Protein kinase A 억제제인 KT5720이 글루카곤 매개성 항산화 효소의 발현감소에 미치는 영향

오수진,조재훈,박창식,김상겸,김봉희,Oh Soo-Jin,Jo Jae-Hoon,Park Chang-Sik,Kim Sang-Kyum,Kim Bong-Hee 환경독성보건학회 2006 환경독성보건학회지 Vol.21 No.3

We reported previously that glucagon decreased alpha- and pi-class glutathione S-transferases (GSTs) and microsomal epoxide hydrolase (mEN) protein levels in primary cultured rat hepatocytes. The present study examines the effects of Protein kinase A (PKA) inhibitor, KT5720, on the glucagon-mediated decrease in expression of GSTs and mEN. To assess cell viability. lactate dehydrogenase release and MTT activity were examined in hepatocytes treated KT5720. Cell viability was significantly decreased in a concentration dependent manner after incubation with KT5720 at the concentrations of 1 $\mu$M or above for 24 h, which was inhibited by the cytochrome P450 inhibitor SKF-525A. In contrast, another PKA inhibitor H89 (up to 25 $\mu$M) was not toxic to hepatocytes. The glucagon-mediated decrease in expression of alpha- and pi-class GSTs and mEH was completely inhibited by 25 $\mu$M H89 and attenuated by 0.1 $\mu$M KT5720. This study demonstrates that KT5720 may cause cytotoxicity in rat hepatocytes through cytochrome P450-dependent bioactivation. The present study implicates PKA in mediating the inhibitory effect of glucagon on expression of alpha- and pi- class GSTs and mEH.

모모세포종과 복합모반을 동반한 피지샘 모반

오수진 ( Su Jin Oh ),한성수 ( Sung Soo Han ),박형권 ( Hyung Kwon Park ),유희준 ( Hee Joon Yu ),김정수 ( Joung Soo Kim ) 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.9

Nevus sebaceous is a common congenital cutaneous hamartoma occurring mainly on the face and scalp. It is well known that secondary neoplasms can be easily observed in the primary lesion. However, a case of trichoblastoma and compound nevus concurrently arising from nevus sebaceous has not been previously reported. A 26-year-old woman presented with a well-demarcated atrophic skin-colored plaque on her scalp from birth. On the plaque, a black dome-shaped round nodule and a brownish nodule with irregular margins were found one week previously without subjective symptoms. Histopathological examination of the central plaque lesion revealed epidermal hyperplasia and hyperplasia of the sebaceous glands and eccrine glands. In addition, ectopic, dilated apocrine glands were revealed in the lower dermis, and the hair follicles remained small and primordial, consistent with nevus sebaceous. A section of the black nodule showed palisading basaloid cells surrounded by abundant fibrous stroma. Nests of nevus cells were found at the dermo-epidermal junction and dermis in the brownish nodule. Based on these findings, the black nodule and brownish nodule were diagnosed as trichoblastoma and compound nevus, respectively. Herein, we report an interesting case of trichoblastoma and compound nevus concurrently arising from nevus sebaceous, which is, to our knowledge, the first such report in the dermatologic literature. (Korean J Dermatol 2017;55(9):615∼618)

