Olanzapine이 백서의 Schedule-Induced Polydipsia에 미치는 영향

이기철,이경규,장환일,이정호,김현우,하준명,정재현,정홍경,Lee, Gi-Chul,Lee, Kyung-Kyu,Chang, Hwan-Il,Lee, Jung-Ho,Kim, Hyun-Woo,Ha, Jun-Myung,Jeong, Jae-Hyun,Jeong, Hong-Kyung 대한생물정신의학회 1999 생물정신의학 Vol.6 No.2

Object : This study was designed to evaluate the effects of olanzapine on the schedule-induced polydipsia(SIP) which is one of animal model of obsessive-compulsive disorder in rats. We administered olanzapine as a serotonin and dopamine blocking agent, fluoxetine as a selective serotonin reuptake inhibitor, and haloperidol for the dopamine antagonist to rats which showed schedule-induced polydipsic behavior. Methods : Spraque-Dawley rats weighing 200-250gm were individually housed and maintained and allowed free access to water. The rats were placed on a restricted diet. To induce polydipsia, rats were placed in the cage where a pellet dispenser automatically dispensed 90mg pellets on a fixed-time 60 seconds(FT-60s) feeding schedule over 150 minute test session per day. Water was available at all times in the cage. After 4 weeks of daily exposure to the FT 60s feeding schedule, experimental rats met a predetermined criterion for polydipsic behavior(greater than 3 times of water per session on average). 5 groups of rats were administered olanzapine(3mg/kg, i.p), olanzapine(10mg/kg, i.p), fluoxetine(5mg/kg, i.p.), haloperidol(0.1mg/kg, i.p.), and vehicle(1cc/kg, i.p.) for 3 weeks. The rats were tested once a week to access schedule induced polydipsic behavior. Water bottles were weighed before and after the 150-minute test session. The chronic effects of administration of experimental drugs on schedule induced polydipsic behavior were analyzed with ANOVA and Scheffe test as a posthoc comparison. In order to measure water consumption in non-polydipsic food-deprived rats, a separate group of rats(N=8) were individually housed and given a single bolus(14.5gm) of food per day which maintained them at their average body weight. Results and Conclusion : The results were as follows ; 1) After 4 weeks of scheduled feeding procedure, the experimental group showed significant differences than the bolus control in the amount of water consumption as compared with their average water intakes for 4 weeks. At the same periods, there were no differences between the experimental group and the bolus control in the body weight. 2) The fluoxetine group showed significant decrease in the amount of water intake over the 3 weeks of drug treatment as compared with their average amount of polydipsic water intakes. The olanzapine 3mg group showed significant decrease in the amount of water intake at 3rd weeks of drug treatment as compared with their average amount of polydipsic water intakes. The olanzapine 10mg group showed significant decrease in the amount of water intake at 2nd and 3rd weeks of drug treatment as compared with their average amount of polydipsic water intakes. However, the haloperidol group and the vehicle control group showed no changes of amounts of water intake for 3 weeks of treatment as compared with their average amount of polydipsic water intakes. 3) The fluoxetine group showed significantly lower amounts of water intake than the haloperidol group at 2nd weeks of drug treatment. And also the fluoxetine group showed significantly lower amounts of water intake than the haloperidol group and the vehicle control at 3rd weeks of drug treatment. The olanzapine 3mg group and the olanzapine 10mg group showed significantly lower amounts of water intake than the haloperidol group and the vehicle control at 3rd weeks of drug treatment. Above findings suggest that the fixed time feeding procedure for schedule-induced polydipsia as an animal model of obsessive compulsive disorder was effective to the evaluation of pharmacological challenge study. The authors assume that the serotonin hypothesis and the serotonin-dopamine interaction hypothesis are preferred to the dopamine hypothesis in the biological etiology of obsessive-compulsive disorder.

