천문학의 발생과 발전과정

이용복,Lee, Yong-Bok 한국과학기술단체총연합회 1998 과학과 기술 Vol.31 No.10

유제화에 의한 경구용 항암제인 테가푸르의 장관 임파수송

이용복,남권호,장우익,오인준,고익배,Lee, Yong-Bok,Nam, Kweon-Ho,Chang, Woo-Ik,Oh, In-Joon,Koh, Ik-Bae 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.1

W/O and O/W emulsions of tegafur (50 mg/5 ml/kg) were orally administered to rats to compare with their mesenteric lymphatic delivery effects. And also in order to demonstrate the lymph targeting associated to the oral route, it was deemed necessary to investigate the fate of solution after oral administration as a control. Lymph and plasma samples were periodically taken from each subject of mesenteric lymphatic duct cannulated rats. Then, lymph and plasma levels of tegafur and its active metabolite, 5-FU, were simultaneously observed. Also pharmacokinetic parameters were compared with each others. On the other hand, most previous studies of lymphatic transport have not addressed the question of whether an increase in mesenteric or thoracic lymph transport by the manipulation of a suspected variable was due to a selective delivery to the intestinal lymphatics or an overall increase availability. Therefore, based on a physiologically based pharmacokinetic model which represents the characteristics of lymphatic systems, we are also going to determine the contributions of mesenteric lymph transport versus thoracic lymph transport of tegafur reported in reference(13). In comparison with tegafur solution, AUC and mean residence time of plasma tegafur were significantly increased in W/O emulsion but significantly decreased in O/W emulsion. Lymph flow rates were similar in both solution and W/O emulsion but half in O/W emulsion. AUC of tegafur in mesenteric lymph and in plasma for W/O emulsion were 3.7 times and 2.9 times more than those for O/W emulsion, respectively. And AUC of 5-FU in thoracic lymph for W/O emulsion was 3.7 times more than that for O/W emulsion. These results suggested that lymphatic delivery or tegafur by W/O emulsion was more effective than that by on emulsion due to its differences or formation ability of chylomicrons.

회전체 동역학 및 트라이볼로지 요소의 연구동향

이용복,Lee, Yong-Bok 한국유체기계학회 2011 한국유체기계학회 논문집 Vol.19 No.6

십자형 필릿 용접부에서 재료 두께 및 용접 층수에 따른 피로파괴 특성

이용복,Lee, Yong-Bok 대한용접접합학회 2010 대한용접·접합학회지 Vol.28 No.6

Most of joining processes for machine and steel structure are performed by butt and fillet welding. The mechanical properties and fatigue strength of their welding zone can be effected largely by the differential of generated heat and changes of grain size according to thickness of material and number of passes in welding process. In this study, it was investigated about characteristics of fatigue failure according to thickness of material and number of passes in cruciform fillet weld zone as the basic study for safe and economic design of welding structures. Fracture modes in cruciform fillet weld zone are classified into toe failure and root failure according to non-penetrated depth. It can be accomplished economic design of welding structures considering fatigue strength when the penetrated depth in fillet weld zone is controled properly.

십자형 필릿 용접부에서의 피로파괴 형상과 특성

이용복,정준기,박상흡,Lee, Yong-Bok,Chung, Joon-Ki,Park, Sang-Heup 대한용접접합학회 2011 대한용접·접합학회지 Vol.29 No.4

The proportion of the welding in the production process of machinery, buildings and marine structures is increasing and the joining are mainly conducted by butt and fillet weld. In the case of fillet weld, the shape of structures is complicated depending on the constraint on the geometry of the structures, therefore, the full penetration is mostly difficult. Accordingly, it is necessary to establish safe and economical criteria of design of the structures through the strength based on the penetration state of the fillet weld. Patterns of fatigue failure in cruciform fillet weld jont appear in the form of the root, toe and mixed failure. In the case of toe and mixed failure, the fatigue strength is higher than root failure. Therefore, we have to make the enough depth of penetration or perform the welding work through improving the fatigue strength of cruciform joints in welded structures. So it is necessary to optimize the penetrated depth in the range of the possible mixed failure and find the way in the cost-effective design to lessen the amount of the welding work.

훈련용 워게임 모델의 부대 DB를 분석용 워게임 모델에 재사용하기 위한 변환방법 연구 : 창조21모델과 비전21모델을 중심으로

이용복,박민형,김익현,Lee, Yong-Bok,Park, Min-Hyoung,Kim, Yeek-Hyun 한국시뮬레이션학회 2019 한국시뮬레이션학회 논문지 Vol.28 No.2

