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Allelic Variation and Phylogenetic Analysis of SLA-3 between Korean Native Pigs and Other Pig Breeds
우찬진,최호준,김주현,김남은,박찬규 한국유전학회 2006 Genes & Genomics Vol.28 No.3
Understanding the MHC polymorphisms within a population is important in terms of the immunological and genetic viewpoints. There has been little report on allelic variation of SLA genes for Korean native pigs except for our previous study on SLA-2. To characterize a MHC class I gene, SLA-3, of Korean native pigs, we cloned and analyzed the sequences of SLA-3 alleles from Korean native pigs. We found two new SLA-3 alleles from five Korean native pigs. The average SLA-3 heterozygosity level was 40%, indicating that the genetic diversity of the Korean native pig was significantly reduced and the allelic complexity is also low. To evaluate the genetic relationship of SLA-3 between Korean native pigs and other pig breeds, a phylogenetic analysis was performed. SLA-3*kn01 was clustered with SLA-3*05sw01 and SLA-3*kn02 with SLA-3*0302. The new SLA-3 alleles of Korean native pigs presented here will be useful as the first reference sequences of the SLA-3 gene from any Asian pig breed.
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신정화,우찬진,왕승준,Jipseol Jeong,안인정,황종경,조성덕,유승도,최경희,정현미,서재화,김설희 한국미생물학회 2015 The journal of microbiology Vol.53 No.7
Since 2003, highly pathogenic avian influenza (HPAI) virus outbreaks have occurred five times in Korea, with four HPAI H5N1 outbreaks and one HPAI H5N8 outbreak. Migratory birds have been suggested to be the first source of HPAI in Korea. Here, we surveyed migratory wild birds for the presence of AI and compared regional AI prevalence in wild birds from September 2012 to April 2014 for birds having migratory pathways in South Korea. Finally, we investigated the prevalence of AI in migratory birds before and after HPAI H5N8 outbreaks. Overall, we captured 1617 migratory wild birds, while 18,817 feces samples and 74 dead birds were collected from major wild bird habitats. A total of 21 HPAI viruses were isolated from dead birds, and 86 low pathogenic AI (LPAI) viruses were isolated from captured birds and from feces samples. Spatiotemporal distribution analysis revealed that AI viruses were spread southward until December, but tended to shift north after January, consistent with the movement of migratory birds in South Korea. Furthermore, we found that LPAI virus prevalences within wild birds were notably higher in 2013–2014 than the previous prevalence during the northward migration season. The data from our study demonstrate the importance of the surveillance of AI in wild birds. Future studies including in-depth genetic analysis in combination with evaluation of the movement and ecology of migratory birds might help us to bridge the gaps in our knowledge and better explain, predict, and ultimately prevent future HPAI outbreaks.
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김설희,Moonsuk Hur,서재화,우찬진,왕승준,박응로,황종경,안인정,조성덕,Jeong-Hwa Shin,Seung-Do Yu,최경희,이동훈,Chang-Seon Song 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.3
Nineteen highly pathogenic avian influenza (HPAI) H5N8 viruses were isolated from wild birds in the Donglim reservoir in Gochang, Jeonbuk province, Korea, which was first reported to be an outbreak site on January 17, 2014. Most genes from the nineteen viruses shared high nucleotide sequence identities (i.e., 99.7% to 100%). Phylogenetic analysis showed that these viruses were reassortants of the HPAI H5 subtype and the H4N2 strain and that their hemagglutinin clade was 2.3.4.4, which originated from Eastern China. The hemagglutinin protein contained Q222 and G224 at the receptor-binding site. Although the neuraminidase protein contained I314V and the matrix 2 protein contained an S31N substitution, other mutations resulting in oseltamivir and amantadine resistance were not detected. No substitutions associated with increased virulence and enhanced transmission in mammals were detected in the polymerase basic protein 2 (627E and 701D). Non-structural-1 was 237 amino acids long and had an ESEV motif with additional RGNKMAD amino acids in the C terminal region. These viruses caused deaths in the Baikal teal, which was unusual, and outbreaks occurred at the same time in both poultry and wild birds. These data are helpful for epidemiological understanding of HPAI and the design of prevention strategies.
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