전력계통의 안정도 해석

이기철,Lee, Gi-Cheol 한국전자통신연구원 1982 전자통신 Vol.4 No.3

환경인의 자세

이기철,Lee, Gi-Cheol 환경보전협회 2001 환경정보 Vol.23 No.11

군집분석을 통한 전국 자연휴양림 유형분류

이기철,강기래,Lee, Kee-Cheol,Kang, Kee-Rae 한국조경학회 2009 韓國造景學會誌 Vol.37 No.1

자연휴양림이 도입된지 20년이 지나는 동안 휴양림마다의 특징성이 부각되어 각각의 휴양림이 가진 개성이 있음에도 불구하고 자연휴양림의 유형에 대한 분류가 거의 없는 실정이다. 본 연구는 자연휴양림의 공급적 측면과 이용적 측면을 고려한 유형분류를 실시하여 유형에 따른 효율적인 자연휴양림 운영관리 또는 자연휴양림에 관한 연구 시 연구지 선정의 기초 자료로서의 제공에 그 목적이 있다. 자연휴양림 유형분류를 위한 방법으로는 자연휴양림 유형분류를 위한 최적의 변수로 생각되는 항목들을 선정하기 위한 전문가 설문을 실시하여 전국 자연휴양림을 대상으로 현황설문조사를 실시하였다. 공통성 추출을 위한 요인분석 결과, 4개 요인으로 구분되어 각각의 명명을 변수의 속성과 크기에 따라 이용실적 지표요인, 교육적 지표요인, 내부 활동적 지표요인, 수용 잠재적 지표요인으로 명명하였다. 그리고 추출된 요인점수를 통하여 $85{\times}4$행렬의 군집분석을 시도하였다. 그 결과 5개 군집으로 최종 유형이 분류되었다. 본 연구를 통한 결과는 유형별 휴양림 운영방안 및 관리의 기초자료로 제공되어질 수 있을 것이다. 그리고 향후 자연휴양림의 조사지에 대한 선정 시 기초자료로 참고할 수도 있을 것이며, 또한 전국 자연휴양림의 유형을 제시함으로써 향후 휴양림 적지 선정에 있어서도 기초자료로 제공될 수 있을 것이다. Twenty years have passed since the adoption of natural recreation forests and each forest has its own characteristics. However, there is hardly any classification among the natural recreation forests. The purpose of this study is to classify the forests by considering the supplier's perspective as well as the user's perspective in order to provide fundamental materials for the operation of the natural recreation forests. A factor analysis was conducted to identify the common characteristics of the selected twelve variables by pre-selection and survey of experts. K-means cluster analysis was conducted among those factors to classify the natural recreation forests in Korea. Four factors were drawn after the factor analysis and the factors were named according to the variables and sizes as 'The use performance and visiting condition factor', 'Education and settlement factor', 'Internal activation factor' and 'Potential factor' In addition, the cluster analysis of an $85{\times}4$ matrix was conducted for the points of the drawn factors and the final classification consists of five groups. The results of this study may contribute to providing fundamental materials for the operation and management of natural recreation forests. Also, it may act as a reference when investigating the natural recreation forests of Korea. Proposing the classification natural recreation forests could be helpful in selecting the proper recreation forest in the future. Based on the established model, fundamental materials could be provided to improve the profitability of the natural recreation forests by effectively expanding the number of tourists, creating new natural recreation forests and proper maintenance and management.

자연휴양림 숙박시설만족도 모형연구

이기철,강기래,Lee, Kee-Cheol,Kang, Kee-Rae 한국조경학회 2007 韓國造景學會誌 Vol.34 No.6

Research into the use of recreation forest accommodations, the main facilities in these forests, and user satisfaction with them has been carried out for recreation forests in the suburbs of Daegusi and Gyongsangbukdo. This study aimed at providing background material to support the increasing demand to improve the facilities of recreation forests and to educate recreation forest staff about how to provide better service. User satisfaction with recreation forests as determined through regression analysis was affected by the following factors in this order: indoor recreation, the indoor space, outdoor recreation, time satisfaction factor, and activity opportunities. The level of satisfaction is affected by the force of factors above. The order of effective offerings of accommodations is presented according to the results.

상수관의 세척을 위한 회전식 스왑피그 공법 개발

이기철,김재호,김기성,박정준,Kicheol Lee,Jaeho Kim,Kisung Kim,Jeongjun Park 한국지반신소재학회 2024 한국지반신소재학회 논문집 Vol.23 No.2