캄보디아의 고아원관광에 대한 비판적 고찰

오수진 ( Soo Jin Oh ) 한국동남아학회 2016 동남아시아연구 Vol.26 No.1

캄보디아는 아동을 관광자원으로 활용하는 고아원관광 형태의 관광산업이 상대적으로 일찍 시작되어 이미 산업의 성숙기에 접어든국가 중 하나로 지역사회, 특히, 아동에게 미치는 영향에 대한 심각한 문제들이 대두됨에 따라 서구권을 중심으로 한 국제사회의 주목을 받게 되었다. 외국인들의 달러를 유치하는데 중추적인 역할을 하는 캄보디아의 고아원관광은 캄보디아와 유사하게 관광잠재력을 가진 다른 개발도상국들에게 확산되고 있는 추세를 보이고 있어, 고아원관광은 더 이상 캄보디아 한 국가에 국한된 문제가 아닌 심각한국제적 이슈가 되기에 이르렀다. 고아원관광이 일반 관광산업과 다른 결정적인 이유는 관광활동의 대상이 아동이라는 것이다. 국가의 미래라 불리는 아동을 대상으로 ‘양날의 검’이라는 논리를 앞세우며 경제활성화를 논한다는 것은 국가의 미래를 포기하겠다는 것과 동일한 의미일 것이다. 이러한 이유로 캄보디아는 물론 국제적으로 다양한 반고아원관광 또는 이와 관련한 캠페인 및 활동들이 기획·진행되어 왔으며, 미디어들 또한 이에 대한 심각성을 인식하여 고아원관광에 대한 비판적 보도를 하고있다. 그러나 캄보디아의 모든 고아원들이 부패하거나 아동들을 영리의 목적으로 이용하는 것은 아니라는 사실에 주의해야 한다. 비록 고아원관광이 점차 심각한 국제적 이슈로 대두되고 있지만, 캄보디아 아동들을 위해 고아원관광 근절을 목표로 시행되고 있는 수많은 반고아원관광 캠페인들과 고아원에 대한 부정적인 내용만이 부각되는 언론보도들은 오히려 캄보디아 아동들을 합법적으로 유익하게 양육하는 고아원들에게 막대한 피해를 입히게 될 것이며, 그로 인한피해는 고스란히 아동들에게 돌아갈 것이다. 따라서 관광으로 인한아동들의 피해방지와 고아원관광의 근절 등 반고아원관광을 위한 활동들과 고아원관광에 대한 원색적인 비난만을 조명하는 언론보도에 앞서, 고아원의 폐쇄 또는 반고아원관광 활동들로 인해 아동들에게 닥칠 또 다른 이슈들에 대한 해결책 마련이 선행되어야 할 것이다. 아울러 고아원관광이 상대적으로 일찍 시작된 캄보디아를 반면교사(反面敎師) 삼아 고아원관광의 움직임이 보이는 또는 확산되기 시작한 개발도상국 또는 지역에 이를 사전에 예방 또는 근절할 수있는 대책방안 마련이 시급할 것이다. Cambodia where used to be infamous for brutal Khmer Rouge regime and Killing fields has been re-recognised as ``a country of Angkor Wat`` as tourism industry has rapidly been developing for past few decades. Tourism industry is Cambodia``s second largest economic contributor, amounting to 23.5% of GDP in 2013 with over 4.46 million arrivals per year since 2007 this is on the increase and it is expected 6.9 million arrivals in 2024 (WTTC, 2015). In spite of this remarkable growth of tourism industry, Cambodia is still one of the poorest countries in the world as over 7 millions of Cambodians live with less than US$1 a day. Orphan numbers in Cambodia at their lowest point in decades, whilst orphanage numbers have undergone a significance increase in the last five years, coinciding with a distinctive increase in tourism numbers. Orphanage volunteering (or orphanage tourism) is often described worthwhile experience which helps those who are disadvantaged in ‘developing nations’. Orphanages are heavily reliant on overseas donations or charities for funding, leading the way for orphanage tourism. As a result, orphanage, supposed to take care of children without parents regard and abuse the children as means of attracting foreign tourists (or visitors) for funding. This paper seeks to illustrate the pervasiveness of orphanage tourism in Cambodia, the significant impacts on children and the local community, and movement for anti-orphanage tourism campaigns to alert the significance of such a inhumane phenomenon in developing countries like Cambodia.

상이동 촉매 기법(phase transfer catalyst)을 이용한 rose bengal 시약의 최적 조성에 관한 연구

오수진(Soo-Jin Oh),차원진(Won-Jin Cha),최다운(Da-Woon Choi),홍성욱(Sung-Wook Hong) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.7

