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당뇨병성 다발성 신경병증에 대한 thioctic acid의 유효성 및 안정성에 관한 연구
황진수,염정필,조용근,김종화,이치국,최유진,김현각,류완희,박태선,백홍선 의과학연구소 1999 全北醫大論文集 Vol.23 No.2
Diabetic neuropathy is a major factor in determining the morbidity of diabetic patients and most common complication, so the majority of diabetic patients have diabetic polyneuropathy. The most common causes of amputation of lower extremities are diabetic neuropathy and vascular insufficiency, taken over 50% of all causes. Near-normoglycemia is now generally accepted as the primary goal in the prevention of diabetic neuropathy. However, relatively long periods of near normal glycemic control for several months or even years may be needed to retard the progression of nerve dysfunction in diabetic patients with advanced stages of peripheral neuropathy. Hence, additional pharmachological treatments of painful neuropathic symptoms are frequently required to maintain the quality of life in symptomatic diabetic neuropathy. Antioxidant treatment has been shown to prevent nerve dysfunction in experimental diabetes mellitus, thus providing a rationale of potential therapeutic value for diabetic patients. The effects of thioctic acid, anti-oxidant α-lipoic acid, were studied in a eight weeks schedule in 21 diabetes mellitus patients with symptomatic peripheral neuropathy. They were assigned to treatment with thioctic acid 600㎎ once daily before breakfast. Neuropathic symptoms(pain, burning, parethesia, and numbness) were scored at baseline and each visits(4th week and 8th week later). Biochemical status was checked via blood sampling at baseline and 8th week of treatment. As a result, the mean value of total symptom scores were 6.6±2.0, 6.1±2.2, and 4.5±1.7 at baseline, second, and third visit. Although there was no significant statistical change in total symptom scores of neuropathic symptoms between first and second visit, significant improvements were observed at third visit compared with second visit(p=0.03). But no specific unfavorable effects or biochemical changes were not noted during the treatment with thioctic acid. So, we observed the significant beneficial effects of thioctic acid 600㎎ once daily before the breakfast for eight weeks in controlling symptoms of diabetic neuropathy without specific adverse reaction.
IMIPENEM/CILASTATIN(TIENAM)의 임상적 연구
오상미,염정필,곽재용,임창열,이양근 의과학연구소 1997 全北醫大論文集 Vol.21 No.2
The rapid institution of broad-spectrum antibiotics in febrile neutropenic patients has clearly been shown to limit infectious morbidity and mortality. Imipenem is the first representative of the new thienamycin class of antibiotics. It has an extremely broad antimicrobial spectrum that includes most of the gram-negative and gram-positive organisms that commonly cause infections in neutropenic patients. We have evaluated imipenem as initial therapy for febrile patients with neutropenia and also as secondary therapy in patients failing to respond to other antimicrobial regimen. Clinical response rate was 75%. No serious side effects were noted in any patients. In conclusion, imipenem/cilastatin is a safe and effective antibiotics as monotherapy in febrile granulocytopenic patients.
제2형 당뇨병 환자에서 App E 지단백 유전자형 다형성과 혈청 지질과의 관계
류완희,염정필,김용성,윤경하,이규호,박지현,김현각,박태선,백흥선,김달식 의과학연구소 2000 全北醫大論文集 Vol.24 No.2
Background and purpose : Apolipoprotein E (apo E) has important function for lipoprotein metabolism as a low density lipoprotein (LDL) receptor and hepatic apo E receptor. Apo E has three isoforms, E2, E3 and E4. The purpose of this study is to evaluate the serum lipid profile depending on apo E genotype in the type 2 diabetic patients. Materials and Methods : Two hundred thirty four type 2 diabetic patients and ninty four controls were included in this study. The serum lipid profiles were measured and apo E genotypes were determined by modified Amplification Refractory Mutation system (ARMS) and classified into E2, E3 and E4 subgroups. Results : The apo E genotype frequencies in type 2 diabetic patients were as follows; 70.9% for ε3/3, 15.0% for ε3/4, 8.5% for ε3/2, 2.1% for ε2/2, 2.1% for ε4/4, 1.3% for ε2/4. The calculated apo E allele frequencies were 0.069 for ε2, 0.819 for ε3, 0.112 for ε4. There were no significant differences betwwen type 2 diabetic patients and controls in apo E genotype, and allele frequencies. Mean level of the serum HDL-cholesterol was significantly lower in E4 group than E2 and E3. The subjects with apo ε4 allele had sgnificantly lower level of HDL-cholesterol than the subjects without ε4 allele and subjects with apo ε2 were associated with higher level of LDL-cholesterol and of triglyceride in type 2 diabetic patients. Conclusion : Apo E polymorphism plays an important role in dtermining individual differences in serum lipid level in type 2 diabetic patients.
신장이식 후에 발생한 거대세포바이러스 폐렴에 합병한 침습성 아스페르길루스증 1예
마명신,이경훈,염정필,박재성,김남수,최정기,이흥범,이용철,이양근 의과학연구소 1999 全北醫大論文集 Vol.23 No.1
This 45-year-old woman had undergone renal transplantation on November 25, 1998. In January 1999 she developed dry cough and mild fever. Chest radiographs revealed multifocal patchy and conglomerated consolidation on both lung field, especially lower lung field. Open lung biopsy was performed and aspergillosis and CMV infection were demonstrated in the biopsy specimen. The patient was treated with conventional amphotercin and ganciclovir, but she was progressively aggravated due to fatal combined cytomegalovirus and aspergillosis pneumonia.