Standardized Saw Palmetto Extract Directly and Indirectly Affects Testosterone Biosynthesis and Spermatogenesis

윤정문,이민희,김다경,K. Shyam Prasad,Sangwon Eun,김옥경,이정민 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.6

We investigated whether a standardized saw palmetto extract (SP, mixture of supercritical extract and ethanol extract at a ratio of 9.5 to 0.5) can relieve the symptoms of andropause, including metabolic syndrome, and decreases in muscle endurance and spermatogenesis, in old rats. Twenty-four-week-old male Sprague Dawley rats received oral supplementation of SP at 40, 80, and 160 mg/kg body weight (bw) for 4 weeks. We found that SP supplementation reduced body weight gain by decreasing visceral and epididymal fat weights and the levels of serum triglycerides, total cholesterol, and low-density lipoprotein/very low-density lipoprotein cholesterol. In addition, SP supplementation increased muscle endurance, sperm counts, and testosterone biosynthesis through hormonal regulation. In Leydig cells under hydrogen peroxide-induced oxidative stress, SP treatment directly induced testosterone biosynthesis by activating the mRNA expression of the genes encoding 17,20-desmolase and 3β-hydroxysteroid dehydrogenase 4. In conclusion, our results suggest that supplementation of SP may be useful for alleviating the symptoms of andropause via direct and indirect regulation of testosterone biosynthesis.

Prunus yedoensis Bark Inhibits Lipopolysaccharide-Induced Inflammatory Cytokine Synthesis by IjBa Degradation and MAPK Activation in Macrophages

윤정문,임성빈,노만광,박성현,Han-Al Kwon,이주영,최호영,함인혜,김윤범,이정민,김대옥,박계원,강희 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.4

The bark of Prunus yedoensis is used in antitussive medicines and in oral herbal formulations for inflammatory skin disorders. In the present study, we explored whether P. yedoensis bark extract (PYE) and its solvent partitioned fractions could modulate lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-a and interleukin (IL)-6 in vivo and in vitro. In addition, we examined the effect of PYE extract and its fractions on LPS-induced NF-jB and mitogen-activated protein kinase (MAPK) signaling in mouse peritoneal macrophages. Oral treatment of PYE decreased serum levels of TNF-a and IL-6 in LPS injected mice. PYE inhibited LPS-induced TNF-a and IL-6 in macrophages at the transcriptional level and also suppressed LPS-induced IjBa degradation and MAPK activation in vitro. Among the fractions, the chloroform fraction, which contains genistein, naringenin, sakuranetin, prunetin, and amygdalin, showed inhibitory effects at much lower concentrations than the water and ethyl acetate fractions. Taken together, our results indicate that PYE was able to inhibit LPS-induced expression of TNF-a and IL-6, the latter of which was more prominent. The effects of PYE on inflammatory cytokine synthesis may involve modulation of NF-jB and MAPK activation.