상이동촉매기법을기반으로 한rose bengal 시약은 중성이나염기성용액에서 녹지않는 난용성염을형성 하는칼슘을타겟팅하는 시약으로, 물에 젖은 검체에서 잠재지문 현출시 효과적일 것으로 기대되어 최근 연구가 이루어지고 있다. 그러나 그 동안 선행연구에서는 rose bengal 시약으로 현출된 지문의 형광 특성을 관찰하지 않았을 뿐만 아니라 제시된 시약의 제조법 또한 최적 현출 조건인지 검토되지 않았다. 이에 본 연구는 rose bengal 염료의 최대방출형광을 바탕으로 rose bengal염료와 상이동촉매제(Tetrabutylammonium)의 농도를 달리하여 최적의 시약 조성을 찾고자 하였다. 그 결과 rose bengal과 상이동촉매제의 농도가 각 0.01 M : 0.008 M일 때 가장 효과적인 것을 확인할 수 있었다. The rose bengal reagent, based on the phase transfer catalysis technique, is a calcium-targeting reagent that forms an insoluble salt that does not dissolve in a neutral or basic solution. It is expected to be effective in developing a latent fingerprint in a wet sample. However, many previous studies did not observe the fluorescence of the developed fingerprints, nor were the proposed methods of producing the reagents the optimal develop conditions. The aim of this study was to investigate the optimum reagent composition of rose bengal by varying the concentration of rose bengal dye and phase transfer catalyst based on maximum emission fluorescence of rose bengal. As a result, it was confirmed that rose bengal and surfactant concentration were the most effective when 0.01M: 0.008M, respectively.

전방십자인대 재건술 후 고유수용감각 기능 평가에서의 관절위치감각 검사의 효용성

오수진 ( Soo Jin Oh ),양상진 ( Sang Jin Yang ),하정구 ( Jeong Ku Ha ),서정국 ( Jeong Gook Seo ),최정윤 ( Jeong Yoon Choi ),김진구 ( Jin Goo Kim ) 대한스포츠의학회 2011 대한스포츠의학회지 Vol.29 No.2

We designed a study to evaluate the change of the proprioceptive function with joint position sense (JPS) during 1 year follow-up period after anterior cruciate ligament (ACL) reconstruction using hamstring autograft. Thirty-eight men who underwent ACL reconstruction were tested for International Knee Documentation Committee subjective knee score, Tegner activity score, Lysholm score, KT-2000 arthrometer, isokinetic strength test, functional performance test (carioca, co-contraction, shuttle run test, one-hop test) and JPS at preoperation, 6 months, and 12 months postoperation. The contralateral healthy knee was used as control. There were no significant differences of JPS between the involved knee and healthy knee at any time period. Repeated measures analysis of variance of the active JPS revealed that there was no significant difference during the follow up periods. The change patterns of passive JPS of extension and flexion were out of accordance with the improving clinical status following ACL reconstruction. Most of the clinical parameters did not show the significant correlation with active and passive JPS at any time period. In conclusion, JPS does not reflect the change of proprioceptive function following ACL reconstruction.

성인진입기 대학생의 목표인식특성과 실패내성의 관계에서 그릿(Grit), 실패공포, 숙달접근목표의 매개효과

오수진 ( Soo Jin Oh ),안주현 ( Joo Hyun An ),양수진 ( Su Jin Yang ) 미래를 여는 청소년학회 2022 미래청소년학회지 Vol.19 No.1

