위암 조직에서 Helicobacter Pylori 검출에 대한 연구

이진호(Jin Ho Lee),전수영(Su Yung Jeon),함희용(Hee Yong Hahm),윤진일(Jin Il Yoon),황성보(Sung Bo Whang),정운태(Woon Tae Jeong),신원창(Won Chang Shin),김관엽(Kwan Yop Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.2

N/A Background: Helicobacter pylori infection is closely associated with chronic active gastritis and peptic ulcer. Recently, presence of H. pylori in gastric mucosa could play a role in the pathogenesis of gastric cancer. Method: We compared the positivity of CLO test between 41 cases of gastric cancer group and 54 cases of normal control group according to age and sex. Results: 1) There was no difference between positivity and negativity according to age and sex. 2) Total concordance rate of CLO test on the normal tissue was 73.2% in the gastric cancer group, 83.3% in the normal control group, according to the distribution in the stomach. There was no significant difference between the two groups. 3) Concordance rate between cancer tissue and surrounding normal tissue was 91.6% in upper stomach cancer and 75.8% in lower stomach cancer, total concordance rate was 80.5%. 4) Total concordance rate between cancer tissue and whole stomach was 73.2%. Conclusion: Our results suggest that Helicobacter pylori could play a significant role in the development of gastric cancer.

당뇨유도 신기능장애 백서에서 신장-췌장십이지장 동시이식의 효과

정세일(Se-Il Jung),이기수(Ki-Soo Lee),허준(June Heo),김태효(Tae-Hyo Kim),최동원(Dong-Won Choi),황준승(Jun-Seong Hwang),성열근(Youl-Koon Seong),윤진한(Jin-Han Yoon) 대한비뇨기종양학회 2003 대한비뇨기종양학회지 Vol.1 No.2

기업 광고비와 매출액의 상관관계에 관한 연구

김안호(Kim, Ahn-Ho),윤진일(Yoon, Jin-Il) 조선대학교 지식경영연구원 2007 기업과 혁신연구 Vol.30 No.2

종관자료를 이용한 벼 재배지대별 군락 내 기온 예측

윤영관(Young Kwan Yoon),윤진일(Jin Il Yun) 한국농림기상학회 2001 한국농림기상학회지 Vol.3 No.4

This study was conducted to figure out temperature profiles of a partially developed paddy rice canopy, which are necessary to run plant disease forecasting models. Air temperature over and within the developing rice canopy was monitored from one month after transplanting (June 29) to just before heading (August 24) in 1999 and 2001. During the study period, the temporal march of the within-canopy profile was analyzed and an empirical formula was developed for simulating the profile. A partially developed rice canopy temperature seemed to be controlled mainly by the ambient temperature above the canopy and the water temperature beneath the canopy, and to some extent by the solar altitude, resulting in alternating isothermal and inversion structures. On sunny days, air temperature at the height of maximum leafages was increased at the same rate as the ambient temperature above the canopy after sunrise. Below the height, the temperature increase was delayed until the solar noon. Air temperature near the water surface varied much less than those of the outer-and the upper-canopy, which kept increasing by the time of daily maximum temperature observed at the nearby synoptic station. After sunset, cooling rate is much less at the lower canopy, resulting in an isothermal profile at around the midnight. A fairly consistent drop in temperature at rice paddies compared with the nearby synoptic weather stations across geographic areas and time of day was found. According to this result, a cooling by 0.6 to 1.2℃ is expected over paddy rice fields compared with the officially reported temperature during the summer months. An empirical equation for simulating the temperature profile was formulated from the field observations. Given the temperature estimates at 150㎝ above the canopy and the maximum deviation at the lowest layer, air temperature at any height within the canopy can be predicted by this equation. As an application, temperature surfaces at several heights within rice fields were produced over the southwestern plains in Korea at a 1㎞ by 1㎞ grid spacing, where rice paddies were identified by a satellite image analysis. The outer canopy temperature was prepared by a lapse rate corrected spatial interpolation of the synoptic temperature observations combined with the hourly cooling rate over the rice paddies.

