토복령(土茯笭)이 RAW264.7 대식세포주에서 산화질소 억제에 미치는 영향

이강희,정준희,김이화,이재혁,Lee, Kang-Hee,Jung, Jun-Hee,Kim, Ee-Hwa,Lee, Jae-Hyuk Society for Meridian and Acupoint 2009 Korean Journal of Acupuncture Vol.22 No.2

Objectives : 본 연구의 목적은 제습, 해독, 통리관절등의 효능이 있는 토복령이 RAW264.7 대식세포주에서 lipopolysaccharide(LPS)로 처치하여 생성되는 nitric oxide(NO)와 prostaglandin $E_2$($PGE_2$)에 억제작용이 있는지 관찰하고자 하는 것이다. Methods : 토복령이 RAW264.7 대식세포주에 세포독성이 유무를 관찰하기 위하여 농도별 MTT assay를 수행하여 세포생존율을 측정하였다. 또한 LPS로 염증유발된 RAW264.7 대식세포주에서 토복령의 농도별 처치가 NO 및 $PGE_2$ 생성억제에 미치는 영향을 관찰하고자 NO 및 $PGE_2$ assay를 수행하였다. Results : 토복령의 농도별 처치가 RAW264.7 대식세포주에서 세포독성을 유발하는지 MTT assay로 측정한 결과 세포독성은 관찰되지 않았으며, 토복령은 LPS처치로 인하여 증가된 NO 및 $PGE_2$ 생성을 통계학적으로 유의하게 감소시킴을 관찰하였다. Conclusions : 본 연구를 통하여 토복령은 RAW264.7 대식세포주에서 LPS로 유도된NO 및 $PGE_2$ 생성을 효과적으로 억제시킴으로써 추후 염증질환의 치료제로서 가능성을 확인하였다.

양성자 주입 기술을 이용한 초고속 회복 다이오드의 제작

이강희,김병길,이용현,백종무,이재성,배영호,Lee, Kang-Hee,Kim, Byoung-Gil,Lee, Yong-Hyun,Baek, Jong-Mu,Lee, Jae-Sung,Bae, Young-Ho 한국전기전자재료학회 2004 전기전자재료학회논문지 Vol.17 No.12

Proton irradiation technology was used for the improvement of power diode switching characteristics. Proton irradiation was carried out at the energies of 2.32 MeV, 2.55 MeV, 2.97 MeV so that the projection range of irradiated proton would be at the metallurgical junction, depletion region and neutral region of pn diode, respectively. Dose conditions were varied into three conditions of 1${\times}$10$^{11}$ cm$^{-2}$ , 1${\times}$10$^{12}$ cm$^{-2}$ , 1${\times}$10$^{13}$ cm$^{-2}$ at each condition of energies. Characterization of the device was performed by I-V(current-voltage), C-V(capacitance-voltage) and trr(reverse recovery time) measurement. At the optimum condition of irradiation, the reverse recovery time of device has been reduced about 1/5 compared to that of original un-irradiated device.

강화지역 청소년의 4년간 혈청 지질의 변화와 지속성

이강희,서일,지선하,남정모,김성순,심원흠,하종원,김석일,강형곤,Lee, Kang-Hee,Suh, Il,Jee, Sun-Ha,Nam, Chung-Mo,Kim, Sung-Soon,Shim, Won-Heum,Ha, Jong-Won,Kim, Suk-Il,Kang, Hyung-Gon 대한예방의학회 1997 예방의학회지 Vol.30 No.1