본 연구는 성인진입기 대학생을 대상으로, 자신의 목표에 대한 주도적이고 실제적인 인식이 학업적 실패에 건설적인 태도로 반응하는 경향성인 실패내성을 예측하는지를 확인하고자 하였다. 그리고 그 관계에서 그릿(Grit), 실패공포 그리고 성취목표지향의 하위요인인 숙달접근목표의 매개 역할을 검증하고자 하였다. 만 18~25세의 대학생 449명을 대상으로 자기보고식 설문조사를 실시하였고, Process Macro(Model 81)를 사용하여 매개효과 및 변인들 간의 경로를 분석하였다. 분석 결과, 목표인식특성과 실패내성 간의 직접효과는 나타나지 않았으나 그릿, 실패공포 그리고 숙달접근목표를 통한 단순매개효과는 유의하였다(p< .01). 또한, 두 변인 간의 관계에서 그릿과 실패공포 및 그릿과 숙달접근목표를 통한 순차적 이중매개 효과가 모두 유의하였다(p< .05). 즉, 목표인식특성은 장기적 목표 추구를 위한 그릿을 촉진하여 실패에 대한 공포를 낮추고, 나아가 숙달접근 목표지향성을 높여 실패내성을 강화하는데 기여함을 의미한다. 본 연구는 실패내성을 키우기 위해 고려해야 할 개입 요소로, 단순한 목표 설정 및 인식만이 아닌 지속적인 실행력을 위한 개인의 성격 특성, 실패에 대한 역기능적 신념 극복 및 숙달 과정에 초점을 맞추는 통합적 기제가 중요함을 밝혔다는데 의의가 있다. This study sought to identify whether the leading and practical perception of one's goals predicts failure tolerance, a tendency to respond constructively to academic failures. In addition, we aimed to verify the mediating roles of grit, fear of failure and goal orientation(mastery goals) in the aforementioned relation. The data from 449 college students aged 18 to 25 was analyzed using Process Macro (Model 81). The results showed that although there was no direct effect between goal recognition characteristics and failure tolerance, three simple mediations through grit, fear of failure and mastery goals were all significant (p< .01). Two sets of double medition (grit and fear of failure; grit and mastery goals) were also found to be significant (p< .05). The results signify that goal recognition characteristics contribute to enhancing failure tolerance by promoting grits for long-term goal-pursuit, lowering fear of failure, and further increasing master approach goal orientation. These findings suggest that resilient characteristics to failure can develop by an integrative intervention that strengthens the underlying workings of both personality, beliefs, and goal orientation.

In Vitro Screening Techniques for Reactive Metabolites Detection

오수진(Soo Jin Oh) 한국환경독성학회 2011 한국독성학회 심포지움 및 학술발표회 Vol.2011 No.10

프리캐스트 슬래브 궤도용 시멘트-아스팔트 혼합 모르타르 충전재의 온도변화에 따른 물리적 특성

오수진(Oh Soo Jin),이후삼(Lee Hu Sam),장승엽(Jang Seung Yup),정용(Jeong Yong),정영민(Jung Young Min),윤섭(Yoon Seob) 한국철도학회 2007 한국철도학회 학술발표대회논문집 Vol.- No.-

The cement-asphalt mortar is a mixture of cement and asphalt emulsion, and is utilized as a underpouring materials for the railway track which is used to fill under slab panel space so as to provide a stabilized track support and a tool for reduction of noise and vibration. To increase the workability of grouting, this study investigates the effect of temperature on cement-asphalt mortar by analyzing its physical and mechanical properties before/after hardening according to the temperature (10, 15, 20, 25, 30℃). According to the test results, it is found that as for the physical property of fresh cement-asphalt mortar the more mixture temperature become higher or lower, the more fluidity become worse. But by increasing reducing agent amount and its unit quantity, the required fluidity is met. The compressive strength as physical property of hardened cement-asphalt mortar become lower when temperature is lower but taking it by and large the physical properties of cement-asphalt mortar before/after hardening aren"t so affected by temperature and well satisfy the requirement. And it has proved that rate of expansion and freezing and thawing resistance aren"t affected by temperature.

책읽기 전략에 따른 다운증후군 아동과 일반 아동의 어휘 습득

오수진(Soo Jin Oh),임동선(Dongsun Yim) 한국언어치료학회 2022 言語治療硏究 Vol.31 No.4

지역축제의 서비스 품질요인과 방문객 만족도 및 재방문에 관한 연구

오수진 ( Soo Jin Oh ),이정희 ( Jeong Hee Lee ) 한국이벤트컨벤션학회 2007 이벤트 컨벤션 연구 Vol.3 No.1

This study aims to identify what the festival service product consist of and how the components of service quality have influence on visitors` satisfaction. To achieve the aim, firstly a study on service quality of the festival is introduced. Secondly, a study on measurement models of service quality in the festival and finally, components and consequences of the visitors` satisfaction were studied. Based on the case analysis in this study, several issues are brought as below. First, age and resident area of visitors affect their satisfaction at the festival. Secondly, it is derived ``context``, ``pleasantness``, ``information``, and ``value of indigenous product`` which are four principal factors of the 「2006 Gyongju Korean Traditional Drink & Rice Cake Festival 」from objective evaluation based on previously testified studies. Lastly, visitors` satisfaction have an effect on re-visitation. This study has limitations caused by testifying a specific festival and surveyed only domestic visitors at the festival.