직류 전기장을 인가한 층류부착화염에서 물질-열 확산 및 부력에 의한 화염진동 비교에 관한 연구

한종규(Jong Kyu Han),윤성환(Sung Hwan Yoon),박정(Jeong Park),윤진한(Jin Han Yun),길상인,서상일(Sang Il Seo),김영주(Young Ju Kim) 한국연소학회 2011 한국연소학회지 Vol.16 No.3

In this paper, we describe the behavior of two self-excitations in laminar attached free-jet flames under the influence of DC electric fields, one of buoyancy-driven and the other of diffusion-thermal instability, establi￢shed from the horizontal and vertical injection. In the horizontal injection with removed buoyancy effect, oscillating flames with the frequency of 1.3 - 7.4 Hz were observed in a certain condition with Lewis number more than unity. On the other hand, it was appeared Lewis number induced self-excitation as well as buoyancy-driven self-excitation in the vertical upward injection with DC electric fields. This behavior had frequency range of 1.6 - 9.4 Hz and was exhibited to attribute the buoyancy effect. Finally, a well-defined division about two self-excitations having similar frequency range is briefly discussed.

혈뇨 환자의 방광암 진단에서 UBC™ ( Urinary Bladder Cancer ) 검사의 유용성

길명철(Myung Cheol Gil),강도영(Do Young Kang),성열근(Youl Koon Seong),정세일(Se Il Jung),권헌영(Hyon Young Kwon),정경우(Gyung Woo Jung),김덕규(Duk Kyu Kim),노미숙(Mee Sook Roh),황태호(Tae Ho Hwang),윤진한(Jin Han Yoon) 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.3

N/A Purpose: Urinary cytology and cystoscopic exam are effective methods for diagnosis of transitional cell carcinoma(TCC). But the former shows drawbacks such as the need for a well-trained examiner, and wide imprecision related to the variability of microscopic exam the latter is an invasive method. UBC™ test detects the epitope on specific cytokeratin fragments released from epithelium of bladder cancer by immunoradiometric assay. We compared UBC™ test with urinary cytology for diagnosis of TCC to evaluate the utility of UBC™ test. Materials and Methods: Eighty-four patients with hematuria were included in our study. UBC™ tests (IDL Biotech, Sweden) were assayed in mid-stream urine according to the ordinary assay protocol. Nineteen patients were confirmed as TCC by cystoscopic examination and underwent transurethral resection (Group A). Other patients had various benign urinary tract conditions (Group B). Samples were considered positive as the UBC™ concentration was greater than 12 μg/L. Results: UBC levels were significantly different between group A (95.9±166.4 μg/L) and group B (19.2±85.6 μg/L) (p<0.001). Sensitivity for diagnosis of TCC was 89.5% (17/19) in UBC test and 47.4% (9/19) in cytology (p<0.05). Specificity for diagnosis of TCC was 81.5% (53/65) in UBC test and 100% (65/65) in cytology. UBC test was significantly more sensitive in stage Ta, T tumors (84.6 vs 38.5%, p<0.05) and in grade I (83.3% vs 16.7% p<0.05) than cytology. UBC test showed a tendency to be more sensitive as the grade was higher (83.3% in Grade 1.90% in Grade II and 100% in Grade III). Conclusion: UBC™ test could be a useful method in distinguishing TCC from other benign genitourinary diseases. Moreover, UBC™ test could be an especially valuable marker for diagnosis of TCC in patients with early TCC of low grade TCC compared to urinary cytology. Therefore, mbined use of UBC™ test in association with cytology is helpful to overcome the limited sensitivity of cytology. (Korean J Nucl Med 200135:192-197)

침윤성 방광암 환자에서 방광 보존 치료

윤선민(Seon Min Youn),양광모(Kwang Mo Yang),이형식(Hyung Sik Lee),허원주(Won Joo Hur),오신근(Sin Geun Oh),이종철(Jong Cheol Lee),윤진한(Jin Han Yoon),권현영(Heon Young Kwon),정경우(Kyung Woo Jung),정세일(Se Il Jung) 대한방사선종양학회 2001 Radiation Oncology Journal Vol.19 No.3