장애인스포츠를 통한 스포츠마케팅의 활성화 방안에 관한 연구

윤정문,최호규 공주대학교 KNU 기업경영연구소 2012 기업경영리뷰 Vol.3 No.2

The value of the disabled sports may be recognized as the sector that sponsorship and sports marketing among the essential corporate activities in the sports industry can access to the disabled sports, and the purpose of this study is to activate sports marketing through the disabled sports in the value-oriented view that related persons related with the disabled sports and the general public can sympathy and participate in the time when corporation's activity for contributing the society is required. First, the disabled sports can be recently activated by applying public marketing in respect of corporation's contribution activity for the society, and marketing related with public interests fosters sale as well as improving corporation's brand image and improving recognition degree by emphasizing corporation's social role. Second, this is the time when cultivation of the manpower to specialize in the disabled sports marketing is seriously required. Expert who can gradually realize the speciality of the disabled sports marketing and newly implement corporate image must be cultivated. Third, the disabled sports has the sufficient possibility of transformation to a business through star marketing. Preparation of various methods to exploit the disabled star who is hided can become a hub of communication to connect corporation and society and become a new marketing strategy that can expect factor of sale increase due to improvement of corporate image. Fourth, human marketing methods using media can deliver positive image of a corporation as well as deliver the popularization and emotion of the disabled sports to the public. The sports marketing has the possibility that the corporation and the consumer are familiar due to support of the establishment of the disabled sports team, cultivation of players and sponsorship of the disabled sports event through the induction of corporation's contribution for the society. 본 연구는 대한장애인체육회가 설립된 이후 장애인스포츠가 비약적으로 발전하는 시기에 스포츠마케팅의 발전논의가 부족하다는 점에서 착안하였다. 스포츠산업의 핵심적인 기업활동 중 스폰서십과 스포츠마케팅이 장애인스포츠에 접근 가능한 분야로 장애인스포츠도 그 가치를 부여 받을 수 있으며, 기업의 사회공헌 활동이 요구되는 시기에 장애인스포츠 관련자 그리고 대중이 함께 공감하고 참여할 수 있는 가치 지향적 관점에서 장애인스포츠를 통한 스포츠마케팅을 활성화하는데 연구의 목적을 두고 있다. 구체적인 방안으로는 기업의 사회공헌을 통한 활성화 방안, 장애인 스포츠마케팅의 전문인력 양성, 스타마케팅을 통한 비즈니스로의 가치전환, 미디어를 통한 휴먼마케팅은 장애인스포츠 전반적인 분야의 발전요인이 될 것이며, 사회통합의 긍정적인 방안으로 논의 될 것으로 예상한다. 또한, 향후 선수, 지도자, 체육 담당자 등 관련자 사이에 마케팅활성화 여건에 대한 논의와 연구가 이뤄져야 할 것이며 담당부처인 문화체육관광부 뿐만 아니라 기업의 마케팅 부서와 사회공헌을 유도하는 장애인스포츠 관련단체 사이의 긴밀한 협조를 통할 때만이 바람직한 방향으로 발전 할 수 있을 것으로 기대한다.

호텔기업에서 내부마케팅이지식공유와 직무만족에 미치는 영향

최정문 ( Zheng Wen Cui ),이일룡 ( Ri Long Li ),송빈 ( Bin Song ),윤영일 ( Yeong Il Yoon ) 한국이벤트컨벤션학회 2013 이벤트 컨벤션 연구 Vol.9 No.2

This study is targeted at the domestic Express Hotel Employees share knowledge factors influencing knowledge sharing, internal marketing, job satisfaction and systematic analysis of the impact on effective ways to present and share knowledge better than trying to present the internal marketing factors and implications depending on the purpose of Seoul, Busan, Daegu, Gyeongju Express Hotel employees were surveyed, with AMOS using the SPSS statistical analysis was demonstrated, and the results are as follows. First, the relationship between internal marketing and knowledge sharing, internal communications, internal marketing factors of knowledge sharing and training shown significant influence but compensation does not affect the sharing of knowledge, respectively. Second, the relationship between internal marketing and job satisfaction is a factor of internal marketing training and reward significant effect on job satisfaction have shown natjiman, internal communications on the job satisfaction showed no significant effect. Third, the impact of knowledge sharing on job satisfaction, the path coefficient was 0.838 showed sufficient explanatory power, and knowledge sharing on job satisfaction positively influence.

마비성 수부의 재건술

정문상(Moon Sang Chung),윤병화(Byung Hwa Yoon),한진수(Jin Soo Han) 대한정형외과학회 1988 대한정형외과학회지 Vol.23 No.3

항암화학요법과 수술을 통해 완전 관해를 획득한 진행성 십이지장 유두암 증례

윤해룡,정문재,방승민,박승우,송시영,Hae Ryong Yun,Moon Jae Chung,Seungmin Bang,Seung Woo Park,Si Young Song 대한소화기암연구학회 2014 Journal of digestive cancer reports Vol.2 No.2

