( Sang-hyun Jang ),하승재 ( Seung-jae Ha ),신용태 ( Yongtae Shin ) 한국정보처리학회 2021 한국정보처리학회 학술대회논문집 Vol.28 No.1
한국 농업·농촌의 고령화 현상과 농업인구의 감소가 점차 심화됨에 따라 귀농·귀촌을 통한 인구 유입이 절실한 상황이다. 이를 위해서 귀농·귀촌 희망자가 의사결정 시에 도움을 받을 수 있는 귀농·귀촌 통합플랫폼을 구축 예정이다. 따라서 본 연구를 통해 빅데이터기반 귀농·귀촌 통합플랫폼 사용의도에 영향을 미치는 요인들을 분석하여 실제 플랫폼 구축 시 필요한 시사점을 도출하고자 한다.
이원석 ( Lee Won-suk ),김선우 ( Kim Sun-woo ),윤현도 ( Yun Hyun-do ),김대중 ( Kim Dae-joong ),최경렬 ( Choi Kyoung-lyoul ),강선종 ( Kang Sun-jong ),박동순 ( Park Dong-soon ) 한국구조물진단유지관리공학회 2005 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.9 No.2
Recently, construction wastes are increasing every year. So problem of environmental pollution and lack of natural aggregate are serious, but there are no appropriate design recommendations. This paper reports limited experimental data on the structural performance of reinforced concrete beams with recycled aggregate. The variables in the test program were the existence of shear reinforcement and use of recycled aggregate. Reinforced concrete beams with natural aggregate and recycled aggregate were tested to evaluate their failure modes, shear behavior and crack pattern. Based on the experimental results, shear strength and failure mode of R/C beams with recycled aggregate were about equal to those of R/C beams with natural aggregate.
이원석 ( Won Suk Lee ),호종관 ( Jong Kwan Ho ),김선국 ( Sun Kuk Kim ) 한국건축시공학회 2009 한국건축시공학회 학술발표대회 논문집 Vol.9 No.2
With the increasing use of tower cranes higher than free standing height, the importance of lateral support is also growing. Since the fall of 43 tower cranes hit by the last typhoon ‘Mami’ in 2003, regulations and concerns about safety of construction equipment have increased and construction laws regarding lateral support have been strengthened. In Korea, where there are many large-scale apartment housing construction works with the development of new towns, Rope Guying is a more economical construction method than Wall Brace which fixes building structure like building wall and slab. The safety of this Rope Guying is not verified and many construction works are still carried out based on the experience of site managers. There has been no case of construction work where frame and measurements are applied. The objective of this study is to examine the safety of Rope Guying method and ensure the effective implementation of equipment and prevention of disasters.
연삭 휠 형상 복합가공시스템의 구조 안전성에 관한 연구
이원석(Won-Suk Lee),안범상(Beom-Sang An),김진현(Jin-Hyeon Kim),이종찬(Jong-Chan Lee),우봉근(Bong-Geun Woo),이영식(Young-Sik Lee) 한국기계가공학회 2016 한국기계가공학회지 Vol.15 No.2
This study evaluated the structural safety of a heavy-duty integrated machine for grinding wheel forming. Structural analysis was performed to evaluate the structural safety of the base. The base was designed by dividing the single base and detachable base. The analysis conditions were applied to the own weight and the load of component parts. From the structural analysis results, although the stress of the detachable base was decreased, the amount of deformation was increased. If the deformation of the detachable base decreases, it is expected to be safer than the single base.
귀농·귀촌 의사결정요인에 관한 AHP 분석 연구: 이주지역 선택 결정요인을 중심으로
이원석 ( Won Suk Lee ),장상현 ( Sang-hyun Jang ),최주원 ( Joowon Choi ),신용태 ( Yongtae Shin ) 한국정보처리학회 2021 정보처리학회논문지. 컴퓨터 및 통신시스템 Vol.10 No.3
As the aging population of Korean agriculture and rural areas and the decline of the agricultural population are gradually deepening, the influx of population through returning to farming and rural areas is urgently needed. To this end, the most important problems to be solved were the lack of information that would help those who want to return to farming or rural areas when making decisions. Therefore, a survey was conducted for AHP analysis on related experts to find out the information (decision factors) required when selecting a return-to-farm or return-to-country migration area through this study. The AHP analysis showed that Economic factors were the most important among the three items in the primary class, while Housing and land prices, Metropolitan accessibility and traffic and Residential information were the most important in the secondary class. The results of these studies are reflected in the information system to systematically support the decision-making of those who wish to return to farming or rural areas.It is hoped that it will be indirectly helpful and ultimately contribute to the revitalization and development of Korean agriculture and rural areas, which are aging.