개에서 치주질환과 연관된 하악골절의 치료

심경미,김세은,유경훈,배춘식,최석화,강성수 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.4

A 12-year-old, intact female Toy Poodle and a 10-year-old, intact male Yorkshire terrier were referred with bilateral mandibular fractures, severe periodontal disease and teeth loss. In the second case, mandibular fractures were repaired with periodontal disease treatment. After a follow-up period of 1 year, fracture healing was successful in the second case, however in the first case, bone healing was not satisfactory because mandibular fractures were repaired without the treatment of diseased teeth within the fracture line. Nonunion and inflammation of fracture sites, oral malodor confirmed in the first case and normal union of fracture sites observed in the second case. It suggests that the treatment of diseased teeth within the fracture line is mandatory for successful fracture healing.

Effect of Treatment with Transdermal Ketoprofen on Adjuvant-Induced Arthritis

심경미,Se Eun Kim,배춘식,Seok Hwa Choi,강성수 한국임상수의학회 2006 한국임상수의학회지 Vol.23 No.4

This study demonstrates the anti-arthritic effect of topical application of ketoprofen gel containing N-methyl-2-pyrrolidone (NMP) in adjuvant arthritis therapy. Adjuvant arthritis was induced by a single injection ofFreund's complete adjuvant (FCA). Mature female Sprague-Dawley rats were designated to 3 groups such as controlgroup, K10 group (ketoprofen 10 mg/rat), and NK10 group (ketoprofen 10 mg/rat containing NMP). The anti-arthriticbut also bone damage (X-ray score and regional bone uptake) of the hind paw in arthritis-induced rats. These resultsshowed a higher efficacy of ketoprofen containing NMP than ketoprofen treatment in the adjuvant-induced arthritis.Ketoprofen containing NMP has good intrinsic characteristics for formulation in an efficacious anti-inflammatorytopical application.

하나님의 형상 비혼지체들

심경미 새가정사 2018 새가정 Vol.712 No.-

근대역사문화도시 군산시

심경미 (사)한국도시계획가협회 2016 Urban planners Vol.3 No.1

Case Study of Diagnosis and Treatment of Thoracic Gunshot Trauma in a Dog by Computed Tomography

심경미,김세은,유경훈,박현정,배춘식,최석화,강성수 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.1

A 7-year-old female, Jindo dog was referred to the Veterinary Teaching Hospital with mild dyspnea and anorexia due to a gunshot trauma. The dog was wounded in the thoracic region 3 days ago. Plain radiographs showed the left 8 th rib fracture, interstitial pattern in the left caudal lung field and pleural effusion. Abdominal radiographs showed the lead bullet. Computed tomographs (CT) showed the size of pulmonary contusion, laceration, lung parenchymal injuries, hemothorax and perforation of abdominal wall. The therapeutic plan was based on abnormalities seen on CT scans but not clearly seen in survey radiographs. Thoracic CT significantly provides even more informations compared with the corresponding radiographs in thoracic gunshot trauma. Although thoracic survey radiographs are useful as a screening tool, CT is highly sensitive in detecting thoracic injuries after thoracic trauma and is superior to routine thoracic survey radiographs in visualizing lung contusion, pneumothorax and hemothorax. Therefore, we recommend CT in the initial diagnostic work-up of patients with thoracic injuries and with suspected chest trauma because early and exact diagnosis of all thoracic injuries along with sufficient therapeutic consequences may reduce complications.

개에서 periodontal splint를 이용한 치아유동성의 치료

심경미,김세은,유경훈,배춘식,최석화,강성수 한국임상수의학회 2008 한국임상수의학회지 Vol.25 No.2

A 2-year-old, intact and a 10-year-old, castrated male Maltese were referred for treatment of progressivetooth mobility and periodontal disease. The first case was presented with tooth mobility of mandibular incisors (Grade2-3) and the second case was also presented with tooth mobility of maxillary incisors (Grade 2-3) by periodontal disease.The treatment plan included supragingival scaling, closed root planing, subgingival curettage and removable-fixedperiodontal splinting of the mandibular (case 1) and maxillary (case 2) incisors to stabilize them. Three months aftertherapy, oral examinations were performed for evaluation of success of therapy. In both cases, oral malodor, periodontaldisease and tooth mobility were resolved and periodontal splints were remained rigidly.