Ampulla of Vater (AOV) cancer is rare malignant tumor which arises within the vicinity of the AOV. Metastatic AOV adenocarcinoma has poor prognosis, with an overall survival rate at 2 years ranging from 5 to 10%. The Surveillance, Epidemiology and End Results Program of the National Cancer Institute indicated that lymph node metastasis was present in as many as half of patients which were associated with poor prognosis and liver was the second most common site of distant metastasis in AOV cancer. In this case report, we describe a case of complete resolution of AOV cancer, which was already spread to retroperitoneal lymph node and liver. The patient underwent gemcitabine plus cisplatin chemotherapy for palliative aim. After 12 month of chemotherapy, image study showed partial remission, so intraoperative radiofrequency ablation therapy and pylorus preserving pancreaticoduodenectomy was done. AOV cancer was completely resected and the patient was followed up without recurrence for 7 months.

랫드에 미치는 Permethrin의 발생독성에 관한 연구

윤효정,정문호,Yoon, Hyo-Jung,Chung, Moon-Ho 한국환경보건학회 2005 한국환경보건학회지 Vol.31 No.4

Permethrin, a synthetic pyrethroid insecticide, has been widely used to protect domestic animals and the public health, as well as in agriculture against a variety of pests, which provides potential for environmental exposure. Permethrin is classified as possible human carcinogen and endocrine disrupting chemical by many international authorities. However, its developmental effects have been rarely studied. This study investigated the effects of permethrin during embryo-genesis. Developmental toxicity of permethrin was evaluated using short-term in vitro battery system. Gestation day 9.5 rat embryos (organogenesis) were cultured with permethrin (0.1,0.4 and 0.8 mg/ml) for 48 hours using whole embryo culture system. All the treatments exhibited significant decreases in the total morphological score. Permethrin induced significant growth retardation and the developmental abnormality at doses of 0.4 and 0.8 mg/ml. Moreover, the DNA and protein contents of embryos decreased in dose-dependent manner. These observations suggest that permethrin contributes to toxicity on embryonic developments in rats.

방형회내근 유경골이식을 이용한 Kienböck병의 치료

정문상(Moon Sang Chung),원중희(Choong Hee Won),윤병화(Byung Hwa Yoon) 대한정형외과학회 1987 대한정형외과학회지 Vol.22 No.1

DSP-f28335를 이용한 풍력자원 분석장치 개발

윤영천(Young-Chan Youn),문채주(Chae-Joo Moon),김태곤(Tea-Gon Kim),정문선(Moon Seon Jeong),박지예(Ji-Ye Park) 전력전자학회 2011 전력전자학술대회 논문집 Vol.2011 No.11

소형 풍력발전 적용 풍력자원조사를 위한 데이터로거 개발

윤영천(Young-Chan Youn),정문선(Moon-Seon Jeong),김상만(Sang-Man Kim),김태곤(Tae-Gon Kim),문채주(Chae-Joo Moon) 한국태양에너지학회 2012 한국태양에너지학회 논문집 Vol.32 No.3

To install a wind power generator, the survey on the wind environment resources must be conducted in advance, The survey on the wind environment resources is to collect and analyze data regarding the wind speed and direction on a data logger. The data logger consists of a sensor, signal processing circuit and storage device. According to the analysis of the stored data, the amount of power generation by the types of generators can be predicted and the most optimal generator including safely grade can be selected, and in case of installing a generator in the future, it can be utilized as basic data regarding supporting base and foundation construction method of survey points. Data logger was developed for a small wind power generator that is suitable for the international standard(IEC 61400) by using DSP-F28335 micro controller in this paper. It was developed to measure the wind speed of 1 [㎧]~17 [㎧], the wind direction of 0 [°]~359 [°], and temperature of-30 [℃]~50 [℃], and the comparative experiment with ether companies' data loggers was conducted, and an error was measured to be less than ±0.1 [㎧] for wind speed and less than +1 [°] for wind direction.