초음파로 진단된 지방간의 유병율 조사 및 그 유발인자에 대한 연구

안재억,함정오,황규윤,김주자,이병국,남택승,김정순,김헌,Ahn, Jae-Eog,Ham, Jung-Oh,Hwang, Kyu-Yoon,Kim, Joo-Ja,Lee, Byung-Kook,Nam, Tack-Sung,Kim, Joung-Soon,Kim, Hun 대한예방의학회 1991 예방의학회지 Vol.24 No.2

Fatty liver is caused by derangement of fat metabolism and can be reversed by removal of contributing factors. The contributing factors of fatty liver is known to be overweight, chronic alcoholism, diabetes mellitus, malnutrition, and drug abuse such as tetracycline. This study was carried out on 1335 persons who visited 'Soon Chun Hyang Human Dock Center' from March to June 1990. In analysis of the data, prevalence of fatty liver diagnosed by ultrasonogram by age and sex, laboratory finding between fatty liver group and normal group, and odds ratio of known contributing factors, were compared. The results obtained are as following ; 1) The prevalence rate of fatty liver diagnosed by ultrasonogram is 29.6% in male and 11.5% in female. 2) Age groups with high prevalences are $40{\sim}50's$ in male (32.0%) and 50's in female (24.5%). 3) The fatty liver shows significant association with style (p<0.05), whereas not with hepatitis B-virus surface antigen (p>0.05). 4) All laboratory values except alkaline phosphatase and bilirubin are elevated significantly in accordance with the degree of fatty liver (p<0.01). 5) Fatty liver diagnosed by ultrasonogram showed so strong associations with body index, triglycerides and gamma-glutamyl transferase for males, and body index and fasting blood sugar for females that these factors may be used as supplementary data in establishing diagnosis of fatty liver. 6) Odds ratio of contributing factors are as follows ; If the odds ratio of below 29 year of age is 1.0 then that of $30{\sim}39$ is 1.74 (p=0.33), $40{\sim}49$ is 2.47 (p=0.10), $50{\sim}59$ is 2.86 (p=0.0570), over 60 is 1.81 (p=0.34). If the odds ratio of female is 1.0 then that of male is 5.67 (p<0.01). If the odds ratio of body index below zero is 1.0 then that of $0{\sim}9$ is 5.08 (p<0.01), $10{\sim}19$ is 12.37 (p<0.01), $20{\sim}29$ is 29.19 (p<0.01), 30 above is 154.02 (p<0.01). If the odds ratio of below 99 mg/dl FBS is 1.0 then that of $100{\sim}120$ is 106 (p=0.76), over 120 is 1.91 (p=0.02). If the odds ratio of below $29{\mu}/1{\gamma}-GT$ is 1.0 then that of $30{\sim}s59$ is 2.11 (p<0.01), $60{\sim}90$ is 1.87 (p<0.05), 90 above is 1.69 (p=0.15). If the odds ratio of below 149 mg/dl TG is 1.0 then $150{\sim}199$ is 1.49 (p=0.05), $200{\sim}250$ is 1.09 (P=0.77), 250 above is 2.53 (p<0.01). In summary, early diagnosis of fatty liver could be made by ultrasonogram supplemented with body index and nm triglyceride. The fatty liver could be preventive by avoiding contributing factors such as obesity, alcohol intake, high blood sugar appropriately.

저농도 연폭로에서 혈중 연농도와 자각증상과의 관계

황규윤,안재억,안규동,이병국,김정순,Hwang, Kyu-Yoon,Ahn, Jae-Eog,Ahn, Kyu-Dong,Lee, Byung-Kook,Kim, Joung-Soon 대한예방의학회 1991 예방의학회지 Vol.24 No.2