두개결손부 모델에서 배양된 골막유래세포를 이용한 골이식 시 두개결손부 모델에서 배양된 골막유래세포를 이용한 골이식 시

심경미,김세은,김종춘,배춘식,최석화,강성수 한국방사선학회 2011 한국방사선학회 논문지 Vol.5 No.1

다능성 세포를 포함하는 골막은 골모세포와 연골세포로 분화될 수 있다. 그리고 배양된 골막유래세포는 골형성 능 력을 가지고 있다. 이 연구의 목적은 골막유래 세포들과 골이식재 간의 상호작용을 평가하는 것이다. Sprague-Dawley 랫드의 두개골 골막에서 세포를 분리한 다음, 배양된 골막유래세포를 beta-tricalcium phosphate (β-TCP)와 함께 임계결손부 크기의 두개결손부에 이식하였다. 모든 랫드는 골이식 수술 후 8주째에 희생되었으며, 골이식부의 골형성 능력은 일반방사선, micro CT 및 조직검사를 통해 평가되었다. β-TCP와 함께 이식된 골막유래세 포는 골결손부에서 더욱 증가된 석회화작용을 나타내었으며, 골결손부 안쪽 및 가장자리에 골밀도 증가와 신생골이 형 성되었다. 특히 골막유래세포는 β-TCP만 단독으로 이식하였을때보다 함께 이식 시 효과적으로 신생골을 형성하였다. 이러한 결과는 배양된 골막유래세포가 골결손부에서 골형성을 증진시킬 수 있는 가능성을 보였다. The periosteum contains multipotent cells that can differentiate into osteoblasts and chondrocytes. Cultured periosteum-derived cells (PDCs) have an osteogenic capacity. The purpose of this study was to evaluate the interaction of PDCs with bone graft biomaterial. After cell isolation from the calvarial periosteum of Sprague-Dawley rats, cultured PDCs were placed in critical-sized calvarial defects with beta-tricalcium phosphate (β-TCP). All rats were sacrificed 8 weeks after bone graft surgery, and the bone regenerative ability of bone grafting sides was evaluated by plain radiography, micro-computed tomography (CT), and histological examination. PDCs grafted with β-TCP displayed enhanced calcification in the defect site, density of regenerated bone and new bone formation within the defect and its boundaries. Furthermore, these PDCs more efficiently regenerated new bone as compared to grafted β-TCP only. The results suggest that cultured PDCs have the potential to promote osteogenesis in bone defects.

미니돼지에서 ^99mTc-Tin colloid와 ^99mTc-DISIDA를 사용한 간신티그라피의 비교 연구

심경미,김세은,이원국,궁성수,배춘식,이재영,최석화,한호재,강성수,박수현,Shim, Kyung-Mi,Kim, Se-Eun,Lee, Won-Guk,Koong, Sung-Soo,Bae, Chun-Sik,Lee, Jae-Yeong,Choi, Seok-Hwa,Han, Ho-Jae,Kang, Seong-Soo,Park, Soo-Hyun 한국생명과학회 2006 생명과학회지 Vol.16 No.6

동물 모델에서의 간기능의 비침습적 평가는 하나의 과제로 남아있다. 간신티그라피는 간의 크기 및 모양의 변화에 대한 정보를 제공할 뿐 아니라 간의 전체적인 기능을 파악할 수 있게 해 주며 간이식의 주요 합병증인 간염, 거부반응 및 담도계 합병증의 진단에도 편리하게 사용될 수 있다. 이에 본 연구에서는 미니돼지의 간 기능을 평가하기 위해 사람에서 주로 사용되는 방사성의약품인 $^{99m}Tc-Tin$ colloid와 $^{99m}Tc-DISIDA$를 이용하여 간 및 간담도 신티그라피를 시행하였다. 그 결과, 사람의 간신티그라피와 달리 미니돼지에서는 $^{99m}Tc-Tin$ colloid가 폐, 간, 위벽 및 신장에 섭취되고 폐와 간의 영상이 겹쳐져 간의 관심영역을 설정할 수 없었다. 그러나 $^{99m}Tc-DISIDA$를 사용한 간담도 신티그라피에서는 심장, 폐, 간, 담낭 및 십이지장으로의 연속적 방사능섭취를 관찰할 수 있었다. 따라서 미니돼지에서의 $^{99m}Tc-Tin$ colloid의 사용은 비특이적 결합력으로 인해 간 기능 평가를 위한 영상에는 적합하지 않으나 $^{99m}Tc-DISIDA$는 간담도 기능을 파악하는데 있어 좋은 수단이 될 수 있을 것으로 생각된다. Non-invasive evaluation of liver function in animal models remains a challenge. Hepatoscintigraphy provides information about changes in liver size and shape, and enables to understand general liver function. Futhermore it is readily used to diagnosis complications of liver transplantation like hepatitis, rejections and biliary complications. In this study, we investigated the usefulness of evaluating the liver function in miniature pigs with $^{99m}Tc-Tin$ colloid and $^{99m}Tc-DISIDA$ which are the most commonly used radiopharmaceuticals in human medicine. In result, $^{99m}Tc-Tin$ colloid was uptaked in lung, liver, gastric wall and kidney in miniature pigs. And $^{99m}Tc-DISIDA$ showed continuous uptake images of heart, lung, liver, gallbladder and duodenum, and it was similar to human's. Therefore we could conclude $^{99m}Tc-Tin$ colloid would not be suitable for evaluating hepatic function because of it's nonspecific affinity, however $^{99m}Tc-DISIDA$ scintigraphy would be an effective method for detecting hepatobiliary function in miniature pigs.

新羅 中代 對日關係에 관한 硏究

沈京美 백산학회 1999 白山學報 Vol.- No.52

개에서 개방골절된 견치에 대한 치수절단술의 적용 증례

심경미,김세은,유경훈,박지혜,박현정,배춘식,최석화,강성수 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.1

Two cases of vital pulpotomy for treatment of open fractured canine teeth in dog were referred to the Veterinary Teaching Hospital of College of Veterinary Medicine, Chonnam National University. In case 1, a 2-yearold male Cocker Spaniel was fractured left mandibular canine and the pulp was exposed. In case 2, an 1-year-old male Border Collie was open fractured both mandibular canine teeth. In both cases, we made sure of pulp vitality by oral examination and radiological findings. Therefore, we performed vital pulpotomy in these patients. Two months after therapy, radiological examinations were performed for evaluation of success of therapy. In both cases, the radiographs showed normal periapical anatomy and no changes in the root resorption