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신정아(Shin Jung-a) 동아인문학회 2019 동아인문학 Vol.46 No.-
어린이들을 바르게 기르고 가르쳐야 한다는 소파의 일관된 정신은 1920년 그가 일본에 유학한 시기부터 본격화되었다. 방정환이 유학기간 동안 일본에서 받은 영향은 외국 작품을 번안하거나 전국 각지를 순회하면서 동화구연을 한 것, 그리고 개벽사의 일을 도우면서 『어린이』지를 발행하는 일이었다. 그러나 근대 일본 아동문학의 중심인물인 이와야 사자나미(栗谷小波) 혹은 오가와 미메이(小川未明)와 사상적으로 일치하는 부분을 찾기는 쉽지 않다. 당시 일본의 주요 잡지였던 『소년세계』(少年世界), 『아카이도리』(赤い鳥),『킨노후네』(金の船)등에서도 마찬가지다. 이유인즉 방정환의 어린이문학교육은 독립을 향한 의지와 투철한 민족주의에서 비롯되었기 때문이다. 한편, 그의 번안 작품집 『사랑의 선물』과 소년운동의 실천적 모체인『어린이』지에 선별된 작품은 식민지 상황과 일본의 영향에서 벗어날 수 없었다. 민족의 고통을 동반한 그의 작품은, 식민지 시대를 사는 어린이와 어른이 함께 읽고 느낄 수 있는 작품을 우선시했다. 특히, 어른에게 구박을 받거나 매를 맞는 주인공이 많이 등장하는데, 식민지 조선의 어린이를 동정하고 그들에게 위로를 주는 작품을 읽히는데 주력했다. 이것은 어린이와 어른의 관계이기도 하지만, 한편으로는 식민지 조선과 일본의 관계가 성립되기도 한다. 약자와 강자로 정리되는 관계는 시대적 상황으로 말미암아 이중적인 의미를 부여하는 것이다. Cheondoky`s council for children was established by Kim, Ki-joen, Bang, Jung-hwan, and Lee, Jung-jo on May 1st, 1921 but Bang, Jung-hwan was studying abroad at that time, not involving directly in it. Bang, Jung-hwan was responsible for tasks as a special correspondent in Tokyo for Kaebyeok, a comprehensive magazine which had been established in June, 1920, and for building Tokyo branch of Cheondokyo"s council for youth(Feb 13th, 2921)(Yeom, Hee-kyoung, 78). Since then, he organized Saekdongheo(Coloring Council) with other Korean students who shared his thought, and held the opening ceremony. In addition, early editing for the magazine, Children(Eorinyi) was made in Tokyo. So the Japanese influences on Bang, Jung-hwan during his study in Japan truly affected Korean modern children`s literature education. There have been quite many studies about the Japanese influences on the modern Korean children`s literature education. These studies are dominated with the evaluation that key role of Ywaya Sazanami(hereinafter Sazanami), the father of Japanese children`s literature with regard to the Japanese influences on modern Korean children`s literature education. However, in-depth analysis, Bang, Jung-hwan`s children`s literature education was derived from hope of salvation for Korean people to recover Korean sovereignty lost by Japan during Japanese colonial times, having clear difference from Japanese children`s literature education. Therefore, this study, focusing on Korean modern children`s literature education and the Japanese influences on it, aims at analyzing its truth, and reviewing Bang, Jung-hwan`s idea on children`s literature education through Gift of Love and the magazine, Children(Eorinyi). It is expected that it will be valuable study for building more accurate recognition about Bang, Jung-hwan`s children`s literature education.
신정아 ( Jung Ar Shin ),이창률 ( Chang Ryul Lee ),변민광 ( Min Kwang Byun ),장윤수 ( Yoon Soo Chang ),김세규 ( Se Kyu Kim ),장준 ( Joon Chang ),안철민 ( Chul Min Ahn ),김형중 ( Hyung Jung Kim ) 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.68 No.4
Background: Acyl protein thioesterase-1 (APT1) is a cytosolic protein that may function in the depalmitoylation of numerous proteins, including the Ras family. However, the clinical role of depalmitoyl thioesterase in human cancer is not known. We evaluated the APT1 expression in lung cancer tissue and its clinicopathological findings according APT1 expression pattern. Methods: APT1 expression was examined by immunohistochemistry in the tumor tissue from 79 patients, who had undergone curative surgical removal of the primary lesion; all patients had been diagnosed with stage I non-small cell lung cancer between 1993 and 2004, at Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Results: The APT1 expression was seen in 50 out of 79 (63.3%) cases. The positive APT1 expression was significantly related with histologic subtype and T stage, but was not influenced by differentiation. The positive APT1 expression was not significantly related to patient age, gender, or smoking history. The median follow-up duration was 10.0 years; the 5-year survival rate was 71.0%. The positive APT1 expression group showed significantly worse overall survival and worse disease-free survival without statistical significance. Conclusion: We conclude that positive APT1 expression in stage I lung cancer after surgery is closely associated with overall survival. To evaluate APT1 as a prognostic marker in lung cancer, comprehensive studies on advanced stage cases are needed.
Isoflavonoid의 피부염증균에 대한 항균 및 항산화효과
신정미(Jung Mi Shin),유형원(Hung Won Yu),이현옥(Hyun Ok Lee),이미희(Mi Hee Lee),백승화(Seung Hwa Baek) 大韓藥學會 2006 약학회지 Vol.50 No.1
Puerarin and daidzin have been isolated from Puerariae thunbergiana Benth. Structures were determined by spectroscopic methods. Compounds showed weak antimicrobial activity against S. mutans, S. epidermidis, S. aureus, and C. albicans (MIC, 800㎍/㎖). However, these compounds were not antioxidative. Puerariae thunbergiana Benth. extracts against microorgani는 were evaluated in terms of the minimum inhibitory concentrations (MIC). In general, C. albicans was stronger antimicrobial activity than the other microorgani는. The antioxidative activity of was observed in the etyl acetate extract (IC50, 119.87±0.16㎍/㎖). The DPPH radical scavenging effect (IC50, 1,673.3±0.54μM) of the puerarin was comparable with that of synthetic antioxidant, BHA(IC50, 88.39±1.1)×10-3 μM. These results suggest that puerarin and daidzin have a potential antimicrobial activity.