마시는 물은 인간의 기본적인 생활권 보장을 위한 필수적 요소로 깨끗한 물에 대한 품질은 항상 확보되어야 한다. 하지만 국내 수도시설을 집중 설치하였던 2000년 초반을 기점으로 현재 노후 상수도 시설이 증가하고 있으며, 색도 및 탁도와 같은 물의 변색, 이물질 누출 등의 사고가 빈번히 발생하고 있다. 실제로 모든 관의 교체는 불가능하기 때문에 2021년 제정된 상수관망시설 유지관리업무 세부기준에서는 상수관 세척을 의무화 하였으며, 다양한 세척 공법들을 통해 유지관리가 이루어지고 있는 실정이다. 상수관 세척 공법 중 스왑피그 공법은 관 내 이물질을 물리적으로 제거하는 방법으로 세척 효율이 가장 높은 것으로 평가 받고 있다. 하지만, 세척과정에서 스왑피그의 파손 및 변형에 따라 세척 효율은 변화하며, 분실의 가능성이 존재한다. 따라서 본 연구에서는 피그 자체의 재료를 변경하여, 압축력 및 관 내벽과의 밀착력을 향상시키고자 하며, 세척 효율 극대화를 위해 회전 블레이드를 삽입된 회전식 스왑피그를 개발하였다. 또한, 분실 가능성을 제거하고, 피그의 위치 파악을 위해 고강도 와이어 및 권취 장치를 추가적으로 개발하여, 투입구부터 토출구까지를 연결하였다. 각 세부 기술의 성능 검증 이후에는 30m 구간의 테스트베드에서 본 기술을 적용하였으며, 현장 적용성 평가와 더불어 공정 시간을 측정하여 기술의 성능을 검증하였다. Drinking water is an essential element to ensure the basic human right to live, and the quality of clean water must always be ensured. However, domestic water facilities, which were installed intensively in the early 2000s, are deteriorating. The accidents such as discoloration of water such as chromaticity and turbidity as well as leakage of substances frequently occur. However, since it is virtually impossible to replace all water pipes, the detailed standards for maintenance of water pipe network facilities established in 2021 require water pipe cleaning. The swab pig method, one of the water pipe cleaning methods, is a method of physically removing substances in pipes and is evaluated as having the highest cleaning efficiency. However, Swab is highly likely to be damaged or deformed during the cleaning process, and may even be lost. Therefore, in this study, the material of the pig was changed to a material with high compressibility, and it was made as close as possible to the inner wall of the water pipe. And, to maximize cleaning efficiency, a rotation swab pig with a rotation blade was developed. In addition, high-strength wire and winding equipment were additionally developed to eliminate the possibility of loss and to determine the location of the pig. The inlet and outlet are connected with wires, and after verifying the performance of each detailed technology, the technology was applied on a test bed with a 30m section. As a result of the application, the performance of the technology was verified by measuring the process time and evaluating applicability.

회원작품 - 펀펀하우스

이기철,Lee, Kichul 대한건축사협회 2019 建築士 Vol.598 No.-

아편양 순응제가 백서의 억제된 자발적 교대행동에 미치는 영향

이기철,전성일,장환일,이정호,최영민,김성호,류정환,최미,Lee, Gi-Chul,Jeon, Seong-Il,Chang, Hwan-Il,Lee, Jung-Ho,Choi, Young-Min,Kim, Seong-Ho,Ryu, Jeong-Hwan,Choi, Mi 대한생물정신의학회 1999 생물정신의학 Vol.6 No.2

This study was designed to evaluate the effects of opioid receptor agonists on the spontaneous alternation behaviour in an animal model of obsessivecompulsive disorder in rats. According to the theory that dopamine is related to the biological etiology of obsessive-compulsive disorder, the effect of the nalbuphine(opioid kappa agonist) and the tramadol(opioid mu agonist), which act as manipulating agents on the inhibition or stimulation of dopamine release, in the spontaneous alternation behaviour were evaluated. 24 hours prior to the experiment, rats were food-deprived. These rats were put into the T-maze, in which white and black goal boxes were baited with small amounts of chocolate milk. Each rat was given 2 set of 7 trials during which it was placed in the start box and allowed to choose the one of the goal boxes for each time. After identifying the stable baseline of spontaneous alternation behaviour, nonselective 5-HT agonist 5-MeODMT(1.25mg/kg/IP) disrupted spontaneous alternation. Rats were stratified into fluoxetine(10mg/kg/IP), nalbuphine(10mg/kg/IP), tramadol(46.4mg/kg/IP), and saline(0.5cc/IP) injection group with experimental drug treatment for 21 days. The effects on the 5-MeODMT(1.25mg/kg/IP) induced disruption of spontaneous alternation behaviour were checked at the next day of discontinuation of drug treatment. The results were as follows ; 1) At the day after 21 days of the drug treatment, the nalbuphine treated group and the fluoxetine treated group showed significant difference from the tramadol treated group and the saline treated group in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. 2) Within each drug treatment group, the fluoxetine treated group showed significant difference between before and after the treatment of fluoxetine in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. And also, the nalbuphine treated group showed significant difference between before and after the treatment of nalbuphine in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. There was no difference between the baseline and after the treatment of nalbuphine in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. We indentified that the opioid kappa agonist that act as dopamine release inhibitor affect the spontaneous alternation behaviour which is an animal model of obsessive-compulsive disorder in rat.

상악동화농병치험예보고

이기철,Lee, Gi-Cheol 대한한약협회 1997 大韓漢藥 Vol.1 No.-

건축담론 - 좋은 건축

이기철,Lee, Kichul 대한건축사협회 2019 建築士 Vol.606 No.-