국방 M&S(Modeling&Simulation) 분야에서는 다양한 전투 환경을 동시에 모의하기 위해 다수의 워게임 모델을 연동하는 연구를 활발하게 추진하여 성과를 달성하고 있으나, 워게임 모델을 운용하기 위한 부대 DB(DataBase)는 동일한 자료임에도 불구하고 데이터의 속성(메타데이터)에 대한 표현 방법이 달라서 상호참조가 불가능한 것으로 인식되어 왔다. 이로 인해 워게임 모델을 운용하는 기관에서 같은 부대 DB를 각각 구축하기 위한 시간과 노력의 중복이 발생하고 있다. 본 연구에서는 해상도와 모의 논리는 유사하지만 도메인이 다른 훈련용 워게임 모델의 부대 DB를 분석용 워게임 모델에서 재사용하는 방법을 연구하여 실제 분야에 적용했다. 이를 위해 군단 및 사단 전투지휘훈련용 모델인 '창조21 모델'과 군단 및 사단 작전계획 모의분석용 모델인 '비전21 모델'의 부대 DB 메타데이터를 분석하여 부대 DB를 전환하는 절차를 정의하고, 부대 DB의 서로 다른 메타데이터를 매핑하는 알고리즘을 제안하였다. 본 연구는 국방 M&S 분야에서 워게임 모델 간 부대 DB의 재사용을 위해 이질적인 메타데이터를 의미상으로 통합하여 매핑을 시도한 최초 사례로서 의의가 있다. 또한, 국방 M&S 분야에서 워게임 모델 간 부대 DB의 재사용이 가능하다는 패러다임 전환과, 부대 DB 메타데이터의 표준화 필요성에 대한 시사점을 제공하였다. In the field of defense M&S, we are actively pursuing researches that interoperable multiple war game models to simulate various combat environments at the same time. Although the 'unit DB(Database)' for operating the war game models is originated from the identical data, it has been recognized that the method of expressing the attribute of the data is different and the cross reference is impossible. As a result, it makes unnecessary time and effort in establishing the same unit DB in the organizations that operate the war game model. In this study, a method of reusing the unit DB of the training war game model to the analysis war game model with similar resolution and simulated logic was applied to the actual field. For this purpose, we defined the procedure for converting the unit DB by analyzing metadata of the 'Chang-Jo21', a combat training model for corps and division, and the 'Vision21', an analysis model for corps and division operation plan. And we introduced an algorithm that can map different metadata of two unit DBs. This study was meaningful as the first attempt to map and integrate heterogeneous metadata semantically for the reuse of unit DB between different war game models in defense M&S field. Also, it provided implications for the necessity of paradigm shift that reuse of the unit DB between two different war game models is possible and the need for standardization of the unit DB metadata in the defense M&S filed.

공공기관의 입장에서본 AI

이용복,Lee, Yong-Bok 한국과학기술단체총연합회 1987 과학과 기술 Vol.20 No.11

고압 터보 펌프의 실 및 로토다이나믹스 연구

이용복,김창호,Lee, Yong-Bok,Kim, Chang-Ho 한국유체기계학회 2004 한국유체기계학회 논문집 Vol.20 No.3

시메티딘이 간혈류량에 미치는 영향 - Rat에 있어서 Indocyanine Green의 체내 동태를 중심으로 -

이용복,고익배,Lee, Yong-Bok,Koh, Ik-Bae 한국임상약학회 1993 한국임상약학회지 Vol.3 No.2

The influence of cimetidine pretreatment(100mg/kg, single i.p.) on the hepatic blood flow was investigated using pharmacokinetic parameters of indocyanine green(ICG) in the rat on the basis of hepacc perfusion-limited model. ICG(1mg/kg) was respectively administered via femoral and portal vein to the control and to the cimetidine-pretreated rats. The rate constant K12, K20 and the systemic clearance(CLt) of ICG were significantly(p<0.05) decreased ill the cimetidine-pretrea-to(B rats, but no significant diffirences were observed in hematocrit and liver weight. The biliary excretion rates of ICG were also decreased regardless of the route of administration in the cimetidine-pretreated rats. And also the hepatic blood flow in rats was decreased about $16\%$ by cimetidine. It may be concluded that the decreased hepatic blood flow with cimetidine mainly contributed to the decreased hepatic uptake and the decreased systemic clearance of ICG.

흰쥐 분리 간세포에 있어서 딜티아젬의 간클리어런스에 미치는 페노바르비탈의 영향

이용복,오준교,고익배,Lee, Yong-Bok,Oh, Joon-Kyo,Kho, Ik-Bae 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.1

In order to study the effect of phenobarbital(PB) on the hepatic transport of diltiazem(DTZ), $Ca^{2+}$ channel blocker, we used isolated hepatocytes of rat which was intraperitoneally pretreated with phenobarbital sodium(75 mg/kg) for four days once a day. For the isolation of rat liver cells, a modification of the two step procedure of Seglen was used. DTZ was dissolved in incubation buffer to the final DTZ concentrations of 200, 400, 600, 800 and 1000 ng/ml in order to elucidate the uptake characteristics of DTZ by hepatocytes. Reactions were stopped at 10, 20, 30, 45, 60, 90, 120 and 300 sec. The initial velocity was determined by disappearance of diltiazem in the hepatocyte suspension. On the other hand, to determine the effect of PB on the in vitro hepatic intrinsic clearance of DTZ we obtained the metabolism rates of DTZ in the control and the PB-pretreated rat hepatocyte at various time intervals. According to pretreatment with PB, the size of hepatocyte and the amount of protein per $10^6$ cells were significantly (p<0.01) increased from $26.92{\pm}0.1364\;m$ to $35.31{\pm}1.00\;m$ and from $468{\pm}6.5\;{\mu}g/10^6$ cells to $628.8{\pm}12.1{\mu}g/10^6$ cells, respectively. In the case or hepatic uptake of diltiazem, $K_m$ was not different in the normalization by cell numbers and increased from $2.90\;{\mu}M\;to\;13.89\;{\mu}M$ in the normalization by protein amount. $V_max$ was increased regardless of normalization by protein amount and cell numbers, from $1.21\;{\mu}mole/min \;{\cdot}\;mg\;protein\;to\;3.96\;{\mu}mole/min\;{\cdot}\;mg\;protein\;and\;from\;2.38\;{\mu}mole/min\;{\cdot}\;10^6\;cells\;to\;2.83\;{\mu}mole/min\;{\cdot}\;10^6\;cells$, respectively. The in vitro hepatic intrinsic clearance of DTZ was significantly (p<0.01) increased from $0.640{\pm}0.038\;ml/mim\;{\cdot}\;10^6\;cells\;to\;2.385{\pm}0.212\;ml/min\;{\cdot}\;10^6\;cells$ due to PB-pretreatment. These results suggest that the uptake of DTZ by hepatocyte is extremely fast and PB enhances the hepatic intrinsic metabolic clearance of DTZ.