This study intended to obtain an useful information on the prevalence of subjective symptoms, and to clarify the interrelationships between blood lead and lead related symptoms in low level lead exposure. The 93 male workers exposed to lead and 56 male nonexposed workers were examined for their blood lead(PBB), Zinc-protoporphy(ZPP), hemoglobin(HB) and personnal history, and completed 15 questionnaires related to symptoms of lead absorption : also measured lead concentration in air (PBA) in the workplace. The results obtained were as follows ; 1. The means of blood lead (PBB), blood ZPP and hemoglobin (HB) among workers exposed to lead were $26.1{\pm}8.8{\mu}g/dl,\;28.3{\pm}26.0{\mu}g/dl$ and $16.2{\pm}1.2g/dl$ : whereas those of nonexposed workers were $18.7{\pm}5.1{\mu}g/dl,\;20.6{\pm}8.7{\mu}g/dl$ and $17.3{\pm}1.1g/dl$. The means of above three indicies between two groups showed significant difference statistically (p<0.05). 2. The means of blood lead (PBB), blood ZPP and hemoglobin of workers exposed .to different lead concentration in air were as follows : When it was below $25{\mu}g/m^3$, the indices were $24.7{\pm}79,\;26.1{\pm}26.8{\mu}g/dl\;and\;16.4{\pm}1.1g/dl$ respectively : These indices were $27.1{\pm}8.5,\;23.9{\pm}10.92{\mu}g/dl\;and\;16.2{\pm}1.3g/dl$ when the lead concentration in air was $25{\sim}50{\mu}g/m^3$ : and they were $3.4{\pm}9.3,\;42.3{\pm}31.3{\mu}g/dl\;and\;15.5{\pm}1.2g/dl$ when the concentration of lead was above $50{\mu}g/m^3$. Although there were statistical difference in blood lead and hemoglobin among three different lead concentration in air, there was no statistical difference of blood ZPP among the three groups with different exposure levels (p>0.05). 3. The most frequent by complained symptom was 'Generalized weakness and fatigue', and fewest symptom was 'Intermittent pains in abdomen' 4. Only two symptoms out of fifteen symptoms checked by themselves revealed significant difference between exposed and nonexposed groups. These were 'Intermittent pains of abdomen' and 'Joint pain or arthralgia' (p<0.05), No positive correlation was found between the levels of blood lead and symptom groups categorized as gastrointestinal, neuromuscular and constitutional symptoms, 5. Blood lead (r=0.3995) and ZPP (r=0.2837) showed statistically significant correlation with mean lead concentration in air, whereas correlations were not demonstrated between blood lead and lead related symptoms or blood ZPP and lead related symptoms. 6. Blood lead (PBB) and ZPP showed association (r=0.2466) and the equation PBB=23.75+0.0842 ZPP was derived. 7. On stepwise multiple regression, using blood lead level as a dependent variable and ZPP, hemoglobin (HB), age, work duration (WD) and symptom prevalence as a independent variables, only ZPP significantly contributed a lot to blood lead level. 8. While the ZPP measurement was found to be a good indicator in evaluating health effect of lead absorption in low level lead exposure, lead related symptoms were not sensitive enough to evaluate of lead absorption in low level exposure.

스크리닝을 이용한 건강진단후 건강상담이 $\gamma-GTP$의 변화에 미치는 영향 조사

이용진,안재억,김주자,이병국,Lee, Yong-Jin,Ahn, Jae-Eog,Kim, Joo-Ja,Lee, Byung-Kook 대한예방의학회 1997 Journal of Preventive Medicine and Public Health Vol.30 No.3

1,281 male subjects who had been examined more than 3 times for regular check-up in one human dock center of the university hospital were studied between 1990-1995, to evaluate the effect of health counselling with life style and $\gamma-GTP$ value between 1054 normal group without intervention and 227 abnormal group with intervention, ages from 30 to 69 years old. Total mean value of $\gamma-GTP$ was $45.7{\pm}40.7$ unit with highest $\gamma-GTP$ value in age group 50-59 on initial examination. Total abnormal rate was 17.7% with the highest abnormal rate of 18.6% in age group 50-59. Initially, the value of $\gamma-GTP$ was significantly different according to the degree of alcohol intake, relative weight and smoking in normal group(p<0.01) not in abnormal group. In conclusion, the value of $\gamma-GTP$ were significantly increasing in normal group without intervention and significantly decreasing in abnormal group with intervention(p<0.05), which suggests the effect of health counselling, such as the recommendation to change the health behaviour.

