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녹두의 Vitexin이 비만전구세포에서 세포분화 및 아디포사이토카인 분비능에 미치는 영향
위해리(Haeri Wi),최문지(Munji Choi),최세림(Selim Choi),김애정(Ae-Jung Kim),이명숙(Myoungsook Lee) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.8
Obesity is an important issue worldwide as it may associated with increased prevalence of metabolic diseases. Mung bean is known as a functional food for decreasing the glycemic index and lipid profile of plasma. The purpose of this study was to investigate the anti-obesity effects of vitexin from mung bean on the regulation of adipocyte differentiation and adipocytokine secretion. When 3T3-L1 adipocytes were treated with vitexin from days 0 to 14 at various levels of 25, 50, 100, and 200 μM, there was no change in cell viability. Vitexin treatment at 50, 100, and 200 μM decreased triacylglycerol levels in cells, but only 100 μM vitexin induced lipolysis. At 200 μM of vitexin, phosphorylation of p38 and ERK, which causes secretion of inflammatory adipocytokines, was depressed, whereas there was an increase in expression of PPARγ, the key regulator of adipocyte differentiation. Phosphorylation of AMPK increased at 100 μM vitexin. TNF-α and aP2 mRNA expression increased at 25 μM vitexin, whereas only TNF-α mRNA expression increased at 200 μM vitexin. Further, the mRNA levels of TNF-α and aP2 decreased at other concentrations in a dose-dependent manner. Since we observed that mRNA expression of C/EBP, SREBP1, and PPARγ did not change upon vitexin treatment, our future studies will investigate other genes such as mTOR, which is related with apoptosis signaling, or SIRT1, which is associated with inhibition of adipogenesis. Our results indicate that vitexin at concentrations between 100 and 200 μM is suitable in vivo for the development of mung bean as an anti-obesity therapy or functional food.
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산화스트레스가 유도된 인체 간암세포 (HepG2)에서 Sulforaphane과 Diallyl Sulfide, Capsaicin, Gingerol의 항산화효과 비교연구
이소연(Lee Soyoun),위해리(Wi,Haeri),이명숙(Lee Myoungsook) 韓國營養學會 2011 Journal of Nutrition and Health Vol.44 No.6
Oxygen is necessary to sustain life, yet cellular oxygen metabolism creates destructive elements called free radicals. Free radicals are chemically unbalanced and carrying free electrons that can damage molecules, potentially damaging the cell itself. For this reason, many antioxidant products, including supplements and functional foods, are being developed. In particular, natural products are rich sources of pharmacologically active compounds. The purpose of this study was to investigate the antioxidant effects of target biomaterials in Korean traditional spices such as diallyl sulfide (DAS), capsaicin (CAP), and gingerol (GGR), and to investigate the response of the antioxidant defense system to oxidative stress by hydrogen peroxide (H2O2) compared to sulforaphane (SFN) in HepG2 cells. After the analysis of the cell viability using Cell Counting kit-8 (CCK-8) assay, we determined that the optimum levels were 200 μM DAS, 25 μM CAP, 50 μM GGR, and 12.5 μM SFN. Antioxidant enzymes were measured and protein expression was detected by Western blotting. All treatments showed a significant decrease in antioxidant enzyme activity such as superoxide dismutase, catalse, and glutathione peroxidase in HepG2 cells. Additionally, DAS, CAP, GGR and SFN increased the antioxidant system-related transcription factor Nrf2 which was found to be regulated by the activation of MAPK-JNK in this study. In conclusion, these results indicate the protective effects of DAS CAP, GGR, and SFN against H2O2-induced oxidative stress. (Korean J Nutr 2011; 44(6): 488~497)
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고지방 식이를 섭취한 흰쥐에서 마테의(Ilex praguariensis) 중성지방과 콜레스테롤 저하 효과
박지연,안희정,정주현,변정은,이해진,장원원,위해리,최세림,안진표,이명숙 誠信女子大學校 生活文化硏究所 2012 生活文化硏究 Vol.26 No.2
With obesity caused by high fat intake having various adverse effects on people of today's society, the aim of this study is to examine the lowering effect of proportional mate intake on tissue triglyceride and cholesterol levels. Mate, binomial name Ilex paraguariensis, is a species of holly (family Aquifoliaceae), well-known as the source of the mate beverage, which is native to subtropical South America. Five-week-old male Sprague-Dawleys weighing about 200g were used for this experiment. These rats were fed on a diet mixed with 60% fat and instant Mate powder in market circulation. They were divided into four groups, with the control group on a normal diet (n=6), a group on a high fat diet (HFD) (n=6), a group on a high fat diet containing 2% mate powder (MT2) (n=6), and the last group on a high fat diet containing 4% mate powder (MT4) (n=6). The food efficiency ratio made no difference in the MT2 group compared to the HFD group. With the intake of mate powder, serum and tissue triglycerides were decreased in the MT2 group. Especially notable was the fall of triglyceride levels in the liver in the MT2 group by roughly 60%, compared to those of the HFD group. Cholesterol levels in epididymal fat pads were sig-nificantly decreased - by 60% - in the MT4 group compared to those of the HFD group. Also, as a result of DPPH(1,1-Diphenyl-2-picrylhydrazyl) assay, the anti-oxidant activity of Mate powder showed a similar level to that of vitamin E. These findings indicate that triglyceride and cholesterol levels in liver and epididymal fat pads are decreased by the intake of Mate powder. That the dose of Mate powder in the MT4 group had a signifiant effect means that Mate may be capable of interfering in triglyceride and cholesterol levels.
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뽕잎(leaf of Morus alba)분말의 섭취가 고지방 식이를 섭취한 흰 쥐의 지질저하 및 항산화 효과에 미치는 영향
유승혜,안성희,복민아,김은정,장연,위해리,최세림,안진표,이명숙 誠信女子大學校 生活文化硏究所 2012 生活文化硏究 Vol.26 No.2
People are increasingly becoming interested in the power of phytochemicals to decrease the risk of cardiovascular diseases, because cardiovascular diseases are one of the leading causes of death. Morus alba leaves containing dietary fiber and rutin are said to lower cholesterol and triglyceride levels and to have antioxidant effects. This study investigates the effects of Morus alba leaves on lipid metabolism and antioxidant functions. Male Sprague-Dawley rats were divided into four groups randomly and put on the following diets for six weeks: normal (control), high fat (HF), high fat with 10% Morus alba leaves (B10), high fat with 15% Morus alba leaves (B15). Food efficiency ratio (FER) and weight gain were not decreased. However, food intakes were significantly increased (p=0.000). Total serum cholesterol in the B15 group was reduced by 5%, a higher percentage than that of the HF group and serum triglyceride in the B10 group was reduced by 53%, a higher percentage than that of the HF group. Liver cholesterol in the B15 group was reduced by 40%, a higher percentage than that of the HF group. Liver cholesterol levels in the B10 and B15 groups were reduced by 21% and 54% respectively, higher percentages than those of the HF group. In addition, the total cholesterol level of epididymal fat pads in the B15 and B10 groups was reduced by 44%, 57% lower than that of the HF group. The triglyceride level in the B10 group was decreased by 63% more than that of the HF group. ALT and AST activities, indicators of liver damage, were not increased. The SOD level did not change but TBARS differed between groups. These results indicate that Morus alba leaves have significant effects on the lipid metabolism of serum, liver and epididymis.
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