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백혈구증다증 환자에서 치료적 백혈구성분채집술의 임상적 효과 및 안전성
이세나,공선영,공정희,엄현석,이혜원,박현진,손지연 대한수혈학회 2014 大韓輸血學會誌 Vol.25 No.2
Background: Therapeutic leukapheresis is the cytoreduction procedure performed before chemotherapy in patientswith hyperleukocytosis for prevention of complication. However, there have been clinical concerns about bleedingtendency due to anticoagulant used during the procedure. The aim of our study was to compare the clinicalcharacteristics and hematological parameters before and after therapeutic leukapheresis in order to evaluate its effecton bleeding tendency and to provide a guideline for treatment strategy. Methods: The clinical data for 39 procedures of therapeutic leukapheresis performed on 17 patients withhyperleukocytosis from May 2005 to October 2013 at the National Cancer Center were reviewed retrospectively. Results: The patients consisted of 11 males and six females. The mean age was 41 years old (range, 8∼74). The mean number of therapeutic leukapheresis per patient was two (range, 1∼4). Clinical symptoms improvedin 14 patients (82%) after therapeutic leukapheresis and three patients (18%) were not yet to improve. The meanWBC count was significantly reduced by 32.6% (±17.4) after therapeutic leukapheresis, from 250,146/μL(±117,000) to 174,702/μL (±104,700) (P<0.001). The mean volume of single removal was 298 ml with4.25×1011/L (±1.54) WBCs. After therapeutic leukapheresis, the mean platelet count showed a decline from85×109/L (±43) to 71×109/L (±26). However, the prothrombin time (PT) and activated partial thromboplastin time(aPTT) did not show a significant increase (PT, P=0.637; aPTT, P=0.054). Conclusion: Therapeutic leukapheresis is demonstrated as an effective and safe treatment that can improvesymptoms and reduce leukocytes in hyperleukocytosis.
일부지역 성인의 흡연자와 비흡연자의 주관적 구강건강 인식과 잇솔질 형태
이세나,조민정,최윤정,김혜진,이민경,윤현서,이정화,Lee, Se-Na,Jo, Min-Jeong,Choi, Yun-Jeong,Kim, Hye-Jin,Lee, Min-Kyung,Yoon, Hyun-Seo,Lee, Jung-Hwa 한국임상보건과학회 2013 한국임상보건과학회지 Vol.1 No.2
Purpose: The purpose of this study was to provide basic data of oral health policy and effective nonsmoking educational the basic data comparing the subjective oral health recognition and tooth brushing pattern by smoking whether or not, the subjects were adults to visit dental clinic. Methods: The subjects were a total of about 245 adults visited dental clinics in Busan metropolitan city and Gyeongnam province some areas. The datas were collected from December 17, 2012 to February 17, 2013. Data analyses were done with SPSS program through frequency analysis and chi-square test. Results: The tooth brushing pattern of non-smokers were more brushing after meals and snacks, and then brushing within three minutes before bedtime and brushing with more than 3 minutes, brushing with rotating method is pretty more, smokers were not brushing after the meal, a snack, and then within 3 minutes before going to bed without brushing, more than three minutes brushing with rotation method. Subjective oral health status of non-smokers, the more awareness is pretty healthy, but smokers were the more unhealthy side, the greater the smoking amount among smokers subjective oral health were recognized as a bad side. Conclusion: It was necessary to recognize subjective oral health status and to provide a way to practice corrective brushing pattern according to smoking or not and smoking amount. Subjective oral health awareness and brushing pattern directly related to the smoking or not and smoking amounts of the subject, so when dental care, it should be followed to recognize exactly what to give oral health status of subjects and provide a way of effective oral health management in order to improve the oral health and quality of life.
이세나,위새미,민윤,이기영 대한면역학회 2016 Immune Network Vol.16 No.6
Peroxiredoxin-3 (Prdx3) is a mitochondrial protein of the thioredoxin family of antioxidant peroxidases and is the principal peroxidase responsible for metabolizing mitochondrial hydrogen peroxide. Recent reports have shown that mitochondrial reactive oxygen species (mROS) contribute to macrophage-mediated bactericidal activity in response to Toll-like receptors. Herein, we investigated the functional effect of Prdx3 in bactericidal activity. The mitochondrial localization of Prdx3 in HEK293T cells was confirmed by cell fractionation and confocal microscopy analyses. To investigate the functional role of Prdx3 in bactericidal activity, Prdx3-knockdown (Prdx3KD) THP-1 cells were generated. The mROS levels in Prdx3KD THP-1 cells were significantly higher than those in control THP-1 cells. Moreover, the mROS levels were markedly increased in response to lipopolysaccharide. Notably, the Salmonella enterica serovar Typhimurium infection assay revealed that the Prdx3KD THP-1 cells were significantly resistant to S. Typhimurium infection, as compared with control THP-1 cells. Taken together, these results indicate that Prdx3 is functionally important in bactericidal activity through the regulation of mROS.