사무직 채용 신검에 있어서 간기능 검사에 대한 고찰

신연교,이용진,안재억,우극현,김주자,이병국,Shin, Yeon-Gyo,Lee, Yong-Jin,Ahn, Jae-Eog,Woo, Kuck-Hveun,Kim, Joo-Ja,Lee, Byung-Kook 대한예방의학회 1995 Journal of Preventive Medicine and Public Health Vol.28 No.3

This is to analyze and compare the distribution of the liver function test and its abnormal rates of the preemployment screening for office workers in asymptomatic young age groups between female and male. Liver function test(SGPT and SGOT) of 8,184 young adults(2,633 in female and 5,551 in male ) were examined during the period from Jan.1, 1994 to Dec.31, 1994. The results were as follows; 1. Mean level of SGPT was $9.1{\pm}7.6(IU/L)$ in female, $21.0{\pm}27.9(IU/L)$ in male, and that of SGOT was $15.1{\pm}6.0(IU/L)$ in female, $20.5{\pm}26.5(IU/L)$ in male. There were significant differences(p<0.01) between female and male in both SGPT and 5G07 And also there was significant increasing trend(p<0.05) by age groups in male for SGPT, decreasing trend(p<0.01) in female for SGOT, 2. In the abnormal rates of liver function test by the level of cut-off value, there were significant differences up to twice between the lowest and the highest cut-off value in both female(0.4% vs 0.7%) and male(6.5% vs 32.4%) 3. Abnormal rate of SGPT was 0.4% in female and 6.3% in male, and that of SGOT was 0.2% in female and 1.2% in male with significant differences between female and male in both tests. 일개 대학병원에서 1994년 1월 1일부터 12월 31일까지의 기간 동안 사무직입사를 위하여 건강진단을 실시한 $17\sim29$세의 8,184명(여자 2,633명, 남자 5,551명)의 간기능 검사 결과를 분석하여 간기능 검사의 분포와 이상수준을 남녀별로 비교분석하여 무증상 젊은 여자에 있어서 간기능 검사의 유용성을 검토하였다. 1. 연령별, 성별에 따른 간기능 검사의 항목별 평균값은 SGPT의 경우 여자 $9.1{\pm}7.6(IU/L)$, 남자 $21.0{\pm}27.9(IU/L)$ 였으며, SGOT의 경우 여자 $15.1{\pm}6.0(IU/L)$, 남자 $20.5{\pm}26.5(IU/L)$ 각각 남녀간의 유의한 차를 보였으며(p<0.01), 연령에 따른 평균치의 분포는 SGPT는 남자에서만 유의하게 증가하였으며(p<0.05), SGOT는 여자에서만 유의하게 감소하였다(p<0.01). 2. 각 기준치에 따른 간기능 검사의 이상률로는 가장 낮은 검사실 기준치를 정할때 전체 8.6%(705/8,184), 여자 0.7%(19/2,633), 남자 12.4%(686/5,551)로 1:17.7의 비로 유의한 차를 보이고 있었다(p<0.01). 제일 높게 정한 노동부 고시에 의한 관리한계치로 정할 때의 간기능 이상률은 전체 4.6%(372/8,184) 여자 0.4%(11/2,633) 남자 6.5%(361/5,551)로 1:16.3의 비로 유의한 차를 보이고 있었다(p<0.01). 3. 성별에 따른 간기능 검사의 항목별 이상률은 SGPT의 경우 여자 0.4%(l1/2,633), 남자 6.3%(352/5, 551), SGOT의 경우 여자 0.2%(5/2,633), 남자 1.2%(69/5,551)이었으며 남녀간에 모두 유의한 차를 보이고 있었다(p<0.01). 연령증가에 따른 간기능 이상률은 남자 SGPT에서만 유의하게 나타났다(p<0.01). 이상에서 볼 때 $17\sim29$세 연령군의 여자에서의 간기능 이상률은 매우 낮으므로 무증상의 젊은 여성군에 있어서 일률적으로 간기능 검사를 시행하는 것에 대한 재검토가 필요하다고 사료된다.