It has been known that there is a tracking phenomenon in the level of serum lipids. However, no study has been performed to examine the change and tracking of serum lipids in Korean adolescents. The purpose of this study is to examine the changes of serum lipids in Korean adolescents from 12 to 16 years of age, and to examine whether or not there is a tracking phenomenon in serum lipids level during the period. In 1992 serum lipids(total cholesterol(TC), triglyceride(TG), LDL cholesterol(LDL-C), HDL cholesterol(HDL-C)) were measured in 318 males, 365 females who were 12 years of age in Kangwha county, Korea. These participants have been followed up to 1996 and serum lipids level were examined in 1994 and 1996. Among the participants 162 males and 147 females completed all three examinations in fasting state. To examine the effect of eliminating adolescents with incomplete data, we compared serum lipids, blood pressure and anthropometric measures at baseline between adolescents with complete follow-up and adolescents who were withdrawn. To examine the change of serum lipids we compared mean values of serum lipids according to age in males and females. Repeated analysis of variance was used to test the change according to age. We used three methods to examine the existence of tracking. First, we analyzed the trends in serum lipids over 4-year period within quartile groups formed on the basis of the first-year serum lipids level to see whether or not the relative ranking of the mean serum lipids among the quartile groups remained in the same group for 4-year period. Second, we quantified the degree of tracking by calculating Spearman's rank correlation coefficient between every tests. Third, the persistence extreme quartile method was used. This method divides the population into quartile groups according to the initial level of blood lipids and then calculates the percent of the subjects who stayed in the same group at follow-up measurement. The decreases in levels were noted during 4 years for TC, LDL-C, primarily for boys. The level of HDL-C decreased between baseline and first follow-up for both sexes. Tracking, as measured by both correlation coefficients and persistence extreme quartiles, was evident for all of the lipids. The correlation coefficients of TC between baseline and 4 years later in boys and girls were 0.55 and 0.68, respectively. And the corresponding values for HDL-C were 0.58 and 0.69. More than 50% of adolescents who belonged to the highest quartile group in TC, HDL-C and LDL-C at the baseline were remained at the same group at the examination performed 2 years later for both sexes. The probabilities of remaining at the same group were more than 35% when examined 4 years later. The tracking phenomenon of TG was less evident compared with the other lipids. Percents of girls who stayed at the same group 2 years later and 4 years later were 42.9% and 25.7%, respectively. It was evident that serum lipid levels tracked in Korean adolescents. Researches with longer follow-up would be needed in the future to investigate the long-term change of lipids from adolescents to adults.

교육시설 내용년한 산정 연구 - 옥상방수와 바닥마감재를 대상으로 -

이강희,채창우,Lee, Kang-Hee,Chae, Chang-U 한국교육시설학회 2017 교육시설 Vol.24 No.6

Educational facilities have an affect to make a decently learning environment. After constructed, it needs a maintenance plan to keep the performance or function which provide the repair time, repair scope and ratio. But the fundamental data are so insufficient that the field worker can't provide the maintenance plan and has no choice use the other data which concerned with apartment or office building. Above all, the service life is indispensible to make a repair plan because the repair time and scope would be provided within the service life. This study aimed at providing the method to make a service life of component in educational facilities and applying the method into the roof proof and floor finishing. Results are shown that first, it is important to set the $1^{st}$ repair time after constructed. when it proposes the three ways with the probability approach, choice probability model and cumulative cost function. Second, the service life of roof proof is provided with about 35 years. In addition, the service life of the floor finishing is about 40 years. These result would be utilized to conduct the repair plan under the service life.

공동주택 구성재의 내용년수 산정방법에 관한 연구

이강희,장정희,채창우,Lee Kang-Hee,Chang Jung-Hee,Chae Chang-U 한국주거학회 2005 한국주거학회 논문집 Vol.16 No.5

The performance of building should be deteriorated with time while the building would maintain and manage the function and performance to get a living condition. For the efficient maintenance of the building, the repair cycle would be provided and applied during the service-life time. The service-life time of the building components would be needed to determine the repair time and the repair scope. The service-life time of the building components would be calculated with the 1st repair time and the recovery rate of the performance, considering the recovery rate after repaired. In this paper, the 1st repair time would be estimated with the normal probability distribution, choice probability and 3rd quadratic function. The recovery rate of the building components assumes various level according to the research target and utility area. The results of this study are as follows ; first, most of the components of the building work would range about 30 years in the service-life time and the components of the mechanical works range from 28 years to 37 years, those of the electrical works would be about 31 years.

임대공동주택 구성재의 열화도 패턴에 관한 연구

이강희,Lee Kang-Hee 한국주거학회 2006 한국주거학회 논문집 Vol.17 No.4

Most of buildings have been deteriorated with time-elapse by reflection of the building location, material, environmental circumstances and so on. The performance would go down and be demolished if anything could not be done after constructed. The maintenance should be required to preserve a decent living condition or improve a inferior condition by various plans and practices. The maintenance plan needs various data such as a repair scope, a repair time, a forecasted cost, a plan of management and so forth. Among the above required data for planning the maintenance, the deterioration characteristics of the building components would be first analyzed. The deterioration pattern would be a key role to affect and make a maintenance plan. In this paper, it aimed at classifying the deterioration patterns of building components. A deterioration pattern would be analyzed between the cumulative repair cost and time-elapse and modeled with these relations. A deterioration patterns are classified into 4 types-a accelerated type, a straight type, a temporary type and a slowly type. As a result of this research, a accelerated type includes window, window frame, general paintings, general water proofing in building components. A straight type includes the lacquer paintings, furnishings in building components and water supply pipe, boiler, sanitaries in mechanical facilities and lighting in electric facilities. Based on these research results, further study should be conducted to include any other components and an estimating model.