목 적 :침윤성 방광암 환자를 대상으로 TURBT (Transurethral Resection of Bladder Tumor)과 유도 항암화학요법 (neoadjuvant MCV chemotherapy) 후 방사선 항암화학 병용요법(cisplatin chemotherapy and radiotherapy)을 받은 환자 에서 치료의 적응도, 국소 반응율, 방광 보존율과 생존율을 알아보고자 하였다. 대상 및 방법 : 1990년 10월부터 1998년 6월까지 TURBT 시행 후 병리 조직검사 상 침윤성 방광 이행상피암으로 진단 받은 병기 T2-T4, Grade II 환자 21명을 대상으로 하였다. 치료과정은 TURBT 후 4주 간격으로 2회의 유도 MCV (methotrexate, cisplatin, vinblastine) 복합 항암화학요법을 시행하고 그 후 cisplatin과 방사선 동시 병용요법을 시행하였다. 방사선치료는 6∼15 MV X- ray를 사용하여 하루 1.8 Gy씩 39.6∼45 Gy를 전 골반에 4∼5주간에 걸쳐 조사하였 다. 치료 종료 후 방광내시경을 통해 관해율을 판정하여 완전 관해인 경우 1∼2주 후 보강 방사선조사를 cisplatin과 병용하여 19.8 Gy를 시행하였다. 부분 관해인 경우 근치적 방광 절제술을 예정하였고 수술이 불가능한 경우에는 항암제 병용 강화 방사선치료를 받도록 하였다. 환자의 추적관찰기간은 34∼67개월로 중앙값이 49.5개월이었다. 결 과 :총 26명의 환자가 유도 항암화학요법을 위해 등록되었으며 유도 항암화학요법과 방사선 항암화학 병용요법을 완료한 환자는 21명(81%)이었다. 유도 항암화학요법과 방사선 항암화학 병용요법 후 방광내시경을 통해 완전 관해 판정을 받은 환자는 21명 중 7명(33%)이었고 부분 관해 환자는 14명(67%)이었다. 완전 관해 환자 중 강화 항암제 병용 방사선 19.8 Gy를 받은 환자는 7명 중 6명(85%)이었고, 이들 중 5명(14%)은 재발 없이 방광을 보존하였다. 부분관해 환자중 1명이 근치적 방광적출술을 받았으며 3명이 TURBT와 2회의 MCV 항암요법을, 10명이 추가의 항암화학 방사선 병용요법을 받았다. 근치적 방광적출술을 받은 1명은 수술 소견상 방광 내 종양이 존재했으나 수술 후 재발이 없었다. 전체 21명의 환자중 12명(58%)이 방광을 보존하면서 생존하고 있고 8명이 방광암으로 사망하였으며 1명이 다른 질병으로 사망하였다. 전체 환자의 중앙 생존기간은 27개월이며, 5년 생존율은 55% 였다. 유도 항암화학요법과 항암제 방사선치료 후 완전 관해 환자의 경우 5년 생존율은 80%, 부분 관해 환자 14%로 의미 있는 차이를 보였다(p=0.001). 유도 항암화학요법과 항암제 병용 방사선치료를 받은 환자에서 grade 3 이상의 혈액학적 부작용의 빈도는 각각 백혈구 감소증 6명(29%), 혈소판 감소증 1명(4%)이었으며 이로 인한 화학요법의 지연은 1명(4%)에서 관찰되었다. 결 론 :침윤성 방광암 환자에서 유도 항암화학요법 및 항암제 병용 방사선치료를 적용하여 방광 보존율 및 5년 생존율에 있어 만족할 만한 결과를 얻었다. 완전한 TURBT와 유도 MCV 항암요법과 cisplatin 방사선 병용요법에서 완전관해 여부가 방광보존가능성과 생존율에 영향을 미치는 요소로 생각되고 만약 완전관해를 이루지 못하면 근치적방광적출술을 시행하는 것이 바람직할 것이다. Purpose : To assess the tolera nce, complete response rate, bladder preservation rate and survival rate in patients with muscle- invading bladder cancer treated with selective bladder preservation protocol. Method and Materials : From October 1990 to June 1998, twenty s ix patients with muscle- invading bladder cancer (clinical stage T2- 4, N0- 3, M0) were enrolled for the treatment protocol of bladder preservation. They were treated with maximal TURBT (tra nsurethral resection of bladder tumor) and 2 cycles of MCV chemotherapy (methotrexate, crisplatin, and vinblastine) followed by 39.6∼45 Gy pelvic irradiation with concomitant cisplatin. After complete urologic evaluation (biopsy or cytology), the patients who achieved complete response were planed for bladder preservation treatment and treated with consolidation cisplatin and radiothera py (19.8 Gy). The patients who had incomplete response were planed to immediate radical cystectomy. If they refused radical cystectomy, they were treated either with TURBT followed by MCV or cisplatin chemothera py and radiotherapy. The median follow- up duration is 49.5 months . Result : The patients with stage T2- 3a and T3b- 4a underwent complete removal of tumor or gross tumor removal by TURBT, respectively. Twenty one out of 26 patients (81%) successfully completed the protocol of the planned chemo- radiothera py. Seven patients had documented complete response. Six of them were treated with additional consolidation cisplatin and radiothera py. One patient was treated with 2 cycles of MCV chemothera py due to refusal of chemo- radiotherapy. Five of 7 complete responders had functioning tumor- free bladder. Fourteen patients of incomplete responders were further treated with one of the followings : radical cystectomy (1 patient), or TURBT and 2 cycles of MCV chemotherapy (3 patients), or cisplatin and radiotherapy (10 patients). Thirteen patients of them were not treated with planned radical cystectomy due to patients ' refusal (9 patients) or underlying medical problems (4 patients). Among twenty one patients , 12 patients (58%) were alive with their preserved bladder, 8 patients died with the disease,1 patient died of intercurrent disease. The 5 years actuarial surviva l rates according to CR and PR after MCV chemotherapy and cisplatin chemoradiotherapy were 80% and 14%, respectively (p=0.001). Conclusion : In selected patients with muscle- invading bladder cancer, the bladder preservation could be achieved by MCV chemotherapy and cisplatin chemo- radiotherapy. All patients tolerated well this bladder preservation protoco. The availability of complete TURBT and the respons ibility of neoadjuvant chemotherapy and chemoradiotherapy were important predictors for bladder preservation and survival. The patients who had not achieved complete response after neoadjuvant chemotherapy and chemoradiotherapy should be immediate radica l cystectomy. A randomized prospective trial might be essential to determine more accurate indications between cystectomy or bladder preservation.

