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방광암 환자에서 방광내 BCG 점적술 시행 후 발생한 육아종성 간염 1 예
손주익(Ju Ik Son),정준표(Jun Pyo Chung),백승석(Seung Suk Paek),이정일(Jung Il Lee),김정환(Jung Hwan Kim),문병수(Byung Soo Moon),이관식(Kwan Sik Lee),이상인(Sang In Lee),문영명(Young Myoung Moon),박찬일(Chan Il Park),김혜령(Hae Ryoung 대한소화기학회 2002 대한소화기학회지 Vol.39 No.5
Granulomatous hepatitis is a rare but serious systemic complication of intravesical Bacillus Calmette- Guerin (BCG) therapy, which has been proved more effective than most chemotherapeutic agents in the treatment of superficial bladder tumors and carcinoma in situ. Recently, we experienced a 64 year-old male with granulomatous hepatitis which had occurred following an intravesical BCG immunotherapy for an adjuvant treatment of superficial bladder cancer. The patient took isoniazid (300 mg) due to fever that had developed soon after an intravesical BCG immunotherapy. When he presented with clinical features of hepatic failure and sepsis, it was difficult to differentiate granulomatous hepatitis from isoniazid- induced hepatotoxicity. The patient died 20 days after the intravesical BCG immunotherapy (2 days after liver biopsy). This case indicates that granulomatous hepatitis is a fatal complication of the intravesical BCG therapy. Thus, a close follow- up and prompt diagnostic effort with optimal treatment should be instituted. (Korean J Gastroenterol 2002 ; 39: 375-378)
직장 결장암의 간전이 환자에서 VEGF-A, C, D 발현의 비교연구
전광식(Kwang-Sik Chun),이경하(Kyung-Ha Lee),송인상(In-Sang Song),김지연(Ji-Yeon Kim),김제룡(Je-Ryong Kim),안문상(Moon-Sang Ahn),이상일(Sang-Il Lee),박종현(Jong-Hyun Park),최송이(Song-E Choi),강대영(Dae-Young Kang),송규상(Kyu-Sang Son 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.5
Purpose: We aimed to investigate the correlations between expressions of angiogenic cytokines VEGF-A, C, D of primary colorectal cancer and liver metastasis. Methods: We examined paraffin-embedded primary colorectal cancer tissue from 45 patients who had liver resection due to colorectal liver metastasis (metastasis group) and 37 patients who had surgical resection due to colorectal cancer only (control group). In the control group, local recurrence and distant metastasis had not occurred. Immunohistochemical staining for VEGF-A, C and D was performed. We analysed the correlations between expression of VEGF-A, C and D in primary colorectal cancer tissues and clinicopathologic parameters. Results: VEGF-A expressions of primary colorectal carcinoma were not different between the two groups. VEGF-C was more frequently expressed in the metastasis group (P=0.008) but VEGF-D was more expressed in the control group (P=0.003). Patients with VEGF-C negative and VEGF-D positive expression were predominant in the control group (P=0.020). Tumor location, T stage, lymph node metastasis and tumor differentiation were not related with the expressions of VEGF-A, C, D but only preoperative CEA was positively correlated with VEGF-A and C expression. Conclusion: Expressions of VEGF-C in primary tumor were more frequent in metastatic colorectal cancer and expressions of VEGF-D were more frequent in nonmetastatic colorectal cancer. More large-scale prospective studies for VEGF-C and D expression in colorectal cancer are necessary.
이상일,손정일,박문향,김향,김병익,김현승,박범준,송승오,이규백,박찬필 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.6
Although acute renal failure is common in patients with fulminant hepatitis, it has been recognized as a rare complication of non-fulrninant acute hepatitis A. So far about 30 patients have been described in the literature who had acute hepatitis A associated with acute renal failure. Variable renal biopsy findings have been described in previous reports, including mostly acute tubular necrosis, mesangial proliferative glomerulonephritis, and interstitial nephritis. But the exact mechanism by which hepatitis A causes acute renal damage is still obscure. We describe two cases with acute hepatitis A, proven by IgM anti-hepatitis A antibodies complicated by acute renal failure. One patient required hemodialysis. Kidney biopsy findings showed interstitial nephritis with no evidence of glomerular involvement. Our review of these cases and the relevant literature suggests that there is strong evidence to implicate hepatitis A virus as a cause of acute renal failure. It remains to be elucidated why the histologic features are variable in the cases of hepatitis A virus induced acute renal failure and which factors predispose a patients to have immunologic involvement versus interstitial and tubular involvement.
孫一文,李相道 동아대학교 공과대학 부설 한국자원개발연구소 1992 硏究報告 Vol.16 No.2
Modeling the decision making component of inspection is hampered by an incomplete understanding of the way in which humans internally represent information about inspection tasks. In inspection tasks, human are adept at thinking in fuzzy terms at least to the extent that their ratings of the degree to which objects belong to particular class are consistent. Therefore, the ratings can potentially reflect the fuzziness underlying human cognitive processes. In this study, it is considered that an application of fuzzy hierarchical analysis using fuzzy number for modeling the inspection tasks with respect to the cognitive factors. The results of the relative importance of various cognitive factors can serve as a selection criterion for efficient inspection performance and the information of skilled learning for an inspection training program.