공동주택 구성재의 예상수선시기 범위 설정 연구

이강희,Lee Kang-Hee 한국주거학회 2006 한국주거학회 논문집 Vol.17 No.2

Building would be deteriorated with time elapse, influenced by its geographic situation, climate and other environmental conditions. In addition, the systematic maintenance could be provided to keep the resident a recent living condition. The existing breakdown maintenance will be changed into the preventive maintenance. The preventive maintenance is required to get the repair time, the repair scope and frequency. In this paper, it aimed at providing the repair time range over the building components, utilizing the relation between the determination curve and the performance recovery through repair. Results of this study are as follows : First, the forecast of the repair time over the building components could be calculated and equalized with the deterioration and performance degree. Second, the repair time range of building components would be provided into five categories and 3rd repair time. Results of this study will set up the long-term repair plan of building, and finally keep an housing condition comfortable.

공동주택 구성재의 경제적 수선형태 설정 연구

이강희,채창우,Lee, Kang-Hee,Chae, Chang-U 한국주거학회 2006 한국주거학회 논문집 Vol.17 No.5

Building components have been deteriorated by various factors such as location, a building type, a surrounding environment and so on. In addition, each component has a peculiar characteristics, compared with other components in properties of matter an used part. Building components would be required to maintain its function and performance to provide the resident with a decent living condition. It is important to decide the repair time, scope and a required cost in repair plan, considering the each component's characteristics. In this parer, it aimed at providing the economic repair pattern to analyze the relation of the time-elapse and the cumulative repair cost in the apartment housing using 3rd quadratic function. Results of the study are as follows: First, the shape of the function for the economic repair is classified into two type. One is the continuous increase type of the cumulative cost which properly means the iterative repair type after built. The other is that the function has the maximum state at a point which means one-repair after its repair would be delayed to a scheduled time. Second, the iterative repair pattern would include window, roof proof, lighting and water supply pipe. The other repair pattern would include the paintings, heating pipe and sign board.

공동주택의 라이프사이클 에너지와 이산화탄소 추정에 관한 연구

이강희,채창우,Lee, Kang-Hee,Chae, Chang-U 한국주거학회 2008 한국주거학회 논문집 Vol.19 No.4

The environment has played a key role to improve the living condition and develop the industry. In building industries, we should consider the environment and mitigate the environmental affect. For mitigating the its affect, various areas of building technology have been developed and applied into filed work. In addition, the process in applying into field requires to conduct the assessment of the environmental affect and improve its applied technology. A lot of assessment methods are proposed in evaluate the building condition such as post-occupancy evaluation, life cycle management and life cycle assessment. Among these assessment methods, life cycle assessment is effectively utilized the environmental affect in building life cycle. Therefore, this paper aimed at analyzing the energy consumption and $CO_2$ emission in building life cycle, using the life cycle assessment and application of the example in apartment housing. This study shows that the maintenance and the production of building materials stage shares most of the amount of energy consumption and $CO_2$ emission and therefore plays an important role to planning the building in terms of the life cycle. Second, the other stages brings about a very small amount. It is important to decide the building shape and contents to mitigate the environmental affect in terms of material, volume, the pattern of the energy use and others.

공동주택의 관리비 추정모델 연구

이강희,양재혁,채창우,Lee, Kang-Hee,Yang, Jae-Hyuk,Chae, Chang-U 한국주거학회 2010 한국주거학회 논문집 Vol.21 No.2

The maintenance cost plays a important role to plan the scale of the apartment housing such as a number of household, building area and building type. Therefore, it is required to forecast the cost considering various maintenance characteristics. The maintenance characteristics are floor area, number of household, heating type, site area and etc.. In addition, the maintenance cost are classified into 5 area. These are a personal expense, facility maintenance cost, energy and water cost, insurance and sanitary cost. These five cost area are related with various characteristics and brought up the estimation model using the stepwise multiple regression analysis. The energy and heating cost share over the 50% in the total cost and the personal expense cost shares about 40%. The personal expense cost per area is 5,272 won/$m^2{\cdot}yr$ irregardless of heating type and the district heating type is a higher cost than other type. In facility maintenance cost, the central heating type is 2,015 won/$m^2{\cdot}yr$ and higher than other type. The estimation models have good statistics in each model. Most of the model have a determination coefficient over 0.7 and Durbin Watson value between 1.5 and 2.5.