연구보문 : 자연과학 ; 올보리 품종의 출수기 및 수량형질의 지역 안정성

성병열 ( Byung Ryeol Sung ),김정곤 ( Jung Gon Kim ),노재환 ( Jae Hwan Roh ),이혜림 ( Hye Rim Lee ),김대준 ( Dae Jun Kim ),윤진일 ( Jin Il Yoon ) 한국국제농업개발학회 2014 韓國國際農業開發學會誌 Vol.26 No.1

우리나라 보리 품종 중, 농가에 40년 이상 보급되고 있는 올보리 품종에 대하여 출수기 및 정곡수량의 안정성을 전·답리작별 5개 지역에서 검정한 결과를 요약하면 아래와 같다. 1. 올보리 품종의 평균출수기는 전작재배에서 진주가 4월 23일로 가장 빠르고, 밀양 4월 25일, 대구, 대전이 각각 4월 28일, 4월 30일이며, 수원이 5월 4일로 늦었다. 답리작재배에서 평균출수기는 밀양이 4월 24일로 빠르고 진주, 익산, 대구는 4월 26 ~ 27일, 대전이 5월 1일로 늦었다. 2. 정곡수량의 총 평균은 10 a당 전작 444 kg, 답리작 363 kg으로서 전작에서 답리작보다 81 kg 증수되었다. 전작재배에서 10 a당 평균수량 이상의 지역은 진주 488 kg, 대구 469 kg이었으며, 가장 적은 지역은 밀양의 385 kg이며, 수원과 대전은 평균정도의 수량을 얻었다. 답리작 재배 역시 진주에서 425 kg으로 수량이 높은 반면, 익산은 307 kg으로 가장 적었다. 3. m2당수수는 지역별로 거의 비슷한 경향이며, 전작에서 평균 567개로 답리작의 529개보다 38개 많았다. 4. 평균 1수립수는 전작에서 48립으로 답리작의 44립보다 4립 정도 많고, 천립중의 평균은 전작 33.9 g으로 답리작 33.2 g과 비슷하였다. 5. Stroike and Johnson(1973)의 모델을 분석한 결과, 올보리 품종의 환경지수는 -60에서 +60으로서 지수의 폭이 매우 작아 전 지역에서 안정적이며, 회귀계수 및 회귀에 기인하는 평균편차 평방화는 지역간에 다소의 차이가 있었다. 진주와 대구는 회귀계수가 1미만이고 표준편차 평방화도 적어 적응력이 높은 지역으로 나타났다. 6. Finlay and Wilkinson(1983)의 모델을 이용하여 안정성을 검정한 결과에서도 진주가 가장 적응력이 높은 지역인 반면, 전작의 밀양과 답리작의 익산은 안정성이 비교적 낮았으며, 다른 지역은 평균 안정성 지역으로 나타났다. 7. 올보리 품종의 5개 지역에서 정곡수량에 미치는 수량구성요소의 기여도는 중북부 지역인 수원, 대전과 답리작의 대구, 익산에서 m2당수수의 기여도가 매우 높았으며, 천립중은 낮았다. 전·답리작 5개 지역의 평균은 m2당수수 > 1수립수 > 천립중 순서로 높았다. Barley cultivar “Olbori” has been cultivated for more than 40 years in Korea. Here, we report heading date, yield stability of “Olbori” that has been evaluated in five locations of both upland and paddy fields. Models were based on the Stroike and Johnson analysis and Finlay and Wilkinson regression to analyse multi-environmental trials. The mean heading date of “Olbori” is earlist at upland in Jinju (April 23) and followed by Milyang (April 25), Daegu (April 28), Daejeon (April 30), and Suwon (May 4) the latest. The total main point quantity averages for cultivation in upland and paddy field were 444 kg/10 a and 363 kg/10 a, respectively. For upland cultivation, Jinju and Daegu showed 488 kg/10 a and 469 kg/10 a, respectively. These numbers are above the average. Milyang recorded the lowest main point quantity average. Suwon and Daejeon showed around the average. For cultivation on paddy field, Jinju recorded the highest, i.e., 425 kg, whereas Iksan showed the lowest, i.e., 312 kg. According to the analysis for Stroike and Johnson model, the environmental index for “Olbori” was between -60 and +60. This means, for all area, “Olbori” is quite stable to cultivate. The average deviation for squared partial correlation due to regression coefficient and regression, it showed some deviation depending on the area. Jinju and Deagu showed the highest adaptability. According to the stability analysis using Finlay and Wilkinson model, Jinju turned out to be most adaptable, whereas Milyang (for upland cultivation) and Iksan (for paddy field cultivation) showed relatively low stability. Other areas showed average stability.