위암의 수술 후 생존율에 따른 예후인자 분석

임철완(Cheol Wan Lim),박경규(Kyung Kyu Park),이민혁(Min Hyuk Lee),김익수(Ik Soo Kim),안재억(Jae Eog Ahn) 대한외과학회 1994 Annals of Surgical Treatment and Research Vol.47 No.4

총수담관담석 예측인자의 비교

임삼병(Sam Byung Lim),허경열(Kyung Yul Hur),이민혁(Min Hyuk Lee),송영식(Young Sik Song),허경발(Kyung Bal Hur),안재억(Jae Eog Ahn) 대한외과학회 1996 Annals of Surgical Treatment and Research Vol.51 No.5

유방암에서 액와림프절 전이의 예측 인자

조규석(Gyu Seok Cho),임철완(Chul Wan Lim),박내경(Nae Kyung Park),정성필(Sung Pil Jeung),박경규(Kyung Kyu Park),허경열(Kyung Yul Hur),장용석(Yong Seok Jang),안재억(Jae Eog Ahn),박재성(Jai Soung Park),이혜경(Hae Kyung Lee),이민혁(MIn H 대한외과학회 1999 Annals of Surgical Treatment and Research Vol.57 No.6

체지방 측정기(Futrex-1000 body fat tester)로 측정한 소아의 체지방율에 관한 연구 : 학동기와 청소년기 아동을 대상으로

박상철,이동환,신상만,이상주,박준수,최석민,안재억 순천향대학교 1992 논문집 Vol.15 No.2

Using the infrared interactance(NIR method), the percentage body fat in 1,401 Korean children, aged 6-18years, was evaluated for normal and standard values. Correlation of percentage of body fat with age, weight, height, overweight(%), Kaup index and Rohrer index was also analyzed. The following results were obtained ; 1) In all the subject, weight and height showed standard growth(50-90 percentile) compared to growth data of korean children. 2) The percentage of body fat was decreased with increasing age and was measured higher in female than male. 3) The percentage of body fat was decreased with increasing height in both sex. 4) The percentage of body fat correlated negatively with age, heght, weight in both sex. In boys, the Rohrer index appeared to have a significant positive correlation with the percentage of body fat. (r=0.52454) In girls, the overweight(%) appeared to have a significant positive correlation with percentage of body fat. (r=0.56994) The Kaup index had no correlation with the percentage of body fat. This NIR method is safe, non-invasive, rapid, easy to use, and may be useful predict percentage of body fat, especially in the mass screening.

신생아에서 자세 및 경사도에 따른 경피적 산소와 이산화탄소의 분압 및 경피적 산소 포화도의 변화에 대한 연구

이상주,이동환,박준수,박상철,안재억 순천향대학교 1992 논문집 Vol.15 No.2

To determine the optimal positino for the newborn, tcp02, tcpc02 and Sp02 were monitored, in 21 healthy term infants, in 21 healthy preterm infants and in those infants with respiratory disease using the Radiometer(Cophenhagen) TCM2 TC oxygen monitor, ECM 20 TC carbon dixide monitor and PULSOX-7(Minolta) oxygen saturation monitor in both supine and prone position. Also, monitored with tilting in each position. When the healthy preterm infants were prone, tcP02 rose by a mean of 5.8mmHg(p=0.0185), an increase of 8.7%, and Sp02 was not significantly increased by a mean of 0.6%(p=0.1859). In those infants with respiratory disease, tcP02 was not significantly increased by a means of 6.9mm/Hg(p=0.1014), and Sa02 was not significantly changed. There was no change of tcPC02 in all infants. This improved oxygenation in the prone position appears to be the result of enhanced ventilation/perfusion ratios. Tilting the body in a 20head-down, or 20 head-down partially produce significant change in tcP02, or Sp02 in the newborns. These findings may have important implications in the management of preterm infants requiring neonatal intensive care and the infants with respiratry disease.

보건관리정보시스템 조사 및 구축에 대한 연구

안재억 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

The purpose of this study was the introduction and development of Health Management Information System(Computer Software Program) and data management. The results were as follows : 1. The Health Management Information System was already used at Korean Industrial Health Association, Soonchunhyang Hospital Health Management Center & Institute of Occupational Medicine, POSCO Health Care Center, Central Gil Hospital Health Management Center, Some commercial program (Junung, BIT, KIMS) was used at local clinic. 2. The first difficulty of development of Health Management Information System in many screening center was Computer Software Program. 3. altogether, Ministry of Labour, Korean Industrial Health Association, the Korean Society for Preventive Medicine, the Korean Society of Occupational Medicine have to make a good Health Management Information System(Computer Software Program) for epidemiologic study. 4. In order to use the health management information for epidemilogic study in the screening test, we have to make much discussion and need much suggestion from the Korean Society for Preventive Medicine and the Korean Society of Occupational Medicine.