한국 노인 복지정책 개선을 위한 양로·요양시설 급식관리체계 및 급식서비스 현황 조사

양일선 (Yang Il Sun),이진미 (Lee Jin Mee),채인숙 (Chai In Sook),윤진 (Yoon Gene) 한국영양학회 1996 Journal of Nutrition and Health Vol.29 No.7

위 분문부에 발생한 원발성 흑색종

박종익,강성구,박상수,윤진,김일명,신동규,Park, Jong-Ik,Kang, Sung-Gu,Park, Sang-Su,Yoon, Jin,Kim, Il-Myung,Shin, Dong-Gue 대한위암학회 2006 대한위암학회지 Vol.6 No.3

Melanoma is a malignant neoplasm of melanocytes most frequently arising from the skin, but primary melanoma can also arise from the mucosa of the gastrointestinal tract. Gastrointestinal melanomas are most commonly metastases from a cutaneous melanoma. Primary melanoma of the stomach is rare and carries a poor prognosis. Reported here is the case of a 75-year-old man with a primary gastric melanoma who presented with a melena, abdominal pain, and weight loss. Most cases of melanoma are treated by excision of the primary tumor. Patients with melanoma have been treated with adjuvant chemotherapy, radiation therapy, and immunotherapy. None of these modalities has been demonstrated to prolong the survival rate. To improve long-term disease-free survival, early diagnosis and surgical intervention are very important. 흑색종은 피부나 점막에 존재하는 멜라닌 세포에서 기원하는 악성 종양으로 피부에 가장 흔하게 발생한다. 위장관계 점막에서도 흑색종이 발생할 수 있는데 원발성은 매우 드물고 대부분은 피부의 원발성 흑색종으로부터 전이되어 나타난다. 위에 발생한 원발성 흑색종은 매우 드물고 치료 성적이 나쁘고 전이 속도가 빨라서 예후가 매우 나쁘다. 저자들은 혈변, 복통과 체중 감소를 주소로 내원한 75세 남자로 수술 전 진행성 위암으로 진단되어 위전절제술을 시행하였으나 수술 후 위 분문부의 원발성 흑색종으로 식도-위 접합부까지 침범한 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. 흑색종 치료에서 수술은 가장 표준적인 치료법이다. 수술 후 보조 요법으로 항암화학요법, 방사선 치료, 면역 치료 등을 시도해 보았지만 생존율 증가가 입증된 치료 방법은 아직 없는 실정이다. 장기간 생존율을 향상시키기 위해서는 조기 진단과 수술적 치료가 가장 중요하다.